Prof. Dr. med. Ulrich Bogdahn

Direktor Klinik und Poliklinik für Neurologie Prodekan der Medizinischen Fakultät der Universität Regensburg

Tel.: +49 (941) 941-0 Fax: +49 (941) 941 3005 ulrich.bogdahn@medbo.de ulrich.bogdahn@klinik.uni-regensburg.de

Anschrift

Klinik und Poliklinik für Neurologie der Universität Regensburg
Am Bezirksklinikum
Universitätsstraße 84
D-93053 Regensburg

Klinische Qualifikationen

Klinisch-wissenschaftliche Interessen

• NeuroOnkologie
• Neurologische Intensivmedizin
• Bildgebung Neurologischer Erkrankungen, Schwerpunkt MR und Ultraschall

Publikationen

Originalpublikationen (1991 - 1996)

1. Koehler MR, Bosserhoff AK, von Beust G, Bauer A, Blesch A, Buettner R, Schlegel J, Bogdahn U, Schmid M (1996) Assignment of the Human Melanoma Inhibitory Activity Gene (MIA) to 19q13.32-q13.33 by Fluorescence in situ Hybridization (FISH). Genomics 35, 265-267
2. Bauer A, Becker G, Krone A, Froehlich T, Bogdahn U (1996): Transcranial Duplex Sonography using Ultrasound Contrast Enhancers. Clinical, Radiology 51: Suppl 1: 19-23
3. Jachimczak P, Bogdahn U: Immunological Application of Antisense - Oligodeoxy - Nucleotides. In: Textbook Brysch, Schlingensiepen (Eds.). Blackwell Science 1996
4. Jachimczak P, Fabel-Schulte K, Hessdoerfer B, Brysch W, Schlingensiepen KH, Blesch A, Bogdahn U. (1995) : Transforming Growth Factor -ß -Mediated , Regulation of Human Peripheral Blood Mononuclear Cell proliferation as Detected with Phosphorothioate Antisense Oligonucleotides. Cell Immunol 165: 125-133
5. Bosserhoff A, Hein R, Bogdahn U, Buettner R (1996) : Structure and Promoter Analysis of the Gene encoding the Human Melanoma Inhibiting Activity Protein. MIA. J Biol. Chem. 271: 490-495
6. Bauer A, Becker G, Jachimczak P, Krone A, Bogdahn U (1995): Contrast Enhanced Transcranial Duplex Sonography. Brit. Medical Ultrasound Society Bulletin 3: 26-29
7. Jachimczak P , Brysch W, Schlingensiepen KH, Fabel-Schulte K, Hessdoerfer B, Wismeth C , Blesch A, Bogdahn U (1996) : Transforming Growth Factor-ß - mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides. Int J. Cancer 65: 332-337
8. Bauer A, Jachimczak P, Blesch A, Baur I, Hessdoerfer B, Haase A, Bogdahn U (1995) : Selektive Abtötung und Wachstumshemmung von Tumorzellen durch Deuteriumoxid (D2O). Tumordiagnostik und Therapie 16: 61-68
9. Gold R, Baumgartner R, Fowler B, Bogdahn U, Wendel U,Toyka KV, Kappos L (1995) Hereditary defect of cobalamin metabolism (homocystinuria and methylmalonic aciduria) of juvenile onset resembling multiple sclerosis. J. Neurosurg, Neurology, Psychiatry 60: 107-8
10. Becker G, Becker T, Struck M, Lindner A, Burzer K, Retz W, Bogdahn U, Beckmann H (1995): Reduced Echogenicity of Brainstem Raphe Specific to Unipolar Depression: A Transcranial Color-Coded Real-Time Sonography Study. Biol. Psychiatr. 38: 180-184
11. Lindner A, Becker G, Warmuth-Metz M, Schalke BCG, Bogdahn U, Toyka V (1995): Magnetic Resonance Image Findings of Spinal Intramedullary Abscess Caused by Candida Albicans: Case Report. Neurosurgery: 36: 411-412
12. Kotitschke K, Tonn JC, Goldbrunner R, Bogdahn U, Haase A (1995): 1H-NMR Investigations of Tumor Spheroids Grown from a Human Glioma Biopsy or from a Human Malignant Glioma Cell Line. J. Magn. Res. 109: 39-43
13. Becker G, Seufert J, Bogdahn U, Reichmann H, Reiners K (1995): Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography. Neurology. 45 (1): 182-4
14. Becker G, Bogdahn U, Gehlberg C, Froehlich T, Hofmann E, Schlief MD in: Transcranial color-coded real-time sonography of intracranial veins (1995 ): Normal values of blood flow velocities and findings in superior sagittal sinus thrombosis. J-Neuroimaging. 5 (2) : 87-94
15. Lindner A, Becker G, Bogdahn U, Krone A, Becker T, Hofmann E (1995) Stellenwert der transkraniellen farbkodierten Echtzeitsonographie in der Diagnostik zerebraler Lasionen. Nervenarzt. 66(4): 252-60
16. Bauer A , Bogdahn U, Becker G, Soldner R, Hutzlmeier A, Jachimczak P, Schlief R, Roell S, Henz P, Haase A (1995): Three-dimensional vascular imaging by echo-enhanced transcranial power Doppler sonography Radiology (manuscript submitted)
17. Bauer AL, Kotitschke K, Haase A , Bogdahn U, (1995) Selective killing of malignant glioma cells by deuterium-oxide and monitoring of cell metabolism by 1H-NMR-spectroscopy in vitro. Cancer Research (submitted for publication)
18. Becker G, Krone A, Koulis D, Lindner A, Hofmann E, Roggendorf W, Bogdahn U, (1994) Reliability of transcranial colour-coded real-time sonography in assessment of brain tumours: correlation of ultrasound, computed tomography and biopsy findings. Neuroradiology. 36 (8) : 585-90
19. Becker G, Bogdahn U, Strassburg H-M, Lindner A, Hassel W, Meixensberger J, Hofmann E (1994) Identification of ventricular enlargement and estimation of ventricular pressure by transcranial color-coded real-time sonography. J. Neuroimaging 4: 17-22
20. Schwarz KQ, Bezante GP, Becher H, Schimpfky C, Vorwerk D, Bogdahn U, Schlief R (1994) Efficacy SH U 508 A (Levovist) as blood pool enhancer in the Doppler evaluation of multiple vascular regions. Radiol-Med-Torino. 87(5 Suppl 1): 3-14
21. Becker G, Lindner A, Hofmann E, Bogdahn U, (1994): Contribution of transcranial color- coded real-time sonography to the etiopathogenetic classification of middle cerebral artery stenosis. J-Clin-Ultrasound. 22(8): 471-7
22. Becker G, Struck U, Bogdahn U, Becker T (1994) Echogenicity of the brainstem raphe in patients with major depression. Psychiatry Research Neuroimaging 55: 75-84
23. Kotitschke K, Jung H, Nekolla S, Bauer A, Haase A, Bogdahn U (1994) High- resolution one- and two-dimensional 1H-MRS of human brain tumor and normal glial cells. NMR in Biomedicine 7: 111-120
24. Winkler J, Bogdahn U, Becker G, Durant W, Brunner FX,Eckstein M, Brawanski A, Warmuth M, Mertens HG (1994) Surgical intervention and heparin anticoagulation improve prognosis of rhinogenic/otogenic and posttraumatic meningitis. Acta Neurol Scand 89: 293-298
25. Bogdahn U, Becker G, Froehlich T, Krone A, Schlief R, Schuermann J, Jachimczak P, Hofmann E, Roggendorf W, Roosen K (1994) Contrast-enhanced transcranial color-coded real-time sonography allows detection of primary central nervous system tumor vascularisation. Radiology 192(1): 141-8
26. Jachimczak P, Schwulera U, Bogdahn U (1994) In vitro studies of cytokine- mediated interactions between malignant glioma and autologous peripheral blood mononuclear cells. J Neurosurg 81 (4) : 579-86
27. Schwarz KQ, Bechar H, Schimpfky C, Vorwerk D, Bogdahn U, Schlief R (1994) A Study of the Magnitude of Doppler Enhancement with SH U 508 A in Multiple Vascular Regions. Radiology 193 (1): 195-201
28. Kotitschke K, Schnackerz KD, Dringen R, Haase A, Bogdahn U, v. Kienlin M.: (1994) Investigation of the 1H-NMR Visibility of Lactate in Different Rat and Human Brain Cells. NMR in Biomedicine 7 (8): 349-55
29. Blesch A, Apfel R, Bosserhoff A-K, Behl C, Hessdoerfer B, Jachimczak P, Lottspeich F, Schlingensiepen K-H, Buettner R, Bogdahn U (1994) Cloning of a novel malignant melanoma-derived growth regulatory protein, MIA. Cancer Research 54 (21) : 5695-701
30. Hofmann E, Meixensberger J, Bogdahn U, Majowski A, Becker T, Warmuth-Metz M (1994) : Shunting hydrocephalus: Can "Cine"-MRI predict outcome? Klinische Neuroradiologie 5 : 14-23
31. Bogdahn U, Becker G, Schlief R (1993) Contrast-enhanced transcranial color- coded real-time sonography. Results of a phase-two study. Stroke 24: 676-684
32. Becker G, Hofmann E, Winkler J, Bogdahn U (1993) Differentiation between ischemic and hemorrhagic stroke by transcranial color-coded real-time sonography. J Neuroimaging 3: 42-47
33. Krone A, Glaser M, Pfeuffer-Hess D, Bogdahn U, Haubitz I, Hofmann E (1993) Prognostic factors and surgical indications in spontaneous lobar and putaminal hematomas. Advances in Neurosurgery 21: 12-16
34. Becker G, Lindner A, Bogdahn U (1993) Imaging of the vertebro-basilar system by transcranial color coded real-time sonography (TCSS). J Ultrasound Med 12: 395-401
35. Behl C, Bogdahn U, Winkler J, Apfel R, Brysch W, Schlingensiepen K-H (1993) Autoinduction of platelet derived growth factor-(PDGF)-A-chain mRNA and growth inhibition by PDGF-A-chain mRNA-chain mRNA-specific phosphorothioate- oligo-deoxynucleotides in human malignant melanoma. BBRC 193: 744-751
36. Behl C, Bogdahn U, Apfel R, Schlingensiepen K-H, Brysch W (1993) Autocrine growth regulation in neuroectodermal tumors as detected with oligodeoxynucleotide antisense molecules. Neurosurgery 33: 679-684
37. Jachimczak P, Bogdahn U, Schneider J, Behl C, Meixensberger J, Apfel R, Doerries R, Schlingensiepen K-H, Brysch W (1993) The effect of transforming growth factor-ß2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma. J. Neurosurgery 78: 944-951
38. Jaeger AH, Bogdahn U, Apfel R, Pfeufer B, Dekant A (1993) In vitro studies on interaction of 4-hydroperoxy-ifosfamide and 2-mercaptoethanesulphonate in malignant gliomas. J Cancer Res Clin Oncol 119: 721-726
39. Roesener M, Martin R, Schwulera U, Menke G, Thuma A, Lissner R, Krauseneck P, Bogdahn U (1993) Tolerance and cerebrospinal fluid pharmacokinetics of intrathecally administered human natural interleukin-2: A phase I trial. Eur. Cytokine Netw 4: 189-195
40. Jaeger, AH, Bogdahn U Pfeufer B, Richter J, Apfel R, Dekant A (1993) In vitro studies on interaction of 4-hydroperoxy-ifosfamide and radiotherapy in malignant gliomas. Anticancer Res 13: 2221-2228
41. Becker G, Lindner A, Bogdahn U (1993) Contribution of transcranial color-coded real-time sonography to the etiopathogenetic classification of middle cerebral artery stenosis. J-Clin-Ultrasound. 1994 Oct; 22(8): 471-7
42. Becker G, Krone A, Koulis D, Lindner A, Hofmann E, Roggendorf W, Bogdahn U (1993): Reliability of transcranial color-coded real-time sonography in the assessment of brain tumors: correlation between ultrasound, computerized tomography and biopsy findings. Neuroradiology. 1994 Nov; 36(8): 585-90)
43. Bogdahn U, Brehm B, Behl C, Richter B, Richter J, Meixensberger J, Apfel R (1993) In vitro 60Co-y-radiotherapy and nitrosourea-chemotherapy modify growth factor expression in malignant gliomas. Anticancer Research (submitted for publication)
44. Gold R, Baumgartner R, Fowler B, Bogdahn U, Wendel U,Toyka KV, Kappos L (1993) Hereditary defect of cobalamin metabolism (homocystinuria and methylmalonic aciduria) of juvenile onset resembling multiple sclerosis. N Engl J Med (submitted in revised edition)
45. Apfel R, Lottspeich F, Hoppe J, Behl C, Duerr G, Bogdahn U (1992) Purification and analysis of growth regulation proteinsecreted by a human melanoma cell line. Melanoma Res 2: 327-336
46. Becker G, Perez J, Krone A, Winkler J, Demuth K, Lindner A, Hassel W, Meixensberger J, Hofmann E, Bogdahn U (1992) Transcranial color-coded real- time sonography in the evaluation of intracranial neoplasms and arteriovenous malformations. Neurosurgery 31: 420-428
47. Bogdahn U, Lau W, Hassel W, Brawanski A, Gunreben G (1992) Continuous pressure controlled external ventricular drainage system for treatment of acute hydrocephalus. Neurosurgery 31: 898-904
48. Martin R, Schwulera U, Menke G, Rudolph W, Buch K, Fasold H, Lissner R, Thrun A, Krauseneck P, Bogdahn U (1992) Interleukin-2 and blood brain barrier in cats: pharmacokinetics and tolerance following intrathecal and intravenous administration. Eur Cytokine Netw 3: 399-406
49. Poot M, Hoehn H, Bogdahn U, Otto F (1992)Bromodeoxyuridine hypersensitivity of metastatic melanoma cells. Melanoma Research 2: 241-246
50. Becker G, Greiner K, Kaune B, Winkler J, Brawanski A, Warmuth-Metz M, Bogdahn U (1991) Diagnosis and monitoring of subarachnoid hemorrhage by transcranial color- coded real-time sonography. Neurosurgery 28: 814-820
51. Becker G, Winkler J, Bogdahn U (1991) Die transkranielle farbkodierte Real-Time Sonographie des Erwachsenen. Teil 1: Normalbefund und zerebrovaskulaere Ischaemien. Ultraschall in der Medizin 12: 74-79
52. Becker G, Winkler J, Bogdahn U (1991) Die transkranielle farbkodierte Real-Time Sonographie des Erwachsenen. Teil 2: Zerebrale Blutungen und Tumoren. Ultraschall in der Medizin 12: 211-217
53. Bogdahn U, Drenkard D, Lutz M, Apfel R, Behl C (1991) In vitro studies on drug interaction of ifosfamide and ACNU in primary and metastatic human brain tumours. J Cancer Res Clin Oncol 117 (Suppl IV): 157-163
54. Gunreben G, Bogdahn U (1991) Real-time sonography of acute and chronic muscle denervation. Muscle & Nerve 14: 654-664
55. Seybold JD, Bogdahn U, Seubert W, Krauseneck P (1991) 7S-Immunglobulin zur Infektprophylaxe bei Patienten mit malignen Hirntumoren unter zytostatischer Therapie. Onkologische Klinik 3: 2-8
56. Becker G, Winkler J, Hoffmann E, Bogdahn U (1990)Imaging of cerebral arterio-venous malformations by transcranial colour-coded real-time sonography. Neuroradiology 32: 280-288
57. Bogdahn U, Becker G, Winkler J, Greiner K, Perez J, Meurers B (1990) Transcranial color-coded real-time sonography in adults. Stroke 21: 1680-1688
58. Gunreben G, Meurers B, Bogdahn U (1990)Einzelpotentialanalyse in der Myopathiediagnostik: Entwicklung quantitativer EMG-Parameter. Z EEG-EMG 21: 150-156
59. Weilbach FX, Bogdahn U, Poot M, Apfel R, Behl C, Drenkard D, Martin R, Hoehn H (1990) Melanoma-inhibiting activity inhibits cell proliferation by prolongation of the S-phase and arrest of cells in the G2 compartment. Cancer Research 50: 6981-6986