Previous Research of the Seifert Laboratory

On December 1, 2004, R. Seifert became Chairman of the Department of Pharmacology and Toxicology of the University of Regensburg. His research interests are in the broad areas of G-protein-coupled receptors (GPCRs), G-proteins and effector systems. While being a postdoc with Prof. G. Schultz (Department of Pharmacology, Free University of Berlin) from 1986-1995, R. Seifert worked on the regulation of the superoxide-generating NADPH oxidase of phagocytes, protein kinase C, nucleotide receptors, chemoattractant receptors, histamine H₁- and H₂-receptors, receptor-independent G-protein activation by cationic-amphiphilic substances and non-selective cation channels. From 1995-1998, R. Seifert worked in Dr. B. Kobilka’s laboratory (Stanford University, CA, USA). His research focused on the analysis of b₂-adrenoceptor-G_s-protein coupling taking advantage of the GPCR-Ga fusion protein technique. From 1998-2004, R. Seifert was an Associate Professor in the Department of Pharmacology and Toxicology of the University of Kansas (KU) (Lawrence, KS, USA). During his tenure at KU, research focused on the molecular analysis of histamine H₁- and H₂-receptors, b-adrenoceptors, formyl peptide receptors, G_s-proteins and regulation of adenylyl cyclases (ACs) by fluorescent nucleotides.