Publikationen

2013

Williams TA, Monticone S, Schack VR, Stindl J, Burrello J, Buffolo F, Annaratone L, Castellano I, Beuschlein F, Reincke M, Lucatello B, Ronconi V, Fallo F, Bernini G, Maccario M, Giacchetti G, Veglio F, Warth R, Vilsen B, Mulatero P.
Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas.
Hypertension. 2013 Sep 30. [Epub ahead of print]
Pubmed

Monticone S, Hattangady NG, Penton D, Isales C, Edwards MA, Williams TA, Sterner C, Warth R, Mulatero P, Rainey WE.
A novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III.
J Clin Endocrinol Metab. 2013 Sep 13. [Epub ahead of print]
Pubmed

Burghardt T, Kastner J, Suleiman H, Rivera-Milla E, Stepanova N, Lottaz C, Kubitza M, Böger CA, Schmidt S, Gorski M, de Vries U, Schmidt H, Hertting I, Kopp J, Rascle A, Moser M, Heid IM, Warth R, Spang R, Wegener J, Mierke CT, Englert C, Witzgall R.
LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys.
J Am Soc Nephrol. 2013 Aug 29. [Epub ahead of print]
Pubmed

Bandulik S, Tauber P, Penton D, Schweda F, Tegtmeier I, Sterner C, Lalli E, Lesage F, Hartmann M, Barhanin J, Warth R.
Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intra-adrenal renin-angiotensin system.
Endocrinology. 2013;154(8):2712-22.
[Pubmed]

Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Schack VR, Amar L, Fischer E, Walther A, Tauber P, Schwarzmayr T, Diener S, Graf E, Allolio B, Samson-Couterie B, Benecke A, Quinkler M, Fallo F, Plouin PF, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R, Vilsen B, Zennaro MC, Strom TM, Reincke M.
Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension.
Nat Genet. 2013 Apr;45(4):440-4.
[Pubmed]

2012

El Wakil A, Bandulik S, Guy N, Bendahhou S, Zennaro MC, Niehrs C, Mari B, Warth R, Barhanin J, Lalli E.
Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex.
Hum Mol Genet. 2012; 21(22):4922-9.
[Pubmed]

Penton D, Bandulik S, Schweda F, Haubs S, Tauber P, Reichold M, Dang Cong L, El Wakil A, Budde T, Lesage F, Lalli E, Zennaro MC, Warth R (corresponding author), Barhanin J.
Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension.
Endocrinology. 2012;153(10):4740-8.
[Pubmed]

Chatelain FC, Bichet D, Douguet D, Feliciangeli S, Bendahhou S, Reichold M, Warth R, Barhanin J, Lesage F.
TWIK1, a unique background channel with variable ion selectivity.
Proc Natl Acad Sci U S A. 2012;109(14):5499-504.
[Pubmed]

Williams TA, Monticone S, Crudo V, Warth R, Veglio F, Mulatero P.
Visinin-Like 1 is upregulated in aldosterone-producing adenomas with KCNJ5 mutations and protects from calcium-induced apoptosis.
Hypertension. 2012;59(4):833-9.
[Pubmed]

Mulatero P, Tauber P, Zennaro MC, Monticone S, Lang K, Beuschlein F, Fischer E, Tizzani D, Pallauf A, Viola A, Amar L, Williams TA, Strom TM, Graf E, Bandulik S, Penton D, Plouin PF, Warth R, Allolio B, Jeunemaitre X, Veglio F, Reincke M.
KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism.
Hypertension 2012; 59(2):235-40.
[Pubmed]

2011

Böckenhauer D, Stanescu H, Bandulik S, Reichold M, Zdebik A, Warth R, Kleta R
EAST-Syndrom: Ein neues Krankheitsbild mit renalem Salzverlust.
Nephrologe 2011; 6:529–536.
[PDF]

Freudenthal B, Kulaveerasingam D, Lingappa L, Shah MA, Brueton L, Wassmer E, Ognjanovic M, Dorison N, Reichold M, Bockenhauer D, Kleta R, Zdebik AA.
KCNJ10 mutations disrupt function in patients with EAST syndrome.
Nephron Physiol. 2011 Aug 18;119(3):p40-p48.
[Pubmed]

Liu W, Schreck C, Coleman RA, Wade JB, Hernandez Y, Zavilowitz B, Warth R, Kleyman TR, Satlin LM.
Role of NKCC in BK channel-mediated net K+ secretion in the CCD.
Am J Physiol Renal Physiol. 2011 Nov. 301(5):F1088-97
[Pubmed]

Thompson DA, Feather S, Stanescu HC, Freudenthal B, Zdebik AA, Warth R, Ognjanovic M, Hulton SA, Wassmer E, Van't Hoff W, Russell-Eggitt I, Dobbie A, Sheridan E, Kleta R, Bockenhauer D.
Altered electroretinograms in patients with KCNJ10 mutations and EAST syndrome.
J Physiol. 2011 Apr 1;589(Pt 7):1681-9.
[Pubmed]

Bandulik S, Schmidt K, Bockenhauer D, Zdebik AA, Humberg E, Kleta R, Warth R, Reichold M.
The salt-wasting phenotype of EAST syndrome, a disease with multifaceted symptoms linked to the KCNJ10 K(+) channel.
Pflugers Arch. 2011 Apr;461(4):423-35.
[Pubmed]

2010

Reichold M, Zdebik AA, Lieberer E, Rapedius M, Schmidt K, Bandulik S, Sterner C, Tegtmeier I, Penton D, Baukrowitz T, Hulton SA, Witzgall R, Ben-Zeev B, Howie AJ, Kleta R, Bockenhauer D, Warth R.
KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function.
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14490-5.
[PNAS article]

Weber A, Chung H-J, Springer E, Heitzmann D, Warth R.
The TFIIH subunit p89 (XPB) localizes to the centrosome during mitosis.
Cellular Oncology. 2010;32(1-2):121-30.
[Pubmed]

Gestreau C, Heitzmann D, Thomas J, Dubreuil V, Bandulik S, Reichold M, Bendahhou S, Pierson P, Sterner C, Peyronnet-Roux J, Benfriha C, Tegtmeier I, Ehnes H, Georgieff M, Lesage F, Brunet J-F, Goridis C, Warth R (corresponding author), Barhanin J.
Task2 potassium channels set central respiratory CO2 and O2 sensitivity.
PNAS. 2010;107(5):2325-30.
[PNAS article]

Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins JR, Kunzelmann K.
Expression and Function of Epithelial Anoctamins.
J Biol Chem. 2010;285(10):7838-45.
[Pubmed]

Preston P, Wartosch L, Gunzel D, Fromm M, Kongsuphol P, Ousingsawat J, Kunzelmann K, Barhanin J, Warth R, Jentsch TJ.
Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport.
J Biol Chem. 2010;285(10):7165-75.
[Pubmed]

Bandulik S, Penton D, Barhanin J, Warth R.
TASK1 and TASK3 Potassium Channels: Determinants of Aldosterone Secretion and Adrenocortical Zonation.
Horm Metab Res. 2010;42(6):450-7.
[Pubmed]

2009

Feliciangeli S, Tardy MP, Sandoz G, Chatelain F, Warth R, Barhanin J, Bendahhou S, Lesage F.
Potassium channel silencing by constitutive endocytosis and intracellular sequestration.
J Biol Chem. 2010;285(7):4798-805. Epub 2009 Dec 3.
[Pubmed]

Kunzelmann K, Kongsuphol P, Aldehni F, Tian Y, Ousingsawat J, Warth R, Schreiber R.
Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions.
Cell Calcium. 2009 Oct;46(4):233-41.
[Pubmed]

Bockenhauer D, Feather S, Stanescu HC, Bandulik S, Zdebik AA, Reichold M, Tobin J, Lieberer E, Sterner C, Landoure G, Arora R, Sirimanna T, Thompson D, Cross JH, van't Hoff W, Al Masri O, Tullus K, Yeung S, Anikster Y, Klootwijk E, Hubank M, Dillon MJ, Heitzmann D, Arcos-Burgos M, Knepper MA, Dobbie A, Gahl WA, Warth R, Sheridan E, Kleta R.
Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations.
N Engl J Med. 2009 May 7;360(19):1960-70.
[Pubmed] [read also editorial]

Lee WK, Reichold M, Edemir B, Ciarimboli G, Warth R, Koepsell H, Thevenod F.
The organic cation transporters OCT1, 2, and 3 mediate high affinity transport of the mutagenic vital dye ethidium in the kidney proximal tubule.
Am J Physiol Renal Physiol. 2009; 296(6):F1504-13.
[Pubmed]

2008

Heitzmann D, Warth R.
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Physiol Rev. 2008 Jul;88(3):1119-82.
[Pubmed]

Heitzmann D, Derand R, Jungbauer S, Bandulik S, Sterner C, Schweda F, Elwakil AE, Lalli E, Guy N, Mengual R, Reichold M, Tegtmeier I, Bendahhou S, Gomez-Sanchez CE, Isabel Aller M, Wisden W, Weber A, Lesage F, Warth R, Barhanin J.
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis.
EMBO J. 2008 Jan 9;27(1):179-87.
[Pubmed]

2007

Heitzmann D, Warth R.
No potassium, no acid: K+ channels and gastric acid secretion.
Physiology (Bethesda). 2007 Oct;22:335-41.
[Pubmed]

Feliciangeli S, Bendahhou S, Sandoz G, Gounon P, Reichold M, Warth R, Lazdunski M, Barhanin J, Lesage F.
Does Sumoylation Control K2P1/TWIK1 Background K(+) Channels?
Cell. 2007 Aug 10;130(3):563-9.
[Pubmed]

Fakitsas P, Adam G, Daidié D, van Bemmelen MX, Fouladkou F, Patrignani A, Wagner U, Warth R, Camargo SM, Staub O, Verrey F.
Early aldosterone-induced gene product regulates the epithelial sodium channel by deubiquitylation.
J Am Soc Nephrol. 2007 Apr;18(4):1084-92. Epub 2007 Mar 7.
[Pubmed]

Heitzmann D, Koren V, Wagner M, Sterner C, Reichold M, Tegtmeier I, Volk T, Warth R.
KCNE beta subunits determine pH sensitivity of KCNQ1 potassium channels.
Cell Physiol Biochem. 2007;19(1-4):21-32.
[Pubmed]

Kurtz L, Schweda F, de Wit C, Kriz W, Witzgall R, Warth R, Sauter A, Kurtz A, Wagner C.
Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium.
J Am Soc Nephrol. 2007 Apr;18(4):1103-11. Epub 2007 Feb 28.
[Pubmed]

2005

Ullrich S, Su J, Ranta F, Wittekindt OH, Ris F, Rösler M, Gerlach U, Heitzmann D, Warth R, Lang F.
Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells.
Pflugers Arch. 2005 Dec;451(3):428-36. Epub 2005 Aug 30.
[Pubmed]

2004

Decressac S, Franco M, Bendahhou S, Warth R, Knauer S, Barhanin J, Lazdunski M, Lesage F.
ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6.
EMBO Rep. 2004 Dec;5(12):1171-5.
[Pubmed]

Heitzmann D, Grahammer F, von Hahn T, Schmitt-Gräff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R.
Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
J Physiol. 2004 Dec 1;561(Pt 2):547-57. Epub 2004 Oct 7.
[Pubmed]

Kleta R, Romeo E, Ristic Z, Ohura T, Stuart C, Arcos-Burgos M, Dave MH, Wagner CA, Camargo SR, Inoue S, Matsuura N, Helip-Wooley A, Bockenhauer D, Warth R, Bernardini I, Visser G, Eggermann T, Lee P, Chairoungdua A, Jutabha P, Babu E, Nilwarangkoon S, Anzai N, Kanai Y, Verrey F, Gahl WA, Koizumi A.
Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder.
Nat Genet. 2004 Sep;36(9):999-1002. Epub 2004 Aug 1.
[Pubmed]

Warth R, Barrière H, Meneton P, Bloch M, Thomas J, Tauc M, Heitzmann D, Romeo E, Verrey F, Mengual R, Guy N, Bendahhou S, Lesage F, Poujeol P, Barhanin J.
Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport.
Proc Natl Acad Sci U S A. 2004 May 25;101(21):8215-20. Epub 2004 May 12.
[Pubmed]

Goldschimdt I, Grahammer F, Warth R, Schulz-Baldes A, Garty H, Greger R, Bleich M.
Kidney and colon electrolyte transport in CHIF knockout mice.
Cell Physiol Biochem. 2004;14(1-2):113-20.
[Pubmed]

2003

Warth R.
Potassium channels in epithelial transport.
Pflugers Arch. 2003 Aug;446(5):505-13. Epub 2003 Apr 18.
[Pubmed]

Warth R, Barhanin J.
Function of K+ channels in the intestinal epithelium.
J Membr Biol. 2003 May 15;193(2):67-78.
[Pubmed]

Warth R, Garcia Alzamora M, Kim JK, Zdebik A, Nitschke R, Bleich M, Gerlach U, Barhanin J, Kim SJ.
The role of KCNQ1/KCNE1 K(+) channels in intestine and pancreas: lessons from the KCNE1 knockout mouse.
Pflugers Arch. 2002 Mar;443(5-6):822-8. Epub 2001 Dec 7.
[Pubmed]

2002

Warth R, Barhanin J.
The multifaceted phenotype of the knockout mouse for the KCNE1 potassium channel gene.
Am J Physiol Regul Integr Comp Physiol. 2002 Mar;282(3):R639-48.
[Pubmed]

2001

Arrighi I, Bloch-Faure M, Grahammer F, Bleich M, Warth R, Mengual R, Drici MD, Barhanin J, Meneton P.
Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome.
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8792-7. Epub 2001 Jul 3.
[Pubmed]

Grahammer F, Herling AW, Lang HJ, Schmitt-Gräff A, Wittekindt OH, Nitschke R, Bleich M, Barhanin J, Warth R.
The cardiac K+ channel KCNQ1 is essential for gastric acid secretion.
Gastroenterology. 2001 May;120(6):1363-71.
[Pubmed]

Grahammer F, Warth R, Barhanin J, Bleich M, Hug MJ.
The small conductance K+ channel, KCNQ1: expression, function, and subunit composition in murine trachea.
J Biol Chem. 2001 Nov 9;276(45):42268-75. Epub 2001 Aug 29.
[Pubmed]

Kunzelmann K, Hübner M, Schreiber R, Levy-Holzman R, Garty H, Bleich M, Warth R, Slavik M, von Hahn T, Greger R.
Cloning and function of the rat colonic epithelial K+ channel KVLQT1.
J Membr Biol. 2001 Jan 15;179(2):155-64.
[Pubmed]

Kunzelmann K, Bleich M, Warth R, Levy-Holzman R, Garty H, Schreiber R.
Expression and function of colonic epithelial KvLQT1 K+ channels.
Clin Exp Pharmacol Physiol. 2001 Jan-Feb;28(1-2):79-83.
[Pubmed]

Schulz-Baldes A, Berger S, Grahammer F, Warth R, Goldschmidt I, Peters J, Schütz G, Greger R, Bleich M.
Induction of the epithelial Na+ channel via glucocorticoids in mineralocorticoid receptor knockout mice.
Pflugers Arch. 2001 Nov;443(2):297-305.
[Pubmed]

Vallon V, Grahammer F, Richter K, Bleich M, Lang F, Barhanin J, Völkl H, Warth R.
Role of KCNE1-dependent K+ fluxes in mouse proximal tubule.
J Am Soc Nephrol. 2001 Oct;12(10):2003-11.
[Pubmed]

von Hahn T, Thiele I, Zingaro L, Hamm K, Garcia-Alzamora M, Köttgen M, Bleich M, Warth R.
Characterisation of the rat SK4/IK1 K(+) channel.
Cell Physiol Biochem. 2001;11(4):219-30.
[Pubmed]

2000

Bleich M, Warth R.
The very small-conductance K+ channel KvLQT1 and epithelial function.
Pflugers Arch. 2000 Jun;440(2):202-6.
[Pubmed]

Bleich M, Heitzmann D, Hug MJ, Hoffmann EK, Greger R, Warth R.
Regulation of the Na+ 2Cl- K+ co-transporter--mechanisms in the rectal gland of Squalus acanthias with implications for the thick ascending limb of Henle.
Nephrol Dial Transplant. 2000;15 Suppl 6:16-8.
[Pubmed]

Hasselblatt P, Warth R, Schulz-Baldes A, Greger R, Bleich M.
pH regulation in isolated in vitro perfused rat colonic crypts.
Pflugers Arch. 2000 Nov;441(1):118-24.
[Pubmed]

Heitzmann D, Warth R, Bleich M, Henger A, Nitschke R, Greger R.
Regulation of the Na+2Cl-K+ cotransporter in isolated rat colon crypts.
Pflugers Arch. 2000 Jan;439(3):378-84.
[Pubmed]

Mauricio AC, Slawik M, Heitzmann D, von Hahn T, Warth R, Bleich M, Greger R.
Deoxycholic acid (DOC) affects the transport properties of distal colon.
Pflugers Arch. 2000 Mar;439(5):532-40.
[Pubmed]

Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R, Jentsch TJ.
A constitutively open potassium channel formed by KCNQ1 and KCNE3.
Nature. 2000 Jan 13;403(6766):196-9.
[Pubmed]

Warth R, Bleich M.
K+ channels and colonic function.
Rev Physiol Biochem Pharmacol. 2000;140:1-62.
[Pubmed]