Forschungslabor

Experimental Orthopedics

Prof. Dr. rer. nat. Susanne Grässel

Lab Biopark

Prof. Dr. rer. nat. Susanne Grässel
Orthopedic Surgery
Div. Experimental Orthopedics
ZMB / BioPark 1

Josef-Engert-Str. 9
D-93053 Regensburg

Phone: +49 941 943-5065
Fax: +49 941 943-5066

E-mail: susanne.graessel[at]klinik.uni-regensburg.de
Web: Center for medical Biotechnology

Lab Bad Abbach

Ms. Anja Pasoldt
Orthopedic Surgery
Asklepios Klinikum, Bad Abbach

University of Regensburg
Kaiser-Karl V.-Allee 3
93077 Bad Abbach

Phone: +49 9405 18-2491
E-mail: anja.pasoldt[at]klinik.uni-regensburg.de

Publication record

Joachim Grifka

Please find research profile and publication record of Prof. Dr. Dr. Grifka on the homepage of the Asklepios-Kliniken.

Susanne Grässel

Publication record of the past 5 years (from 2006)

1. Radons J., Bosserhoff A.K., Grässel S., Falk W., Schubert T.E.O.: p38MAPK mediates IL- 1 induced down-regulation of aggrecan gene expression in human chondrocytes. Int. J. Mol. Med. 17 (4): 661-668, 2006

2. Ahmed N., Vogel B., Rohde E., Strunk D., Grifka J., Schulz M B., Grässel S.: CD 45 positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells. Int. J. Mol. Med. 18 (2): 233-40, 2006

3. Eble J.A., Kassner A., Niland S., Mörgelin M., Grifka J., Grässel S: Collagen XVI harbours an integrin a1ß1 recognition site in its C-terminal domains. J. Biol. Chem. Sep 1; 281(35): 25745-56, 2006

4. Opolka A., Ratzinger S., Schubert T.E.O., Spiegel H.-U., Grifka J., Bruckner P., Probst A., Grässel S.: Collagen IX is indispensable for timely maturation of cartilage during fracture repair in mice. Matrix Biology, 26: 85-95, 2006

5. Huber T., Grimal S., Ratzinger S., Mechaly H., Grässel S., Fichard-Caroll A.: Collagen XVI is a component of the developing and regenerating Dorsal Root Ganglia extracellular matrix. Matrix Biology, 26: 206-210, 2007

6. Ahmed N., Dreier R., Göpferich A., Grifka J., Grässel S.: Soluble signalling factors from differentiated cartilage tissue affect chondrogenic differentiation in adult mesenchymal stem cells. Cell. Physiol. Biochem. 20(5):665-678, 2007

7. Grässel S., Ahmed N.: Use of bone marrow mesenchymal stem cells for ex vivo cartilage generation. Der Orthopäde, Mar 36 (3): 227:235, 2007

8. Grässel S., Ahmed N.: Influence of cellular microenvironment and paracrine signals on chondrogenic differentiation. Frontiers in Bioscience 12: 49452-49462, 2007

9. Tingart M.J., Beckmann, J.D., Opolka A., Matsuuro M., Vogel M., Wiech O., Grifka J., Grässel S.: Expression of bone formation and remodelling regulating factors in aseptic osteonecrosis of the femoral head: influence on bone quality. Calcif Tissue Int. Apr;82(4):300-8, 2008

10. Dreier R., Opolka A., Grifka J., Bruckner P., Grässel S.: Collagen IX-deficiency seriously compromises growth cartilage development in mice. Matrix Biol. May; 27(4):319-29, 2008

11. Senner V., Ratzinger S., Mertsch S., Grässel S., Paulus W.: Collagen XVI expression is upregulated in glioblastomas and promotes tumor cell adhesion: FEBS Letters, Oct 15;582(23-24):3293-300, 2008

12. Beckmann J., Matsuuro M., Grässel S., Köck F.X., Grifka J., Tingart M.: Hip resurfacing in patients with osteonecrosis of the femoral head: A µCT analysis of the femoral bone stock. In press Arch. Orthop. Trauma Surg.129 (4): 501-505, 2009

13. Geyer M., Grässel S., Straub R.H., Schett G., Dinser R., Grifka J., Gay S., Neumann E., Müller-Ladner U.: Differential transcriptome analysis of intraarticular lesional vs. intact cartilage reveals new candidate genes in osteoarthritis pathophysiology. Osteoarthritis Cartilage, 17(3):328-35, 2009

14. Wenke AK., Grässel S., Markus Moser M., Bosserhoff AK.: The cartilage specific transcription factor Sox9 regulates AP-2 expression in chondrocytes. FEBS J. 276(9):2494-504, 2009

15. Tingart M., Beckmann J., Opolka A., Matsuuro M., Schaumburger J., Grifka J., Grässel S.: Analysis of bone matrix composition and trabecular microarchitecture of the femoral metaphysis in patients with osteonecrosis of the femoral head. J. Orthop. Res. 27(9):1175-81, 2009

16. Grässel S., Opolka A., Anders S., Straub R.H., Grifka J., Luger T.A., Böhm M.: The melanocortin system in articular chondrocytes: Detection of melanocortin receptors, proopiomelanocortin and precursor proteases - Evidence for a regulatory effect on pro-inflammatory cytokines and extracellular matrix components. rthritis & Rheumatism 60(10):3017-27, 2009

17. Grässel S., Ahmed N., Göttl C.,. Grifka J.: Gene and protein expression profile of naïve and osteogenically differentiated rat bone marrow derived mesenchymal progenitor cells. Int. J. Mol. Med. 23: 745-755, 2009.

18.Appel B., Baumer J., Eyrich D., Sarhan H., Toso S., Englert C., Skodacek D., Ratzinger S., Grässel S., Goepferich A., Blunk T.: Synergistic effects of growth and differentiation factor-5 (GDF-5) and insulin on expanded chondrocytes in a 3-D environment. Osteoarthritis Cartilage 17 (11): 1503-1512, 2009

19. Schubert T., Kaufmann S., Wenke AK., Grässel S., Bosserhoff AK.: A role for Deleted in Colon Carcinoma (DCC) in chondrocytes in osteoarthritis and in chondrocyte migration. Rheumatology (Oxford) 48 (11): 1435-1441, 2009

20. Zaucke F., Grässel S.: Genetic mouse models for the functional analysis of the perifibrillar components collagen IX, COMP and matrilin-3: Implications for growth cartilage differentiation and endochondral ossification. J Histo Histopathol. 24: 1067-1079, 2009

21. Grässel S., Ratzinger S.: COL16A1 (collagen, type XVI, alpha 1). Atlas Genet Cytogenet Oncol Haematol. September 2009.
URL : http://AtlasGeneticsOncology.org/Genes/COL16A1ID44542ch1p35.html

22. Grässel S., Rickert M., Opolka A., Bosserhoff A.K., Angele P., Grifka J., Anders S.: Coculture between periosteal explants and articular chondrocytes induce expression of TGF-ß1 and collagen I. Rheumatology (Oxford) 49 (2): 218-230, 2010

23. Ratzinger S., Eble J.A., Pasoldt A., Opolka A., Rogler G., Grifka J., Grässel S.: Collagen XVI induces formation of focal contacts on intestinal myofibroblasts isolated from the normal and inflamed intestinal tract. Matrix Biol. Apr;29 (3):177-93, 2010

24. Jenei-Lanzl Z., Dienstknecht T., Huber M., Kujat R., Angele M., Straub R., Grässel S., Nerlich M., Angele P.: Estradiol inhibits chondrogenic differentiation of mesenchymal stem cells via non-classical signalling. Arthritis & Rheumatism. Apr;62(4):1088-96, 2010

25. Schubert T., Schlegel J., Schmid R., Opolka A., Grässel S., Bosserhoff A.: Modulation of cartilage differentiation by MIA/CD-RAP. Exp. Mol. Med. Mar 31;42(3):166-74, 2010

26. Grässel S., Beckmann J., Rath B., Vogel M., Grifka J., Tingart M.: Expression profile of matrix metalloprotease-2 and -9 and their endogenous inhibitors in osteonecrotic femoral heads. Int. J. Mol. Med. Jul;26(1):127-33, 2010

27. Riepl B., Grässel S., Wiest R., Fleck M., Straub R.H.: Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis. Arthritis Res Ther. Jun 4;12(3):R110, 2010

28. Schmid R., Schiffner S., Opolka A., Grässel S., Schubert T., Moser M., Bosserhoff A.K.: Enhanced cartilage regeneration in MIA/CD-RAP deficient mice. Cell Death Dis., 1:e97-107, 2010

29. Rickert M., Dreier R., Radons J., Opolka A., Grifka J., Anders S., Grässel S.: Interaction of periosteal explants with articular chondrocytes alter expression profile of matrix metalloproteinases. J. Orthop. Res. Dec; 28 (12):1576-85, 2010

30. Wenke A.K., Niebler S., Grässel S., Bosserhoff A.K.: The transcription factor AP-2ɛ regulates CXCL1 during cartilage development and in osteoarthritis. Osteoarthritis Cartilage. Feb;19(2):206-12, 2011

31. Ratzinger S., Grässel S., Dowejko A., Reichert T.E., Bauer R.J.: Induction of type XVI collagen expression facilitates proliferation of oral cancer cells. Matrix Biol. 30(2):118-25, 2011

32. Bauer R., Ratzinger S., Wales L., Bosserhoff A., Senner V., Grifka J., Grässel S.: Inhibition of collagen XVI expression reduces glioma cell invasiveness. Cell. Physiol. Biochem., Apr 27 (3-4):217-226, 2011

33. Rath B., Nam J., Deschner J., Schaumburger J., Tingart M., Grässel S., Grifka J., Agarwal S.: Biomechanical forces exert anabolic effects on osteoblasts by activation of SMAD 1/5/8 through type 1 BMP receptor. Biorheology, Jan 1;48(1):37-48, 2011

34. Lechler P, Balakrishnan S, Schaumburger J, Grässel S, Baier C, Grifka J, Straub RH, Renkawitz T. The oncofetal gene survivin is re-expressed in osteoarthritis and promotes proliferation and cell survival in chondrocytes in vitro. BMC Musculoskeletal Disorders 12:150, 2011

35.Opolka A., Straub R.H., Pasoldt A., Grifka J., Grässel S.: Substance P and norepinephrine modulate chondrocyte proliferation and apoptosis. Arthritis & Rheumatism, accepted

36. Böhm M., Grässel S.: Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system. Endocrine Rev. in revision