Publikationen
(Prof. Dr. Jörg Wilhelm Karl Heilmann)




Original Paper

  1. Romagnoli, R.; Baraldi, P.G.; Iaconinoto, M.A.; Carrion, M.D.; Tabrizi, M.A.; Gambari, R.; Borgatti, M.; Heilmann, J.
    Synthesis and biological activity of alpha-bromoacryloyl lexitropsin conjugates
    European Journal of Medicinal Chemistry, in press 2005
  2. Karioti, A.; Heilmann, J.; Skaltsa, H.
    Labdane diterpenes from Marrubium velutinum and Marrubium cylleneum
    Phytochemistry 66, 1060-1066, 2005
  3. Cottiglia, F.; Casu, L.; Bonsignore, L.; Casu, M.; Floris, C.; Leonti, M.; Gertsch, J.; Heilmann, J.
    New cytotoxic prenylated isoflavonoids from Bituminaria morisiana
    Planta Medica 71, 254-260, 2005
  4. Meremeti, A.; Karioti, A.; Skaltsa, H.; Heilmann, J.; Sticher, O.
    Secondary metabolites from Stachys ionica
    Biochemical Systematics and Ecology 32, 139-151, 2004
  5. Cottiglia, F.; Dhanapal, B.; Sticher, O.; Heilmann, J.
    New chromanone acids with anti-bacterial activity from Calophyllum brasiliense
    Journal of Natural Products 67, 537-541, 2004
  6. Gertsch, J.; Sticher, O.; Schmidt, T. J.; Heilmann, J.
    Influence of helenanolide-type sesquiterpene lactones on gen transcription profiles in Jurkat T-cells and human peripheral blood cells: Anti-inflammatory and cytotoxic effects
    Biochemical Pharmacology 66, 2141-2153, 2003
  7. Hördegen, P.; Hertzberg, H.; Heilmann, J.; Gray, D.; Langhans, W.; Maurer, V.
    The anthelmintic efficacy of five plant products against gastrointestinal trichostrongylids in artificially infected lambs
    Veterinary Parasitology, 17, 56-60, 2003
  8. Hilmi, F.; Gertsch, J., Bremner, P.; Valovic, S.; Heinrich, M.; Sticher, O.; Heilmann, J.
    Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-type sesquiterpene lactones
    Bioorganic and Medicinal Chemistry 11, 3659-3663, 2003
  9. Winkelmann, K.; Metin, S.; Kypriotakis, Z.; Skaltsa, H.; Bosilij, B.; Heilmann, J.
    Antibacterial and cytotoxic activity of prenylated bicyclic acylphloroglucinol derivatives from Hypericum amblycalyx
    Z. Naturforsch. 58c, 527-532, 2003
  10. Karioti, A.; Skaltsa, H.; Heilmann, J.; Sticher O.
    Acylated flavonoid and phenylethanoid glycosides from Marrubium velutinum
    Phytochemistry 64, 655-660, 2003
  11. Gertsch, J.; Thöni Tobler, R.; Brun, R.; Sticher, O.; Heilmann, J.
    Antifungal, antiprotozoal, cytotoxic and properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum; Planta Medica 69, 413-419, 2003
  12. Akbay, P.; Çalis, I. Heilmann, J.; Sticher, O.
    Ionone, iridoid and phenylethanoid glycosides from Ajuga salicifolia
    Z. Naturforsch. 58c, 177-180, 2003
  13. Akbay, P.; Çalis, I.; Heilmann, J.; Sticher O.
    New stigmastane sterols from Ajuga salicifolia
    Journal of Natural Products 66, 461-465 2003
  14. Sagen, A.-L.; Gertsch, J.; Becker, R.; Heilmann, J.; Sticher, O.
    Quinolizidine alkaloids from the curare plant Clathrothropis glaucophylla
    Phytochemistry 61, 975-978, 2002
  15. Heilmann, J.; Winkelmann, K.; Sticher, O.
    Studies on the antioxidative activity of phloroglucinol derivatives isolated from Hypericum species
    Planta Medica 69, 193-201, 2003
  16. Mian, P.; Heilmann, J.; Bürgi, H.-R.; Sticher, O.
    Biological screening of terrestrial and freshwater cyanobacteria for antimicrobial activity, brine shrimp lethality, and cytotoxicity
    Pharmaceutical Biology 41, 243-247, 2003
  17. Hilmi, F.; Sticher, O.; Heilmann, J.
    Further new cytotoxic sesquiterpene lactones from Warionia saharae
    Planta Medica 69, 459-461, 2003
  18. Gertsch, J.; Güttinger, M.; Heilmann, J.; Sticher, O.
    Curcumin differentially modulates mRNA profiles in Jurkat T and human mononuclear cells
    Bioorganic and Medicinal Chemistry 11, 1057-1063, 2003
  19. Schmidt, T.J.; Heilmann, J.
    Quantitative Structure-Cytotoxicity Relationships of sesquiterpene lactones derived from partial charge-based fractional Accessible Surface Area Descriptors (Q_frASAs)
    Quantitative Structure Activity Relationships 21, 277-287, 2002
  20. Akbay, P.; Çalis, I.; Gertsch, J.; Heilmann, J.; Zerbe, O.; Sticher, O.
    Novel antileukemic sterol glycosides from Ajuga salicifolia
    Helvetica Chimica Acta 85, 1930-1942, 2002
  21. Prinz, S.; Müllner, U.; Heilmann, J.; Winkelmann, K., Sticher, O.; Haslinger, E., Hüfner, A.
    New oxidation products of abietic acid and its methyl ester
    Journal of Natural Products 65, 1530-1534, 2002
  22. Hilmi, F.; Sticher, O.; Heilmann, J.
    New cytotoxic 6,7-cis and 6,7-trans configured guaianolides from Warionia saharae
    Journal of Natural Products 65, 523-526, 2002
  23. Gertsch, J.; Güttinger, M.; Sticher, O.; Heilmann, J.
    Relative quantification of mRNA levels in Jurkat T cells with RT - real time - PCR: New possibilities for the screening of anti-inflammatory and cytotoxic natural compounds
    Pharmaceutical Research 19, 1235-1242, 2002
  24. Jager, H.; Meinel, L.; Dietz, B.; Lapke, C.; Bauer, R.; Merkle, H.P.; Heilmann, J.
    Transport of alkamides from Echinacea species through Caco-2 monolayers
    lanta Medica 68, 469-471, 2002
  25. Winkelmann, K.; Heilmann, J.; Zerbe, O.; Rali, T.; Sticher, O.
    Further prenylated bi- and tricyclic phloroglcinol derivatives from Hypericum papuanum
    Helvetica Chimica Acta 84, 3380-3392, 2001
  26. Heilmann, J.; Wasescha, M.R.; Schmidt, T.J.
    The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells
    Bioorganic and Medicinal Chemistry 9, 2189-2194, 2001
  27. Heilmann, J.; Brun, R.; Mayr, S.; Rali, T.; Sticher, O.
    Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum
    Phytochemistry 57, 1281-1285, 2001
  28. Çalis, I.; Heilmann, J.; Tasdemir, D.; Linden, A.; Ireland, C.; Sticher, O.
    Flavonoid, iridoid and lignan glycosides from Putoria calabrica
    Journal of Natural Products 64, 961-964, 2001
  29. Dietz, B.; Heilmann, J.; Bauer, R.
    Bioavailability of dodeca-2E, 4E, 8Z, 10 E/Z-tetraenoic acid isobutylamides after oral application of Echinacea purpurea tincture
    Planta Medica 67, 863-864, 2001
  30. Winkelmann, K.; Heilmann, J.; Zerbe, O.; Rali, T.; Sticher, O.
    New prenylated bi- and tricyclic phloroglucinol derivatives from Hypericum papuanum
    Journal of Natural Products 64, 701-706, 2001
  31. Resch, M.; Heilmann, J.; Steigel, A.; Bauer, R.
    Further constituents from the rhizomes of Atractylodes lancea and their anti-inflammatory activity
    Planta Medica 67, 437-442, 2001
  32. Heilmann, J.; Mayr, S.; Brun, R.; Rali, T.; Sticher, O.
    Antiprotozoal activity and cytotoxicity of novel 1,7-dioxa-dispiro?5.1.5.2?pentadeca-9,12-dien-11-one derivatives from Amomum aculeatum
    Helvetica Chimica Acta 83, 2939-2945, 2000
  33. Liu, H.; Heilmann, J.; Rali, T.; Sticher, O.
    New Tirucallane-type triterpenes from Dysoxylum variabile
    Journal of Natural Products 64, 159-163, 2001
  34. Jaki, B.; Zerbe, O.; Heilmann, J.; Sticher, O.
    Two novel cyclic peptides with antifungal activity from the cyanobacterium Tolypothrix byssoidea (EAWAG 195)
    Journal of Natural Products 64, 154-158, 2001
  35. Wirz, A.; Simmen, U.; Heilmann, J.; Çalis, I.; Meier, B.; Sticher, O.
    Bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors
    Phytochemistry 55, 941-947, 2000
  36. Jaki, B.; Heilmann, J.; Sticher, O.
    New antibacterial metabolites from the cyanobacterium Nostoc commune (EAWAG 122b)
    Journal of Natural Products 63, 1283-1285, 2000
  37. Quadri-Spinelli, T.; Heilmann, J.; Rali, T.; Sticher, O.
    Bioactive coumarin derivatives from the fern Cyclosorus interruptus
    Planta Medica 66, 728-733, 2000
  38. Schühly, W.; Heilmann, J.; Çalis, I.; Sticher, O.
    Novel triterpene saponins from Zizyphus joazeiro
    Helvetica Chimica Acta 83, 1509-1515, 2000
  39. Heilmann, J; Çalis, I; Kirmizbekmez, H.; Schühly, W.; Harput, S.; Sticher, O.
    Radical scavenger activity of phenylethanoid glycosides in FMLP stimulated human polymorphonuclear leukocytes - structure activity relationships
    Planta Medica 66, 746-748, 2000
  40. Schmidt, T.J.; Heilmann, J.
    Tetrahydrofuran lignans from Illicium floridanum and their activity in a luminol enhanced chemiluminescence assay
    Planta Medica 66, 749-751, 2000
  41. Ankli, A.; Heilmann, J.; Heinrich, M.; Sticher, O.
    Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri
    Phytochemistry 54, 531-537, 2000
  42. Winkelmann, K.; Heilmann, J.; Zerbe, O.; Rali, T.; Sticher, O.
    New phloroglucinol derivatives from Hypericum papuanum
    Journal of Natural Products 63, 104-108, 2000
  43. Jaki, B.; Orjala, J.; Heilmann, J.; Vogler, B.; Sticher, O.
    Novel extracellular diterpenoids with biological activity from cyanobacterium Nostoc commune
    Journal of Natural Products 63, 339-343, 2000
  44. Schühly, W.; Heilmann, J.; Çalis, I.; Sticher, O.
    New triterpenoids with antibacterial activity from Zizyphus joazeiro
    Planta Medica 65, 740-743, 1999
  45. Heilmann, J.; Müller, E.; Merfort, I.
    Flavonoid glucosides and dicaffeoylquinic acids from flowerheads of Buphthalmum salicifolium
    Phytochemistry 51, 713-718, 1999
  46. Lobitz, G.O.; Heilmann, J.; Zschocke, S.; Tamayo-Castillo, G.; Bauer, R.; Merfort, I.
    Bornyl cinnamate derivatives with anti-inflammatory activity from Verbesina turbacensis
    Pharmaceutical and Pharmacological Letters 8, 115-118, 1998
  47. Heilmann, J.; Resch, M., Bauer, R.
    Antioxidant activity of constituents from Atractylodes lancea
    Pharmaceutical and Pharmacological Letters 8, 69-71, 1998
  48. Merfort, I.; Heilmann, J.; Weiss, M.; Pietta, P.; Gardana, C.
    Radical scavenger activity of three flavonoid metabolites studied by inhibition of chemiluminescence in human PMNs
    Planta Medica 62, 289-292, 1996.
  49. Heilmann, J.; Merfort, I.; Weiss, M.
    Radical scavenger activity of different 3',4'-dihydroxy-flavonols and 1,5-dicaffeoylquinic acid studied by inhibition of chemiluminescence
    Planta Medica 61, 435-438, 1995.
  50. Merfort, I.; Heilmann, J.; Hagedorn-Leweke, U.; Lippold, B.C.
    In vivo skin penetration studies of chamomile flavones
    Pharmazie 49, 509-511, 1994



Reviews

  1. v. Raison, J.; Heilmann, J.; Merfort, I.; Schmidt, T.J.; Brock, F.E.; Leven, W.; Bomme, U.; Bauer, R.
    Arnika - Arzneipflanze mit Tradition und Zukunft
    Zeitschrift für Phytotherapie 21, 39-54, 2000
  2. Heilmann, J.; Merfort, I.
    Aktueller Kentnisstand zum Metabolismus von Flavonoiden. II. Resorption und Metabolismus von Flavonen, Flavanonen, Flavanen, Proanthocyanidinen und Isoflavonoiden
    Pharmazie in unserer Zeit 27, 173-183, 1998
  3. Heilmann, J.; Merfort, I.
    Aktueller Kenntnisstand zum Metabolismus von Flavonoiden. I. Resorption und Metabolismus von Flavonolen
    Pharmazie in unserer Zeit 27, 58-65, 1998
  4. Merfort, I.; Heilmann, J.
    Bericht über die 41. Jahrestagung der Gesellschaft für Arzneipflanzenforschung in Düsseldorf
    Pharmazie in unserer Zeit 22, 323-328, 1993