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2017


2016

Hosseini H, Obradović MM, Hoffmann M, Harper KL, Sosa MS, Werner-Klein M, Nanduri LK, Werno C, Ehrl C, Maneck M, Patwary N, Haunschild G, Gužvić M, Reimelt C, Grauvogl M, Eichner N, Weber F, Hartkopf AD, Taran FA, Brucker SY, Fehm T, Rack B, Buchholz S, Spang R, Meister G, Aguirre-Ghiso JA, Klein CA. Early dissemination seeds metastasis in breast cancer. Nature. 2016 Dec 22;4540(7634):552-8.

Harper KL, Sosa MS, Entenberg D, Hosseini H, Cheung JF, Nobre R, Avivar-Valderas A, Nagi C, Girnius N, Davis RJ, Farias EF, Condeelis J, Klein CA, Aguirre-Ghiso JA. Mechanism of early dissemination and metastasis in Her2+ mammary cancer. Nature. 2016 Dec 22;540(7634):588-92.

   Comment on the papers:

Ghajar CM, Bissell MJ. Pathways of parallel progression. Nature. 2016 Dec 22;540(7634)528-9.

Alderton GK. Planting metastasis early. Nat Rev Cancer 2017 Jan 27; 17(2):75.

Alberter B, Klein CA, Polzer B. Single-cell analysis of CTCs with diagnostic precision: opportunities and challenges for personalized medicine. Expert Rev Mol Diagn. 2016 Jan;16(1):25-38.


2015

Czyż ZT, Klein CA. Deterministic Whole-Genome Amplification of Single Cells. Methods Mol Biol. 2015;1347:69-86.
Frances D, Sharma N, Pofahl R, Maneck M, Behrendt K, Reuter K, Krieg T, Klein CA, Haase I, Niemann C. A role for Rac1 activity in malignant progression of sebaceous skin tumors. Oncogene. 2015 Oct;34(43):5505-12.

2014

Gužvić M, Braun B, Ganzer R, Burger M, Nerlich M, Winkler S, Werner-Klein M, Czyż ZT, Polzer B, Klein CA. Combined genome and transcriptome analysis of single disseminated cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes. Cancer Res. 2014 Dec 15;74(24):7383-94.
Vay C, Hosch SB, Stoecklein NH, Klein CA, Vallböhmer D, Link BC, Yekebas EF, Izbicki JR, Knoefel WT, Scheunemann P. Integrin expression in esophageal squamous cell carcinoma: loss of the physiological integrin expression pattern correlates with disease progression. PLoS One. 2014 Nov 14;9(11):e109026.
Polzer B, Medoro G, Pasch S, Fontana F, Zorzino L, Pestka A, Andergassen U, Meier-Stiegen F, Czyz ZT, Alberter B, Treitschke S, Schamberger T, Sergio M, Bregola G, Doffini A, Gianni S, Calanca A, Signorini G, Bolognesi C, Hartmann A, Fasching PA, Sandri MT, Rack B, Fehm T, Giorgini G, Manaresi N, Klein CA. Molecular profiling of single circulating tumor cells with diagnostic intention. EMBO Mol Med. 2014 Oct 30;6(11):1371-86.
Neves RP, Raba K, Schmidt O, Honisch E, Meier-Stiegen F, Behrens B, Möhlendick B, Fehm T, Neubauer H, Klein CA, Polzer B, Sproll C, Fischer JC, Niederacher D, Stoecklein NH. Genomic High-Resolution Profiling of Single CKpos/CD45neg Flow-Sorting Purified Circulating Tumor Cells from Patients with Metastatic Breast Cancer. Clin Chem. 2014 Oct;60(10):1290-7.
Wang J, Lu X, Sakk V, Klein CA, Rudolph KL. Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres. Blood. 2014 Nov 20;124(22):3237-40.
Werner-Klein M, Proske J, Werno C, Schneider K, Hofmann HS, Rack B, Buchholz S, Ganzer R, Blana A, Seelbach-Göbel B, Nitsche U, Männel DN, Klein CA. Immune humanization of immunodeficient mice using diagnostic bone marrow aspirates from carcinoma patients. PLoS One. 2014 May 15;9(5):e97860.
Ulmer A, Dietz K, Hodak I, Polzer B, Scheitler S, Yildiz M, Czyz Z, Lehnert P, Fehm T, Hafner C, Schanz S, Röcken M, Garbe C, Breuninger H, Fierlbeck G, Klein CA. Quantitative measurement of melanoma spread in sentinel lymph nodes and survival. PLoS Med. 2014 Feb 18;11(2):e1001604.
Czyz ZT, Hoffmann M, Schlimok G, Polzer B, Klein CA. Reliable single cell array CGH for clinical samples. PLoS One. 2014 Jan 21;9(1):e85907.

2013

Gužvic M, Klein CA. Cancer dormancy: time to explore its clinical relevance. Breast Cancer Res. 2013 Dec 20;15(6):321.
Hittinger M, Czyz ZT, Huesemann Y, Maneck M, Botteron C, Kaeufl S, Klein CA, Polzer B. Molecular profiling of single Sca-1+/CD34+,- cells - the putative murine lung stem cells. PLoS One. 2013 Dec 31;8(12):e83917.

Fischer JC, Niederacher D, Topp SA, Honisch E, Schumacher S, Schmitz N, Zacarias Föhrding L, Vay C, Hoffmann I, Kasprowicz NS, Hepp PG, Mohrmann S, Nitz U, Stresemann A, Krahn T, Henze T, Griebsch E, Raba K, Rox JM, Wenzel F, Sproll C, Janni W, Fehm T, Klein CA, Knoefel WT, Stoecklein NH. Diagnostic leukapheresis enables reliable detection of circulating tumor cells of nonmetastatic cancer patients. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16580-5.

Klein CA. Selection and adaptation during metastatic cancer progression. Nature. 2013 Sep 19;501(7467):365-72.

Polzer B, Klein CA. Metastasis awakening: the challenges of targeting minimal residual cancer. Nat Med. 2013 Mar;19(3):274-5.


2012

Lichtenauer U, Shapiro I, Sackmann S, Drouin J, Scheele J, Maneck M, Klein C, Beuschlein F. The side population phenomenon enriches for designated adrenocortical progenitor cells in mice. J Endocrinol. 2012 Dec;215(3):383-91.

Kirsch S, Klein CA. Sequence error storms and the landscape of mutations in cancer. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14289-90.

Cucuruz B, Dango S, Jurinovic V, Mayer O, Follo M, Böhm J, Freudenberg N, Elze M, Sienel W, Klein CA, Passlick B, Polzer B. MAGE qPCR Improves the Sensitivity and Accuracy of EBUS-TBNA for the Detection of Lymphatic Cancer Spread. J Thorac Oncol. 2012 Apr;7(4):690-7.

Luebke AM, Baudis M, Matthaei H, Vashist YK, Verde PE, Hosch SB, Erbersdobler A, Klein CA, Izbicki JR, Knoefel WT, Stoecklein NH. Losses at chromosome 4q are associated with poor survival in operable ductal pancreatic adenocarcinoma. Pancreatology. 2012 Jan;12(1):16-22.


2011

Chambers KF, Pearson JF, Pellacani D, Aziz N, Gužvić M, Klein CA, Lang SH. Stromal upregulation of lateral epithelial adhesions: Gene expression analysis of signalling pathways in prostate epithelium. J Biomed Sci. 2011 Jun 22;18:45.

VerMilyea MD, Maneck M, Yoshida N, Blochberger I, Suzuki E, Suzuki T, Spang R, Klein CA, Perry AC. Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres. EMBO J. 2011 May 4;30(9):1841-51.

Klein CA. Framework models of tumor dormancy from patient-derived observations. Curr Opin Genet Dev. 2011 Feb;21(1):42-9.

Conrad C, Hüsemann Y, Niess H, von Luettichau I, Huss R, Bauer C, Jauch KW, Klein CA, Bruns C, Nelson PJ. Linking Transgene Expression of Engineered Mesenchymal Stem Cells and Angiopoietin-1-induced Differentiation to Target Cancer Angiogenesis. Ann Surg. 2011 Mar;253(3):566-71.


2010

Fehm T, Müller V, Aktas B, Janni W, Schneeweiss A, Stickeler E, Lattrich C, Löhberg CR, Solomayer E, Rack B, Riethdorf S, Klein C, Schindlbeck C, Brocker K, Kasimir-Bauer S, Wallwiener D, Pantel K. HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial. Breast Cancer Res Treat. 2010 Nov;124(2):403-12.

Eberle J, Spangler B, Becker JC, Heinemann SH, Klein CA, Kunz M, Kuphal S, Langer P, Mauch C, Meierjohann S, Paschen A, Schadendorf D, Schartl M, Schittek B, Schönherr R, Tüting T, Zigrino P, Bosserhoff AK; German Melanoma Research Network of the German Cancer Aid. Multicentre study on standardisation of melanoma cell culture--an initiative of the German Melanoma Research Network. Pigment Cell Melanoma Res. 2010 Apr;23(2):296-8.

Stoecklein NH, Klein CA. Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis. Int J Cancer. 2010 Feb 1;126(3):589-98.

Dango S, Wang XT, Gold M, Cucuruz B, Klein CA, Passlick B, Sienel W. Expression of melanoma-antigen-A (MAGE-A) in disseminated tumor cells in regional lymph nodes of patients with operable non-small cell lung cancer. Lung Cancer. 2010 Mar;67(3):290-5.

Polzer B, Klein CA. Looking at the DNA of a single cell. In Unraveling single cell genomics: Micro and nanotools, edited by Bontoux N, Dauphinot L, Potier MC. 2010; p.73-80. Royal society of Chemistry Publishing, Cambridge, UK.

Polzer B, Klein CA. Application to carcinogenesis: towards targeted cancer therapies. In Unraveling single cell genomics: Micro and nanotools, edited by Bontoux N, Dauphinot L, Potier MC. 2010; p.54-60. Royal society of Chemistry Publishing, Cambridge, UK.


2009

Klein CA, Stoecklein NH. Lessons from an Aggressive Cancer: Evolutionary Dynamics in Esophageal Carcinoma. Cancer Res. 2009 Jul 1;69(13):5285-8.

Klein CA. Parallel progression of primary tumours and metastases. Nat Rev Cancer. 2009 Apr;9(4):302-12.

   Comment on the paper:

Koscielny S, Tubiana M. Parallel progression of tumour and metastases. Nat Rev Cancer. 2010 Feb;10(2):156.

   Author's reply:

Klein CA. Tumour cell dissemination and growth of metastasis. Nat Rev Cancer. 2010 Feb;10(2):156.

Hafner C, Stoehr R, van Oers JM, Zwarthoff EC, Hofstaedter F, Klein C, Landthaler M, Hartmann A, Vogt T. The Absence of BRAF, FGFR3, and PIK3CA Mutations Differentiates Lentigo Simplex from Melanocytic Nevus and Solar Lentigo. J Invest Dermatol. 2009 Nov;129(11):2730-5.

Imle A, Polzer B, Alexander S, Klein CA, Friedl P. Genomic instability of micronucleated cells revealed by single-cell comparative genomic hybridization. Cytometry A. 2009 Jul;75(7):562-8.

   Comment on the paper:

Balazs M. Single-cell comparative genomic hybridization analysis of micronucleated cells. Cytometry A. 2009 Jul;75(7):557-9.

Gužvić M, Klein CA. The biology of cancer metastasis. In The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies, edited by Molls M, Vaupel P, Nieder C, Anscher MS. 2009; p.117-128. Springer, Berlin, Heidelberg.

Weckermann D, Polzer B, Ragg T, Blana A, Schlimok G, Arnholdt H, Bertz S, Harzmann R, Klein CA. Perioperative Activation of Disseminated Tumor Cells in Bone Marrow of Patients With Prostate Cancer. J Clin Oncol. 2009 Apr 1;27(10):1549-56.

   Edtorial:

Scher HI, Pantel K. Bone Marrow Aspiration for Disseminated Tumor Cell Detection: A Must-Have Test or Is the Jury Still Out? J Clin Oncol. 2009 Apr 1;27(10):1531-3.

   Comment on the paper:

Moss J, Israel RJ. Effects of Anesthetics on Cancer Recurrence. J Clin Oncol. 2009 Sep 1;27(25):e89.

   Author's reply:

Weckermann D, Forst H, Polzer B, Klein CA. Reply to J. Moss and R. J. Israel. J Clin Oncol. 2009 Sep 1;27(25):e90.

Gires O, Klein CA, Baeuerle PA. On the abundance of EpCAM on cancer stem cells. Nat Rev Cancer. 2009 Feb;9(2):143.

Hüsemann Y, Klein CA. The analysis of metastasis in transgenic mouse. Transgenic Res. 2009 Feb;18(1):1-5.

Polzer B, Hartmann CH, Klein CA. Genome and transcriptome analysis of single tumor cells. In Single Cell Analysis: Technologies and Applications, edited by Anselmetti D. 2009; p.235-249. Wiley-VCH Verlag GmbH & Co, KGaA, Weinheim.


2008

Klein CA. The direct molecular analysis of metastatic precursor cells in breast cancer: A chance for a better understanding of metastasis and for personalised medicine. Eur J Cancer. 2008 Dec;44(18):2721-5.

Klein CA. The Metastasis Cascade. Science. 2008 Sep 26; 321(5897):1785-7.

Sienel W, Polzer B, Elshawi K, Lindner M, Morresi-Hauf A, Vay C, Eder F, Passlick B, Klein CA. Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9. Mod Pathol. 2008 Sep;21(9):1130-8.

Stoecklein NH, Hosch SB, Bezler M, Stern F, Hartmann CH, Vay C, Siegmund A, Scheunemann P, Schurr P, Knoefel WT, Verde PE, Reichelt U, Erbersdobler A, Grau R, Ullrich A, Izbicki JR, Klein CA. Direct Genetic Analysis of Single Disseminated Cancer Cells for Prediction of Outcome and Therapy Selection in Esophageal Cancer. Cancer Cell. 2008 May 6;13(5):441-453.

   Comment on the paper:

Grugan KD, Nakagawa H. HER2 amplification in micrometastatic esophageal cancer cells predicts prognosis. Gastroenterology. 2008 Sep;135(3):1000-2.

   Author's reply:

Klein CA, Stoecklein NH. Reply. Gastroenterology. 2008 Sep;135(3):1002-3.

Fuhrmann C, Schmidt-Kittler O, Stoecklein NH, Petat-Dutter K, Vay C, Bockler K, Reinhardt R, Ragg T, Klein CA. High-resolution array comparative genomic hybridization of single micrometastatic tumor cells. Nucleic Acids Res. 2008 Apr;36(7):e39.

Hahtola S, Burghart E, Jeskanen L, Karenko L, Abdel-Rahman WM, Polzer B, Kajanti M, Peltomäki P, Pettersson T, Klein CA, Ranki A. Clinicopathological Characterization and Genomic Aberrations in Subcutaneous Panniculitis-Like T-Cell Lymphoma. J Invest Dermatol. 2008 Mar 13; 128(9):2304-09.

Hüsemann Y, Geigl JB, Schubert F, Musiani P, Meyer M, Burghart E, Forni G, Eils R, Fehm T, Riethmüller G, Klein CA. Systemic spread is an early step in breast cancer. Cancer Cell. 2008 Jan;13(1):58-68.

   Comment on the paper:

J. Thomas Parsons: Evaluation for Hüsemann Y et al Cancer Cell 2008. Faculty of 1000 Biology, 29 Jan 2008.

Klein CA, Hartmann CH. Amplification of cDNA from single or rare cells by global PCR (exponential amplification). In Microarrays in Inflammation, edited by Bosio A, Gerstmayer G. 2008; p.81-94. Birkhäuser Verlag, Basel, CH.

Hahtola S, Burghart E, Puputti M, Karenko L, Abdel-Rahman WM, Väkevä L, Jeskanen L, Virolainen S, Karvonen J, Salmenkivi K, Kinnula V, Joensuu H, Peltomäki P, Klein CA, Ranki A. Cutaneous T-cell lymphoma-associated lung cancers show chromosomal aberrations differing from primary lung cancer. Genes Chromosomes Cancer. 2008 Feb;47(2):107-17.


2007

Weckermann D, Polzer B, Klein C. Bedeutung Cytokeratin-positiver Zellen im Knochenmark bei Patienten mit klinisch organbegrenztem Prostatakarzinom. Urologe A. 2007 Sep;46(9):1078-80.


2006

Klein CA. Random mutations, selected mutations: A PIN opens the door to new genetic landscapes. Proc Natl Acad Sci U S A. 2006. Nov 28;103(48):18033-4.

Hartmann CH, Klein CA. Gene expression profiling of single cells on large-scale oligonucleotide arrays. Nucleic Acids Res. 2006;34(21):e143.

Klein CA, Holzel D. Systemic Cancer Progression and Tumor Dormancy: Mathematical Models Meet Single Cell Genomics. Cell Cycle. 2006 Aug 15;5(16):1788-98.

Bahar R, Hartmann CH, Rodriguez KA, Denny AD, Busuttil RA, Dolle ME, Calder RB, Chisholm GB, Pollock BH, Klein CA, Vijg J. Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature. 2006 Jun 22;441(7096):1011-4.

   Comment on the paper:

Tower J. The murmur of old broken heartstrings. Cell Metab. 2006 Aug;4(2):101-3.


2005

Schardt JA, Meyer M, Hartmann CH, Schubert F, Schmidt-Kittler O, Fuhrmann C, Polzer B, Petronio M, Eils R, Klein CA. Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. Cancer Cell. 2005 Sep;8(3):227-39.

Ulmer A, Fischer JR, Schanz S, Sotlar K, Breuninger H, Dietz K, Fierlbeck G, Klein CA. Detection of melanoma cells displaying multiple genomic changes in histopathologically negative sentinel lymph nodes. Clin Cancer Res. 2005 Aug 1;11(15):5425-32.

Wang XT, Sienel W, Eggeling S, Ludwig C, Stoelben E, Mueller J, Klein CA, Passlick B. Detection of disseminated tumor cells in mediastinoscopic lymph node biopsies and lymphadenectomy specimens of patients with NSCLC by quantitative RT-PCR. Eur J Cardiothorac Surg. 2005 Jul;28(1):26-32.

Klein CA. Single cell amplification methods for the study of cancer and cellular ageing. Mech Ageing Dev. 2005 Jan;126(1):147-51.

Klein CA, Zohlnhöfer D, Petat-Dutter K, Wendler N. Gene expression analysis of a single or few cells. In Curr Protoc Hum Genet edited by Haines JL, Korf BR, Morton CC, Seidman CE, Seidman JG, Smith DR. 2005; 11.8.1-11.8.18. John Wiley & sons, Hoboken, NJ, USA.


2004

Stoecklein NH, Luebke AM, Erbersdobler A, Knoefel WT, Schraut W, Verde PE, Stern F, Scheunemann P, Peiper M, Eisenberger CF, Izbicki JR, Klein CA, Hosch SB. Copy number of chromosome 17 but not HER2 amplification predicts clinical outcome of patients with pancreatic ductal adenocarcinoma. J Clin Oncol. 2004 Dec 1;22(23):4737-45. (Erratum in: J Clin Oncol. 2005 Jan 1;23(1):248.)

Ulmer A, Schmidt-Kittler O, Fischer J, Ellwanger U, Rassner G, Riethmuller G, Fierlbeck G, Klein CA. Immunomagnetic enrichment, genomic characterization, and prognostic impact of circulating melanoma cells. Clin Cancer Res. 2004 Jan 15;10(2):531-7.

Klein CA. Gene expression sigantures, cancer cell evolution and metastatic progression. Cell Cycle. 2004 Jan;3(1):29-31.


2003

Klein CA. The systemic progression of human cancer: a focus on the individual disseminated cancer cell - the unit of selection. Adv Cancer Res. 2003;89:35-67.

Jentsch I, Geigl J, Klein CA, Speicher MR. Seven-fluorochrome mouse M-FISH for high-resolution analysis of interchromosomal rearrangements. Cytogenet Genome Res. 2003;103(1-2):84-8.

Schmidt-Kittler O, Ragg T, Daskalakis A, Granzow M, Ahr A, Blankenstein TJ, Kaufmann M, Diebold J, Arnholdt H, Muller P, Bischoff J, Harich D, Schlimok G, Riethmuller G, Eils R, Klein CA. From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7737-42.

   Comments on the paper:

Tutt A, Ashworth A. Close relatives or distant cousins? Lancet Oncol. 2003 Oct;4(10):593-4.

Gray JW. Evidence emerges for early metastasis and parallel evolution of primary and metastatic tumors. Cancer Cell. 2003 Jul;4(1):4-6.

Croager E. Time to disperse. Nature Rev Cancer. 2003 Jul; 3:474.

Skipper M. A wake-up call. Nature Rev Genetics. 2003 Jul; 4: 488.

Sienel W, Hellers J, Morresi-Hauf A, Lichtinghagen R, Mutschler W, Jochum M, Klein C, Passlick B, Pantel K. Prognostic impact of matrix metalloproteinase-9 in operable non-small cell lung cancer. Int J Cancer. 2003 Feb 20;103(5):647-51.

Klein CA. From single disseminated tumor cells to metastasis insights from molecular genetic analyses of single cells. Verh Dtsch Ges Pathol. 2003;87:158-64.

Klein CA, Zohlnhöfer D, Petat-Dutter K, Wendler N. Gene expression analysis of a single or few cells. In Curr Protoc Mol Biol edited by Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K. 2003; 25B.8.1-25B.8.18. John Wiley & sons, Hoboken, NJ, USA.


2002

Klein CA, Blankenstein TJ, Schmidt-Kittler O, Petronio M, Polzer B, Stoecklein NH, Riethmuller G. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet. 2002 Aug 31;360(9334):683-9.

Klein CA, Wilke M, Pool J, Vermeulen C, Blokland E, Burghart E, Krostina S, Wendler N, Passlick B, Riethmueller G, Goulmy E. The hematopoietic system-specific minor histocompatibility antigen HA-1 shows aberrant expression in epithelial cancer cells. J Exp Med. 2002 Aug 5;196(3):359-68.

Stoecklein NH, Erbersdobler A, Schmidt-Kittler O, Diebold J, Schardt JA, Izbicki JR, Klein CA. SCOMP is superior to degenerated oligonucleotide primed-polymerase chain reaction for global amplification of minute amounts of DNA from microdissected archival tissue samples. Am J Pathol. 2002 Jul;161(1):43-51. (Erratum in: Am J Pathol. 2003 Dec;163(6):2645.)

Klein CA, Seidl S, Petat-Dutter K, Offner S, Geigl JB, Schmidt-Kittler O, Wendler N, Passlick B, Huber RM, Schlimok G, Baeuerle PA, Riethmuller G. Combined transcriptome and genome analysis of single micrometastatic cells. Nat Biotechnol. 2002 Apr;20(4):387-92.

Klein CA. Direct molecular analysis of single disseminated cancer cells: a prerequisite for the development of adjuvant therapies? Acta Med Austriaca Suppl. 2002;59:10-3.


2001

Riethmuller G, Klein CA. Early cancer cell dissemination and late metastatic relapse: clinical reflections and biological approaches to the dormancy problem in patients. Semin Cancer Biol. 2001 Aug;11(4):307-11.

Zohlnhofer D, Richter T, Neumann F, Nuhrenberg T, Wessely R, Brandl R, Murr A, Klein CA, Baeuerle PA. Transcriptome analysis reveals a role of interferon-gamma in human neointima formation. Mol Cell. 2001 May;7(5):1059-69.

Zohlnhofer D, Klein CA, Richter T, Brandl R, Murr A, Nuhrenberg T, Schomig A, Baeuerle PA, Neumann FJ. Gene expression profiling of human stent-induced neointima by cDNA array analysis of microscopic specimens retrieved by helix cutter atherectomy: Detection of FK506-binding protein 12 upregulation. Circulation. 2001 Mar 13;103(10):1396-402.


2000

Klein CA. The biology and analysis of single disseminated tumour cells. Trends Cell Biol. 2000 Nov;10(11):489-93.


1999

Riethmuller G, Klein CA, Pantel K. Hunting down the seminal cells of clinical metastases. Immunol Today. 1999 Jul;20(7):294-6.

Klein CA, Schmidt-Kittler O, Schardt JA, Pantel K, Speicher MR, Riethmuller G. Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4494-9.


  1. HOMEPAGE UR

Faculty of Medicine

Experimental Medicine and Therapy Research

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Prof. Christoph Klein
Franz-Josef-Strauss Allee 11
93053 Regensburg
D1.4.01
Tel. +49 941 944-6720
Fax. +49 941 944-6719
Email