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Lehrstuhl Mikrobiologie - Grohmann News

Fakultät für Biologie und Vorklinische Medizin
Institut für Biochemie, Genetik und Mikrobiologie
Lehrstuhl für Mikrobiologie & Archaeenzentrum
Prof. Dr. Dina Grohmann - News

November 2018

Following up on our ChemBioChem paper, we now published an in depth protocol that describes and evulates the incorporation of non-natural amino acids into proteins expressed in human cells for subsequent small-scale purification and fluorescence labelling via different bioorthogonal chemistries in detail.
See here https://www.sciencedirect.com/science/article/pii/S2405580818301729

Bene Moissl
November 2018

Welcome to Benedikt Moissl who starts his PhD thesis in the Grohmann lab

Elisabeth Wörle
November 2018

Welcome to Elisabeth Woerle who starts her PhD thesis in the Grohmann lab.

September 2018

Can we use super-resolution microscopy to unravel the structural organisation of a protein? We are getting there. Have a look at out latest publication

Benji Moissl
March 2018

Congratulation to Benedikt Moissl who finished his Master thesis in the Grohmann lab.

Katrin Hofweber
February 2018

Welcome to Katrin Hofweber who starts her Master thesis in the Grohmann lab.

Cens _home
Dezember 2017

Our paper "Molecular force spectroscopy with a DNA origami based nanoscopic force clamp" (published in Science http://science.sciencemag.org/content/354/6310/305 won the CeNS Publication Award 2017 for the best interdisciplinary publication. We are grateful for the fantastic collaboration with the Tinnefeld lab and Liedl lab that made this interdisciplinary work possible.


November 2017
Congratulations to Adrian Zander for successfully defending his PhD thesis titled “Biochemical characterisation of the archaeal Argonaute protein from Methanocaldococcus jannaschii and structural investigations using single-molecule Förster resonance energy transfer”. Well done!
November 2017

Nature Microbiology celebrates the 40th anniversary of the seminal publication by Woese and Fox introducing the third domain of life, Archaea. You can find the "40 years of Archaea" channel here https://naturemicrobiologycommunity.nature.com/channels/1431-40-years-of-archaea. Among other researchers in the archaeal field, Prof. Dr. Dina Grohmann contributed to the anniversary channel and you can find her Snapshot interview here https://naturemicrobiologycommunity.nature.com/channels/1431-40-years-of-archaea/posts/22139-snapshot-dr-dina-grohmann

Nina Ostheimer
November 2017
Welcome to Nina Ostheimer who starts her Master thesis in the Grohmann lab.
October 2017

Congratulations to Alexander Gust who won the Poster prize at the SFB960 conference.

August 2017

In a fantastic collaboration with the Vannini Lab (ICR London) we characterised the initiation of gene transcription by RNAP III initiation

Juni 2017

Our back-to-back publication describing the structure and catalytic flexibility of the archaeal Argonaute protein was highlighted by a News & Views article written by Lennart Randau in Nature Microbiology

Juni 2017

Welcome to Benedikt Moissl who starts his Master thesis in our lab.

MAY 2017

A warm welcome to Elke Papst who joins the Grohmann lab.

April 2017

Multicellular organisms have a sophisticated immune system encompassing many specialised cell types like macrophages or T cells to fend off attackers (e.g. viruses or bacteria). But how do unicellular organisms like archaea defend themselves against invaders? Our latest study provides insights in the defence mechanisms of the archaeal organisms M. jannaschii, which utilises the so-called Argonaute protein to degrade foreign genetic material and to use its guide-independent activity to prime Argonaute for sequence-specific action. We are especially happy that we could publish this story back-to-back with our structural characterisation of this archaeal Argonaute variant. see press release:

Our papers can be found here:

Zander A., Willkomm S., Ofer S., van Wolferen M., Egert L., Buchmeier S., Stöckl S., Tinnefeld P., Schneider S., Klingl A., Albers S.-V., Werner F. and Grohmann D.* (2017). Guide-independent DNA cleavage by archaeal Argonaute from Methanocaldococcus jannaschii. Nature Microbiology (epub ahead of print)

Willkomm S., Oellig C. A., Zander A., Restle T., Keegan R., Grohmann D.* and Schneider, S.* (2017). Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein. Nature Microbiology (epub ahead of print)

April 2017

A warm welcome to Elisabeth Piechatschek who joins the Grohmann lab.

February 2017
Blombach F. and Grohmann D. (2017). Same same but different: the evolution of TBP in archaea and their eukaryotic offspring. Transcription. (accepted)
Dezember 2016

Willkomm S., Zander A. and Grohmann D. (2017) Site-Specific Fluorescent Labeling of Argonaute for FRET-based Bio-Assays. Methods in Molecular Biology, 1517:291-304

Dezember 2016
Kucher S, Korneev S. Tyagi S., Apfelbaum R., Grohmann D., Lemke E.A., Klare, J., Steinhoff H.-J., Klose, D. (2016) Orthogonal spin labelling using click chemistry for in vitro and in vivo applications. Journal of Magnetic Resonance,
November 2016

Sheppard C., Blombach F., Belsom A., Schulz S., Daviter T., Smollett K., Mahieu E., Erdmann S., Tinnefeld P., Garrett R., Grohmann D., Rappsilber J., Werner F. (2016) Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP. Nature Communications, 7:13595

October 2016

The development of a new type of DNA origami-based force clamp by the Liedl and Tinnefeld groups allowed us to probe the force dependency of TBP-dependent DNA bending. The results are published in: Nickels P.C., Wünsch B., Holzmeister P., Bae W., Kneer L.M., Grohmann D., Tinnefeld P. and Liedl T. (2016), Molecular Force Spectroscopy with a DNA Origami-Based Nanoscopic Force Clamp. Science. 354(6310):305-307.
Press release

October 2016

New publication: Willkomm S., Zander A., Grohmann D and Restle T. (2016). Mechanistic insights into archaeal and human Argonaute substrate binding and cleavage properties. PLOS one, 11(10):e0164695


July 2016

Congratulations to Sarah Schulz who successfully defended her PhD thesis titled "Single-molecule fluorescence microscopy reveals the dynamics of the archaeal RNA polymerase clamp" at the Technical University Braunschweig.

Leo Jakob
April 2016
A warm welcome to Leonhard Jakob who joins the Grohmann lab
March 2016

We are very happy that our article "TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycle", recently published in the journal Proceedings of the National Academy of Sciences of the United States of America (DOI: 10.3410/f.726221182.793515969), has been recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member James Coker.

November 2015

Heinrich Dräger Wissenschaftspreis awarded to Sarah Willkomm
(https://www.uni-luebeck.de/ aktuelles/nachricht/artikel/ preisverleihungsfeier- der-universitaet-zu-luebeck-kopie-1.html) !
Congratulations Sarah!!

November 2015

The Virtual University of Bavaria funds the development of the multidmedia based teaching modul "Microbiology for medical students".  This is a joint effort between Prof. Dr.  Marc Bramkamp / Dr. Kathrin Dethleffsen (LMU Munich) and Prof. Dr. Dina Grohmann / Prof. Dr. Reinhard Wirth (Regensburg university).

  1. Fakultät für Biologie und Vorklinische Medizin
  2. Faculty Research

Lehrstuhl für Mikrobiologie & Archaeenzentrum

Prof. Dr. Dina Grohmann


Lehrstuhl für Mikrobiologie
Universitätsstraße 31
93053 Regensburg

Phone: +49 941 9433147
Fax: +49 941 9432403
Mail: dina.grohmann@ur.de