Selected Publications of Prof. Dr. Jens Schlossmann

Antl M, v. Brühl ML, Eiglsperger C, Werner M, Konrad I, Köcher T, Wilm M, Hofmann F & Massberg S & Schlossmann J. IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Blood 109: 552-559 (2007).

Sausbier M, Zhou XB, Beier C, Sausbier U, Wolpers D, Maget  S, Martin C, Dietrich A, Ressmeyer AR, Schlossmann J, Hofmann F, Neuhuber W, Gudermann T, Uhlig S, Korth M, Ruth P. Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+ channel. FASEB Journal 21:812-822 (2007).

Bernhard D, Moosmang S, Hofmann F & Schlossmann J. Relaxation of vascular smooth muscle by the cGMP kinase substrate IRAG. Naunyn-Schmiedeberg`s Archives of Pharmacology 372: 140 (2006).

Feil S, Zimmermann P, Knorn A, Brummer S, Schlossmann J, Hofmann F & Feil R. Distribution of cGMP-dependent protein kinase type 1 and its isoforms in the mouse brain and retina. Neuroscience 135: 863-868 (2005).    

Werner CG, Godfrey V, Arnold RR, Featherstone GL, Bender D, Schlossmann J, Schiemann M, Hofmann F & Pryzwansky KB. Neutrophil Dysfunction In cGMP-Dependent Protein Kinase I Deficient Mice. Journal of Immunology 175: 1919-1929 (2005).

Geiselhöringer A, Werner M, Sigl K, Smital P, Wörner R, Acheo L, Stieber J., Weinmeister P., Feil R, Feil S, Wegener J, Hofmann F, Schlossmann J. IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP Kinase. EMBO Journal 23: 4222-4231 (2004).

Geiselhöringer A, Gaisa M., Hofmann F, Schlossmann J. Distribution of IRAG and cGKI-isoforms in murine tissues. FEBS Lett. 575: 19-22 (2004).

Koller A, Schlossmann J, Ashman K, Uttenweiler-Joseph S, Ruth P, Hofmann F.Association of phospholamban with a cGMP kinase signalling complex. Biochem Biophys Res Commun 3;300(1):155-60 (2003).

Ammendola A, Geiselhoringer A, Hofmann F, Schlossmann J. Molecular determinants of the interaction between the inositol 1,4,5- trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta. J Biol Chem 276: 24153-24159 (2001).

Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F & Ruth P. Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. Nature 404: 197-201 (2000).

Selected Reviews and Textbooks

Schlossmann J & Hofmann F (2007) Receptor-mediated mechanisms. Chapter for „Introduction to Toxicology“(Wiley &Sons Inc.) edited by Greim and Snyder.

Hofmann F, Feil R, Kleppisch T & Schlossmann J (2006) Function of cGMP-dependent Protein Kinase as revealed by gene deletion. Physiological Reviews 86: 1-23.

Schlossmann J & Hofmann F (2005) cGMP-dependent protein kinases in drug discovery. Drug Discovery Today 10: 627-634.