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Universität Regensburg
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Publikationen

Originalarbeiten

  1. Reinehr S, Rahim Pamuk M, Fuchshofer R, Burkhard Dick H, Joachim SC. Increased inflammation in older high-pressure glaucoma mice. Neurobiol Aging. 2025 Jan; 145:55-64. doi: 10.1016

  2. Reinehr S, Wulf J, Theile J, Schulte KK, Peters M, Fuchshofer R, Dick HB, Joachim SC. In a novel autoimmune and high-pressure glaucoma model a complex immune response is induced. Front Immunol. 2024 Mar 7;15:1296178. doi: 10.3389

  3. Dillinger AE, Kuespert S, Seleem AA, Neuendorf J, Schneider M, Fuchshofer R. CCN2/CTGF tip the balance of growth factors towards TGF-β2 in primary open-angle glaucoma. Front Mol Biosci. 2023 May 11;10:1045411. doi: 10.3389

  4. Reinehr S, Girbig RM, Schulte KK, Theile J, Asaad MA, Fuchshofer R, Dick HB, Joachim SC. Enhanced glaucomatous damage accompanied by glial response in a new multifactorial mouse model. Front Immunol. 2023 Jan 17;13:1017076. doi: 10.3389

  5. Dillinger AE, Weber GR, Mayer M, Schneider M, Göppner C, Ohlmann A, Shamonin M, Monkman GJ, Fuchshofer R. CCN2/CTGF-A Modulator of the Optic Nerve Head Astrocyte. Front Cell Dev Biol. 2022 Apr 14;10:864433. doi: 10.3389

  6. Mietzner R, Pawlak R, Tamm ER, Goepferich A, Fuchshofer R, Breunig M. Angiopoietin-1 Mimetic Nanoparticles for Restoring the Function of Endothelial Cells as Potential Therapeutic for Glaucoma. Pharmaceuticals (Basel). 2021 Dec 24;15(1):18. doi: 10.3390

  7. Reinehr S, Doerner JD, Mueller-Buehl AM, Koch D, Fuchshofer R, Dick HB, Joachim SC. Cytokine and Complement Response in the Glaucomatous βB1-CTGF Mouse Model. Front Cell Neurosci. 2021 Nov 18;15:718087. doi: 10.3389

  8. Schneider M, Dillinger AE, Ohlmann A, Iozzo RV, Fuchshofer R. Decorin-An Antagonist of TGF-β in Astrocytes of the Optic Nerve. Int J Mol Sci. 2021 Jul 17;22(14):7660. doi: 10.3390

  9. Sonntag T, Froemel F, Stamer WD, Ohlmann A, Fuchshofer R, Breunig M. Distribution of Gold Nanoparticles in the Anterior Chamber of the Eye after Intracameral Injection for Glaucoma Therapy. Pharmaceutics. 2021 Jun 17;13(6):901. doi: 10.3390

  10. Weiss M, Reinehr S, Mueller-Buehl AM, Doerner JD, Fuchshofer R, Stute G, Dick HB, Joachim SC. Activation of Apoptosis in a βB1-CTGF Transgenic Mouse Model. Int J Mol Sci. 2021 Feb 17;22(4):1997. doi: 10.3390

  11. Schneider M, Pawlak R, Weber GR, Dillinger AE, Kuespert S, Iozzo RV, Quigley HA, Ohlmann A, Tamm ER, Fuchshofer R. A novel ocular function for decorin in the aqueous humor outflow. Matrix Biol. 2021 Mar;97:1-19. doi: 10.1016

  12. Mietzner R, Kade C, Froemel F, Pauly D, Stamer WD, Ohlmann A, Wegener J, Fuchshofer R, Breunig M. Fasudil Loaded PLGA Microspheres as Potential Intravitreal Depot Formulation for Glaucoma Therapy. Pharmaceutics. 2020 Jul 27;12(8):706. doi: 10.3390

  13. Boesl F, Drexler K, Müller B, Seitz R, Weber GR, Priglinger SG, Fuchshofer R, Tamm ER, Ohlmann A. Endogenous Wnt/β-catenin signaling in Müller cells protects retinal ganglion cells from excitotoxic damage. Mol Vis. 2020 Mar 5;26:135-149

  14. Kassumeh S, von Studnitz A, Priglinger SG, Fuchshofer R, Luft N, Moloney G, Dirisamer M, Ohlmann A. Ex vivo excimer laser ablation of cornea guttata and ROCK inhibitor-aided endothelial recolonization of ablated central cornea. Acta Ophthalmol. 2020 Sep;98(6):e773-e780. doi: 10.1111

  15. Kassumeh S, Leopold S, Fuchshofer R, Thomas CN, Priglinger SG, Tamm ER, Ohlmann A. Norrin Protects Retinal Ganglion Cells from Excitotoxic Damage via the Induction of Leukemia Inhibitory Factor. Cells. 2020 Jan 23;9(2):277. doi: 10.3390

  16. Reinehr S, Koch D, Weiss M, Froemel F, Voss C, Dick HB, Fuchshofer R, Joachim SC. Loss of retinal ganglion cells in a new genetic mouse model for primary open-angle glaucoma J Cell Mol Med. 2019 Aug;23(8):5497-5507. doi: 10.1111

  17. Dillinger AE, Guter M, Froemel F, Weber GR, Perkumas K, Stamer WD, Ohlmann A, Fuchshofer R*, Breunig M.* Intracameral Delivery of Layer-by-Layer Coated siRNA Nanoparticles for Glaucoma Therapy. Small. 2018 Dec;14(50):e1803239. doi: 10.1002/smll.201803239    (*contributed equally)

  18. Seitz R, Weber G, Albrecht S, Fuchshofer R, Tamm ER, Ohlmann A. Cross-Inhibition of Norrin and TGF-β Signaling Modulates Development of Retinal and Choroidal Vasculature. Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2240-2251. doi: 10.1167/iovs.17-23403

  19. Leopold SA, Zeilbeck LF, Weber G, Seitz R, Bösl MR, Jägle H, Fuchshofer R, Tamm ER, Ohlmann A. Norrin protects optic nerve axons from degeneration in a mouse model of glaucoma. Sci Rep. 2017 Oct 27;7(1):14274. doi: 10.1038/s41598-017-14423-8

  20. Kugler, M; Schlecht, A; Fuchshofer, R; Schmitt, SI; Kleiter, I; Aigner, L; Tamm, ER; Braunger, BM; : SMAD7 deficiency stimulates Müller progenitor cell proliferation during the development of the mammalian retina. Histochem Cell Biol, 2017 148: 1 pp.21-32 

  21. Reichhart N, Haase N, Crespo-Garcia S, Skosyrski S, Herrspiegel C, Kociok N, Fuchshofer R, Dillinger A, Poglitsch M, Müller DN, Joussen AM, Luft FC, Dechend R, Strauß O. (2016) Hypertensive retinopathy in a transgenic angiotensin-based model. Clin Sci (Lond). 2016 Jul 1;130(13):1075-88.

  22. Hennig R, Kuespert S, Haunberger A, Goepferich A, Fuchshofer R (2016) Cyclic RGD peptides target human trabecular meshwork cells while ameliorating connective tissue growth factor-induced fibrosis. Journal of drug targeting Mar 27:1-8

  23. Friedrich U, Datta S, Schubert T, Plössl K, Schneider M, Grassmann F, Fuchshofer R, Tiefenbach KJ, Längst G, Weber BH. (2015) Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling. Hum Mol Genet. 24(22):6361-73 

  24.  Kugler M, Schlecht A, Fuchshofer R, Kleiter I, Aigner L, Tamm ER, Braunger BM. (2015) Heterozygous modulation of TGF-β signaling does not influence Müller glia cell reactivity or proliferation following NMDA-induced damage. Histochem Cell Biol. 2015 Jul 28.

  25. Kuespert S, Junglas B, Braunger BM, Tamm ER,Fuchshofer R (2015) The regulation of connective tissue growth factor expression influences the viability of human trabecular meshwork cells. J Cell Mol Med. May;19(5):1010-20. 

  26. Braunger BM, Ademoglu B, Koschade SE, Fuchshofer R, Gabelt BT, Kiland JA, Hennes-Beann EA, Brunner KG, Kaufman PL, Tamm ER (2014) Identification of adult stem cells in Schwalbe's line region of the primate eye. Invest Ophthalmol Vis Sci. Oct 16;55(11):7499-507. 

  27. Ganzer R, Stolzenburg JU, Neuhaus J, Weber F, Fuchshofer R, Burger M, Bründl J. (2014) Anatomical Study of Pelvic Nerves in Relation to Seminal Vesicles, Prostate and Urethral Sphincter: Immunohistochemical Staining, Computerized Planimetry and 3-Dimensional Reconstruction. J Urol.  Oct 6. [Epub ahead of print] 

  28. Gallenberger M, Kroeber M, März L, Koch M, Fuchshofer R, Braunger BM, Iwata T, Tamm ER. (2014) Heterozygote Wdr36-deficient mice do not develop glaucoma. Exp Eye Res. Nov;128:83-91. 

  29. Overby DR, Zhou EH, Vargas-Pinto R, Pedrigi RM, Fuchshofer R, Braakman ST, Gupta R, Perkumas KM, Sherwood JM, Vahabikashi A, Dang Q, Kim JH, Ethier CR, Stamer WD, Fredberg JJ, Johnson M. (2014) Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma.Proc Natl Acad Sci Sep 23;111(38):13876-81 

  30. Sippl C, Zeilbeck LF, Fuchshofer R, Tamm ER. (2014) Optineurin associates with the podocyte Golgi complex to maintain its structure. Cell Tissue Res. Nov;358(2):567-83.

  31. Fuchshofer R, Kuespert S, Junglas B, Tamm ER. (2014) The prostaglandin f2α analog fluprostenol attenuates the fibrotic effects of connective tissue growth factor on human trabecular meshwork cells. J Ocul Pharmacol Ther. Mar-Apr;30(2-3):237-45.

  32. Pollinger K, Hennig R, Ohlmann A, Fuchshofer R, Wenzel R, Breunig M, Tessmar J, Tamm ER, Goepferich A. (2013) Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application. Proc Natl Acad Sci Apr 9;110(15):6115-20. 

  33. Herrnberger L, Seitz R, Kuespert S, Bösl MR, Fuchshofer R, Tamm ER. (2012) Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice. Histochem Cell Biol. Nov;138(5):709-24 

  34. Junglas B, Kuespert S, Seleem AA, Struller T, Bösl M, Bosserhoff A, Köstler J, Wagner R, Tamm ER, Fuchshofer R (2012) Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork. American Journal of Pathology  Jun;180(6):2386-403

  35. Fuchshofer R, Ullmann S, Zeilbeck L, Baumann M, Junglas B, Tamm ER(2011)  Connective tissue growth factor modulates podocyte actin cytoskeleton and extracellular matrix synthesis and is induced in podocytes upon injury. Histochem Cell Biol. Sep;136(3):301-19

  36. Braig S, Wallner S, Junglas B, Fuchshofer R, Bosserhoff AK. (2011) CTGF is overexpressed in malignant melanoma and promotes cell invasion and migration. Br J Cancer. Jul 12;105(2):231-8

  37. Kritzenberger M, Junglas B, Framme C, Helbig H, Gabel VP, Fuchshofer R, Tamm ER, Hillenkamp J. (2011) Different collagen types define two types of idiopathic epiretinal membranes. Histopathology. May;58(6):953-65

  38. Fuchshofer R, Kottler UB, Ohlmann AV, Schlötzer-Schrehardt U, Jünemann A, Kruse FE, Ohlmann A. (2011), SPARC is expressed in scars of the Tenon's capsule and mediates scarring properties of human Tenon's fibroblasts in vitro. Mol Vis. Jan 19;17:177-85

  39. Bohr D, Koch M, Kritzenberger M, Fuchshofer R, Tamm ER (2011), Increased expression of olfactomedin-1 and myocilin in podocytes during puromycin aminonucleoside nephrosis. Nephrology Dialysis Transplantation. Jan;26(1):83-92

  40. Karlstetter M, Walczak Y, Weigelt K, Ebert S, Van den Brulle J, Schwer H, Fuchshofer R, Langmann T. (2010), The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response, J Immunol. Sep 15;185(6):3379-90

  41. Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, Moehle C, Fuchshofer R, Langmann T. (2010) Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype, J Neuroinflammation. Jan 14;7(1):3

  42. Junglas B, Yu A.L., Welge-Lüssen U., Tamm ER. Fuchshofer R. (2009) Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells, Exp. Eye. Res. Jun;88(6):1065-75

  43. Fuchshofer R, Stephan DA, Russel P, Tamm ER. (2009) Gene expression profiling of TGFβ2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-β2 signaling, Exp Eye Res. Jun;88(6):1020-32

  44. Yu AL, Fuchshofer R, Kook D, Kampik A, Bloemendal H, Welge-Lüssen U. (2009) Subtoxic oxidative stress induces senescence in retinal pigment epithelial cells via TGF-beta release. IOVS  Feb;50(2):926-35

  45. Yu AL, Moriniere J, Birke M, Neumann C, Fuchshofer R, Kampik A, Bloemendal H, Welge-Lussen U. (2009) Reactivation of optic nerve head astrocytes by transforming growth factor-beta2 and hydrogen peroxide is accompanied by increased heat shock protein 32 and 47 expression. IOVS 2009 Apr;50(4):1707-17

  46. Fuchshofer R, Yu AL, Welge-Lüssen U. (2008) Hypoxia and Reoxygenation induce CTGF and PAI-1 in cultured human retinal pigment epithelium cells. Exp Eye Res. May;88(5):889-99

  47. Yu AL, Fuchshofer R, Kampik A, Welge-Lüssen U. (2008). Effects of oxidative stress in trabecular meshwork cells are reduced by prostaglandin analogues. IOVS. ;49: 4872-80

  48. Yu AL, Fuchshofer R, Birke M, Kampik A, Bloemendal H, Welge-Lüssen U. (2008) Oxidative stress and TGF-beta2 increase heat shock protein 27 expression in human optic nerve head astrocytes. IOVS 49: 5403-11

  49. Paper W, Kroeber M, Heersink S, Stephan DA, Fuchshofer R, Russell P, Tamm ER (2008) Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression. Exp Eye Res.;87: 257-67

  50. Wurm A, Sock E, Fuchshofer R, Wegner M, Tamm ER. (2008) The high-mobility-group transcription factor Sox11 has an important role during early eye development, Exp. Eye Res, 86:895-907

  51. Yu AL, Fuchshofer R, Birke M, Priglinger SG, Eibl KH, Kampik A, Bloemendal H, Welge-Lüssen U (2007). Hypoxia/reoxygenation and transforming growth factor-β increase αB-crystallin expression in human optic nerve head astrocytes. Exp. Eye Res., 84: 694-706 

  52. Fuchshofer R, Welge-Lüssen U, Yu AL, Tamm ER (2007) BMP7, a natural antagonist of TGF-β2 in human trabecular meshwork cells. IOVS, 48, 715-26 

  53. Fuchshofer R, Welge-Lussen U, Lütjen-Drecoll E, Birke M., (2006). Biochemical and morphological analysis of basement membrane component expression in corneoscleral and cribriform human trabecular meshwork cells. IOVS, 47: 794-801

  54. Fuchshofer R, Birke M, Welge-Lüssen U, Kook D, Lütjen-Drecoll E., (2005). TGF-β2 modulated extracellular matrix component expression in cultured human optic nerve head astrocytes. IOVS, 46: 568-78.

  55. Flugel-Koch C, Ohlmann A, Fuchshofer R, Welge-Lüssen U, Tamm ER., (2004). Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-β1 and dexamethasone in vitro. Exp Eye Res. 79, 649-66

  56. Fuchshofer R, Welge-Lussen U, Lutjen-Drecoll E., (2003). The effect of TGF-β2 on human trabecular meshwork extracellular proteolytic system. Exp Eye Res. 77:757-765

 Übersichtsartikel und White Papers

  1. Acott TS, Fautsch MP, Mao W, Ethier CR, Huang AS, Kelley MJ, Aga M, Bhattacharya SK, Borras T, Bovenkamp D, Chowdhury UR, Clark AF, Dibas MI, Du Y, Elliott MH, Faralli JA, Gong H, Herberg S, Johnstone MA, Kaufman PL, Keller KE, Kelly RA, Krizaj D, Kuehn MH, Li HL, Lieberman R, Lin SC, Liu Y, McDonnell FS, McDowell CM, McLellan GJ, Mzyk P, Nair KS, Overby DR, Peters DM, Raghunathan V, Rao PV, Roddy GW, Sharif NA, Shim MS, Sun Y, Thomson BR, Toris CB, Willoughby CE, Zhang HF, Freddo TF, Fuchshofer R, Hill KR, Karimi A, Kizhatil K, Kopcyznski CC, Liton P, Patel G, Peng M, Pattabiraman PP, Prasanna G, Reina-Torres E, Samples EG, Samples JR, Steel CL, Strohmaier CA, Subramanian P, Sugali CK, van Batenburg-Sherwood J, Wong C, Youngblood H, Zode GS, White E, Stamer WD. Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches. Invest Ophthalmol Vis Sci. 2024 Dec 2;65(14):32. doi: 10.1167/iovs.65.14.32.

  2. Keller KE, Bhattacharya SK, Borrás T, Brunner TM, Chansangpetch S, Clark AF, Dismuke WM, Du Y, Elliott MH, Ethier CR, Faralli JA, Freddo TF, Fuchshofer R, Giovingo M, Gong H, Gonzalez P, Huang A, Johnstone MA, Kaufman PL, Kelley MJ, Knepper PA, Kopczynski CC, Kuchtey JG, Kuchtey RW, Kuehn MH, Lieberman RL, Lin SC, Liton P, Liu Y, Lütjen-Drecoll E, Mao W, Masis-Solano M, McDonnell F, McDowell CM, Overby DR, Pattabiraman PP, Raghunathan VK, Rao PV, Rhee DJ, Chowdhury UR, Russell P, Samples JR, Schwartz D, Stubbs EB, Tamm ER, Tan JC, Toris CB, Torrejon KY, Vranka JA, Wirtz MK, Yorio T, Zhang J, Zode GS, Fautsch MP, Peters DM, Acott TS, Stamer WD. Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res. 2018 Jun;171:164-173. doi: 10.1016/j.exer.2018.03.001.

  3. McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WD. Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):12. doi: 10.1167/iovs.63.2.12.

  4. Schneider M, Fuchshofer R. The role of astrocytes in optic nerve head fibrosis in glaucoma. Exp Eye Res. 2016 Jan;142:49-55. doi: 10.1016/j.exer.2015.08.014.

  5. Braunger BM, Fuchshofer R, Tamm ER (2015) The aqueous humor outflow pathways in glaucoma: A unifying concept of disease mechanisms and causative treatment. Eur J Pharm Biopharm. 2015 May 7 

  6. Fuchshofer R, Tamm ER (2012) The role of TGF-β in the pathogenesis of primary open-angle glaucoma. Cell Tissue Res. Jan;347(1):279-90

  7. Fuchshofer R (2011), The pathogenic role of transforming growth factor-β2 in glaucomatous damage to the optic nerve head, Exp Eye Res. Aug;93(2):165-9. 

  8. Fuchshofer R, Tamm ER (2009) Modulation of extracellular matrix turnover in the trabecular meshwork. Exp Eye Res. Apr;88(4):683-8 

  9. Tamm ER, Fuchshofer R. (2007) What increases outflow resistance in primary open-angle glaucoma?. Survey of Ophthalmology, 52 Suppl 2:S101-4. 

Buchbeiträge

  1. Fuchshofer R: Regulation of Extracellular Matrix Turnover in the Aqueous Humor Outflow Pathways. In: Dartt DA, Besharse J. (Hrsg): Encyclopedia of the Eye - Four-Volume Set. Elsevier, chapt. 97. 2010

  2. Fuchshofer R: Innate Immunity of the Eye Glaucoma. In: Zierhut M, Paulsen F, Niederkorn J, Schraermeyer U: Innate Immunity and the Eye. JAYPEE, chapt. 18, pp. 210-217
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