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PD Dr. Oliver Bosch

 


Research

Research


Maternal behaviour is the behaviour of the mother ensuring the well-being and development of her offspring. In order to become maternal, the mother’s brain undergoes remarkable physiological and behavioural changes in the peripartum period to meet the demands of the offspring. These adaptations, which start as complex and direct consequences of hormonal signals arising from the foetus, continue in lactation as a result of close interactions between mother and offspring - the maternal behaviour. Our group is interested in the neurobiological regulation of maternal behaviour, i.e. maternal care, maternal motivation and maternal aggression, with special focus on the mother's innate anxiety. We focus on the role of yet less investigated brain neuropeptides using techniques such as microdialysis, retrodialysis, osmotic minipumps, viral vector-mediated gene transfer, in situ hybridisation, receptor autoradiography, blood sampling.

 

Grants / Awards


2011-2014

DFG grant (BO 1958/6-1) to investigate in depth the role of the brain vasopressin system in mediating maternal care in rodents


2008-2010

DAAD Travel grant for collaboration with Dr. Simone Meddle, University of Edinburgh


2003

Armin Ermisch Memorial Award


2000-2001

PhD-Stipend of the University of Regensburg (Promotionsstipendium)

 

 

Profile

Profile

 

1992-1995
undergraduate studies in biology at the University of Regensburg
 

 
1995-1997
Graduate studies in biology at the University of Regensburg with focus on Zoology / Insect physiology

 

1998
MSc (Diplom) in biology at the University of Regensburg
Diploma/Master thesis: "Über die Attraktivität verschiedener Komponenten des menschlichen Hautduftes und die Bedeutung der Struktur von Duftwolken für die Attraktivität von Duftstoffen - Messungen an der Gelbfiebermücke Aedes aegypti (L.)"

 

1998-2001
PhD studies in biology at the University of Regensburg with focus on Zoology / Insect physiology

 

2001
PhD degree in biology at the University of Regensburg
PhD thesis: "Wirtsdüfte und deren Komponenten im Spiegelbild der olfaktorischen Sinneszellen bei der Gelbfiebermücke Aedes aegypti (L.)"

 

2001-2007
Postdoc in Prof. Inga Neumann’s group at the University of Regensburg with focus on maternal behavior, anxiety and stress coping in a rat model for extremes in anxiety

 

2007 to date
Senior Scientist

 

2011
Habilitation in Zoology at the University of Regensburg to achieve the "Dr. habil." and Privatdozent PD
Habilitation thesis: "The neuroendocrine regulation of maternal behaviour and the impact on the offspring in rodents."

 

Publications

Publications

Pubmed
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2014

Bosch OJ, Slattery DA, Neumann ID (2014) The 5th Parental Brain Conference. J Neuroendocrinol in press.

Klampfl SM, Brunton PJ, Bayerl DS, Bosch OJ (2014) Hypo-activation of CRF receptors, predominantly type 2, in the medial-posterior BNST is vital for adequate maternal behavior in lactating rats. J Neurosci 34: 9665-9676.

 

2013

Bosch OJ (2013) Maternal aggression in rodents: Brain oxytocin and vasopressin mediate pup defence. Phil Trans R Soc B: 368 20130085.

Klampfl SM, Neumann ID, Bosch OJ (2013) Reduced brain CRF receptor activation is required for adequate maternal care and maternal aggression in lactating rats. Eur J Neurosci 38: 2742-2750.

 

2012

Okimoto N, Bosch OJ, Slattery DA, Pflaum K, Matsushita H, Wei F-Y, Ohmori M, Nishiki T-I, Ohmori I, Hiramatsu Y, Matsui H, Neumann ID, Tomizawa K (2012) RGS2 mediates the anxiolytic effect of oxytocin. Brain Res 1453: 26-33.

Bosch OJ, Neumann ID (2012) Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: From central release to sites of action. Horm Behav 61: 293-303.

 

2011

Caughey S, Klampfl SM, Bishop VR, Pförtsch J, Neumann ID, Bosch OJ, Meddle SL (2011) Changes in the intensity of maternal aggression and central oxytocin and vasopressin V1a receptors across the peripartum period in the rat. J Neuroendocrinol 23: 1113-1124.

Bosch OJ (2011) Maternal nurturing is dependent on her innate anxiety: The behavioral roles of brain oxytocin and vasopressin. Horm Behav 59: 201-212.

Bosch OJ, Kessler MS, Bunck M, Landgraf R, Neumann ID (2011) Maternal care differs in mice bred for high versus low trait anxiety: Impact of brain vasopressin and cross-fostering. Social Neuroscience 6: 156-168.

 

2010

Bosch OJ, Pförtsch J, Beiderbeck DI, Landgraf R, Neumann ID (2010) Maternal behaviour is associated with vasopressin release in the medial preoptic area and bed nucleus of the stria terminalis in the rat. J Neuroendocrinol 22: 420-429.

Bosch OJ, Neumann ID (2010) Vasopressin released within the central amygdala promotes maternal aggression. Eur J Neurosci 31: 883-891.

Waldherr M, Nyuyki K, Maloumby R, Bosch OJ, Neumann ID (2010) Attenuation of the neuronal stress responsiveness and corticotrophin releasing hormone synthesis after sexual activity in male rats. Horm Behav 57: 222-229.

 

2009

Bosch OJ, Nair HP, Ahern TH, Neumann ID, Young LJ (2009) The CRF system mediates increased passive stress-coping behavior following the loss of a bonded partner in a monogamous rodent. Neuropsychopharmacology 34: 1406-1415.

Lucassen PJ, Bosch OJ, Jousma E, Kromer S, Andrews R, Seckl J, Neumann ID (2009) Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low anxiety: possible key role of placental 11ß-hydroxysteroid dehydrogenase type 2. Eur J Neurosci 29: 97-103.

 

2008

Bosch OJ, Neumann ID (2008) Brain vasopressin is an important regulator of maternal behavior independent of dams' trait anxiety. PNAS 105: 17139-17144.

Neumann ID, Bosch OJ (2008) Maternal stress adaptations peripartum: Mom's innate anxiety determines maternal care and aggression. In: Neurobiology of the parental brain. pp. 115-130. Bridges R [ed.]; Elsevier.

Blume A, Bosch OJ, Miklos S, Torner L, Wales L, Waldherr M, Neumann ID (2008) Oxytocin reduces anxiety via ERK1/2 activation: local effect within the rat hypothalamic paraventricular nucleus. Eur J Neurosci 27: 1947-1956.

 

2007

Bosch OJ, Sartori SB, Singewald N, Neumann ID (2007) Extracellular amino acid levels in the paraventricular nucleus and the central amygdala in high- and low-anxiety dams during maternal aggression: Regulation by oxytocin. Stress 10: 261-270.

Bosch OJ, Müsch W, Bredewold R, Slattery DA, Neumann ID (2007) Prenatal stress increases HPA-axis activity and impairs maternal care in lactating female offspring: implications for postpartum mood disorder. Psychoneuroendocrinology 32: 267-278.

Douglas AJ, Meddle SL, Kroemer S, Muesch W, Bosch OJ, Neumann ID (2007) Social stress induces hypothalamo-pituitary-adrenal axis responses in lactating rats bred for high trait anxiety. Eur J Neurosci 25: 1599-1603.

 

2006

Bosch OJ, Krömer SA, Neumann ID (2006) Prenatal stress: opposite effects on anxiety and hypothalamic expression of vasopressin and corticotropin-releasing hormone in rats selectively bred for high and low anxiety. Eur J Neurosci 23: 541-551.

Bosch OJ, Waldherr SA, Nair HP, Young LJ, Neumann ID (2006) Viral vector-mediated overexpression of oxytocin receptors in the amygdala of virgin rats increases aggression and reduces anxiety. Front Neuroendocrinol 27: 124-125.

 

2005

Bosch OJ, Meddle SL, Beiderbeck DI, Douglas AJ, Neumann ID (2005) Brain oxytocin correlates with maternal aggression: link to anxiety. J Neurosci 25: 6807-6815.

Neumann ID, Krömer S, Bosch OJ (2005) Effects of psycho-social stress during pregnancy on neuroendocrine and behavioural parameters in lactation depend on the genetically determined stress vulnerability. Psychoneuroendocrinology 30: 791-806.

Neumann ID, Wigger A, Krömer S, Frank E, Landgraf R, Bosch OJ (2005) Differential effects of periodic maternal separation on adult stress coping in a rat model of extremes in trait anxiety. Neuroscience 132: 867-877.

Douglas AJ, Meddle SL, Toschi N, Bosch OJ, Neumann ID (2005) Reduced activity of the noradrenergic system in the paraventricular nucleus at the end of pregnancy: implications for stress hyporesponsiveness. J Neuroendocrinol 17: 40-48.

Ebner K, Bosch OJ, Kromer SA, Singewald N, Neumann ID (2005) Release of oxytocin in the rat central amygdala modulates stress-coping behavior and the release of excitatory amino acids. Neuropsychopharmacology 30: 223-230.

 

2004

Bosch OJ, Krömer SA, Brunton PJ, Neumann ID (2004) Release of oxytocin in the hypothalamic paraventricular nucleus, but not amygdala or septum in lactating residents and virgin intruders during maternal defence. Neuroscience 124: 439-448.

 

2003

Douglas AJ, Brunton PJ, Bosch OJ, Russel JA, Neumann ID (2003) Neuroendocrine responses to stress in mice: hyporesponsiveness in pregnancy and parturition. Endocrinology 144: 5268-5276.

Neumann ID, Bosch OJ, Toschi N, Torner L, Douglas AJ (2003) No stress response of the hypothalamo-pituitary-adrenal axis in parturient rats: lack of involvement of brain oxytocin. Endocrinology 144: 2473-2479.

 

2000

Bosch OJ, Geier M, Boeckh J (2000) Contribution of fatty acids to olfactory host finding of female Aedes aegypti. Chem Senses 25: 323-330.

 

1999

Geier M, Bosch OJ, Boeckh J (1999) Influence of odour plume structure on upwind flight of mosquitoes towards hosts. J Exp Biol 202: 1639-1648.

Geier M, Bosch OJ, Boeckh J (1999) Ammonia as an attractive component of host odour for the yellow fever mosquito, Aedes aegypti. Chem Senses 24: 647-653.

 

People

Ag Bosch 2014


Junior Group Leader

PD Dr. Oliver J. Bosch 0941 / 943 3076 D4.2.317 E-Mail


PhD Students

Stefanie Klampfl 0941 / 943 3080 D4.2.309 E-Mail
Doris Bayerl 0941 / 943 3119 D4.2.315 E-Mail


Master Students


Bachelor Students

Milena Schramm
Johanna Zöller

  1. Fakultäten
  2. Fakultät für Biologie und Vorklinische Medizin

PD Dr. Oliver Bosch

 

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Bio D4.2.317
Tel. +49-941-943-3076

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