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A - E

Dr. Iris Aiglstorfer

Dissertation: Argininamide und Argininamid-Analoga: Synthese und Struktur-Wirkungsbeziehungen neuer Neuropeptid Y Y1-Rezeptorantagonisten


Dr. Peter Altenschöpfer

Dissertation: Tumorpharmakologische und analytische Untersuchungen zur Optimierung neuer Zytostatika-beladener bioabbaubarer Implantate für die Chemotherapie maligner Hirntumoren


Dr. Paul Baumeister

Dissertation: Molecular tools for G-protein coupled receptors:
Synthesis, pharmacological characterization and [3H]-labeling of subtype-selective ligands for histamine H4 and NPY Y2 receptors. Dissertation, Universität Regensburg


Dr. Tobias Birnkammer

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Highly potent and selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships of mono- and bivalent ligands


Dr. Alexander Botzki

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Structure-based design of hyaluronidase inhibitors


Dr. Stephan Braun

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships


Dr. Albert Brennauer

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity


Dr. Irena Brunskole

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Molecular and cellular analysis of aminergic G protein-coupled receptors: histamine H2, H4 and β2-adrenergic receptors, a scientific paradigm


Dr. Noemi Colombo

Dissertation: Synthesis and Conformational Analysis of Polypeptides Related to the Inhibitor of DNA Binding and Cell Differentiation Id2


Dr. Stefanie Dukorn

Dissertation: Pharmacological tools for the NPY receptors: [35 S]GTPyS binding assays, luciferase gene reporter assays and labeled peptides


Dr. Daniela Erdmann

Dissertation: Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools


Dr. Miriam Ertel

Dissertation: Ambivalence of drug metabolism: Exploration of cilazapril and candesartan prodrugs for transdermal delivery and search for toxic reactive intermediates of N(G)-acylated hetarylpropylguanidines


F - J

Dr. Johannes Felixberger

Dissertation: Luciferase complementation for the determination of arrestin recruitment: investigaions at histamine and NPY receptors


Dr. Stephan Fellner

Dissertation: Pharmakokinetische und pharmakodynamische Untersuchungen zur Koapplikation von MDR-Modulatoren (SDZ PSC 833) und Hyaluronidase bei der Chemotherapie maligner Gliome


Dr. Karin Geßele

Dissertation: Zelluläre Testsysteme zur pharmakologischen Charakterisierung neuer Neuropeptid Y-Rezeptorantagonisten: Rezeptorbindungsstudien und funktionelle Untersuchungen zur Calciummobilisierung und cAMP-Bildung


Dr. Roland Geyer

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships


Dr. Prasanta Ghorai

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity


Dr. Detlef Glaß

Dissertation: Synthese und Pharmakologie nonsteroidaler Kardiotonika mit kombinierter Histamin H2-agonistischer und PDE III-inhibitorischer Aktivität


Dr. Carsten Götte

Dissertation: Synthese, Enantiomerentrennung und Struktur-Wirkungs-Beziehungen neuer Histamin H2-Rezeptoragonisten des Arpromidin-Typs


Dr. Florian Graichen

Dissertation: Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden


Dr. Dietmar Gross

Dissertation: New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy


Dr. Ulrich Gürtler

Dissertation: Entwicklung eines computerunterstützten Rattenmodels für die hypertherme isolierte Extremitätenperfusion


Dr. Janina Hamberger

Dissertation: Characterization of mammalian hyaluronidase-2 activity and identification of inhibitors of Streptococcal hyaluronan lyase


Dr. Peter Höcherl

Dissertation: New tariquidar-like ABCB1 modulators in cancer chemotherapy: Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies


Dr. Julia Hoechstetter

Dissertation: Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy


Dr. Edith Hofinger

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Recombinant expression, purification and characterization of human hyaluronidases


Dr. Tobias Holzammer

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Homology modeling, molecular dynamics simulations and site-directed mutagenesis of histamine H2 receptors


Dr. Martina Hubensack

Dissertation: Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor


Dr. Stefan Huber

Dissertation: Investigations on bendamustine esters as new antitumor agents and the role of ABCG2 as a surogate marker of breast cancer initiating cells


Dr. Christoph Hutzler

Dissertation: Synthese und pharmakologische Aktivität neuer Neuropeptid Y Rezeptorliganden: Von N,N-disubstitutierten Alkanamiden zu hochpotenten Y1-Antagonisten der Argininamid-Reihe


Dr. Patrick Igel

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists


Dr. Peter Jarzyna

Dissertation: Preclinical investigations on the effect of the human hyaluronidase Hyal-1 on growth and metastasis of human colon carcinoma

K - o

Dr. Melanie Kaske

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: In search for potent and selective NPY Y4 receptor ligands: acylguanidines, argininamides and peptide analogs


Dr. Stephan Kießling

Dissertation: Funktionelle Untersuchungen zur Expression des Interleukin-11 Rezeptors α in humanen Kolonepithelzellen


Dr. Sebastian Donatus Kiewitz

Dissertation: Structural investigations of the Id helix-loop-helix dimerization domain


Dr. Sebastian Knieps

Dissertation: Guanidine der Arpromidin-Reihe als Modellsubstanzen zur Entwicklung nichtpeptidischer Neuropeptid Y-Rezeptorliganden: Synthese und pharmakologische Prüfung neuer NPY Y1-Antagonisten


Dr. Julia Kracht

Dissertation: Bestimmung der Affinität und der funktionellen Aktivität subtypselektiver Histamin- und Neuropeptid Y-Rezeptorliganden an konventionellen und neuen pharmakologischen In-vitro-Modellen


Dr. Anja Kraus

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships


Dr. Matthias Kühnle

Dissertation: Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts


Dr. Kilian Kuhn

Member of Research Training Group Medicinal Chemistry GRK 1910

Dissertation: Molecular Tools for NPY Y4Receptor Derived from the C-Terminus of hPP and from Argininamide-type Y1R Antagonist


Dr. Liantao Li

Dissertation: Synthesis and Pharmacological Activity of Fluorescent Ligands for Neuropeptide Y, Histamine H1 und H2 Receptors


Dr. Sebastian Lieb

Dissertation: Investigations on histamine and neuropeptide Y receptors by label-free and label-dependent methods


Dr. Miroslaw Lopuch

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods


Dr. Matthias Mayer

Dissertation: Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen


Dr. Adolf Meister

Dissertation: Pharmakologische Charakterisierung neuer Histamin- und Neuropeptid Y-Rezeptorliganden: Etablierung und Validierung funktioneller Testmodelle an isolierten Organen


Dr. Martin Memminger

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells


Dr. Carolin Meyer

Dissertation: Synthesis and structure-activity relationships of inhibitors of bacterial hyaluronidase - An approach to obtain compounds with drug-like properties


Dr. Johannes Mosandl

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells


Dr. Christiane Moser

Dissertation: Pharmakologische Untersuchungen zur Neuropeptid Y Y1-, Y2- und Y5-Rezeptorselektivität peptidischer und nichtpeptidischer Liganden: Klonierung und funktionelle Expression des humanen Y5-Rezeptors in HEC-1-B-Zellen


Dr. Ingo Muckenschnabel

Dissertation: Analytische Untersuchungen zum Einsatz von Hyaluronidase als Adjuvans in der Krebschemotherapie


Dr. Christine Müller

Dissertation: New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition


Dr. Manfred Müller

Dissertation: Neue Leitstrukturen zur Entwicklung nichtpeptidischer Neuropeptid Y Y1-Rezeptor¬antagonisten: Synthese und Struktur-Wirkungs-Beziehungen basisch substituierter Carbonsäureamide


Dr. Uwe Nordemann

Dissertation: Radioligand binding and reporter gene assays for histamine H3 and H4 receptor species orthologs


José Esteban Obreque-Balboa

Research project

Modulation von ABC-Transportern zur Überwindung der Blut-Hirn-Schranke und der Chemoresistenz von Tumoren


Dr. Martin Oettl

Dissertation: Biochemische Charakterisierung boviner testikulärer Hyaluronidase und Untersuchungen zum Einfluß von Hyaluronidase und Hyaluronsäure auf das Wachstum von Tumoren

P - T

Dr. Senthil Kumar Palaniappan

Postdoctoral Researcher

Research project: Design and synthesis of neuropeptide Y Y4 receptor antagonists


Dr. Nicole Plank

Dissertation: Dimeric histamine H2 receptor agonists as molecular tools and genetically engineered HEK293T cells as an assay platform to unravel signaling pathways of hH1R and hH2R


Dr. Nikola Pluym

Dissertation: Application of the guanidine–acylguanidine bioisosteric approach to NPY Y2 receptor antagonists: bivalent, radiolabeled and fluorescent pharmacological tools


Dr. Nathalie Pop

Dissertation: Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout


Dr. Hendrik Preuß

Dissertation: Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis


Dr. Martin Rothenhöfer

Dissertation: Analytical approaches to the study of hyaluronan and hyaluronidases: Development and application of hyphenated chromatographic and electrophoretic methods


Dr. Sunnhil Salmen

Dissertation: Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships


Dr. Fabian Schalkhaußer

Dissertation: Herstellung unsymmetrischer Guanidine in Lösung und an polymeren Trägern: Synthese und pharmakologische Wirkung neuer hochpotenter Histamin H2-Rezeptoragonisten


Dr. Erich Schneider

Dissertation: Development of Fluorescence-Based Methods fort he Determination of Ligand Affinity, Selectivity and Activity at G-Protein Coupled Receptors


Dr. Andreas Schuster

Dissertation: Enantiomerenanalytik von Histamin-H2-Rezeptoragonisten der Arpromidin-Reihe, deren Ester-Prodrugs- und Synthesebausteinen mit HPLC und CE


Dr. Oksana Sereda

Postdoctoral Researcher


Dr. Xueke She

associated Member of Research Training Group Medicinal Chemistry GRK 1910

Dissertation: Synthesis and pharmacological characterization of dibenzodiazepinone-type heterodimeric and fluorescently labeled muscarinic receptor ligands


Dr. Martin Spickenreither

Dissertation: Inhibitors of Bacterial and Mammalian Hyaluronidases: Design, Synthesis and Structure-Activity Relationships with Focus on Human Enzymes


Dr. Shangjun Teng

Postdoctoral Resarcher


Dr. Christian Textor

Dissertation: Small Molecules as inhibitors of streptococcal hyaluronidases: A computer-assisted and multicomponent synthesis approach

U - Z

Dr. Anka Uffrecht

Dissertation: Synthese und in-vitro-Pharmakologie nichtpeptidischer und peptidischer Neuropeptid Y-Antagonisten mit Guanidin- oder Argininamid-Partialstruktur


Dr. Jianfei Wan

associated Member of Research Training Group Medicinal Chemistry GRK 1910

Dissertation: Synthesis and pharmacological characterization of homo- and hetero-dimeric compounds, targeting the hH₁R and/or hH₄R


Dr. Ralf Ziemek

Dissertation: Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors


Dr. Jochen Zimmermann

Dissertation: Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation.

  1. Faculty of Chemistry and Pharmacy
  2. Institute of Pharmacy

Department of Pharmaceutical/Medicinal Chemistry II

Prof. Dr.
Armin Buschauer

 

Herr Prof. Dr. Armin Buschauer
 
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