Publikationen

2014

Müller C, Más Gómez N, Ruth P, Strauß O.
CaV1.3L-type channels, maxiK Ca2+-dependent K+ channels and bestrophin-1 regulate rhythmic photoreceptor outer
segment phagocytosis by retinal pigment epithelial cells. 
Cell Signal. 2014 May;26(5):968-78. doi: 10.1016/j.cellsig.2013.12.021. Epub 2014 Jan 7.

Koch MA, Rosenhammer B, Koschade SE, Braunger BM, Volz C, Jägle H, Tamm ER.
Myocilin modulates programmed cell death during retinal development.
Exp Eye Res. 2014 May 15;125C:41-52. [Epub ahead of print]

Karlstetter M, Sorusch N, Caramoy A, Dannhausen K, Aslanidis A, Fauser S, Boesl MR, Nagel-Wolfrum K, Tamm ER, Jägle H,
Stoehr H, Wolfrum U, Langmann T.
Disruption of the retinitis pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to progressive
retinal degeneration.
Hum Mol Genet. 2014 May 15. pii: ddu242. [Epub ahead of print]

Fuchshofer R, Kuespert S, Junglas B, Tamm ER.
The prostaglandin f2α analog fluprostenol attenuates the fibrotic effects of connective tissue growth factor on human trabecular
meshwork cells.
J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):237-45. doi: 10.1089/jop.2013.0205. Epub 2014 Feb 27.

Ratnapriya R, Zhan X, Fariss RN, Branham KE, Zipprer D, Chakarova CF, Sergeev YV, Campos MM, Othman M, Friedman JS,
Maminishkis A, Waseem NH, Brooks M, Rajasimha HK, Edwards AO, Lotery A, Klein BE, Truitt BJ, Li B, Schaumberg DA,
Morgan DJ, Morrison MA, Souied E, Tsironi EE, Grassmann F, Fishman GA, Silvestri G, Scholl HP, Kim IK, Ramke J, Tuo J,
Merriam JE, Merriam JC, Park KH, Olson LM, Farrer LA, Johnson MP, Peachey NS, Lathrop M, Baron RV, Igo RP Jr, Klein R,
Hagstrom SA, Kamatani Y, Martin TM, Jiang Y, Conley Y, Sahel JA, Zack DJ, Chan CC, Pericak-Vance MA, Jacobson SG,
Gorin MB, Klein ML, Allikmets R, Iyengar SK, Weber BH, Haines JL, Léveillard T, Deangelis MM, Stambolian D, Weeks DE,
Bhattacharya SS, Chew EY, Heckenlively JR, Abecasis GR, Swaroop A.
Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration.
Hum Mol Genet. 2014 Jun 4 [Epub ahead of print]

Goldhacker M, Rosengarth K, Plank T, Greenlee MW (2014).
The effect of feedback on performance and brain activation during perceptual learning.
Vision Research, 99, 99-110.

Anstis S, Greenlee MW (2014).
Contour erasure and filling-in: New observations.
i-Perception, 5(2), 79–86.

Volz C, Mirza M, Langmann T, Jägle H.
Retinal function in aging homozygous cln3 (δex7/8) knock-in mice.
Adv Exp Med Biol. 2014;801:495-501.

Karlstetter M, Langmann T.
Microglia in the aging retina.
Adv Exp Med Biol. 2014;801:207-12.

Aslanidis A, Karlstetter M, Walczak Y, Jägle H, Langmann T.
RETINA-Specific Expression of Kcnv2 Is Controlled by Cone-Rod Homeobox (Crx) and Neural Retina Leucine Zipper (Nrl).
Adv Exp Med Biol. 2014;801:31-41.

Zeilbeck LF, Müller B, Knobloch V, Tamm ER, Ohlmann A. (2014)
Differential angiogenic properties of lithium chloride in vitro and in vivo.
PLoS One 9(4):e95546.

Forkwa TK, Tamm ER, Ohlmann A. (2014)
Ambiguous role of glucocorticoids on survival of retinal neurons.
Adv. Exp. Med. Biol. 801:365-71.

Seitz R, Tamm ER.
Müller cells and microglia of the mouse eye react throughout the entire retina in response to the procedure of an intravitreal injection.
Adv Exp Med Biol. 2014;801:347-53.

Sippl C, Tamm ER.
What is the Nature of the RGC-5 Cell Line?
Adv Exp Med Biol. 2014;801:145-54.

Strauß O, Müller C, Reichhart N, Tamm ER, Gomez NM.
The role of bestrophin-1 in intracellular ca(2+) signaling.
Adv Exp Med Biol. 2014;801:113-9.

Braunger BM, Demmer C, Tamm ER.
Programmed cell death during retinal development of the mouse eye.
Adv Exp Med Biol. 2014;801:9-13.

Grassmann F, Heid IM, Weber BH.
Genetic risk models in age-related macular degeneration.
Adv Exp Med Biol. 801:291-300 (2014)

Brandl C, Zimmermann SJ, Milenkovic VM, Rosendahl SM, Grassmann F, Milenkovic A, Hehr U, Federlin M, Wetzel CH, Helbig H, Weber BH.
In-Depth Characterisation of Retinal Pigment Epithelium (RPE) Cells Derived from Human Induced Pluripotent Stem Cells (hiPSC).
Neuromolecular Med. 2014 May 7 [Epub ahead of print]

Karlstetter M, Sorusch N, Caramoy A, Dannhausen K, Aslanidis A, Fauser S, Boesl MR, Nagel-Wolfrum K, Tamm ER, Jägle H,
Stoehr H, Wolfrum U, Langmann T.
Disruption of the Retinitis Pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to
progressive retinal degeneration.
Hum Mol Genet. 2014 May 15.

Pauly D, Nagel BM, Reinders J, Killian T, Wulf M, Ackermann S, Ehrenstein B, Zipfel PF, Skerka C, Weber BH.
A Novel Antibody against Human Properdin Inhibits the Alternative Complement System and Specifically Detects Properdin
from Blood Samples.
PLoS One. 2014 May 5;9(5):e96371

Fleckenstein M, Schmitz-Valckenberg S, Lindner M, Bezatis A, Becker E, Fimmers R, Holz FG.
Fundus Autofluorescence in Age-Related Macular Degeneration Study Group. The "diffuse-trickling" fundus autofluorescence
phenotype in geographic atrophy.
Invest Ophthalmol Vis Sci. (2014) May 2;55(5):2911-20.

Zeilbeck LF, Müller B, Knobloch V, Tamm ER, Ohlmann A.
Differential angiogenic properties of lithium chloride in vitro and in vivo.
PLoS One. 2014 Apr 21;9(4):e95546.

Ersoy L, Ristau T, Hahn M, Karlstetter M, Langmann T, Dröge K, Caramoy A, den Hollander AI, Fauser S.
Genetic and environmental risk factors for age-related macular degeneration in persons 90 years and older.
Invest Ophthalmol Vis Sci. 2014 Mar 25;55(3):1842-7.

Langmann T, Ueffing M, Kirchhof B, Holz FG, Pauleikhoff D. [In Process Citation].
Klin Monbl Augenheilkd. 2014 Mar;231(3):266-8.

Fuchshofer R, Kuespert S, Junglas B, Tamm ER.
The prostaglandin f2α analog fluprostenol attenuates the fibrotic effects of connective tissue growth factor on human
trabecular meshwork cells.
J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):237-45.

Weber BH, Charbel Issa P, Pauly D, Herrmann P, Grassmann F, Holz FG.
The role of the complement system in age-related macular degeneration. Dtsch Arztebl Int. 2014 Feb 21;111(8):133-8.

Forkwa TK, Neumann ID, Tamm ER, Ohlmann A, Reber SO.
Short-term psychosocial stress protects photoreceptors from damage via corticosterone-mediated activation of the AKT pathway.
Exp Neurol. 2014 Feb;252:28-36.

Karlstetter M, Nothdurfter C, Aslanidis A, Moeller K, Horn F, Scholz R, Neumann H, Weber BH, Rupprecht R, Langmann T.
Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation
and phagocytosis.
J Neuroinflammation. 2014 Jan 8;11:3.


2013


Rosengarth K, Keck I, Brandl-Rühle S, Frolo J, Hufendiek K, Greenlee MW and Plank T.
Functional and structural brain modifications induced by oculomotor training in patients with age-related macular degeneration.
Front. Psychol. 4:428. doi: 10.3389/fpsyg.2013.00428 (2013).

Hernowo AT, Prins D, Baseler HA, Plank T, Gouws AD, Hooymans JM, Morland AB, Greenlee MW, Cornelissen FW.
Morphometric analyses of the visual pathways in macular degeneration.
Cortex. 2014 Jul;56:99-110. doi: 10.1016/j.cortex.2013.01.003. Epub 2013 Jan 16.

Seitz R, Tamm ER.
N-methyl-D-aspartate (NMDA)-mediated excitotoxic damage: A mouse model of acute retinal ganglion cell damage.
Methods Mol. Biol. 935, 99-109 (2013).

Zhan X, Larson DE, Wang C, Koboldt DC, Sergeev YV, Fulton RS, Fulton LL, Fronick CC, Branham KE, Bragg-Gresham J,
Jun G, Hu Y, Kang HM, Liu D, Othman M, Brooks M, Ratnapriya R, Boleda A, Grassmann F, von Strachwitz C, Olson LM,
Buitendijk GH, Hofman A, van Duijn CM, Cipriani V, Moore AT, Shahid H, Jiang Y, Conley YP, Morgan DJ, Kim IK, Johnson MP,
Cantsilieris S, Richardson AJ, Guymer RH, Luo H, Ouyang H, Licht C, Pluthero FG, Zhang MM, Zhang K, Baird PN, Blangero J,
Klein ML, Farrer LA, DeAngelis MM, Weeks DE, Gorin MB, Yates JR, Klaver CC, Pericak-Vance MA, Haines JL, Weber BH,
Wilson RK, Heckenlively JR, Chew EY, Stambolian D, Mardis ER, Swaroop A, Abecasis GR.
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration.
Nat Genet. 45:1375-9 (2013)

Fritsche LG, Chen W, Schu M, Yaspan BL, Yu Y, Thorleifsson G, Zack DJ, Arakawa S, Cipriani V, Ripke S, Igo RP Jr,
Buitendijk GH, Sim X, Weeks DE, Guymer RH, Merriam JE, Francis PJ, Hannum G, Agarwal A, Armbrecht AM, Audo I, Aung T,
Barile GR, Benchaboune M, Bird AC, Bishop PN, Branham KE, Brooks M, Brucker AJ, Cade WH, Cain MS, Campochiaro PA,
Chan CC, Cheng CY, Chew EY, Chin KA, Chowers I, Clayton DG, Cojocaru R, Conley YP, Cornes BK, Daly MJ, Dhillon B,
Edwards AO, Evangelou E, Fagerness J, Ferreyra HA, Friedman JS, Geirsdottir A, George RJ, Gieger C, Gupta N, Hagstrom SA,
Harding SP, Haritoglou C, Heckenlively JR, Holz FG, Hughes G, Ioannidis JP, Ishibashi T, Joseph P, Jun G, Kamatani Y,
Katsanis N, N Keilhauer C, Khan JC, Kim IK, Kiyohara Y, Klein BE, Klein R, Kovach JL, Kozak I, Lee CJ, Lee KE, Lichtner P,
Lotery AJ, Meitinger T, Mitchell P, Mohand-Saïd S, Moore AT, Morgan DJ, Morrison MA, Myers CE, Naj AC, Nakamura Y,
Okada Y, Orlin A, Ortube MC, Othman MI, Pappas C, Park KH, Pauer GJ, Peachey NS, Poch O, Priya RR, Reynolds R,
Richardson AJ, Ripp R, Rudolph G, Ryu E, Sahel JA, Schaumberg DA, Scholl HP, Schwartz SG, Scott WK, Shahid H,
Sigurdsson H, Silvestri G, Sivakumaran TA, Smith RT, Sobrin L, Souied EH, Stambolian DE, Stefansson H, Sturgill-Short GM,
Takahashi A, Tosakulwong N, Truitt BJ, Tsironi EE, Uitterlinden AG, van Duijn CM, Vijaya L, Vingerling JR, Vithana EN, Webster AR,
Wichmann HE, Winkler TW, Wong TY, Wright AF, Zelenika D, Zhang M, Zhao L, Zhang K, Klein ML, Hageman GS, Lathrop GM,
Stefansson K, Allikmets R, Baird PN, Gorin MB, Wang JJ, Klaver CC, Seddon JM, Pericak-Vance MA, Iyengar SK, Yates JR,
Swaroop A, Weber BH, Kubo M, Deangelis MM, Léveillard T, Thorsteinsdottir U, Haines JL, Farrer LA, Heid IM, Abecasis GR;
AMD Gene Consortium.
Seven new loci associated with age-related macular degeneration.
Nat Genet. 45:433-9 (2013)

Keilhauer CN, Fritsche LG, Guthoff R, Haubitz I, Weber BH.
Age-related macular degeneration and coronary heart disease: evaluation of genetic and environmental associations.
Eur J Med Genet. 56:72-9 (2013)

Tamm ER
[Functional morphology of the outflow pathways of aqueous humor and their changes in open angle glaucoma]. [Article in German]
Ophthalmologe. 2013 Nov;110(11):1026-35.

Mirza M, Volz C, Karlstetter M, Langiu M, Somogyi A, Ruonala MO, Tamm ER, Jägle H, Langmann T.
Progressive Retinal Degeneration and Glial Activation in the CLN6 (nclf) Mouse Model of Neuronal Ceroid Lipofuscinosis:
A Beneficial Effect of DHA and Curcumin Supplementation.
PLoS One. 2013 Oct 4;8(10):e75963.

Clark A, Tamm ER, Al-Ubaidi MR, Hollyfield JG.
On the use of immortalized ocular cell lines in vision research: the unfortunate story of RGC-5.
Exp Eye Res. 2013 Nov;116:433. doi: 10.1016/j.exer.2013.08.002. Epub 2013 Sep 7.

Langmann T.
Class A scavenger receptors shed light on immune cell recruitment and CNV.
Invest Ophthalmol Vis Sci. 2013 Sep 5;54(9):5971.

Tamm ER, Grehn F, Pfeiffer N.
Neuroprotection in glaucoma.
Cell Tissue Res. 2013 Aug;353(2):201-3.

Braunger BM, Pielmeier S, Demmer C, Landstorfer V, Kawall D, Abramov N, Leibinger M, Kleiter I, Fischer D, Jägle H, Tamm ER.
TGF-β signaling protects retinal neurons from programmed cell death during the development of the mammalian eye.
J Neurosci. 2013 Aug 28;33(35):14246-58.

Seitz R, Ohlmann A, Tamm ER.
The role of Müller glia and microglia in glaucoma.
Cell Tissue Res. 2013 Aug;353(2):339-45.

Tamm ER, Schmetterer L, Grehn F.
Status and perspectives of neuroprotective therapies in glaucoma: the European Glaucoma Society White Paper.
Cell Tissue Res. 2013 Aug;353(2):347-54.

Groh J, Kühl TG, Ip CW, Nelvagal HR, Sri S, Duckett S, Mirza M, Langmann T, Cooper JD, Martini R.
Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis.
Brain. 2013 Apr;136(Pt 4):1083-101.

Hlawatsch J, Karlstetter M, Aslanidis A, Lückoff A, Walczak Y, Plank M, Böck J, Langmann T. Sterile alpha motif containing 7
(samd7) is a novel crx-regulated transcriptional repressor in the retina.
PLoS One. 2013;8(4):e60633. 

Pollinger K, Hennig R, Ohlmann A, Fuchshofer R, Wenzel R, Breunig M, Tessmar J, Tamm ER, Goepferich A.
Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application.
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6115-20. 


Gómez NM, Tamm ER, Strauβ O.
Role of bestrophin-1 in store-operated calcium entry in retinal pigment epithelium.
Pflugers Arch. 2013 Apr;465(4):481-95.

Braunger BM, Ohlmann A, Koch M, Tanimoto N, Volz C, Yang Y, Bösl MR, Cvekl A, Jägle H, Seeliger MW, Tamm ER.
Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage.
Neurobiol Dis. 2013 Feb;50:1-12.

2012


Keilhauer CN, Fritsche LG, Guthoff R, Haubitz I, Weber BH.
Age-related macular degeneration and coronary heart disease: Evaluation of genetic and environmental associations.
Eur J Med Genet. 2013 Feb;56(2):72-9. doi: 10.1016/j.ejmg.2012.10.005. Epub 2012 Oct 25.

Braunger B.M., Ohlmann A., Koch M., Tanimoto N., Volz C., Yang Y., Bösl M.R., Cvekl A., Jägle H., Seeliger M.W., Tamm E.R. (2012).
Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage.
Neurobiol. Dis. 50, 1-12.

Mas Gomez, Tamm, Strauß (2012)
Role of bestrophin-1 in store-operated calcium entry in retinal pigment epithelium.
Pflugers Arch. 2013 Apr;465(4):481-95. doi: 10.1007/s00424-012-1181-0. Epub 2012 Dec 4.

Plank T, Frolo J, Farzana F, Brandl-Rühle S, Renner AB, Greenlee MW.
Neural correlates of visual search in patients with hereditary retinal dystrophies.
Hum Brain Mapp. 2013 Oct;34(10):2607-23. doi: 10.1002/hbm.22088. Epub 2012 Apr 16.

Herrnberger L., Ebner K., Junglas B., Tamm E.R. (2012).
The role of plasmalemma vesicle-associated protein (PLVAP) in endothelial cells of Schlemm's canal and ocular capillaries.
Exp. Eye Res. 105, 27-33

Tamm E.R., Ohlmann A. (2012)
Entwicklung des menschlichen Auges. [Development of the human eye].
Ophthalmologe, 109, 911-28.

Herrnberger L., Seitz R., Kuespert S. Bösl M.R., Fuchshofer R., Tamm E.R. (2012).
Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice.
Histochem Cell Biol. 138,709-24.

Zach F, Grassmann F, Langmann T, Sorusch N, Wolfrum U, Stöhr H.
The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association.
Hum Mol Genet. 2012 Nov 1;21(21):4573-86. doi: 10.1093/hmg/dds268. Epub 2012 Jul 12.

Junglas B, Kuespert S, Seleem AA, Struller T, Ullmann S, Bösl M, Bosserhoff A, Köstler J, Wagner R, Tamm ER, Fuchshofer R.
Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork.
Am J Pathol. 2012 Jun;180(6):2386-403.

Ohlmann A, Tamm ER.
Norrin: molecular and functional properties of an angiogenic and neuroprotective growth factor.
Prog Retin Eye Res. 2012 May;31(3):243-57.

Grassmann F, Fritsche LG, Keilhauer CN, Heid IM, Weber BH.
Modelling the genetic risk in age-related macular degeneration.
PLoS One. 2012;7(5):e37979.

Baas DC, Ho L, Tanck MW, Fritsche LG, Merriam JE, van het Slot R, Koeleman BP, Gorgels TG, van Duijn CM, Uitterlinden AG, de Jong PT,
Hofman A, ten Brink JB, Vingerling JR, Klaver CC, Dean M, Weber BH, Allikmets R, Hageman GS, Bergen AA.
Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration.
Mol Vis. 2012;18:657-74.

Fritsche LG, Fleckenstein M, Fiebig BS, Schmitz-Valckenberg S, Bindewald-Wittich A, Keilhauer CN, Renner AB, Mackensen F, Mößner A,
Pauleikhoff D, Adrion C, Mansmann U, Scholl HP, Holz FG, Weber BH.
A subgroup of age-related macular degeneration is associated with mono-allelic sequence variants in the ABCA4 gene.
Invest Ophthalmol Vis Sci. 2012 Apr 30;53(4):2112-8.

Sofat R, Casas JP, Webster AR, Bird AC, Mann SS, Yates JR, Moore AT, Sepp T, Cipriani V, Bunce C, Khan JC, Shahid H, Swaroop A,
Abecasis G, Branham KE, Zareparsi S, Bergen AA, Klaver CC, Baas DC, Zhang K, Chen Y, Gibbs D, Weber BH, Keilhauer CN, Fritsche LG,
Lotery A, Cree AJ, Griffiths HL, Bhattacharya SS, Chen LL, Jenkins SA, Peto T, Lathrop M, Leveillard T, Gorin MB, Weeks DE, Ortube MC,
Ferrell RE, Jakobsdottir J, Conley YP, Rahu M, Seland JH, Soubrane G, Topouzis F, Vioque J, Tomazzoli L, Young I, Whittaker J,
Chakravarthy U, de Jong PT, Smeeth L, Fletcher A, Hingorani AD.
Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype.
Int J Epidemiol. 2012 Feb;41(1):250-62

Braunger B.M., Tamm E.R. (2012).
The different functions of norrin.
Adv. Exp. Med. Biol., 723, 679-683.

Fuchshofer R, Tamm ER.
The role of TGF-β in the pathogenesis of primary open-angle glaucoma.
Cell Tissue Res. 2012 Jan;347(1):279-90.

Ohlmann A., Merkl R., Tamm E.R. (2012).
Focus on Molecules: Norrin.
Exp. Eye Res., 102,109-110.



2011

Beer AL, Plank T, Greenlee MW.
Diffusion tensor imaging shows white matter tracts between human auditory and visual cortex.
Exp Brain Res. 2011 Sep;213(2-3):299-308.

Karlstetter M, Lippe E, Walczak Y, Moehle C, Aslanidis A, Mirza M, Langmann T.
Curcumin is a potent modulator of microglial gene expression and migration.
J Neuroinflammation. 2011 Sep 29;8:125.

Sippl C, Bosserhoff AK, Fischer D, Tamm ER.
Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins.
Exp Eye Res. 2011 Aug 27.

Milenkovic VM, Röhrl E, Weber BH, Strauss O.
Disease-associated missense mutations in bestrophin-1 affect cellular trafficking and anion conductance.
J Cell Sci. 2011 Sep 1;124(Pt 17):2988-96.

Fuchshofer R.
The pathogenic role of transforming growth factor-β2 in glaucomatous damage to the optic nerve head.
Exp Eye Res. 2011 Aug;93(2):165-9.

Ohlmann A., Merkl R., Tamm ER.
Focus on Molecules: Norrin.
Exp. Eye Res., Jun 30. [Epub ahead of print] 

Plank T, Frolo J, Brandl-Rühle S, Renner AB, Hufendiek K, Helbig H, Greenlee MW.
Gray matter alterations in visual cortex of patients with loss of central vision due to hereditary retinal dystrophies.
Neuroim
age. 2011 Jun 1;56(3):1556-65.

Tamm ER
Entwicklung des Kammerwinkels und kongenitales Glaukom [Development of the iridocorneal angle and congenital glaucoma].
Ophthalmologe, 108, 610-617.
 
Kritzenberger M, Junglas B, Framme C, Helbig H, Gabel V-P, Fuchshofer R, Tamm ER, Hillenkamp J
Different collagen types define two types of idiopathic epiretinal membranes.
Histopathology, ;58, 953-965. 

Milenkovic VM, Krejcova S, Reichhart N, Wagner A, Strauß O.
Interaction of Bestrophin-1 and Ca Channel β-Subunits: Identification of New Binding Domains on the Bestrophin-1 C-Terminus. 
PLoS One. 2011 Apr 29;6(4):e19364.

Friedrich U, Stöhr H, Hilfinger D, Loenhardt T, Schachner M, Langmann T, Weber BH.
The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis.
Hum Mol Genet. 2011 Mar 15;20(6):1132-42. Epub 2010 Dec 31.

Friedrich U, Myers CA, Fritsche LG, Milenkovich A, Wolf A, Corbo JC, Weber BH.
Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due
to protein deficiency.
Hum Mol Genet. 2011 Apr 1;20(7):1387-99. Epub 2011 Jan 20.

Kraus D, Karlstetter M, Walczak Y, Hilfinger D, Langmann T, Weber BH.
Retinal expression of the X-linked juvenile retinoschisis (RS1) gene is controlled by an upstream CpG island and two opposing CRX-bound regions.
Biochim Biophys Acta. 2011 Mar 14. Epub 2011 Mar 23.


Gallenberger M, Meinel DM, Kroeber M, Wegner M, Milkereit P, Boesl MR, Tamm ER.
Lack of WDR36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro.
Hum Mol Genet. 2011 Feb 1;20(3):422-35. Epub 2010 Nov 3.

Fuchshofer R, Kottler UB, Ohlmann AV, Schloetzer-Schrehardt U, Juenemann A, Kruse FE, Ohlmann A.
SPARC is expressed in scars of the Tenon's capsule and mediates scarring properties of human Tenon's fibroblasts in vitro.
Mol Vis. 2011 Jan 19;17:177-85.


2010

Fritsche LG, Lauer N, Hartmann A, Stippa S, Keilhauer CN, Oppermann M, Pandey MK, Köhl J, Zipfel PF, Weber BH, Skerka C.
An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related
macular degeneration (AMD). Hum Mol Genet. 2010 Dec 1;19(23):4694-704. Epub 2010 Sep 15.

He S, Pirity MK, Wang WL, Wolf L, Chauhan BK, Cveklova K, Tamm ER, Ashery-Padan R, Metzger D, Nakai A, Chambon P, Zavadil J, Cvekl A.
Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation.
Epigenetics Chromatin. 2010 Nov 30;3(1):21.

Milenkovic VM, Brockmann M, Stohr H, Weber BH, Strauss O.
Evolution and functional divergence of the anoctamin family of membrane proteins. 
BMC Evol Biol. 2010 Oct 21;10(1):319. 

Karlstetter M, Walczak Y, Weigelt K, Ebert S, Van den Brulle J, Schwer H, Fuchshofer R, Langmann T.

The Novel Activated Microglia/Macrophage WAP Domain Protein, AMWAP, Acts as a Counter-Regulator of Proinflammatory Response.
J Immunol.
 
2010 Sep 15;185(6):3379-90. Epub 2010 Aug 13.

Langmann T, Di Gioia SA, Rau I, Stöhr H, Maksimovic NS, Corbo JC, Renner AB, Zrenner E, Kumaramanickavel G, Karlstetter M,
Arsenijevic Y, Weber BH, Gal A, Rivolta C.
Nonsense Mutations in FAM161A Cause RP28-Associated Recessive Retinitis Pigmentosa.
Am J Hum Genet. 
2010 Sep 10;87(3):376-81. Epub 2010 Aug 12.

Corbo JC, Lawrence KA, Karlstetter M, Myers CA, Abdelaziz M, Dirkes W, Weigelt K, Seifert M, Benes V, Fritsche LG, Weber BH, Langmann T.
CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors.
Genome Res.
2010 Nov;20(11):1512-25. Epub 2010 Aug 6.

Langmann T, Rehli M.
Editorial.
Immunobiology. 2010 Sep-Oct;215(9-10):673.

Karlstetter M, Ebert S, Langmann T.
Microglia in the healthy and degenerating retina: Insights from novel mouse models.
Immunobiology. 2010 September -October;215(9-10):685-691.

Reichhart N, Milenkovic VM, Halsband CA, Cordeiro S, Strauß O.
Effect of bestrophin-1 on L-type Ca(2+) channel activity depends on the Ca(2+) channel beta-subunit.
Exp Eye Res. 
2010 Nov;91(5):630-9. Epub 2010 Aug 7.

Cordeiro S, Strauss O.
Expression of Orai genes and I(CRAC) activation in the human retinal pigment epithelium.
Graefes Arch Clin Exp Ophthalmol. 2011 Jan; 246(1):47-54. Epub 2010 Jul 6.   
 

Ruether K, Feigenspan A, Pirngruber J, Leitges M, Baehr W, Strauss O.
PKC{alpha} is Essential for the Proper Activation and Termination of the Rod Bipolar Cell Response.
Invest Ophthalmol Vis Sci. 
2010 Nov;51(11):6051-8. Epub 2010 Jun 16.

Cordeiro S, Seyler S, Stindl J, Milenkovic VM, Strauss O.
Heat-Sensitive TRPV Channels Regulate VEGF-A Secretion in Retinal Pigment Epithelial Cells.
Invest Ophthalmol Vis Sci. 
2010 Nov;51(11):6001-8. Epub 2010 Jun 10.

Milenkovic VM, Brockmann M, Meyer C, Desch M, Schweda F, Kurtz A, Todorov V, Strauss O.
Regulation of the renin expression in the retinal pigment epithelium by systemic stimuli.
Am J Physiol Renal Physiol. 2010 Aug;299(2):F396-403. Epub 2010 Jun 2.

Kroeber M, Davis N, Holzmann S, Kritzenberger M, Shelah-Goraly M, Ofri R, Ashery-Padan R, Tamm ER.
Reduced Expression of Pax6 in Lens and Cornea of Mutant Mice Leads to Failure of Chamber Angle Development and Juvenile Glaucoma.

Hum Mol Genet. 1;19(17):3332-42. Epub 2010 Jun 10.

Seitz R, Hackl S, Seibuchner T, Tamm ER, Ohlmann A.
Norrin mediates neuroprotective effects on retinal ganglion cells via activation of the Wnt/beta-catenin signaling pathway
and the induction of neuroprotective growth factors in Muller cells.

J Neurosci. 2010 Apr 28;30(17):5998-6010.

Neussert R, Müller C, Milenkovic VM, Strauß O.
The presence of bestrophin-1 modulates the Ca(2+) recruitment from Ca (2+) stores in the ER.

Pflugers Arch. 2010 Apr 22. 

Ohlmann A, Seitz R, Braunger B, Seitz D, Bösl MR, Tamm ER.
Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice.
J Neurosci. 2010 Jan 6;30(1):183-93.

Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, Moehle C, Fuchshofer R, Langmann T.
Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype.
J Neuroinflammation. 2010 Jan 14;7:3.

Ohlmann A, Seitz R, Braunger B, Seitz D, Boesl MR, Tamm ER. 
Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice.
J Neurosci. 2010 Jan 6;30(1):183-93.

 

2009

Konz DD, Fluegel-Koch C, Ohlmann A, Tamm ER.
Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma. 
Graefes Arch Clin Exp Ophthalmol. 2009 Dec;247(12):1643-9. Epub 2009 Aug 7.

Hendig D, Langmann T, Zarbock R, Schmitz G, Kleesiek K, Goetting C.
Characterization of the ATP-binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line.
Mol Cell Biochem. 2009 Aug;328(1-2):85-92.

Brandl C, Florian C, Driemel O, Weber BH, Morsczeck C.
Identification of neural crest-derived stem cell-like cells from the corneal limbus of juvenile mice.
Exp Eye Res. 2009 Aug;89(2):209-17.

Ebert S, Weigelt K, Walczak Y, Drobnik W, Mauerer R, Hume DA, Weber BH, Langmann T.
Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration.

J Neurochem. 2009 Jul 17. 

Qi JH, Dai G, Luthert P, Chaurasia S, Hollyfield J, Weber BH, Stoehr H, Anand-Apte B.
S156C Mutation in Tissue Inhibitor of Metalloproteinases-3 Induces Increased Angiogenesis.
J Biol Chem. 2009 Jul 24;284(30):19927-36.

Fritsche LG, Freitag-Wolf S, Bettecken T, Meitinger T, Keilhauer CN, Krawczak M, Weber BH.
Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene.
Hum Mutat. 2009 Jul;30(7):1048-53.

Renner AB, Fiebig BS, Cropp E, Weber BH, Kellner U.
Progression of retinal pigment epithelial alterations during long-term follow-up in female carriers of choroideremia and report of a
novel CHM mutation.
Arch Ophthalmol. 2009 Jul;127(7):907-12.

Krumbiegel M, Pasutto F, Mardin CY, Weisschuh N, Paoli D, Gramer E, Zenkel M, Weber BH, Kruse FE, Schlotzer-Schrehardt UM, Reis A.
Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2796-801.

Kellner U, Kellner S, Weber BH, Fiebig B, Weinitz S, Ruether K.
Lipofuscin- and melanin-related fundus autofluorescence visualize different retinal pigment epithelial alterations in patients with retinitis pigmentosa.

Eye. 2009 Jun;23(6):1349-59.

Allikmets R, Bergen AA, Dean M, Guymer RH, Hageman GS, Klaver CC, Stefansson K, Weber BH.
International Age-related Macular Degeneration Genetics Consortium. Geographic atrophy in age-related macular degeneration and TLR3.
N Engl J Med. 2009 May 21;360(21):2252-4; author reply 2255-6.

Stoehr H, Heisig JB, Benz PM, Schöberl S, Milenkovic VM, Strauss O, Aartsen WM, Wijnholds J, Weber BH, Schulz HL.
TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.
J Neurosci. 2009 May 27;29(21):6809-18.

Babilas P, Fiebig BS, Aslanidis C, Hansen J, Röcken C, Schroeder J, Schmitz G, Weber BH, Landthaler M, Vogt T.
Identification of an oncostatin M receptor mutation associated with familial primary cutaneous amyloidosis.
Br J Dermatol. 2009 May 21. 

Kellner S, Kellner U, Weber BH, Fiebig B, Weinitz S, Ruether K.
Lipofuscin- and melanin-related fundus autofluorescence in patients with ABCA4-associated retinal dystrophies.
Am J Ophthalmol. 2009 May;147(5):895-902, 902.e1.

Renner AB, Fiebig BS, Weber BH, Wissinger B, Andreasson S, Gal A, Cropp E, Kohl S, Kellner U.
Phenotypic variability and long-term follow-up of patients with known and novel PRPH2/RDS gene mutations.
Am J Ophthalmol. 2009 Mar;147(3):518-530.e1.

Weigelt K, Lichtinger M, Rehli M, Langmann T.
Transcriptomic profiling identifies a PU.1 regulatory network in macrophages.
Biochem Biophys Res Commun. 2009 Mar 6;380(2):308-12.

Yang R, Chen B, Hemminki K, Wappenschmidt B, Engel C, Sutter C, Ditsch N, Weber BH, Niederacher D, Arnold N, Meindl A, Bartram CR,
Schmutzler RK, Burwinkel B. Polymorphisms in BRCA2 resulting in aberrant codon-usage and their analysis on familial breast cancer risk.
Breast Cancer Res Treat. 2009 Feb 20. 

Mauerer R, Ebert S, Langmann T.
High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1
in human macrophages.
Exp Mol Med. 2009 Feb 28;41(2):126-32.

Tchatchou S, Jung A, Hemminki K, Sutter C, Wappenschmidt B, Bugert P, Weber BH, Niederacher D, Arnold N, Varon-Mateeva R, Ditsch N,
Meindl A, Schmutzler RK, Bartram CR, Burwinkel B.
A variant affecting a putative miRNA target site in estrogen receptor (ESR) 1 is associated  with breast cancer risk in premenopausal women.
Carcinogenesis. 2009 Jan;30(1):59-64.

Foerster JR, Lochnit G, Stoehr H.
Proteomic analysis of the membrane palmitoylated protein-4 (MPP4)-associated protein complex in the retina.
Exp Eye Res. 2009 Jan;88(1):39-48.

Stoecker K, Weigelt K, Ebert S, Karlstetter M, Walczak Y, Langmann T.
Induction of STAP-1 promotes neurotoxic activation of microglia.
Biochem Biophys Res Commun. 2009 Jan 30;379(1):121-6.

Farwick A, Dasch B, Weber BH, Pauleikhoff D, Stoll M, Hense HW.
Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina study.
Eye. 2009 Jan 23. 

Walczak Y, Ebert S, Kaschkoetoe J, Schild T, Ferlinz A, Goni R, Langmann T.
Expression profiling of microglia and macrophages using a novel lipidomic TaqMan array and TaqMan express plates.
Biotechniques 2009;46(4):315-17.

Langmann T, Ebert S, Walczak Y, Weigelt K, Ehrengruber MU, Stiewe T, Weber BH.
Induction of early growth response-1 mediates microglia activation in vitro but is dispensable in vivo.
Neuromolecular Med. 2009;11(2):87-96.

Wolf L.V., Yang Y., Wang J., Xie Q., Braunger B., Tamm E.R., Zavadil J., Cvekl A. 
Identification of pax6-dependent gene regulatory networks in the mouse lens.
PLoS ONE 4, e4159.

Tamm E.R., Ethier C.R.
Current aspects of aqueous humor dynamics and glaucoma. Exp. Eye Res. 88. 618-9.

Tamm E.R.
The trabecular meshwork outflow pathways: structural and functional aspects.
Exp Eye Res. 88, 648-55.

Fuchshofer R., Tamm E.R.
Modulation of extracellular matrix turnover in the trabecular meshwork.
Exp. Eye Res. 88, 683-8.

Fuchshofer R., Stephan D.A., Russell P., Tamm E.R.
Gene expression profiling of TGFβ2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-β2 signaling. 
xp. Eye Res. 88, 1020-32.

Junglas B., Yu A.H.L., Welge-Lüssen U., Tamm E.R. Fuchshofer R.
Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells.
Exp. Eye Res. 88, 1065-75.

Davis N., Yoffe C., Raviv S., Antes R., Berger J., Holzmann S., Stoykova A., Overbeek P.A., Tamm E.R., Ashery-Padan R. 
Pax6 dosage requirements in iris and ciliary body differentiation.

Dev Biol. 2009.

 

2008

Hendig D, Langmann T, Kocken S, Zarbock R, Szliska C, Schmitz G, Kleesiek K, Götting C,
Gene expression profiling of ABC transporters in dermal fibroblasts of pseudoxanthoma elasticum patients identifies new candidates involved
in PXE pathogenesis.

Lab Invest. 2008 Dec;88(12):1303-15.

Decker E, Stellzig-Eisenhauer A, Fiebig BS, Rau C, Kress W, Saar K, Rüschendorf F, Hubner N, Grimm T, Weber BH.
PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption.
Am J Hum Genet. 2008 Dec;83(6):781-6.

Langmann T, Lai CC, Weigelt K, Tam BM, Warneke-Wittstock R, Moritz OL, Weber BH.
CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene.
Nucleic Acids Res. 2008 Nov;36(20):6523-34.

Florian C, Langmann T, Weber BH, Morsczeck C.
Murine Müller cells are progenitor cells for neuronal cells and fibrous tissue cells.
Biochem Biophys Res Commun. 2008 Sep 19;374(2):187-91.

Van den Brulle J*, Fischer M*, Langmann T*, Horn G, Waldmann T, Arnold S, Fuhrmann M, Schatz O, O'Connell T, O'Connell D,
Auckenthaler A, Schwer H.
A novel solid phase technology for high-throughput gene synthesis.
Biotechniques. 2008 Sep;45(3):340-3. *these authors contributed equally

Ebert S, Schoeberl T, Walczak Y, Stoecker K, Stempfl T, Moehle C, Weber BH, Langmann T.
Chondroitin sulfate disaccharide stimulates microglia to adopt a novel regulatory phenotype.
J Leukoc Biol. 2008 Sep;84(3):736-40.

Weigelt K, Moehle C, Stempfl T, Weber B, Langmann T.
An integrated workflow for analysis of ChIP-chip data.
Biotechniques. 2008 Aug;45(2):131-2, 134, 136 passim.

Janssen A, Hoellenriegel J, Fogarasi M, Schrewe H, Seeliger M, Tamm ER, Ohlmann A, May CA, Weber BH, Stöhr HB.
Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3.
Invest Ophthalmol Vis Sci. 2008 Jul;49(7):2812-22.

Scholl HP, Charbel Issa P, Walier M, Janzer S, Pollok-Kopp B, Boerncke F, Fritsche LG, Chong NV, Fimmers R, Wienker T, Holz FG,
Weber BH, Oppermann M.
Systemic complement activation in age-related macular degeneration.
PLoS ONE. 2008 Jul 2;3(7):e2593.

Fritsche LG, Loenhardt T, Janssen A, Fisher SA, Rivera A, Keilhauer CN, Weber BH.
Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA.
Nat Genet. 2008 Jul;40(7):892-6.

Fogarasi M, Janssen A, Weber BH, Stoehr H.
Molecular dissection of TIMP3 mutation S156C associated with Sorsby fundus dystrophy.
Matrix Biol. 2008 Jun;27(5):381-92.

Janssen A, Min SH, Molday LL, Tanimoto N, Seeliger MW, Hauswirth WW, Molday RS, Weber BH.
Effect of late-stage therapy on disease progression in AAV-mediated rescue of photoreceptor cells in the retinoschisin-deficient mouse.
Mol Ther. 2008 Jun;16(6):1010-7.

Pasutto F, Krumbiegel M, Mardin CY, Paoli D, Lämmer R, Weber BH, Kruse FE, Schlötzer-Schrehardt U, Reis A.
Association of LOXL1 Common Sequence Variants in German and Italian Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma
.
Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1459-63.

Renner AB, Kellner U, Fiebig B, Cropp E, Foerster MH, Weber BH.
ERG variability in X-linked congenital retinoschisis patients with mutations in the RS1 gene and the diagnostic importance of fundus
autofluorescence and OCT.

Doc Ophthalmol. 2008 Mar;116(2):97-109.

Milenkovic VM, Langmann T, Schreiber R, Kunzelmann K, Weber BH.
Molecular evolution and functional divergence of the bestrophin protein family.
BMC Evol Biol. 2008 Feb 28;8:72.

Yang R, Frank B, Hemminki K, Bartram CR, Wappenschmidt B, Sutter C, Kiechle M, Bugert P, Schmutzler RK, Arnold N, Weber BH,
Niederacher D, Meindl A, Burwinkel B.
SNPs in ultraconserved elements and familial breast cancer risk.
Carcinogenesis. 2008 Feb;29(2):351-5.

Pasutto F, Mardin CY, Michels-Rautenstrauss K, Weber BH, Sticht H, Chavarria-Soley G, Rautenstrauss B, Kruse F, Reis A.
Profiling of WDR36 Missense Variants in German Patients with Glaucoma.
Invest Ophthalmol Vis Sci. 2008 Jan;49(1):270-4.

About the Authors: Langmann
Laboratory and Center of Excellence for Fluorescent Bioanalytics. University of Regensburg, Institute of Human Genetics, Regensburg, Germany.

BioTechniques.
2008 45(2): p 118

Wurm, A. Sock, E., Fuchshofer, R., Wegner, M., Tamm, ER. 
Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11.
Exp. Eye Res., 86:895-907. 

Paper W, Kroeber M, Heersink S, Stephan DA, Fuchshofer R, Russell P, Tamm ER. 
Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression.
Exp Eye Res., 87:257-67. 

Wimmers S, Coeppicus L, Rosenthal R, Strauss O. 
Expression profile of voltage-dependent Ca2+ channel subunits in the human retinal pigment epithelium.
Graefes Arch Clin Exp Ophthalmol. 246(5):685-92


Karl MO, Kroeger W, Wimmers S, Milenkovic VM, Valtink M, Engelmann K, Strauss O. 
Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by retinal pigment epithelium.
Cell Signal. 20:1159-68.

Tamm E.R..
Molecular Approaches to Glaucoma: Intriguing Clues for Pathology. In: Current Topics in Membranes, The Eye’s Aqueous
Humor (Ed. Civan M.M.).
Elsevier Inc.  pp. 379-425.

Tamm E.R.
The Functional Role of Myocilin in Glaucoma. In: Ophthalmology Research: Mechanisms of the Glaucomas
(Eds. Shields M.B., Tombran-Tink J., Barnstable C.J.). Humana Press, Totowa, NJ, pp. 219-231.

Tamm E.R., Kellenberger A.
Aqueous Humor Dynamics and Trabecular Meshwork. In: Eye, Retina, and Visual System of the Mouse.
III Organization of the Adult Mouse Eye and Central Visual System (Eds. Chalupa L.M., Williams R.W.). MIT Press, p. 129-33.