Medicinal and Pharmaceutical Chemistry
Aiming at the development of new drugs medicinal and
pharmaceutical chemistry deals with design, synthesis and investigation
of biologically active compounds, including molecular mechanism of
action, structure-activity relationships and pharmacokinetics. This
implies a broad spectrum of chemical, analytical, biochemical,
pharmacological, and theoretical methods.
In the Department of Pharmaceutical Chemistry II
are synthesized following rational drug design
approaches. The compounds are pharmacologically tested in cellular
assays, on isolated organs and, if promising, in vivo.
are used to analyze quantitative structure-activity
relationships (QSAR), to investigate ligand-receptor interactions, and
to predict new more active drugs.
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