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Faculty of Biology and Preclinical Medicine
Institute of Biophysics and Physical Biochemistry
Biophysics I


Remco Silke Nmr Druck

Research

The functions of proteins rely on their structures and the structural changes they can undergo. Structural biology hence provides unique insights into biomolecular function and thereby into cellular processes. Furthermore, the knowledge of protein structures is an invaluable starting point in the development of drugs to treat human disease. Nuclear magnetic resonance (NMR) spectroscopy is the only method available to study biomolecular structure and dynamics with atomic resolution in solution. NMR provides information on the three-dimensional fold of proteins and the way proteins interact with other biomolecules. Finally, NMR spectroscopy gives insights into how protein complexes move and change conformation, aspects that are important for many enzymatic reactions. The information gained by NMR about biomolecular structure, interactions and dynamics allows us to understand how proteins are able to perform specific tasks in the cell.

Group

Team

Name
Phone
room
Email
Team Leaders
Prof. Dr. Remco Sprangers 7751 7.2.07 Email
Prof. Dr. Werner Kremer 2185 7.2.09a Email
Dr. Silke Wiesner 7752 7.2.25 Email
Prof. Dr. Dr. Hans Robert Kalbitzer 2594 7.2.09 Email
SeCRETARIAT
Patricia Albrecht 2194 7.2.08 Email
Technical Assistants
Mira Schuetz 7754 7.2.24 Email
Johanna Stoefl 2491 7.2.07 Email
Simon Peter Grunert 4181 7.2.24 Email
Dörte Repenning-Rochelt 4181 7.2.24 Email
Post-docs
Philip Wurm 2491 7.2.07 Email
Daniela Lazzaretti 2491 7.2.07 Email
Jobst Liebau 2491 7.2.07 Email
Markus Beck Erlach 4351 7.1.22 Email
Claudia E. Munte 4351 7.1.22 Email
Tobias Harsch 4351 7.1.22 Email
Johannes Hiltl 4351 7.1.22 Email
PHD  Students
Anna Fuchs 2491 7.2.07 Email
Stefan Schuetz 2491 7.2.07 Email
Jan Overbeck 2491 7.2.07 Email
Carsten Stollmaier 2492 7.2.24 Email

contact

Bio-molecular NMR spectroscopy

Institute of  Biophysics and Physical Biochemistry
Room 7.2.08

Address:

University of Regensburg
Universitätsstrasse 31
93053 Regensburg

From the university bus station it is a 5 minute walk to our labs. For directions to the entrance of the building, please look here. Then, go up on floor, after which our labs are directly in front of you.


Postal Address:
University of Regensburg
93040 Regensburg

Secretary:
Room 7.2.08
Phone +49-941-943 2194 / 2194
Fax +49-941-943 2479

Overview of Telephone Numbers:

Office Remco Sprangers (7.2.07): 7751

Office Silke Wiesner (7.2.25): 7752

Office Werner Kremer (7.2.09a): 2185

Sekretariat (7.2.08): 2194

Office Team Sprangers (7.2.06): 2491

Computer office (7.2.05): 2495

Office Team Wiesner (7.2.24): 2492 / 4181

Lab Sprangers (7.2.03/04): 7753

Lab Wiesner (7.2.22/23): 7754

500 MHz Spectrometer: 2184

600 MHz Spectrometer: 4183

800 MHz Spectrometer: 2848

NMR Operating And Usage Concept

publications

Vacancies

Interested students for Bachelor and Master work can contact us as of now


In our new laboratory in Regensburg (Southern Germany, 100 km North of Munich), we have an open position for a Postdoc and for a PhD student.


Our lab is interested in applying and developing methods in NMR spectroscopy (including methyl TROSY techniques) for very large protein complexes (> 100 kDa). Our aim is to understand how motions in large
enzyme complexes influence function.

Methodologically, we combine high resolution NMR spectroscopy with other structural techniques (X-ray crystallography, cryo-EM), biophysical methods (including ITC, fluorescence anisotropy), activity
measurements and protein/RNA chemistry. From a biological point of view our interests are enzymes that are involved in the degradation of mRNA.

For our recent work, please refer to Pubmed and our home-page

Our wetlabs and offices are newly renovated and fully equipped for modern molecular biology methods. In addition, we run three NMR spectrometers (800, 600 and 500 MHz) that will be fully upgraded with new consoles and cryo/prodigy prodeheads early 2018.

Regensburg is a lively and attractive UNESCO world heritage city with a high density of pubs and bars. The faculty of biology at the Regensburg university has a focus on RNA biology.

We are looking for enthousisatic PhD/ Postdoc candidates with a strong interest and background in biomolecular NMR spectroscopy. In addition, experience in standard molecular biology techniques (cloning, protein expression and purification) is a strong plus.

Interested individuals should contact me directly (remco.sprangers@ur.de) and include names of two peers that can provide letters of recommendations. In addition, a concise description of skills, previous work experiences and scientific interest should be included.

Looking forward to your response.

With kinds regards,

Remco Sprangers

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Biophysik 1

Bio-molecular NMR spectroscopy