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Open Positions

Publications Dr. A. Straßer (since 2004)


Strasser A, Wittmann HJ (2013) Modelling of GPCRs - A Practical Handbook. Springer-Verlag


3. Strasser A, Wittmann HJ, Buschauer A, Schneider E, Seifert R (2013) Species-dependent activities of GPCR ligands: Lessons from histamine receptor orthologs. Trends Pharmacol Sci; in press

2. Strasser A, Wittmann HJ (2012) Binding of ligands to GPCRs: How valid is a thermodynamic discrimination of antagonists and agonists? J Physic Chem Biophysic; in press

1. Strasser A (2009) Molecular modelling and QSAR-based design of histamine receptor ligands. Expert Opin Drug Discov 4:1-15

Original research

25. Strasser A., Wittmann HJ (2011) hb2R-Gas-complex: Prediction versus crystal structure - How valuable are predictions based on molecular modelling studies? J Mol Model, in press

24. Ferstl M, Strasser A, Wittmann HJ, Drechsler M, Rischer M, Engel J, Göpferich A (2011) Nanofibers resulting from cooperative electrostatic and hydrophobic interactions between peptides and polyelectrolytes of opposite charge. Langmuir, in press

23. Appl H, Holzammer T, Dove S, Haen E, Strasser A, Seifert R (2011) Interactions of recombinant human histamine H1-, H2-, H3- and H4-receptors with 34 antidepressants and antipsychotics. Naunyn Schmiedeberg's Arch Pharmacol, in press

22.Wagner E, Wittmann HJ, Elz S, Strasser A (2011) Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH1R, but low affinity to hH4R. Bioorg Med Chem Lett 21:6274-6280

21. Wittmann HJ, Seifert R, Strasser A (2011) Influence of the N-terminus and the E2-loop onto the binding kinetics of the antagonist mepyramine and the partial agonist phenoprodifen to H1R. Biochem Pharmacol 82:1910-1918

20. Brunskole I, Strasser A, Seifert R, Buschauer A (2011) Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation. Naunyn Schmiedeberg's Arch Pharmacol 384:301-317

19. Wittmann HJ, Seifert R, Strasser A (2011) Na-methylated phenylhistamines exhibit affinity to the hH4R - a pharmacological and molecular modelling study. Naunyn Schmiedeberg's Arch Pharmacol 384:287-299

18. Silva ME, Heim R, Strasser A, Elz S, Dove S (2011) Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor. J Comput Aided Mol Des 25:51-66

17. Seifert R, Schneider E, Dove S, Brunskole I, Neumann D, Strasser A, Buschauer A (2011) Paradoxical stimulatory effects of the "standard" histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Mol Pharmacol 79:631-638

16. Strasser A, Wittmann HJ (2010) In silico analysis of the histaprodifen induced pathway of the guinea-pig histamine H1 receptor. J Comput Aided Mol Des 24:759-769

15. Schnell D, Strasser A, Seifert R (2010) Comparison of the pharmacological properties of human and rat histamine H3-receptors. Biochem Pharmacol 80:1437-1449

14. Schneider EH, Strasser A, Thurmond RL, Seifert R (2010) Structural requirements for inverse agonism an neutral antagonism of indole-, benzimidazole- and thienopyrrole-derived histamine H4R ligands. J Pharmacol Exp Ther 334:513-521

13. Strasser A, Wittmann HJ (2010) 3D-QSAR CoMFA study to predict orientation of suprahistaprodifens and phenoprodifens in the binding-pocket of four-histamine H1-receptor species. Mol Inf 29:333-341

12. Schneider EH, Schnell D, Strasser A, Dove S, Seifert R (2010) Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor. J Pharmacol Exp Ther 333:382-392

11. Strasser A, Wittmann HJ (2010) Distinct interactions between the human adrenergic b2 receptor and Gas - an in silico study. J Mol Model 16:1307-1318

10. Igel P, Geyer R, Strasser A, Dove S, Seifert R, Buschauer A (2009) Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists. J Med Chem 52:6297-6313

9. Deml KF, Beermann S, Neumann D, Strasser A, Seifert R (2009) Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor. Mol Pharmacol 76:1019-1030

8. Wittmann HJ, Seifert R, Strasser A (2009) Contribution of binding enthalpy and entropy to affinity of antagonist and agonist binding at human and guinea pig histamine H1-receptor. Mol Pharmacol 76:25-37

7. Strasser A, Wittmann HJ, Kunze M, Elz S, Seifert R (2009) Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-receptor compared with the guinea-pig H1-receptor. Mol Pharmacol 75:454-465

6. Strasser A, Wittmann HJ, Seifert R (2008) Ligand-specific contribution of the N-terminus and E2-loop to pharmacological properties of the histamine H1-receptor. J Pharmacol Exp Ther 326:783-791

5. Strasser A, Striegl B, Wittmann HJ, Seifert R (2008) Pharmacological profile of histaprodifens at four recombinant H1-receptor species isoforms. J Pharmacol Exp Ther 324:60-71

4. Strasser A, Wittmann HJ (2007) Analysis of the activation mechanism of the guinea-pig histamine H1-receptor. J Comput Aided Mol Des 21:499-509

3. Strasser A, Wittmann HJ (2007) LigPath: A module for predictive calculation of a ligands pathway into a receptor - application to the gpH1-receptor. J Mol Model 13:209-218

2. Pertz HH, Görnemann T, Schurad B, Seifert R, Strasser A (2006) Striking differences of action of lisuride stereoisomers at guinea-pig and human histamine H1 receptors. Naunyn-Schmiedeberg's Arch Pharmacol 374:215-222

1. Krienke H, Schmeer G, Strasser A (2004) Thermodynamic properties of water from combined quantum and statistical mechanics in the temperature range from 273.16 to 423.15 K. J Mol Liq 113:115-124

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