Interdisciplinary publications in the preparation phase of the Research Unit (until January 2006)

Project Straub/Falk with others

Prof. Dr. J. Grifka, Director of the Department of Orthopaedic Surgery of the University of Regensburg, and Dr. S. Anders, consultant in this department, are representative for the excellent cooperation with this group (Dr. S. Grässel).

Prof. Dr. F. Hofstädter, Director of the Institute of Pathology of the University of Regensburg is representative for the excellent cooperation with this department (Dr. T. Schubert, Prof. Dr. A. Bosserhoff).

Miller LE, Grifka J, Schölmerich J, Straub RH. Norepinephrine from synovial tyrosine hydroxylase and CD163 positive cells is a strong indicator of synovial inflammation in rheumatoid arthritis. J. Rheumatol. 2002;29:427-435.

Bataille F, Klebl F, Rümmele P, Straub RH, Wild P, Schölmerich J, Hofstädter F. Histopathologic parameters as predictors for the course of Crohn’s disease. Virchow Arch. 2003;443:501-507

Miller LE, Weidler C, Falk W, Angele P, Grifka J, Schölmerich J, Straub RH. The prevalence of Semaphorine 3C, a repellent of sympathetic nerve fibers, is increased in the synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 2004;50:1156-1163.

Straub RH, Weidler C, Demmel B, Herrmann M, Kees F, Schmidt M, Schölmerich J, Schedel J. Renal clearance and excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus. Ann. Rheum. Dis., 2004;63:961-968.

Weidler C, Kröll R, Miller LE, Schölmerich J, Grifka J, Straub RH. Low density of CD1+ cells in the synovial tissue of patients with rheumatoid arthritis: Interrelation with classical inflammatory markers and medication. Clin. Exp. Rheumatol. 2004;22:433-440

Weidler C, Holzer C, Harbuz M, Hofbauer R, Angele P, Schölmerich J, Straub RH. Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium. Ann. Rheum. Dis. 2005;64:13-20.

Schubert TEO, Weidler C, Lerch K, Hofstädter F, Straub RH. Achilles tendinosis is associated with sprouting of substance P positive nerve fibres. Ann. Rheum. Dis. 2005;64:1083-1086.

Schmidt M, Weidler C, Naumann H, Anders S, Schölmerich J, Straub RH. Reduced capacity for the reactivation of glucocorticoids in rheumatoid arthritis synovial cells: possible role of the sympathetic nervous system? Arthritis Rheum. 2005;52:1711-1720.

Schmidt M, Weidler C, Naumann H, Anders S, Schölmerich J, Straub RH. Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes - androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens. Arthritis Res Ther. 2005;7:R938-R948.

Schubert TEO, Weidler C, Borisch N, Schubert C, Hofstädter F, Straub RH. Dupuytren’s contracture is associated with sprouting of SP-positive nerve fibers and infiltration by mast cells. Ann. Rheum. Dis., in press.

Radons J, Falk W, Schubert TEO. Interleukin-10 does not affect IL-1-induced interleukin-6 and metal-loproteinase production in human chondrosarcoma cells, SW1353. Int J Mol Med, in press.

Radons J, Bosserhoff AK, Grässel S, Falk W, Schubert TEO. p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes. Int J Mol Med, in press.

Submitted

Capellino S, Weidler C, Anders S, Baerwald CGO, Buttgereit F, Straub RH. Placental growth factor–1 (PlGF-1) is related to vascularization, DHEAS to DHEA conversion, and aromatase expression in patients with arthritis – a placental role of PlGF-1 in the synovium.

Project Angele with others

Angele P, Faltermeier H, Kujat R, Englert C, Moeller HD, Nerlich M. Amplifikationsoptimierung humaner Chondrozyten durch Wachstumsfaktoren. Acta Chir. Austriaca 1999;31:257-260.

Angele P, Schumann D, Angele M, Kinner B, Englert C, Hente R, Füchtmeier B, Nerlich M, Neumann C, Kujat R. Cyclic, mechanical compression of mesenchymal progenitor cells enhances the expression of chondrogenic markers in tissue engineering scaffolds. Biorheology 2004;41:335-346.

Angele P, Abke J, Kujat R, Faltermeier H, Schumann D, Nerlich M, Kinner B, Englert C, Ruszczak Z, Mehrl R, Mueller R. Influence of different collagen species on physico-chemical properties of crosslinked collagen matrices. Biomaterials 2004;25:2831-2841.

Miller LE, Weidler C, Falk W, Angele P, Grifka J, Schölmerich J, Straub RH. The prevalence of Semaphorine 3C, a repellent of sympathetic nerve fibers, is increased in the synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 2004;50:1156-1163.

Kellner K, Tessmar J, Milz S, Angele P, Nerlich M, Schulz MB, Blunk T, Göpferich A. PEGylation does not impair insulin efficacy in three-dimensional cartilage culture: an investigation toward biomimetic polymers. Tissue Eng. 2004;10:429-440.

Weidler C, Holzer C, Harbuz M, Hofbauer R, Angele P, Schölmerich J, Straub RH. Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium. Ann. Rheum. Dis. 2005;64:13-20.

Mueller R, Abke J, Schnell E, Macionczyk F, Gbureck U, Mehrl R, Ruszczak Z, Kujat R, Englert C, Nerlich M, Angele P. Surface engineering of stainless steel materials by tantalum coating and collagen immobilization to improve implant biocompatibility. Biomaterials. 2005;26:6962-6972.

Angele P, Zellner J, Englert C, Nerlich M. Surgical treatment options for focal articular lesions – mi-crofracture, osteochondral transplantation. Akt Traumatol 2005;35:255-259.

Appel B, Maschke A, Weiser B, Sarhan H, Englert C, Angele P, Blunk T, Göpferich A., Lipidic implants for controlled release of bioactive insulin: Effects on cartilage engineered in vitro. Int J Pharm 2005, in press.

Submitted

Englert C, Thalmeier U, Fierlbeck J, Bender A, Lehn N, Angele P. Staphylococcus aureus joint infection increased by osteoarthritis.

Angele P, Mueller R, Schumann D, Englert C, Zellner J, Johnstone B, Yoo JU, Angele MK, Nerlich M, Kujat R. Esterified hyaluronan-gelatin composite polymers with improved cell binding- and chondroge-nic differentiation characteristics of mesenchymal stem cells.

Project Grässel with others

Prof. Dr. J. Grifka, Director of the Department of Orthopaedic Surgery of the University of Regensburg, and Dr. S. Anders, consultant in this department, are representative for the excellent cooperation with Project #1 and #2 (Prof. Dr. R.H. Straub, Prof. Dr. W. Falk).

Miller LE, Grifka J, Schölmerich J, Straub RH. Norepinephrine from synovial tyrosine hydroxylase and CD163 positive cells is a strong indicator of synovial inflammation in rheumatoid arthritis. J. Rheumatol. 2002;29:427-435.

Miller LE, Weidler C, Falk W, Angele P, Grifka J, Schölmerich J, Straub RH. The prevalence of Semaphorine 3C, a repellent of sympathetic nerve fibers, is increased in the synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 2004;50:1156-1163.

Weidler C, Kröll R, Miller LE, Schölmerich J, Grifka J, Straub RH. Low density of CD1+ cells in the synovial tissue of patients with rheumatoid arthritis: Interrelation with classical inflammatory markers and medication. Clin. Exp. Rheumatol. 2004;22:433-440

Schmidt M, Weidler C, Naumann H, Anders S, Schölmerich J, Straub RH. Reduced capacity for the reactivation of glucocorticoids in rheumatoid arthritis synovial cells: possible role of the sympathetic nervous system? Arthritis Rheum. 2005;52:1711-1720.

Schmidt M, Weidler C, Naumann H, Anders S, Schölmerich J, Straub RH. Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes - androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens. Arthritis Res Ther. 2005;7:R938-R948.

Radons J, Bosserhoff AK, Grässel S, Falk W, Schubert TEO. p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes. Int J Mol Med, in press.

Submitted

Capellino S, Weidler C, Anders S, Baerwald CGO, Buttgereit F, Straub RH. Placental growth factor–1 (PlGF-1) is related to vascularization, DHEAS to DHEA conversion, and aromatase expression in patients with arthritis – a placental role of PlGF-1 in the synovium.

Project Englert/Blunk with others

Angele P, Faltermeier H, Kujat R, Englert C, Moeller HD, Nerlich M. Amplifikationsoptimierung humaner Chondrozyten durch Wachstumsfaktoren. Acta Chir. Austriaca 1999;31:257-260.

Kellner K, Tessmar J, Milz S, Angele P, Nerlich M, Schulz MB, Blunk T, Göpferich A. PEGylation does not impair insulin efficacy in three-dimensional cartilage culture – an investigation toward biomimetic polymers. Tissue Eng. 2004;10:429-440.

Angele P, Abke J, Kujat R, Faltermeier H, Schumann D, Nerlich M, Kinner B, Englert C, Ruszczak Z, Mehrl R, Mueller R. Influence of different collagen species on physico-chemical properties of crosslinked collagen matrices. Biomaterials 2004;25:2831-2841.

Angele P, Schumann D, Angele M, Kinner B, Englert C, Hente R, Fuchtmeier B, Nerlich M, Neumann C, Kujat R. Cyclic, mechanical compression enhances chondrogenesis of mesenchymal progenitor cells in tissue engineering scaffolds. Biorheology 2004;41:335-346.

Mueller R, Abke J, Schnell E, Macionczyk F, Gbureck U, Mehrl R, Ruszczak Z, Kujat R, Englert C, Nerlich M, Angele P. Surface engineering of stainless steel materials by tantalum coating and collagen immobilization to improve implant biocompatibility. Biomaterials. 2005;26:6962-6972.

Angele P, Zellner J, Englert C, Nerlich M. Surgical treatment options for focal articular lesions – mi-crofracture, osteochondral transplantation. Akt Traumatol 2005;35:255-259

Appel B, Maschke A, Weiser B, Sarhan H, Englert C, Angele P, Blunk T, Göpferich A., Lipidic implants for controlled release of bioactive insulin: Effects on cartilage engineered in vitro. Int J Pharm 2005, in press.

Submitted

Englert C, Thalmeier U, Fierlbeck J, Bender A, Lehn N, Angele P. Staphylococcus aureus joint infection increased by osteoarthritis.

Englert C, Angele P, Fierlbeck J, Dendorfer S, Schubert TEO, Müller R, Lienhard S, Zellner J, Nerlich M, Neumann C. Konduktives Knochenersatzmaterial mit erweitertem Indikationsspektrum.

Project Bosserhoff/Schubert with others

Muller-Ladner U, Bosserhoff AK, Dreher K, Hein R, Neidhart M, Gay S, Scholmerich J, Buettner R, Lang B: MIA (melanoma inhibitory activity): a potential serum marker for rheumatoid arthritis. Rheumatology (Oxford). 1999; 38:148-54.

Neidhart M, Muller-Ladner U, Frey W, Bosserhoff AK, Colombani PC, Frey-Rindova P, Hummel KM, Gay RE, Hauselmann H, Gay S: Increased serum levels of non-collagenous matrix proteins (cartilage oligomeric matrix protein and melanoma inhibitory activity) in marathon runners. Osteoarthritis Cartilage. 2000; 8:222-9.

Bataille F, Klebl F, Rümmele P, Straub RH, Wild P, Schölmerich J, Hofstädter F. Histopathologic parameters as predictors for the course of Crohn’s disease.  Virchow Arch. 2003;443:501-507

Karrer S, Bosserhoff AK, Weiderer P, Distler O, Landthaler M, Szeimies RM, Muller-Ladner U, Scholmerich J, Hellerbrand C: The -2518 promotor polymorphism in the MCP-1 gene is associated with systemic sclerosis. J Invest Dermatol. 2005;124:92-8.

Schubert TEO, Weidler C, Lerch K, Hofstädter F, Straub RH. Achilles tendinosis is associated with sprouting of substance P positive nerve fibres. Ann. Rheum. Dis. 2005;64:1083-1086.

Karrer S, Bosserhoff AK, Weiderer P, Distler O, Landthaler M, Szeimies RM, Müller-Ladner U, Schöl-merich J, Hellerbrand C. The –2518 promoter polymorphism in the MCP-1 gene is associated with sy-stemic sclerosis. J Invest Dermatol 124, 92-98, 2005.

Schubert TEO, Weidler C, Borisch N, Schubert C, Hofstädter F, Straub RH. Dupuytren’s contracture is associated with sprouting of SP-positive nerve fibers and infiltration by mast cells. Ann. Rheum. Dis., in press.

Radons J, Falk W, Schubert TEO. Interleukin-10 does not affect IL-1-induced interleukin-6 and metal-loproteinase production in human chondrosarcoma cells, SW1353. Int J Mol Med, in press.

Radons J, Bosserhoff AK, Grässel S, Falk W, Schubert TEO. p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes. Int J Mol Med, in press.

Submitted

Grum F, Härle P, Bataille F, Schölmerich J, Schubert TEO, Straub RH. Differential loss of sympathetic nerves and increase of substance P positive nerves in the colon in Crohn's disease - a role for the nerve repellent factor semaphorin 3C.

Englert C, Angele P, Fierlbeck J, Dendorfer S, Schubert TEO, Müller R, Lienhard S, Zellner J, Nerlich M, Neumann C. Konduktives Knochenersatzmaterial mit erweitertem Indikationsspektrum.

         Project Schedel/Müller-Ladner with others

Prof. Dr. J. Grifka, Director of the Department of Orthopaedic Surgery of the University of Regensburg, is representative for the excellent cooperation with this group (Dr. S. Grässel).

Dr. M. Woenckhaus, Institute of Pathology of the University of Regensburg, is representative for the excellent cooperation with this group (Dr. Th. Schubert, Prof. Dr. A. Bosserhoff).

Neumann E, Judex M, Kullmann F, Grifka J, Robbins PD, Pap T, Gay RE, Evans CH, Gay S, Schölmerich J, Müller-Ladner U. Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway. Gene Ther 2002;9:1508-19.

Neumann E, Lechner S, Tarner IH, Grifka J, Gay S, Rüschoff J, Renke B, Schölmerich J, Kullmann F, Müller-Ladner U. Evaluation of differentially expressed genes by a combination of cDNA array and RAP-PCR using the AtlasImage 2.0 software. J Autoimmun 2003;21:161-6.

Judex M, Neumann E, Lechner S, Dietmaier W, Ballhorn W, Grifka J, Gay S, Schölmerich J, Kullmann F, Müller-Ladner U. Laser-mediated microdissection facilitates analysis of area-specific gene expression in rheumatoid synovium. Arthritis Rheum 2003;48:97-102.

Weidler C, Härle P, Schedel J, Schmidt M, Schölmerich J, Straub RH. Patients with RA and SLE have increased renal excretion of mitogenic estrogens in relation to endogenous antiestrogens. J Rheumatol 2004;31:489-94.

Straub RH, Weidler C, Demmel B, Herrmann M, Kees F, Schmidt M, Schölmerich J, Schedel J. Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis 2004,63:961-8.

Weidler C, Härle P, Schedel J, Schmidt M, Schölmerich J, Straub RH. Patients with RA and SLE have increased renal excretion of mitogenic estrogens in relation to endogenous antiestrogens. J Rheumatol 2004;31:489-94.

Schedel J, Distler O, Woenckhaus M, Gay RE, Simmen B, Michel BA, Müller-Ladner U, Gay S. Discrepancy between mRNA and protein expression of tumour suppressor maspin in synovial tissue may contribute to synovial hyperplasia in rheumatoid arthritis. Ann Rheum Dis. 2004;63:1205-1211.

Schedel J, Mayer S, Woenckhaus M, Kiss E, Schölmerich J, Rogler G. Autoimmune cholangitis with vasculitic ulcers, rheumatoid arthritis and IgA glomerulonephritis. Dtsch Med Wochenschr. 2004;129:2409-2412.

Karrer S, Bosserhoff AK, Weiderer P, Distler O, Landthaler M, Szeimies RM, Müller-Ladner U, Schöl-merich J, Hellerbrand C. The –2518 promoter polymorphism in the MCP-1 gene is associated with sy-stemic sclerosis. J Invest Dermatol 124, 92-98, 2005.

Rainer H. Straub, August 2006