Research
Research
Maternal behaviour is the behaviour of the lactating mother ensuring the well-being and proper development of the offspring. Both components of maternal behaviour, i.e. maternal care and maternal aggression, are mediated by the neuropeptide oxytocin. Recent studies from our lab have demonstrated that the related neuropeptide vasopressin (AVP) and its V1a receptor also play an important role in the expression of maternal behaviour. Following these previous findings my main research interest is focused on a more in-depth investigation of the function of the brain AVP system in maternal care, maternal aggression and anxiety during lactation in rats. Here, I study the neuropeptide- and receptor-specific effects mediated via brain regions which have been identified as being involved in the expression of maternal behaviour. The techniques I apply include pharmacological and/ or genetic (shRNA) manipulations followed by behavioural observations, as well as in situ hybridization, receptor autoradiography and immunohistochemistry.
Profile
Profile
05/2016 to date
Postdoctoral fellow in the group of PD Dr. Oliver Bosch at the University of Regensburg, Germany.
09/2012 - 04/2016
PhD student in neurobiology in the group of PD Dr. Oliver Bosch (laboratory of Prof. Neumann) at the University of Regensburg ,Germany.
2010 - 2012
M.Sc. with main focus on neurobiology (Master thesis: “Impact of chronic pregnancy stress on the mother and her offspring – and its potential reversal by a GSK3ß- inhibitor”)
2006 – 2010
B.Sc. in Biology at the University of Regensburg (Bachelor thesis: “Reversal of behavioural and physiological consequences of pregnancy stress by antidepressant treatment”)
born November 1st 1986 in Pfaffenhofen/Ilm, Germany
Publications
Publications
2016
Klampfl SM, Schramm M, Stinnett G, Bayerl DS, Seasholtz AF, Bosch OJ (2016) Brain CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats. Horm Beh (in press).
Bayerl DS, Hönig JN, Bosch OJ (2016) Vasopressin V1a, but not V1b, receptors within the PVN of lactating rats mediate maternal care and anxiety-related behaviour. Behav Brain Res 305:18-22.
Bayerl DS, Kaczmarek V, Jurek B, van den Burg EH, Neumann ID, Gaßner BM, Klampfl SM, Bosch OJ (2016) Antagonism of V1b receptors promotes maternal motivation to retrieve pups in the MPOA and impairs pup-directed behavior during maternal defense in the mpBNST of lactating rats. Horm Behav 79: 18-27.
2015
Klampfl SM, Brunton PJ, Bayerl DS, Bosch OJ (2015) CRF-R1 activation in the anterior-dorsal BNST induces maternal neglect in lactating rats via an HPA axis-independent central mechanism. Psychoneuroendocrinology 64: 89-98.
2014
Bayerl DS, Klampfl SM, Bosch OJ (2014) Central V1b receptor antagonism in lactating rats: Impairment of maternal care but not of maternal aggression. J Neuroendocrinol 26: 918-926.
Klampfl SM, Brunton PJ, Bayerl DS, Bosch OJ (2014) Hypo-activation of CRF receptors, predominantly type 2, in the medial-posterior BNST is vital for adequate maternal behavior in lactating rats. J Neurosci 34: 9665-9676.
