Selected Publications of Prof. Dr. Roland Seifert
A. Strasser, B. Striegl, H.J. Wittmann, R. Seifert. Pharmacological profile of histaprodifens at four recombinant histamine H1 receptor species isoforms. J Pharmacol Exp Ther. 324: 60-71 (2008).
H. Preuss, P. Ghorai, A. Kraus, S. Dove, A. Buschauer, R. Seifert.
Point mutations in the second extracellular loop of the histamine H(2)
receptor do not affect the species-selective activity of guanidine-type
agonists. Naunyn Schmiedebergs Arch Pharmacol. 376:253-264 (2007).
B. Schlegel, C. Laggner, T. Langer, D. Schnell, R. Seifert, H. Stark, H.-D. Höltje, W. Sippl. Generation of a homology model of the human histamine H3-receptor for ligand docking and pharmacophore-based screening. J Computer-Aided Molecular Design. 21: 437-53 (2007).
F. Kees, M. Bucher, F. Schweda, H. Gschaidmeier, L. Faerber, R. Seifert.
Neoimmun versus Neoral: a bioequivalence study in healthy volunteers,
and influence of a fat-rich meal on the bioavailability of Neoimmun. Naunyn Schmiedebergs Arch Pharmacol. 375: 393-399 (2007).
Göttle, M., Dove, S., Steindel, P., Shen,
Y., Tang, W.J., Geduhn, J., König, B., Seifert, R. Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides. Mol Pharmacol. 72: 526-35 (2007).
Lorenz, V., Pinto, C.S., Seifert, R.
Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase
expression in hypoxanthine phosphoribosyl transferase deficiency. Neurosci Lett. 420:6-11 (2007).
Preuss, H., Ghorai, P., Kraus, A., Dove, S., Buschauer, A., Seifert, R. Mutations of Cys-17 and Ala-271 in the Human Histamine H2 Receptor Determine the Species-Selectivity of
Guanidine-type Agonists and Increase Constitutive Activity. J Pharmacol Exp Ther. 321:975-82 (2007).
Wang, J.L., Guo, J.X., Zhang, Q.Y., Wu, J.J., Seifert, R.,
Lushington, G.H. A conformational transition in the adenylyl cyclase
catalytic site yields different binding modes for ribosyl-modified and
unmodified nucleotide inhibitors. Bioorg Med Chem. 15:2993-3002; (2007).
Rottlaender, D., Matthes, J., Vatner, S.F., Seifert, R.,
Herzig, S. Functional adenylyl cyclase inhibition in murine
cardiomyocytes by 2'(3')-O-(N-methylanthraniloyl)- guanosine
5'-[{gamma}-thio]triphosphate. J Pharmacol Exp Ther 321:608-15; (2007).
Preuss, H., Ghorai, P., Kraus, A., Dove, S., Buschauer, A., Seifert, R. Constitutive Activity and Ligand Selectivity of Human, Guinea Pig, Rat, and Canine Histamine H2 Receptors. J Pharmacol Exp Ther 321(3):983-95; (2007).
Xie, S. X., Schalkhausser F., Ye, Q. Z., Seifert, R., Buschauer, A. Effects of impromidine- and arpromidine-derived guanidines on recombinant human and guinea pig histamine H1- and H2-receptors. Arch Pharm 340:9-16 (2007).
Pertz, H. H., Görnemann, T., Schurad, B., Seifert, R., Strasser, A. Striking differences of action of lisuride stereoisomers at guinea pig and human histamine H1receptors. Naunyn-Schmiedeberg's Arch Pharmacol 374:215-222 (2006).
Mou, T.C., Gille, A., Suryanarayana, S., Richter, M., Seifert, R.,
Sprang, S.R. Broad Specificity of Mammalian Adenylyl Cyclase for
Interaction with 2’,3’-Substituted Purine- and Pyrimidine
Nucleotide Inhibitors. Mol Pharmacol 70, 878-886 (2006).
Xie, S.X., Petrache, G., Schneider, E., Ye, Q. Z., Bernhardt, G., Seifert, R., Buschauer, A. Synthesis and Pharmacological Characterization of Novel Fluorescent Histamine H2-Receptor Ligands Derived from Aminopotentidine. Bioorg Med Chem Lett 16, 3886-3890 (2006).
Xie, S.X., Kraus, A., Ghorai, P., Ye, Q. Z., Buschauer, A., Seifert, R. N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)propyl]guanidine, a potent partial agonist for the human histamine H1- and H2-receptor. J Pharmacol Exp Ther 317, 1262-1268 (2006).
Xie, S.X., Ghorai, P., Ye, Q. Z., Buschauer, A., Seifert, R. Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated imidazolylpropylguanidines. J Pharmacol Exp Ther 317, 139-146 (2006).
Pinto, C. S., Seifert, R.
Decreased GTP-stimulated adenylyl cyclase activity in HPRT-deficient
human and mouse fibroblast and rat B103 neuroblastoma cell membranes. J Neurochem 96, 454-459 (2006).
Gille, A., Guo, J., Mou, T.C., Doughty, M.B., Lushington, G.H., Seifert, R.
Differential interactions of G-proteins and adenylyl cyclase with
nucleoside 5'-triphosphates, nucleoside 5'-[γ-thio]triphosphates
and nucleoside 5'-[β,γ-imido]triphosphates. Biochem Pharmacol 71, 89-97 (2005).
Pinto, C. S., Jinnah, H. A., Shirley, T. L., Nyhan, W. L., Seifert, R.
Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts:
Comparison with HPRT knock-out mice and HPRT-deficient cell lines. J Neurochem 93,
1579-1586
(2005).
Mou, T. C., Gille, A., Fancy, D. A. Seifert, R., Sprang, S. R. Structural basis for the inhibition of mammalian membrane adenylyl cyclase by MANT-GTP. J Biol Chem 280, 7253-7261 (2005).
Gille, A., Lushington, G. H., Mou, T.-C., Doughty, M. B., Johnson, R. A., Seifert, R. Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides. J Biol Chem. 279, 19955-19969 (2004).
Seifert, R.,
Wenzel-Seifert, K., Bürckstümmer, T., Pertz, H. H., Schunack,
W., Dove, S., Buschauer, A., Elz, S. Multiple differences in agonist
and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther 305, 1104-1115 (2003).
Seifert, R., Wenzel-Seifert, K. The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors. Life Sci 73, 2263-2280 (2003).
Gille, A., Seifert, R. 2’(3’)-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors. J Biol Chem 278, 12672-12679 (2003).
Gille, A., Wenzel-Seifert, K., Doughty, M. B., Seifert, R. GDP-affinity and order state of the catalytic site are critical for function of xanthine nucleotide-selective Gαs proteins. J Biol Chem 278, 7822-7828 (2003).
Gille, A., Liu, H.-Y., Sprang, S. R., Seifert, R. Distinct interactions of GTP, UTP and CTP with Gs-proteins. J Biol Chem 277, 34434-34442 (2002).
Kelley, M. T., Bürckstümmer, T., Wenzel-Seifert, K., Dove, S., Buschauer, A., Seifert, R. Distinct interaction of human and guinea pig histamine H2-receptor with guanidine-type agonists. Mol Pharmacol 60, 1210-1225 (2001).
Seifert, R. Monovalent anions differentially modulate coupling of the β2-adrenoceptor to Gsα splice variants. J Pharmacol Exp Ther 298, 840-847 (2001).
Seifert, R. , Wenzel-Seifert, K., Kobilka, B. K. GPCR-G a fusion proteins: Molecular analysis of receptor/G-protein coupling. Trends Pharmacol Sci 20, 383-389 (1999).
Seifert, R. , Gether, U., Wenzel-Seifert, K., Kobilka, B. K. Effects of guanine-, inosine- and xanthine nucleotides on β2-adrenoceptor/Gs interactions: Evidence for multiple receptor conformations. Mol Pharmacol 56, 348-358 (1999).
Seifert, R. , Wenzel-Seifert, K., Lee, T. W., Gether, U., Sanders-Bush, E., Kobilka, B. K. Different effects of Gsα splice variants on β2-adrenoreceptor-mediated signaling: The β2-adrenoreceptor coupled to the long splice variant of Gαs has properties of a constitutively active receptor. J Biol Chem 273, 5109-5116 (1998).
Wenzel-Seifert, K., Krautwurst, D., Musgrave, I., Seifert, R. Thapsigargin activates univalent- and bivalent-cation entry in human neutrophils by a SK&F 96365- and Gd3+-sensitive
pathway and is a partial secretagogue: Involvement of pertussis
toxin-sensitive G-proteins and protein phosphatases 1/2A and 2B in the
signal transduction pathway. Biochem J 314, 679-686 (1996).
Klinker, J. F., Wenzel-Seifert, K., Seifert, R. G-Protein-coupled receptors in HL-60 human leukemia cells. Gen Pharmacol 27, 33-54 (1996).
Hagelüken, A., Nürnberg, B., Harhammer, R., Grünbaum, L., Schunack, W., Seifert, R. The class III antiarrhythmic drug, amiodarone, directly activates pertussis toxin-sensitive G-proteins. Mol Pharmacol 47, 234-240 (1995).
Seifert, R.,
Hagelüken, A., Höer, A., Höer, D., Grünbaum, L.,
Offermanns, S., Schwaner, I., Zingel, V., Schunack, W., Schultz, G. The
H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes. Mol Pharmacol 45, 578-586 (1994).
Seifert, R. , Höer, A., Offermanns, S., Buschauer, A., Schunack, W. Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1-receptors and is an incomplete secretagogue. Mol Pharmacol 42, 227-234 (1992).
Seifert, R. , Höer, A., Schwaner, I., Buschauer, A. Histamine increases cytosolic Ca2+ in HL-60 promyelocytes via H2-receptors with an unique agonist/antagonist profile and induces functional differentiation. Mol Pharmacol 42, 235-241 (1992).
Seifert, R. , Schultz, G. The superoxide-forming NADPH oxidase of phagocytes: An enzyme system regulated by multiple mechanisms. Rev Physiol Biochem Pharmacol 117, 1-338 (1991).
Seifert, R. , Wenzel,
K., Eckstein, F., Schultz, G. Purine and pyrimidine nucleotides
potentiate activation of NADPH oxidase and degranulation by chemotactic
peptides and induce aggregation of human neutrophils via G proteins. Eur J Biochem 181, 277-285 (1989).
Seifert, R. , Schultz,
G. Fatty acid-induced activation of NADPH oxidase in plasma membranes
of human neutrophils depends on neutrophil cytosol and is potentiated
by stable guanine nucleotides. Eur J Biochem 162, 563-569 (1987).
Seifert, R. , Schächtele, C., Schultz, G. Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol. Biochem Biophys Res Commun 149, 762-768 (1987).
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