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Experimental Orthopedics

Principal investigator

Prof. Dr. rer. nat. Susanne Grässel

Lab Biopark


Prof. Dr. rer. nat. Susanne Grässel
Orthopedic Surgery
Div. Experimental Orthopedics
ZMB / BioPark 1

Josef-Engert-Str. 9
D-93053 Regensburg

Phone: +49 941 943-5065
Fax: +49 941 943-5066

E-mail: susanne.graessel[at]klinik.uni-regensburg.de
Web: Center for medical Biotechnology

Lab Bad Abbach


Ms. Anja Pasoldt
Orthopedic Surgery
Asklepios Klinikum, Bad Abbach

University of Regensburg
Kaiser-Karl V.-Allee 3
93077 Bad Abbach

Phone: +49 9405 18-2491
E-mail: anja.pasoldt[at]klinik.uni-regensburg.de

Publication record

Joachim Grifka

Please find research profile and publication record of Prof. Dr. Dr. Grifka on the homepage of the Asklepios-Kliniken.

Susanne Grässel

Publication record of the past 5 years (from 2006)

1. Radons J., Bosserhoff A.K., Grässel S., Falk W., Schubert T.E.O.: p38MAPK mediates IL- 1 induced down-regulation of aggrecan gene expression in human chondrocytes. Int. J. Mol. Med. 17 (4): 661-668, 2006

2. Ahmed N., Vogel B., Rohde E., Strunk D., Grifka J., Schulz M B., Grässel S.: CD 45 positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells. Int. J. Mol. Med. 18 (2): 233-40, 2006

3. Eble J.A., Kassner A., Niland S., Mörgelin M., Grifka J., Grässel S: Collagen XVI harbours an integrin a1ß1 recognition site in its C-terminal domains. J. Biol. Chem. Sep 1; 281(35): 25745-56, 2006

4. Opolka A., Ratzinger S., Schubert T.E.O., Spiegel H.-U., Grifka J., Bruckner P., Probst A., Grässel S.: Collagen IX is indispensable for timely maturation of cartilage during fracture repair in mice. Matrix Biology, 26: 85-95, 2006

5. Huber T., Grimal S., Ratzinger S., Mechaly H., Grässel S., Fichard-Caroll A.: Collagen XVI is a component of the developing and regenerating Dorsal Root Ganglia extracellular matrix. Matrix Biology, 26: 206-210, 2007

6. Ahmed N., Dreier R., Göpferich A., Grifka J., Grässel S.: Soluble signalling factors from differentiated cartilage tissue affect chondrogenic differentiation in adult mesenchymal stem cells. Cell. Physiol. Biochem. 20(5):665-678, 2007

7. Grässel S., Ahmed N.: Use of bone marrow mesenchymal stem cells for ex vivo cartilage generation. Der Orthopäde, Mar 36 (3): 227:235, 2007

8. Grässel S., Ahmed N.: Influence of cellular microenvironment and paracrine signals on chondrogenic differentiation. Frontiers in Bioscience 12: 49452-49462, 2007

9. Tingart M.J., Beckmann, J.D., Opolka A., Matsuuro M., Vogel M., Wiech O., Grifka J., Grässel S.: Expression of bone formation and remodelling regulating factors in aseptic osteonecrosis of the femoral head: influence on bone quality. Calcif Tissue Int. Apr;82(4):300-8, 2008

10. Dreier R., Opolka A., Grifka J., Bruckner P., Grässel S.: Collagen IX-deficiency seriously compromises growth cartilage development in mice. Matrix Biol. May; 27(4):319-29, 2008

11. Senner V., Ratzinger S., Mertsch S., Grässel S., Paulus W.: Collagen XVI expression is upregulated in glioblastomas and promotes tumor cell adhesion: FEBS Letters, Oct 15;582(23-24):3293-300, 2008

12. Beckmann J., Matsuuro M., Grässel S., Köck F.X., Grifka J., Tingart M.: Hip resurfacing in patients with osteonecrosis of the femoral head: A µCT analysis of the femoral bone stock. In press Arch. Orthop. Trauma Surg.129 (4): 501-505, 2009

13. Geyer M., Grässel S., Straub R.H., Schett G., Dinser R., Grifka J., Gay S., Neumann E., Müller-Ladner U.: Differential transcriptome analysis of intraarticular lesional vs. intact cartilage reveals new candidate genes in osteoarthritis pathophysiology. Osteoarthritis Cartilage, 17(3):328-35, 2009

14. Wenke AK., Grässel S., Markus Moser M., Bosserhoff AK.: The cartilage specific transcription factor Sox9 regulates AP-2 expression in chondrocytes. FEBS J. 276(9):2494-504, 2009

15. Tingart M., Beckmann J., Opolka A., Matsuuro M., Schaumburger J., Grifka J., Grässel S.: Analysis of bone matrix composition and trabecular microarchitecture of the femoral metaphysis in patients with osteonecrosis of the femoral head. J. Orthop. Res. 27(9):1175-81, 2009

16. Grässel S., Opolka A., Anders S., Straub R.H., Grifka J., Luger T.A., Böhm M.: The melanocortin system in articular chondrocytes: Detection of melanocortin receptors, proopiomelanocortin and precursor proteases - Evidence for a regulatory effect on pro-inflammatory cytokines and extracellular matrix components. rthritis & Rheumatism 60(10):3017-27, 2009

17. Grässel S., Ahmed N., Göttl C.,. Grifka J.: Gene and protein expression profile of naïve and osteogenically differentiated rat bone marrow derived mesenchymal progenitor cells. Int. J. Mol. Med. 23: 745-755, 2009.

18.Appel B., Baumer J., Eyrich D., Sarhan H., Toso S., Englert C., Skodacek D., Ratzinger S., Grässel S., Goepferich A., Blunk T.: Synergistic effects of growth and differentiation factor-5 (GDF-5) and insulin on expanded chondrocytes in a 3-D environment. Osteoarthritis Cartilage 17 (11): 1503-1512, 2009

19. Schubert T., Kaufmann S., Wenke AK., Grässel S., Bosserhoff AK.: A role for Deleted in Colon Carcinoma (DCC) in chondrocytes in osteoarthritis and in chondrocyte migration. Rheumatology (Oxford) 48 (11): 1435-1441, 2009

20. Zaucke F., Grässel S.: Genetic mouse models for the functional analysis of the perifibrillar components collagen IX, COMP and matrilin-3: Implications for growth cartilage differentiation and endochondral ossification. J Histo Histopathol. 24: 1067-1079, 2009

21. Grässel S., Ratzinger S.: COL16A1 (collagen, type XVI, alpha 1). Atlas Genet Cytogenet Oncol Haematol. September 2009.
URL : http://AtlasGeneticsOncology.org/Genes/COL16A1ID44542ch1p35.html

22. Grässel S., Rickert M., Opolka A., Bosserhoff A.K., Angele P., Grifka J., Anders S.: Coculture between periosteal explants and articular chondrocytes induce expression of TGF-ß1 and collagen I. Rheumatology (Oxford) 49 (2): 218-230, 2010

23. Ratzinger S., Eble J.A., Pasoldt A., Opolka A., Rogler G., Grifka J., Grässel S.: Collagen XVI induces formation of focal contacts on intestinal myofibroblasts isolated from the normal and inflamed intestinal tract. Matrix Biol. Apr;29 (3):177-93, 2010

24. Jenei-Lanzl Z., Dienstknecht T., Huber M., Kujat R., Angele M., Straub R., Grässel S., Nerlich M., Angele P.: Estradiol inhibits chondrogenic differentiation of mesenchymal stem cells via non-classical signalling. Arthritis & Rheumatism. Apr;62(4):1088-96, 2010

25. Schubert T., Schlegel J., Schmid R., Opolka A., Grässel S., Bosserhoff A.: Modulation of cartilage differentiation by MIA/CD-RAP. Exp. Mol. Med. Mar 31;42(3):166-74, 2010

26. Grässel S., Beckmann J., Rath B., Vogel M., Grifka J., Tingart M.: Expression profile of matrix metalloprotease-2 and -9 and their endogenous inhibitors in osteonecrotic femoral heads. Int. J. Mol. Med. Jul;26(1):127-33, 2010

27. Riepl B., Grässel S., Wiest R., Fleck M., Straub R.H.: Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis. Arthritis Res Ther. Jun 4;12(3):R110, 2010

28. Schmid R., Schiffner S., Opolka A., Grässel S., Schubert T., Moser M., Bosserhoff A.K.: Enhanced cartilage regeneration in MIA/CD-RAP deficient mice. Cell Death Dis., 1:e97-107, 2010

29. Rickert M., Dreier R., Radons J., Opolka A., Grifka J., Anders S., Grässel S.: Interaction of periosteal explants with articular chondrocytes alter expression profile of matrix metalloproteinases. J. Orthop. Res. Dec; 28 (12):1576-85, 2010

30. Wenke A.K., Niebler S., Grässel S., Bosserhoff A.K.: The transcription factor AP-2ɛ regulates CXCL1 during cartilage development and in osteoarthritis. Osteoarthritis Cartilage. Feb;19(2):206-12, 2011

31. Ratzinger S., Grässel S., Dowejko A., Reichert T.E., Bauer R.J.: Induction of type XVI collagen expression facilitates proliferation of oral cancer cells. Matrix Biol. 30(2):118-25, 2011

32. Bauer R., Ratzinger S., Wales L., Bosserhoff A., Senner V., Grifka J., Grässel S.: Inhibition of collagen XVI expression reduces glioma cell invasiveness. Cell. Physiol. Biochem., Apr 27 (3-4):217-226, 2011

33. Rath B., Nam J., Deschner J., Schaumburger J., Tingart M., Grässel S., Grifka J., Agarwal S.: Biomechanical forces exert anabolic effects on osteoblasts by activation of SMAD 1/5/8 through type 1 BMP receptor. Biorheology, Jan 1;48(1):37-48, 2011

34. Lechler P, Balakrishnan S, Schaumburger J, Grässel S, Baier C, Grifka J, Straub RH, Renkawitz T. The oncofetal gene survivin is re-expressed in osteoarthritis and promotes proliferation and cell survival in chondrocytes in vitro. BMC Musculoskeletal Disorders 12:150, 2011

35.Opolka A., Straub R.H., Pasoldt A., Grifka J., Grässel S.: Substance P and norepinephrine modulate chondrocyte proliferation and apoptosis. Arthritis & Rheumatism, accepted

36. Böhm M., Grässel S.: Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system. Endocrine Rev. in revision

  1. Fakultät für Medizin


Experimentelle Orthopädie
Prof. Dr. Susanne Grässel

Zentrum für Medizinische Biotechnologie

Prof. Dr. Susanne Grässel

Tel. +49 (0) 941 943-5065
Fax +49 (0) 941 943-5066