Foto: UR / Julia Dragan 2025
Firmke BKM, Fuchs MAA, Süß LM, Forst AL, Kurtz A, Broeker KA. Hypoxia-inducible factor-2 stabilization is not sufficient to induce erythropoietin production in deeper medullary fibroblasts. J Physiol. 2025 Aug 25.
Pubmed (externer Link, öffnet neues Fenster)
Heckscher S, Ihlo NA, Schueler J, Kellermeier F, Werner JM, Nuebel B, Gross V, May M, Wullich B, Kammerl M, Gnewuch C, Burkhardt R, Buchholz B, Pion E, Aung T, Banas M, Schlitt HJ, Oefner PJ, Dettmer K, Gronwald W, Behr M, Haerteis S, Schmidt KM: Metabolomic profiling of renal cyst fluid in advanced ADPKD: insights from dialysis and transplantation cohorts. Metabolomics 2025
Springer (externer Link, öffnet neues Fenster)
2024
Kraus A, Skoczynski K, Brötsch M, Burzlaff N, Leipziger J, Schiffer M, Büttner-Herold M, Buchholz B: P2Y2R and Cyst Growth in Polycystic Kidney Disease. J Am Soc Nephrol. 10.1681/ASN.0000000000000416, 2024
Pubmed (externer Link, öffnet neues Fenster)
Schueler J, Kuenzel J, Thuesing A, Pion E, Behncke RY, Haegerling R, Fuchs D, Kraus A, Buchholz B, Huang B, Merhof D, Werner JM, Schmidt KM, Hackl C, Aung T, Haerteis S: Ultra high frequency ultrasound enables real-time visualization of blood supply from chorioallantoic membrane to human autosomal dominant polycystic kidney tissue. Sci Rep 14: 10063, 2024
Pubmed (externer Link, öffnet neues Fenster)
Skoczynski K, Kraus A, Daniel C, Büttner-Herold M, Amann K, Schiffer M, Hermann K, Herrnberger-Eimer L, Tamm ER, Buchholz B: The extracellular matrix protein fibronectin promotes metanephric kidney development. Pflüg Arch - Eur J Physiol 476: 963–974, 2024
Pubmed (externer Link, öffnet neues Fenster)
2023
Dagorn PG, Buchholz B, Kraus A, Batchuluun B, Bange H, Blockken L, Steinberg GR, Moller DE, Hallakou-Bozec S: A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease. Kidney Int 103: 917–929, 2023
Pubmed (externer Link, öffnet neues Fenster)
Fuchs MAA, Schrankl J, Wagner C, Daniel C, Kurtz A, Broeker KA-E: Localization and characterization of proenkephalin-A as a potential biomarker for kidney disease in murine and human kidneys. Biomarkers 28: 76–86, 2023
Pubmed (externer Link, öffnet neues Fenster)
Grampp S, Kraus A, Skoczynski K, Schiffer M, Krüger R, Naas S, Schödel J, Buchholz B: Hypoxia induces polycystin-1 expression in the renal epithelium. R Soc Open Sci 10: 220992, 2023
Pubmed (externer Link, öffnet neues Fenster)
Kraus A, Lüdke A, Teschemacher B, Skoczynski K, Buchholz B: In vitro cyst puncture and injury-induced tubule formation using renal epithelial cells. STAR Protoc 4: 101874, 2023
Pubmed (externer Link, öffnet neues Fenster)
Kunzelmann K, Ousingsawat J, Kraus A, Park JH, Marquardt T, Schreiber R, Buchholz B: Pathogenic Relationships in Cystic Fibrosis and Renal Diseases: CFTR, SLC26A9 and Anoctamins. Int J Mol Sci 24: 13278, 2023
Pubmed (externer Link, öffnet neues Fenster)
2022
Bichlmayer E-M, Mahl L, Hesse L, Pion E, Haller V, Moehwald A, Hackl C, Werner J, Schlitt H, Schwarz S, Kainz P, Brochhausen C, Groeger C, Steger F, Daniel C, Amann K, Kraus A, Buchholz B, Haerteis S: A 3D In Vivo Model for Studying Human Renal Cystic Tissue and Mouse Kidney Slices. Cells 11: 2269, 2022
Pubmed (externer Link, öffnet neues Fenster)
Broeker KAE, Schrankl J, Fuchs MAA, Kurtz A: Flexible and multifaceted: the plasticity of renin-expressing cells. Pflugers Arch - Eur J Physiol474: 799–812, 2022
Pubmed (externer Link, öffnet neues Fenster)
Broeker KAE, Fuchs MAA, Schrankl J, Lehrmann C, Schley G, Todorov VT, Hugo C, Wagner C, Kurtz A: Prolyl-4-hydroxylases 2 and 3 control erythropoietin production in renin-expressing cells of mouse kidneys. The Journal of Physiology 600: 671–694, 2022
Pubmed (externer Link, öffnet neues Fenster)
Fuchs MAA, Schrankl J, Leupold C, Wagner C, Kurtz A, Broeker KA-E: Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice. American Journal of Physiology-Renal Physiology 322: F295–F307, 2022
Pubmed (externer Link, öffnet neues Fenster)
Scholz JK, Kraus A, Lüder D, Skoczynski K, Schiffer M, Grampp S, Schödel J, Buchholz B: Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation. iScience 25: 104359, 2022
Pubmed (externer Link, öffnet neues Fenster)
2021
Burgmaier K, Kilian S, Arbeiter K, Atmis B, Büscher A, Derichs U, Dursun I, Duzova A, Eid LA, Galiano M, Gessner M, Gokce I, Haeffner K, Hooman N, Jankauskiene A, Körber F, Longo G, Massella L, Mekahli D, Miloševski-Lomić G, Nalcacioglu H, Rus R, Shroff R, Stabouli S, Weber LT, Wygoda S, Yilmaz A, Zachwieja K, Zagozdzon I, Dötsch J, Schaefer F, Liebau MC, ARegPKD Consortium: Early childhood height-adjusted total kidney volume as a risk marker of kidney survival in ARPKD. Sci Rep 11: 21677, 2021
Pubmed (externer Link, öffnet neues Fenster)
Burgmaier K, Brinker L, Erger F, Beck BB, Benz MR, Bergmann C, Boyer O, Collard L, Dafinger C, Fila M, Kowalewska C, Lange-Sperandio B, Massella L, Mastrangelo A, Mekahli D, Miklaszewska M, Ortiz-Bruechle N, Patzer L, Prikhodina L, Ranchin B, Ranguelov N, Schild R, Seeman T, Sever L, Sikora P, Szczepanska M, Teixeira A, Thumfart J, Uetz B, Weber LT, Wühl E, Zerres K, ESCAPE Study group, GPN study group, Dötsch J, Schaefer F, Liebau MC, ARegPKD consortium: Refining genotype-phenotype correlations in 304 patients with autosomal recessive polycystic kidney disease and PKHD1 gene variants. Kidney Int 100: 650–659, 2021
Pubmed (externer Link, öffnet neues Fenster)
Fuchs MAA, Broeker KAE, Schrankl J, Burzlaff N, Willam C, Wagner C, Kurtz A: Inhibition of transforming growth factorβ1 signaling in resident interstitial cells attenuates profibrotic gene expression and preserves erythropoietin production during experimental kidney fibrosis in mice. Kidney International 100: 122–137, 2021
Pubmed (externer Link, öffnet neues Fenster)
Schrankl J, Fuchs M, Broeker K, Daniel C, Kurtz A, Wagner C: Localization of angiotensin II type 1 receptor gene expression in rodent and human kidneys. American Journal of Physiology-Renal Physiology 320: F644–F653, 2021
Pubmed (externer Link, öffnet neues Fenster)
Talbi K, Cabrita I, Kraus A, Hofmann S, Skoczynski K, Kunzelmann K, Buchholz B, Schreiber R: The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model. FASEB J 35: e21897, 2021
Pubmed (externer Link, öffnet neues Fenster)
Vonbrunn E, Serikova S, Daniel C, Amann K, Schödel J, Buchholz B, Ferrazzi F, Heller (Pressmar) K, Apel H, Büttner M: Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA. Front Med 8: 656840, 2021
Pubmed (externer Link, öffnet neues Fenster)
2020
Broeker KAE, Fuchs MAA, Schrankl J, Kurt B, Nolan KA, Wenger RH, Kramann R, Wagner C, Kurtz A: Different subpopulations of kidney interstitial cells produce erythropoietin and factors supporting tissue oxygenation in response to hypoxia in vivo. Kidney Int 98: 918–931, 2020
Pubmed (externer Link, öffnet neues Fenster)
Buchholz B, Eckardt K-U: Role of oxygen and the HIF-pathway in polycystic kidney disease. Cell Signal 69: 109524, 2020
Pubmed (externer Link, öffnet neues Fenster)
Burgmaier K, Ariceta G, Bald M, Buescher AK, Burgmaier M, Erger F, Gessner M, Gokce I, König J, Kowalewska C, Massella L, Mastrangelo A, Mekahli D, Pape L, Patzer L, Potemkina A, Schalk G, Schild R, Shroff R, Szczepanska M, Taranta-Janusz K, Tkaczyk M, Weber LT, Wühl E, Wurm D, Wygoda S, Zagozdzon I, Dötsch J, Oh J, Schaefer F, Liebau MC, ARegPKD consortium: Severe neurological outcomes after very early bilateral nephrectomies in patients with autosomal recessive polycystic kidney disease (ARPKD). Sci Rep 10: 16025, 2020
Pubmed (externer Link, öffnet neues Fenster)
Cabrita I, Kraus A, Scholz JK, Skoczynski K, Schreiber R, Kunzelmann K, Buchholz B: Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo. Nat Commun 11: 4320, 2020
Pubmed (externer Link, öffnet neues Fenster)
Cabrita I, Buchholz B, Schreiber R, Kunzelmann K: TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells. J Mol Med Berl Ger 98: 659–671, 2020
Pubmed (externer Link, öffnet neues Fenster)
Nunius C, Büttner-Herold M, Bertz S, Schiffer M, Buchholz B: Isolated thrombotic microangiopathy of the small intestine in a patient with atypical hemolytic uremic syndrome - a case report. BMC Nephrol 21: 104, 2020
Pubmed (externer Link, öffnet neues Fenster)
Safi W, Kraus A, Grampp S, Schödel J, Buchholz B: Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner. J Mol Med Berl Ger 98: 1547–1559, 2020
Pubmed (externer Link, öffnet neues Fenster)
2019
Mayer M, Fey K, Heinze E, Wick CR, Abboud MI, Yeh T-L, Tumber A, Orth N, Schley G, Buchholz B, Clark T, Schofield CJ, Willam C, Burzlaff N: A Fluorescent Benzo[g]isoquinoline-Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging. ChemMedChem 14: 94–99, 2019
Pubmed (externer Link, öffnet neues Fenster)
Schrankl J, Neubauer B, Fuchs M, Gerl K, Wagner C, Kurtz A: Apparently normal kidney development in mice with conditional disruption of ANG II-AT1 receptor genes in FoxD1-positive stroma cell precursors. American Journal of Physiology-Renal Physiology 316: F1191–F1200, 2019
Pubmed (externer Link, öffnet neues Fenster)
Schreiber R, Buchholz B, Kraus A, Schley G, Scholz J, Ousingsawat J, Kunzelmann K: Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A. J Am Soc Nephrol JASN 30: 228–242, 2019
2014 - 2018
2018
Burgmaier K, Kunzmann K, Ariceta G, Bergmann C, Buescher AK, Burgmaier M, Dursun I, Duzova A, Eid L, Erger F, Feldkoetter M, Galiano M, Geßner M, Goebel H, Gokce I, Haffner D, Hooman N, Hoppe B, Jankauskiene A, Klaus G, König J, Litwin M, Massella L, Mekahli D, Melek E, Mir S, Pape L, Prikhodina L, Ranchin B, Schild R, Seeman T, Sever L, Shroff R, Soliman NA, Stabouli S, Stanczyk M, Tabel Y, Taranta-Janusz K, Testa S, Thumfart J, Topaloglu R, Weber LT, Wicher D, Wühl E, Wygoda S, Yilmaz A, Zachwieja K, Zagozdzon I, Zerres K, Ranguelov N, Godefroid N, Collard L, Lombet J, Maquet J, Schalk G, Querfeld U, Beck BB, Benzing T, Buettner R, Grundmann F, Kurschat C, Benz K, Tzschoppe A, Buchholz B, Buescher R, Häffner K, Pohl M, Gross O, Krügel J, Stock J, Patzer L, Oh J, Bernhardt W, Doyon A, Vinke T, Sander A, Henn M, Derichs U, Beetz R, Jeck N, Lange-Sperandio B, Ponsel S, Kusser F, Uetz B, Benz M, Schmidt S, Huppertz-Kessler C, Kranz B, Titieni A, Wurm D, Leichter HE, Bald M, Billing H, Nabhan MM, Lara LE, Papachristou F, Emma F, Cerkauskiene R, Azukaitis K, Wasilewska A, Balasz-Chmielewska I, Miklaszewska M, Tkaczyk M, Sikora P, Zaniew M, Niemirska A, Antoniewicz J, Lesiak J, Afonso AC, Teixeira A, Milosevski-Lomic G, Paripović D, Peco-Antic A, Papizh S, Bayazit AK, Anarat A, Soylu A, Kavukcu S, Candan C, Caliskan S, Canpolat N, Emre S, Alpay H, Akinci N, Conkar S, Poyrazoglu HM, Dusunsel R, Dötsch J, Schaefer F, Liebau MC: Risk Factors for Early Dialysis Dependency in Autosomal Recessive Polycystic Kidney Disease. J Pediatr 199: 22-28.e6, 2018
Karger C, Machura K, Schneider A, Hugo C, Todorov VT, Kurtz A: COX-2-derived PGE2 triggers hyperplastic renin expression and hyperreninemia in aldosterone synthase-deficient mice. Pflugers Arch 470: 1127–1137, 2018
Kraus A, Peters DJM, Klanke B, Weidemann A, Willam C, Schley G, Kunzelmann K, Eckardt K-U, Buchholz B: HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease. Kidney Int 94: 887–899, 2018
Neubauer B, Schrankl J, Steppan D, Neubauer K, Sequeira-Lopez ML, Pan L, Gomez RA, Coffman TM, Gross KW, Kurtz A, Wagner C: Angiotensin II Short-Loop Feedback: Is There a Role of Ang II for the Regulation of the Renin System In Vivo? Hypertension 71: 1075–1082, 2018
Schenk LK, Buchholz B, Henke SF, Michgehl U, Daniel C, Amann K, Kunzelmann K, Pavenstädt H: Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria. Am J Physiol Renal Physiol 315: F1777–F1786, 2018
Steppan D, Geis L, Pan L, Gross K, Wagner C, Kurtz A: Lack of connexin 40 decreases the calcium sensitivity of renin-secreting juxtaglomerular cells. Pflugers Arch 470: 969–978, 2018
Steppan D, Pan L, Gross KW, Kurtz A: Analysis of the calcium paradox of renin secretion. Am J Physiol Renal Physiol 315: F834–F843, 2018
2017
Ebner K, Schaefer F, Liebau MC, ARegPKD Consortium: Recent Progress of the ARegPKD Registry Study on Autosomal Recessive Polycystic Kidney Disease. Front Pediatr 5: 18, 2017
Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B: Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. Am J Pathol 187: 1496–1511, 2017
Kurtz A: Endocrine functions of the renal interstitium. Pflugers Arch 469: 869–876, 2017
Schellinger IN, Cordasic N, Panesar J, Buchholz B, Jacobi J, Hartner A, Klanke B, Jakubiczka-Smorag J, Burzlaff N, Heinze E, Warnecke C, Raaz U, Willam C, Tsao PS, Eckardt K-U, Amann K, Hilgers KF: Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease. Kidney Int 91: 616–627, 2017
2016
Buchholz B, Schley G, Eckardt KU: The impact of hypoxia on nephrogenesis. Curr Opin Nephrol Hypertens 25: 180–6, 2016
Gerl K, Nolan KA, Karger C, Fuchs M, Wenger RH, Stolt CC, Willam C, Kurtz A, Kurt B: Erythropoietin production by PDGFR-β(+) cells. Pflugers Arch 468: 1479–1487, 2016
Kraus A, Grampp S, Goppelt-Struebe M, Schreiber R, Kunzelmann K, Peters DJ, Leipziger J, Schley G, Schodel J, Eckardt KU, Buchholz B: P2Y2R is a direct target of HIF-1alpha and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells. Purinergic Signal 12: 687–695, 2016
Kraus A, Schley G, Kunzelmann K, Schreiber R, Peters DJ, Stadler R, Eckardt KU, Buchholz B: Glucose promotes secretion-dependent renal cyst growth. J Mol Med Berl 94: 107–17, 2016
2015
Forschbach V, Goppelt-Struebe M, Kunzelmann K, Schreiber R, Piedagnel R, Kraus A, Eckardt KU, Buchholz B: Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation. Cell Death Dis 6: e1899, 2015
Gerl M, Vöckl J, Kurt B, van Veen TAB, Kurtz A, Wagner C: Inducible deletion of connexin 40 in adult mice causes hypertension and disrupts pressure control of renin secretion. Kidney Int 87: 557–563, 2015
Gerl K, Miquerol L, Todorov VT, Hugo CPM, Adams RH, Kurtz A, Kurt B: Inducible glomerular erythropoietin production in the adult kidney. Kidney Int 88: 1345–1355, 2015
Kurtz A: Connexins, renin cell displacement and hypertension. Curr Opin Pharmacol 21: 1–6, 2015
Kurt B, Kurtz A: Plasticity of renal endocrine function. Am J Physiol Regul Integr Comp Physiol 308: R455-466, 2015
Kurt B, Gerl K, Karger C, Schwarzensteiner I, Kurtz A: Chronic hypoxia-inducible transcription factor-2 activation stably transforms juxtaglomerular renin cells into fibroblast-like cells in vivo. J Am Soc Nephrol 26: 587–596, 2015
Machura K, Neubauer B, Müller H, Tauber P, Kurtz A, Kurtz L: Connexin 40 is dispensable for vascular renin cell recruitment but is indispensable for vascular baroreceptor control of renin secretion. Pflugers Arch 467: 1825–1834, 2015
Schley G, Scholz H, Kraus A, Hackenbeck T, Klanke B, Willam C, Wiesener MS, Heinze E, Burzlaff N, Eckardt KU, Buchholz B: Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis. Kidney Int 88: 1283–1292, 2015
2014
Buchholz B, Schley G, Faria D, Kroening S, Willam C, Schreiber R, Klanke B, Burzlaff N, Jantsch J, Kunzelmann K, Eckardt KU: Hypoxia-inducible factor-1alpha causes renal cyst expansion through calcium-activated chloride secretion. J Am Soc Nephrol 25: 465–74, 2014
Buchholz B, Faria D, Schley G, Schreiber R, Eckardt KU, Kunzelmann K: Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells. Kidney Int 85: 1058–67, 2014
Kurt B, Karger C, Wagner C, Kurtz A: Control of renin secretion from kidneys with renin cell hyperplasia. Am J Physiol Renal Physiol 306: F327-332, 2014