Zu Hauptinhalt springen
Gewählte Sprache ist Deutsch Select language
Startseite UR

Wird geladen...

Lebenslauf

  • 1994 Diplom-Mathematik, Ludwig-Maximilians-Universität München
  • 1994-1996 Datenanalyst und Junior Statistikerin am Cancer Center Statistics, Mayo Clinic, Rochester, USA; Gaststudentin an der Mayo Medical School
  • 1997-1998 Systemanalyst, Produktions- und Planungssoftware für Papierindustrie, Mathematische Analysen- und Systeme GmbH, Regensburg
  • 1998-2009 Wissenschaftliche Mitarbeiterin am Institut für Epidemiologie, Helmholtz Zentrum München und Ludwig-Maximilians Universität München
  • 2002 Promotion zum Dr. der Humanbiologie, Ludwig-Maximilians Universität München
  • 2004-2009 Leiterin der Forschungseinheit “GenStat” der AG Genetic Epidemiology, Helmholtz Zentrum München
  • 2009 Habilitation Epidemiologie/Biometrie
  • 2009-2013 Professorin für Public Health und Gender Studies, Institut für Epidemiologie und Präventivmedizin, Universität Regensburg
  • Seit 2013 Inhaberin des Lehrstuhls für Genetische Epidemiologie an der Universität Regensburg


Forschungsschwerpunkte

  • Genetische Epidemiologie
  • Quantitative Methoden in Public Health mit einem Schwerpunkt in Meta-Analysen und Fehler-in-den-Variablen (Messfehler, Fehlklassifikation)
  • Gender Studies der Universität Regensburg
  • Reviewer für Circulation, Diabetes, PloS Genetics, Human Molecular Genetics, International Society of Obesity, PloS One, Human Mutation, Molecular Cell Biology of Lipids, Genetic Epidemiology, Statistics in Medicine, International Journal of Obesity, Experimental Gerontology
  • Grant Audits für Medical Research Council Cambridge, Österreichische Nationalbank, International Society of Obesity

Ausgewählte Publikationen

  • Fritsche L G, Igl W, Bailey J N, Grassmann F, Sengupta S, Bragg-Gresham J L, Burdon K P, Hebbring S J, Wen C, Gorski M, Kim I K, Cho D, Zack D, Souied E, Scholl H P, Bala E, Lee K E, Hunter D J, Sardell R J, Mitchell P, Merriam J E, Cipriani V, Hoffman J D, Schick T, Lechanteur Y T, Guymer R H, Johnson M P, Jiang Y, Stanton C M, Buitendijk G H, Zhan X, Kwong A M, Boleda A, Brooks M, Gieser L, Ratnapriya R, Branham K E, Foerster J R, Heckenlively J R, Othman M I, Vote B J, Liang H H, Souzeau E, McAllister I L, Isaacs T, Hall J, Lake S, Mackey D A, Constable I J, Craig J E, Kitchner T E, Yang Z, Su Z, Luo H, Chen D, Ouyang H, Flagg K, Lin D, Mao G, Ferreyra H, Stark K, von Strachwitz C N, Wolf A, Brandl C, Rudolph G, Olden M, Morrison M A, Morgan D J, Schu M, Ahn J, Silvestri G, Tsironi E E, Park K H, Farrer L A, Orlin A, Brucker A, Li M, Curcio C A, Mohand-Said S, Sahel J A, Audo I, Benchaboune M, Cree A J, Rennie C A, Goverdhan S V, Grunin M, Hagbi-Levi S, Campochiaro P, Katsanis N, Holz F G, Blond F, Blanche H, Deleuze J F, Igo R P, Jr., Truitt B, Peachey N S, Meuer S M, Myers C E, Moore E L, Klein R, Hauser M A, Postel E A, Courtenay M D, Schwartz S G, Kovach J L, Scott W K, Liew G, Tan A G, Gopinath B, Merriam J C, Smith R T, Khan J C, Shahid H, Moore A T, McGrath J A, Laux R, Brantley M A, Jr., Agarwal A, Ersoy L, Caramoy A, Langmann T, Saksens N T, de Jong E K, Hoyng C B, Cain M S, Richardson A J, Martin T M, Blangero J, Weeks D E, Dhillon B, van Duijn C M, Doheny K F, Romm J, Klaver C C, Hayward C, Gorin M B, Klein M L, Baird P N, den Hollander A I, Fauser S, Yates J R, Allikmets R, Wang J J, Schaumberg D A, Klein B E, Hagstrom S A, Chowers I, Lotery A J, Leveillard T, Zhang K, Brilliant M H, Hewitt A W, Swaroop A, Chew E Y, Pericak-Vance M A, DeAngelis M, Stambolian D, Haines J L, Iyengar S K, Weber B H, Abecasis G R, Heid I M. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet 2016; 48(2): 134-143.
  • Shungin D, Winkler T W, Croteau-Chonka D C, Ferreira T, Locke A E, Magi R, Strawbridge R J, …, Heid I M, Loos R J, Cupples L A, Morris A P, Lindgren C M, Mohlke K L. New genetic loci link adipose and insulin biology to body fat distribution. Nature 2015; 518(7538): 187-196.
  • Locke A E, Kahali B, Berndt S I, Justice A E, Pers T H, Day F R, Powell C, Vedantam S, …, Winkler T W, …, Heid I M, O'Connell J R, Strachan D P, Stefansson K, van Duijn C M, Abecasis G R, Franke L, Frayling T M, McCarthy M I, Visscher P M, Scherag A, Willer C J, Boehnke M, Mohlke K L, Lindgren C M, Beckmann J S, Barroso I, North K E, Ingelsson E, Hirschhorn J N, Loos R J, Speliotes E K. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015; 518(7538): 197-206.
  • Winkler T W, Kutalik Z, Gorski M, Lottaz C, Kronenberg F, Heid I M. EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data. Bioinformatics 2015; 31(2): 259-261.
  • German National Cohort C. The German National Cohort: aims, study design and organization. Eur J Epidemiol 2014; 29(5): 371-382.
  • Gorski M, Tin A, Garnaas M, McMahon G M, Chu A Y, Tayo B O, Pattaro C, Teumer A, Chasman D I, Chalmers J, Hamet P, Tremblay J, Woodward M, Aspelund T, Eiriksdottir G, Gudnason V, Harris T B, Launer L J, Smith A V, Mitchell B D, O'Connell J R, Shuldiner A R, Coresh J, Li M, Freudenberger P, Hofer E, Schmidt H, Schmidt R, Holliday E G, Mitchell P, Wang J J, de Boer I H, Li G, Siscovick D S, Kutalik Z, Corre T, Vollenweider P, Waeber G, Gupta J, Kanetsky P A, Hwang S J, Olden M, Yang Q, de Andrade M, Atkinson E J, Kardia S L, Turner S T, Stafford J M, Ding J, Liu Y, Barlassina C, Cusi D, Salvi E, Staessen J A, Ridker P M, Grallert H, Meisinger C, Muller-Nurasyid M, Kramer B K, Kramer H, Rosas S E, Nolte I M, Penninx B W, Snieder H, Fabiola Del Greco M, Franke A, Nothlings U, Lieb W, Bakker S J, Gansevoort R T, van der Harst P, Dehghan A, Franco O H, Hofman A, Rivadeneira F, Sedaghat S, Uitterlinden A G, Coassin S, Haun M, Kollerits B, Kronenberg F, Paulweber B, Aumann N, Endlich K, Pietzner M, Volker U, Rettig R, Chouraki V, Helmer C, Lambert J C, Metzger M, Stengel B, Lehtimaki T, Lyytikainen L P, Raitakari O, Johnson A, Parsa A, Bochud M, Heid I M, Goessling W, Kottgen A, Kao W H, Fox C S, Boger C A. Genome-wide association study of kidney function decline in individuals of European descent. Kidney international 2015; 87(5): 1017-1029.
  • Winkler T W, Day F R, Croteau-Chonka D C, Wood A R, Locke A E, Magi R, Ferreira T, Fall T, Graff M, Justice A E, Luan J, Gustafsson S, Randall J C, Vedantam S, Workalemahu T, Kilpelainen T O, Scherag A, Esko T, Kutalik Z, Heid I M, Loos R J, Genetic Investigation of Anthropometric Traits C. Quality control and conduct of genome-wide association meta-analyses. Nature protocols 2014; 9(5): 1192-1212.
  • Grassmann F, Heid I M, Weber B H. Genetic risk models in age-related macular degeneration.  Adv Exp Med Biol 2014; 801: 291-300. (IF: 1.958)
  • Gorski M, Winkler T W, Stark K, Muller-Nurasyid M, Ried J S, Grallert H, Weber B H, Heid I M. Harmonization of Study and Reference Data by PhaseLift: Saving Time When Imputing Study Data. Genetic epidemiology 2014; 38(5): 381-388.
  • Luchner A, Behrens G, Stritzke J, Markus M, Stark K, Peters A, Meisinger C, Leitzmann M, Hense H W, Schunkert H, Heid I M. Long-term pattern of brain natriuretic peptide and N-terminal pro brain natriuretic peptide and its determinants in the general population: contribution of age, gender, and cardiac and extra-cardiac factors. European journal of heart failure 2013.
  • Leitritz M A, Hense H W, Schiefer U, Nagel M, Greiser H, Linseisen J, Heid I, Fischer B, Thierry S, Bartz-Schmidt K U, Ueffing M. Development and first results of fast and cost-effective examination methods for an ophthalmological screening within the National Cohort. Klin Monbl Augenheilkd 2013; 230(12): 1238-1246.
  • Fritsche L G, Chen W, Schu M, Yaspan B L, Yu Y, Thorleifsson G, Zack D J, Arakawa S, Cipriani V, …, Swaroop A, Weber B H, Kubo M, Deangelis M M, Leveillard T, Thorsteinsdottir U, Haines J L, Farrer L A, Heid I M, Abecasis G R. Seven new loci associated with age-related macular degeneration. Nature genetics 2013; 45(4): 433-439, 439e431-432.
  • Voight B F, Kang H M, Ding J, Palmer C D, Sidore C, Chines P S, Burtt N P, Fuchsberger C, Li Y, …, Heid I M, Samani N J, Schunkert H, Hirschhorn J N, Altshuler D, McCarthy M I, Abecasis G R, Boehnke M. The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS genetics 2012; 8(8): e1002793.
  • Grassmann F, Fritsche L G, Keilhauer C N, Heid I M, Weber B H. Modelling the genetic risk in age-related macular degeneration. PLoS One 2012; 7(5): e37979.
  • Heid I M, Winkler T. Wie groß sind die kleinen genetischen Risiken? Medizinische Genetik 2011; 23(3): 377-384.
  • Del Greco M F, Pattaro C, Luchner A, Pichler I, Winkler T, Hicks A A, Fuchsberger C, Franke A, …, Heid I M, …, Pramstaller P P. Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster. Human molecular genetics 2011; 20(8): 1660-1671.
  • Behrens G, Winkler T W, Gorski M, Leitzmann M F, Heid I M. To stratify or not to stratify: power considerations for population-based genome-wide association studies of quantitative traits. Genetic epidemiology 2011; 35(8): 867-879.
  • Stark K, Esslinger U B, Reinhard W, Petrov G, Winkler T, Komajda M, Isnard R, Charron P, …, Heid I M, Regitz-Zagrosek V, Hengstenberg C. Genetic association study identifies HSPB7 as a risk gene for idiopathic dilated cardiomyopathy. PLoS genetics 2010; 6(10): e1001167.
  • Lamina C, Kuchenhoff H, Chang-Claude J, Paulweber B, Wichmann H E, Illig T, Hoehe M R, Kronenberg F, Heid I M. Haplotype misclassification resulting from statistical reconstruction and genotype error, and its impact on association estimates. Annals of human genetics 2010; 74(5): 452-462.
  • Kottgen A, Pattaro C, Boger C A, Fuchsberger C, Olden M, …, Heid I M*, Fox C S*. New loci associated with kidney function and chronic kidney disease. Nature genetics 2010; 42(5): 376-384. (IF: 36.377) *contributed equally
  • Holzapfel C, Grallert H, Huth C, Wahl S, Fischer B, Doring A, Ruckert I M, Hinney A, Hebebrand J, Wichmann H E, Hauner H, Illig T, Heid I M. Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA. International journal of obesity 2010; 34(10): 1538-1545.
  • Heid I M, Jackson A U, Randall J C, Winkler T W, …, Lindgren C M. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nature genetics 2010; 42(11): 949-960.
  • Heid I M, Henneman P, Hicks A, Coassin S, Winkler T, Aulchenko Y S, Fuchsberger C, Song K, Hivert M F, Waterworth D M, Timpson N J, Richards J B, Perry J R, Tanaka T, Amin N, Kollerits B, Pichler I, Oostra B A, Thorand B, Frants R R, Illig T, Dupuis J, Glaser B, Spector T, Guralnik J, Egan J M, Florez J C, Evans D M, Soranzo N, Bandinelli S, Carlson O D, Frayling T M, Burling K, Smith G D, Mooser V, Ferrucci L, Meigs J B, Vollenweider P, Dijk K W, Pramstaller P, Kronenberg F, van Duijn C M. Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis 2010; 208(2): 412-420.
  • Finner H, Strassburger K, Heid I M, Herder C, Rathmann W, Giani G, Dickhaus T, Lichtner P, Meitinger T, Wichmann H E, Illig T, Gieger C. How to link call rate and p-values for Hardy-Weinberg equilibrium as measures of genome-wide SNP data quality. Statistics in medicine 2010; 29(22): 2347-2358.
  • Lindgren C M*, Heid I M*, …, McCarthy M I. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS genetics 2009; 5(6): e1000508. (IF: 9.532) *contributed equally
  • Muller M, Doring A, Kuchenhoff H, Lamina C, Malzahn D, Bickeboller H, Vollmert C, Klopp N, Meisinger C, Heinrich J, Kronenberg F, Wichmann H E, Heid I M. Quantifying the contribution of genetic variants for survival phenotypes. Genetic epidemiology 2008; 32(6): 574-585.
  • Heid I M, Lamina C, Kuchenhoff H, Fischer G, Klopp N, Kolz M, Grallert H, Vollmert C, Wagner S, Huth C, Muller J, Muller M, Hunt S C, Peters A, Paulweber B, Wichmann H E, Kronenberg F, Illig T. Estimating the single nucleotide polymorphism genotype misclassification from routine double measurements in a large epidemiologic sample. American journal of epidemiology 2008; 168(8): 878-889.
  • Heid I M, Boes E, Muller M, Kollerits B, Lamina C, Coassin S, Gieger C, Doring A, Klopp N, Frikke-Schmidt R, Tybjaerg-Hansen A, Brandstatter A, Luchner A, Meitinger T, Wichmann H E, Kronenberg F. Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions. Circulation Cardiovascular genetics 2008; 1(1): 10-20.
  • Heid I M, Wagner S A, Gohlke H, Iglseder B, Mueller J C, Cip P, Ladurner G, Reiter R, Stadlmayr A, Mackevics V, Illig T, Kronenberg F, Paulweber B. Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians. Diabetes 2006; 55(2): 375-384.
  • Heid I M, Kuchenhoff H, Rosario A S, Kreienbrock L, Wichmann H E. Impact of measurement error in exposures in german radon studies. Journal of toxicology and environmental health Part A 2006; 69(7): 701-721.
  • Heid I M, Vollmert C, Hinney A, Doring A, Geller F, Lowel H, Wichmann H E, Illig T, Hebebrand J, Kronenberg F. Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys. Journal of medical genetics 2005; 42(4): e21.
  • Darby S, Hill D, Auvinen A, Barros-Dios J M, Baysson H, Bochicchio F, Deo H, Falk R, Forastiere F, Hakama M, Heid I, Kreienbrock L, Kreuzer M, Lagarde F, Makelainen I, Muirhead C, Oberaigner W, Pershagen G, Ruano-Ravina A, Ruosteenoja E, Rosario A S, Tirmarche M, Tomasek L, Whitley E, Wichmann H E, Doll R. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ 2005; 330(7485): 223.
  • Heid I M, Kuchenhoff H, Wellmann J, Gerken M, Kreienbrock L, Wichmann H E. On the potential of measurement error to induce differential bias on odds ratio estimates: an example from radon epidemiology. Statistics in medicine 2002; 21(21): 3261-3278.
  • Heid I M, O'Fallon J R, Schwenk N M, Gabriel S E. Increasing the proportion of women in academic medicine: one institution's response. Mayo Clinic proceedings Mayo Clinic 1999; 74(2): 113-119.

  1. Fakultät für Medizin

Prof. Dr. Iris Heid

Lehrstuhl für Genetische Epidemiologie

Heid-iris 2

Telefon: 0941 944-5210
Telefax: 0941 944-5212
E-Mail