Research
Research
In many mammalian species, including humans, it is known that stress and anxiety reduce the time and energy allocated to reproductive behaviors such as mating and parental care. Reversely, reproductive status and reproductive behavior strongly influence emotionality and risk-taking.
The oxytocin (OT) and serotonin (5-HT) neurotransmitter systems are both strongly involved in reproductive behavior as well emotionality. The separate roles of OT and 5-HT in these behaviors have been studied extensively, but the importance of existing connections between the two systems in the paraventricular hypothalamic nucleus (PVN) and median raphe nucleus (MRN) is much less understood.
My project aims to map the behavioral effects (reproductive and emotional) of 5-HT-mediated OT neurotransmission in the PVN as well as OT-mediated 5-HT neurotransmission in the MRN.
In order to do this, I will make use of various behavioral paradigms in combination in vivo microdialysis (OT+5-HT in PVN and raphe nuclei), microinfusion (oxytocinergic and serotonergic drugs), and neuroanatomical techniques.
Profile
Profile
2011-2013:
Humboldt Foundation Postdoctoral Fellowship at the Dept. of Behavioral and Molecular Neurobiology, University of Regensburg, Germany
2008-2010:
Postdoctoral Fellow at the Dept. of Biology-Behavioral Neuroendocrinology, University of California, Riverside, USA.
2006-2007:
Postdoctoral Fellow at the Dept. of Psychoharmacology, Utrecht University, the Netherlands.
01/12/2005
PhD degree at the Dept. of Psychopharmacology, Utrecht University, the Netherlands
30/08/2001:
Drs degrees (equivalent to MSc/MA) in Biology and Journalism at the University of Groningen, the Netherlands.
Publications
Publications
In Press
Chauke M, de Jong TR, Garland T Jr., Saltzman W. Paternal responsiveness is associated with, but not mediated by reduced neophobia in male California mice (Peromyscus californicus). In press in Physiology and Behavior
De Jong TR, Korosi A, Harris BN, Perea-Rodriguez JP, Saltzman W. Behavioral and physiological associations between rank and paternal care in virgin Peromyscus californicus. Physiological and Biochemical Zoology (in press).
2011
Snoeren, EMS, Chan JSW, de Jong TR, Olivier BA, Oosting, RS. A new female rat animal model for Hypoactive Sexual Desire Disorder; behavioral and pharmacological evidence. Journal of Sexual Medicine 8(1): 44-56
Chauke M, Malisch JL, Harris BN, Robinson C, De Jong TR, Saltzman W. Effects of fatherhood and male-female pair bonding on corticosterone responses to stress in biparental California mice (Peromyscus californicus). Hormones and Behavior 60(1):128-138
2010
De Jong TR, Measor K, Chauke M, Harris BN, Saltzman W. Brief pup exposure induces Fos expression in the lateral habenula and serotonergic caudal dorsal raphe nucleus of paternally experienced male California mice (Peromyscus californicus). Neuroscience 169(3): 1094-1104
Veening JG, de Jong TR, Barendregt HP. Oxytocin messages via the cerebrospinal fluid: behavioral effects; a review. Physiology and Behavior 101(2): 193-210
Millan MJ, Dekeyne A, Gobert A, la Cour CM, Brocco M, Rivet JM, Di Cara B, Lejeune F, Cremers TI, Flik G, de Jong TR, Olivier B, de Nanteuil G. S41744, a dual neurokinin (NK)(1) receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: A comparison to aprepitant (MK869) and paroxetine. European Neuropsychopharmacology 20(9): 599-621
2009
De Jong TR, Chauke M, Harris BN, Saltzman W. From here to paternity: Neural correlates of the onset of paternal behavior in California mice (Peromyscus californicus). Hormones and Behavior 56(2): 220-231
2008
Chan JS, Olivier B, de Jong TR, Snoeren EM, Kooijman E, van Hasselt FN, Limpens JH, Kas MJ, Waldinger MD, Oosting RS. Translational research into sexual disorders: Pharmacology and genomics. European Journal of Pharmacology 585(2-3): 426-35
Brocco M, Dekeyne A, Mannoury la Cour C, Touzard M, Girardon S, Veiga S, de Nanteuil G, de Jong TR, Olivier B, Millan MJ. Cellular and behavioural profile of the novel, selective neurokinin(1) receptor antagonist, vestipitant: A comparison to other agents. European Neuropsychopharmacology, 18(10): 729-50
2007
De Jong TR, Veening JG, Olivier B, Waldinger MD. Oxytocin involvement in SSRI-induced delayed ejaculation: a review of animal studies. Journal of Sexual Medicine 4(1): 14-28
Olivier JDA, de Jong TR, Dederen PJ, van Oorschot R, Heeren D, Pattij T, Waldinger MD, Coolen LM, Cools AR, Olivier B, Veening JG. Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat. European Journal of Pharmacology 576(1-3): 61-76
2006
De Jong TR, Veening JG, Waldinger MD, Cools AR, Olivier, B. Serotonin and the neurobiology of the ejaculatory threshold. Neuroscience and Biobehavioral Reviews 30(7): 893-907
De Jong TR, Snaphaan LJAE, Pattij T, Veening JG, Waldinger MD, Cools AR, Olivier, B. Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats. Euro-pean Neuropsychopharmacology 16(1): 39-48
Olivier B, Chan JS, Pattij T, de Jong TR, Oosting RS, Veening JG, Waldinger MD. Psychopharmacology of male rat sexual behavior: modeling human sexual dysfunctions? International Journal of Impotence Research 18: S14-S24
2005
De Jong TR, Pattij T, Veening JG, Dederen PJ, Waldinger MD, Cools AR and Olivier B. Effects of chronic paroxetine pretreatment on (+/-)-8-hydroxy-2-(di-npropyl- amino)tetralin induced c-fos expression following sexual behavior. Neuroscience 134(4): 1351-1361
De Jong TR, Pattij T, Veening JG, Waldinger MD, Cools AR and Olivier B. Effects of chronic selective serotonin reuptake inhibitors on 8-OH-DPAT-induced facilitation of ejaculation in rats: comparison of fluvoxamine and paroxetine. Psychopharmacology (Berlin) 179: 509-15
De Jong TR, Pattij T, Veening JG, Dederen PJ, Waldinger MD, Cools AR and Olivier B. Citalopram combined with WAY 100635 inhibits ejaculation and ejaculation-related Fos immunoreactivity. European Journal of Pharmacology 509: 49-59
Pattij T, de Jong TR, Uitterdijk A, Waldinger MD, Veening JG, Cools AR, van der Graaf PH, Olivier B. Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders. European Journal of Neuroscience 22: 724-734
Veening JG, Coolen LM, de Jong TR, Joosten HW, de Boer SF, Koolhaas JM, Olivier B. Do similar neural systems subserve aggressive and sexual behaviour in male rats? Insights from c-Fos and pharmacological studies. European Journal of Pharmacology 526(1-3): 226-39
