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Fakultät für Biologie und Vorklinische Medizin
Institut für Anatomie
Lehrstuhl für Molekulare und Zelluläre Anatomie





(1) Dummer R., G. Posseckert, F. Nestle, R. Witzgall, M. Burger, J. C. Becker, E. Schä- fer, J. Wiede, W. Sebald, G. Burg. Soluble interleukin-2 receptors inhibit interleukin 2-dependent proliferation and cytotoxicity: Explanation for diminished natural killer cell activity in cutaneous T-cell lymphomas in vivo? J. Invest. Dermatology 98: 50-54 (1992).   PDF


(2) Witzgall R., E. O´Leary, R. Gessner, A. J. Ouellette, J.V. Bonventre.  Kid-1, a puta- tive renal transcription factor: Regulation during ontogeny, and in response to ischemia and toxic injury.  Mol. Cell. Biol. 13: 1933-1942 (1993).   PDF


(3) Witzgall R., D. Brown, C. Schwarz, J.V. Bonventre.  Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the post-ischemic kidney. Evidence for a heterogeneous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.  J. Clin. Invest. 93: 2175- 2188 (1994).  PDF


(4) Witzgall R., R. Volk, R. Yeung, J.V. Bonventre.  Genomic structure and chromoso- mal location of the rat gene encoding the zinc finger transcription factor Kid-1.  Genomics 20: 203-209 (1994).   PDF


(5) Witzgall R., E. O´Leary, A. Leaf, D. Önaldi, J.V. Bonventre.  The Krüppel-associat-ed box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repres- sion. Proc. Natl. Acad. Sci. USA 91: 4514-4518 (1994).   PDF


(6) Witzgall R., E. O´Leary, J.V. Bonventre.  A mammalian expression vector for the expression of GAL4 fusion proteins with an epitope tag and histidine tail.  Anal. Bio- chem. 223: 291-298 (1994).   PDF


(7) Sapirstein A., R. A. Spech, R. Witzgall, J. V. Bonventre.  Cytosolic phospholipase A2 (PLA2), but not secretory PLA2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cells. J. Biol. Chem. 271: 21505-21513 (1996).   PDF


(8) Kim S.-S., Y.-M. Chen, E. O’Leary, R. Witzgall, M. Vidal, J. V. Bonventre.  A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins.  Proc. Natl. Acad. Sci. USA 93: 15299-15304 (1996).   PDF


(9) Bonventre J. V., J. M. Kyriakis, R. Spech, R. Witzgall, T. Force.  Phospholipase A2 and lipids as potential modulators of c-Raf-1 kinase. Am. J. Ther. 3, 287-293 (1996)PDF


(10) Obermüller N., N. Gretz, W. Kriz, F. J. van der Woude, R. F. Reilly, H. Murer, J. Biber, R. Witzgall.  Differentiation and cell polarity during renal cyst formation in the Han:SPRD (cy/+) rat, a model for ADPKD.  Am. J. Physiol. 273: F357-F371 (1997).  PDF


(11) Schaub T. P., J. Kartenbeck, J. König, O. Vogel, R. Witzgall, W. Kriz, D. Keppler.  Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules.  J. Am. Soc. Nephrol.  8: 1213-1221 (1997).  PDF


(12) Obermüller N., B. Kränzlin, R. Verma, N. Gretz, W. Kriz, R. Witzgall.  Renal osmotic stress induced cotransporter:  Expression in the newborn, adult and post-ischemic rat kidney.  Kidney Int.  52: 1584-1592 (1997).   PDF


(13) Elser B., W. Kriz, J. V. Bonventre, C. Englert, R. Witzgall.  The Krüppel-associated box (KRAB)-zinc finger protein Kid-1 and the Wilms’ tumor protein WT1, two transcriptional repressor proteins, bind to heteroduplex DNA.  J. Biol. Chem.  272: 27908-27912 (1997).   PDF


(14) Obermüller N., N. Gretz, W. Kriz, R. F. Reilly, R. Witzgall.  The swelling -activated chloride channel ClC-2, the chloride channel ClC-3, and ClC-5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells.  J. Clin. Invest. 101: 635-642 (1998).   PDF


(15) Witzgall R., N. Obermüller, U. Bölitz, J. P. Calvet, B. D. Cowley Jr., C. Walker, W. Kriz, N. Gretz, J. V. Bonventre.  Kid-1 expression is high in differentiated renal proximal tubule cells and suppressed in cyst epithelia.  Am. J. Physiol. 275: F928-F937 (1998).   PDF


(16) Huang Z., B. Philippin, E. O’Leary, J. V. Bonventre, W. Kriz, R. Witzgall.  Expression of the transcriptional repressor protein Kid-1 leads to the disintegration of the nucleolus.  J. Biol. Chem. 274, 7640-7648 (1999).   PDF


(17) Cai Y., Y. Maeda, A. Cedzich, V. E. Torres, G. Wu, T. Hayashi, T. Mochizuki, J. H. Park, R. Witzgall, S. Somlo.  Identification and characterization of polycystin-2, the PKD2 gene product.  J. Biol. Chem. 274, 28557-28565 (1999).   PDF


(18) Obermüller N., A. R. Gallagher, Y. Cai, N. Gassler, N. Gretz, S. Somlo, R. Witzgall.  The rat Pkd2 protein assumes distinct subcellular distributions in different organs.  Am. J. Physiol. 277, F914-F925 (1999).   PDF


(19) Gallagher A. R., A. Cedzich, N. Gretz, S. Somlo, R. Witzgall.  The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton.  Proc. Natl. Acad. Sci. USA 97, 4017-4022 (2000).   PDF


(20) Obermüller N., B. Kränzlin, W. F. Blum, N. Gretz, R. Witzgall.  An endocytosis defect as a possible cause of proteinuria in polycystic kidney disease.  Am. J. Physiol. Renal Physiol. 280, F244-F253 (2001).   PDF


(21) Obermüller N., N. Morente, B. Kränzlin, N. Gretz, R. Witzgall.  A possible role for metalloproteinases in renal cyst development.  Am. J. Physiol. Renal Physiol. 280, F540-F550 (2001).   PDF


(22) Gassler, N., F. Autschbach, G. Heuschen, R. Witzgall, H. F. Otto, N. Obermüller.  Expression of clusterin in Crohn’s disease of terminal ileum.  Histol. Histopathol. 16, 755-762 (2001).   PDF


(23) Klimaschewski, L., N. Obermüller, R. Witzgall.  Regulation of clusterin expres- sion following spinal cord injury.  Cell Tissue Res. 306, 209-216 (2001).  PDF


(24) Koulen P., Y. Cai, L. Geng, Y. Maeda, S. Nishimura, R. Witzgall, B. E. Ehrlich, S. Somlo.  Polycystin-2 is an intracellular calcium release channel.  Nat. Cell Biol. 4, 191-197 (2002).   PDF


(25) Wärntges S., B. Friedrich, G. Henke, C. Duranton, P. A. Lang, S. Waldegger, R. Meyermann, D. Kuhl, E. J. Speckmann, N. Obermüller, R. Witzgall, A. F. Mack, H. J. Wagner, C. A. Wagner, S. Bröer, F. Lang.  Cerebral localization and regulation of the cell volume-sensitive serum- and glucocorticoid-dependent kinase SGK1.  Pflügers Arch. - Eur. J. Physiol. 443, 617-624 (2002).   PDF


(26) Rohr C., J. Prestel, L. Heidet, H. Hosser, W. Kriz, R. L. Johnson, C. Antignac, R. Witzgall.  The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes.  J. Clin. Invest. 109, 1073-1082 (2002).   PDF


(27) Obermüller N., Y. Cai, B. Kränzlin, R. B. Thomson, N. Gretz, W. Kriz, S. Somlo, R. Witzgall.  Altered expression pattern of polycystin-2 in acute and chronic renal tubular diseases.  J. Am. Soc. Nephrol. 13, 1855-1864 (2002).   PDF


(28) Friedrich B., S. Wärntges, K. Klingel, M. Sauter, R. Kandolf, T. Risler, G. A. Müller, R. Witzgall, W. Kriz, H. J. Gröne, F. Lang. Up-regulation of the human serum and glucocorticoid-dependent kinase 1 in glomerulonephritis. Kidney Blood Press. Res. 25, 303-307 (2002).   PDF


(29) Hidaka S., B. Kränzlin, N. Gretz, R. Witzgall. Urinary clusterin levels in the rat correlate with the severity of tubular damage and may help to differentiate between glomerular and tubular injuries. Cell Tissue Res. 310: 289-296 (2002).   PDF


(30) Gallagher A. R., K. Schönig, N. Brown, H. Bujard, R. Witzgall. Use of the tetracycline system for inducible protein synthesis in the kidney. J. Am. Soc. Nephrol. 14: 2042-2051 (2003).   PDF


(31) Wolf M. T. F., B. E. Mucha, M. Attanasio, I. Zalewski, S. M. Karle, H. P. H. Neumann, N. Rahman, B. Bader, C. A. Baldamus, E. Otto, R. Witzgall, A. Fuchshuber, F. Hildebrandt. Mutations of the Uromodulin gene in MCKD type 2 patients cluster in exon 4, which encodes three EGF-like domains. Kidney Int. 64: 1580-1587 (2003).  PDF


(32) Cai Y., G. Anyatonwu, D. Okuhara, K.-B. Lee, Z. Yu, T. Onoe, C.-L. Mei, Q. Qian, L. Geng, R. Witzgall, B. E. Ehrlich, S. Somlo. Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812. J. Biol. Chem. 279: 19987-19995 (2004).   PDF


(33) Hidaka S., V. Könecke, L. Osten, R. Witzgall. PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2. J. Biol. Chem. 279, 35009-35016 (2004).   PDF


(34) Karcher C., A. Fischer, A. Schweickert, E. Bitzer, S. Horie, R. Witzgall, M. Blum. Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in primarycilia. Differentiation 73, 425-432 (2005).   PDF


(35) Brown J. H., M.-T. Bihoreau, S. Hoffmann, B. Kränzlin, I. Tychinskaya, N. Obermüller, D. Podlich, S. N. Boehn, P. J. Kaisaki, N. Megel, P. Danoy, R. R. Copley, J. Broxholme, R. Witzgall, M. Lathrop, N. Gretz, D. Gauguier. Missense mutation in sterile a motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat. J. Am. Soc. Nephrol. 16, 3517-3526 (2005).   PDF


(36) Pelucchi B., G. Aguiari, A. Pignatelli, E. Manzati, R. Witzgall, L. del Senno, O. Belluzzi. Nonspecific cation current associated with native polycystin-2 in HEK-293 cells. J. Am. Soc. Nephrol. 17, 388-397 (2006).   PDF


(37) Gallagher, A. R., S. Hoffmann, N. Brown, A. Cedzich, S.Meruvu, D. Podlich, Y. Feng, V. Könecke, U. de Vries, H.-P. Hammes, N. Gretz, R. Witzgall. A truncated polycystin-2 protein causes polycystic kidney disease and retinal degeneration in transgenic rats. J. Am. Soc. Nephrol. 17, 2719-2730 (2006).   PDF


(38) Banzi M., G. Aguiari, V. Trimi, A. Mangolini, P. Pinton, R. Witzgall, R. Rizzuto, L. del Senno.  Polycystin-1 promotes PKCa-mediated NF-kB activation in kidney cells.  Biochem. Biophys. Res. Commun. 350, 257-262 (2006).   PDF


(39) Kurtz L., F. Schweda, C. de Wit, W. Kriz, R. Witzgall, R. Warth, A. Sauter, A. Kurtz, C. Wagner. Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium. J. Am. Soc. Nephrol. 18, 1103-1111 (2007).   PDF


(40) Suleiman H., D. Heudobler, A.-S. Raschta, Y. Zhao, Q. Zhao, I. Hertting, H. Vitzthum, M. J. Moeller, L. B. Holzman, R. Rachel, R. Johnson, H. Westphal, A. Rascle, R. Witzgall. The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes. Dev. Biol. 304, 701-712 (2007).   PDF


(41) Endele, S., S. Klein, S. Richter, T. Molter, K. Amann, B. Klanke, R. Witzgall, R. L. Johnson, K. F. Hilgers, A. Winterpacht. Renal phenotype in heterozygous Lmx1b knockout mice (Lmx1b+/-) after unilateral nephrectomy. Transgenic Res. 16, 723-729 (2007).   PDF


(42) Aguiari G., V. Trimi, M. Bogo, A. Mangolini, G. Szabadkai, P. Pinton, R. Witzgall, P. C. Harris, P. A. Borea, R. Rizzuto, L. del Senno. Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells. Cell Prolif. 41: 554-573 (2008).   PDF


(43) Felekkis K. N., P. Koupepidou, E. Kastanos, R. Witzgall, C.-X. Bai, L. Li, L. Tsiokas, N. Gretz, C. Deltas. Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2. BMC Nephrol. 9: 10 (2008).   PDF


(44) Rascle A., T. Neumann, A.-S. Raschta, A. Neumann, E. Heining, J. Kastner, R. Witzgall. The LIM-homeodomain transcription factor LMX1B regulates expression of NF-kappa B target genes. Exp. Cell Res. 315: 76-96 (2009).   PDF


(45) Schumann, F. H., H. Hoffmeister, M. Schmidt, R. Bader, E. Besl, R. Witzgall, H. R. Kalbitzer. NMR-assignments of a cytosolic domain of the C-terminus of polycystin-2. Biomol. NMR Assign. 3: 141-144 (2009).   PDF


(46) Osten L., M. Kubitza, A. R. Gallagher, J. Kastner, H. Olbrich, U. de Vries, F. Kees, B. Lelongt, S. Somlo, H. Omran, R. Witzgall. Doxycycline accelerates renal cyst growth and fibrosis in the pcy/pcy mouse model of type 3 nephronophthisis, a form of recessive polycystic kidney disease. Histochem. Cell Biol. 132: 199-210 (2009).   PDF


(47) Schumann F., H. Hoffmeister, R. Bader, M. Schmidt, R. Witzgall, H. R. Kalbitzer.  Ca2+-dependent conformational changes in a C-terminal cytosolic domain of polycystin-2.  J. Biol. Chem. 284: 24372-24383 (2009).   PDF


(48) Barro-Soria R., F. Aldehni, J. Almaça, R. Witzgall, R. Schreiber, K. Kunzelmann.  ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel.  Pflügers Arch. - Eur. J. Physiol. 459: 485-497 (2010).   PDF


(49) Behn D., S. Bosk, H. Hoffmeister, A. Janshoff, R. Witzgall, C. Steinem.  Quantifying the interaction of the C-terminal regions of polycystin-2 and polycystin-1 attached to a lipid bilayer by means of QCM.  Biophys. Chem. 150: 47-53 (2010).   PDF


(50) Reichold M., A. A. Zdebik, E. Lieberer, M. Rapedius, K. Schmidt, S. Bandulik, C. Sterner, I. Tegtmeier, D. Penton, T. Baukrowitz, S.-A. Hulton, R. Witzgall, B. Ben-Zeev, A. J. Howie, R. Kleta, D. Bockenhauer, R. Warth.  KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function.  Proc. Natl. Acad. Sci. USA 107: 14490-14495 (2010).   PDF


(51) Hoffmeister H., A.-R. Gallagher, A. Rascle, R. Witzgall.  The human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-termini.  Biochem. J. 433: 285-294 (2011).   PDF


(52) Tian Y., P. Kongsuphol, M. Hug, J. Ousingsawat, R. Witzgall, R. Schreiber, K.  Kunzelmann.  Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A.  FASEB J. 25: 1058-1068 (2011).   PDF


(53) Hoffmeister H., K. Babinger, S. Gürster, A. Cedzich, C. Meese, K. Schadendorf, L. Osten, U. de Vries, A. Rascle, R. Witzgall.  Polycystin-2 takes different routes to the somatic and ciliary plasma membrane.  J. Cell Biol. 192: 631-645 (2011).   PDF


(54) Pollinger K., R. Hennig, M. Breunig, J. Tessmar, A. Ohlmann, E.R. Tamm, R. Witzgall, A. Goepferich. Kidney podocytes as specific targets for cyclo(RGDfC)-modified nanoparticles. Small 8: 3368-3375 (2012).   PDF    


(55) Burghardt T., J. Kastner, H. Suleiman, E. Rivera-Milla, N. Stepanova, C. Lottaz, M. Kubitza, C. A. Böger, S. Schmidt, M. Gorski, U. de Vries, H. Schmidt, I. Hertting, J. Kopp, A. Rascle, M. Moser, I. M. Heid, R. Warth, R. Spang, J. Wegener, C. T. Mierke, C. Englert, R. Witzgall.  LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys.  J. Am. Soc. Nephrol. 24, 1830-1848 (2013).   PDF    


(56) Morick D., M. Schatz, R. Hubrich, H. Hoffmeister, A. Krefft, R. Witzgall, C. Steinem.  Phosphorylation of C-terminal polycystin-2 influences the interaction with PIGEA14: A QCM study based on solid supported membranes.  Biochem. Biophys. Res. Commun. 437: 532-537 (2013).   PDF               


(57) Holzhauser C., S. Kracher, M. M. Rubner, W. Schmucker, H.-A. Wagenknecht, R. Witzgall.  Photochemically active fluorophore-DNA/RNA conjugates for cellular imaging of nucleic acids by readout in electron microscopy.  ChemistryOpen 2: 136-140 (2013).   PDF     


(58) Klootwijk, E. D., M. Reichold, A. Helip-Wooley, A. Tolaymat, C. Broeker, S. L. Robinette, J. Reinders, D. Peindl, K. Renner, K. Eberhart, N. Assmann, P. J. Oefner, K. Dettmer, C. Sterner, J. Schroeder, N. Zorger, R. Witzgall, S. W. Reinhold, H. C. Stanescu, D. Bockenhauer, G. Jaureguiberry, H. Courtneidge, A. M. Hall, A. D. Wijeyesekera, E. Holmes, J. K. Nicholson, K. O’Brien, I. Bernardini, D. M. Krasnewich, M. Arcos-Burgos, Y. Izumi, H. Nonoguchi, Y. Jia, J. K. Reddy, M. Ilyas, R. J. Unwin, W. A. Gahl, R. Warth, R. Kleta.  N. Engl. J. Med. 370, 129-138 (2014).   PDF


(59) Pollinger K., R. Hennig, S. Bauer, M. Breunig, J. Tessmar, A. Buschauer, R. Witzgall, A. Goepferich.  Biodistribution of quantum dots in the kidney after intravenous injection.  J. Nanosci. Nanotechnol. 14: 3313-3319 (2014).  


(60) Faria D., J. R. Rock, A. M. Romao, F. Schweda, S. Bandulik, R. Witzgall, E. Schlatter, D. Heitzmann, H. Pavenstädt, E. Herrmann, K. Kunzelmann, R. Schreiber.  The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function.  Kidney Int. 85: 1369-1381 (2014).   PDF          


(61) Dong L., S. Pietsch, Z. Tan, B. Perner, R. Sierig, D. Kruspe, M. Groth, R. Witzgall, H.-J. Gröne, M. Platzer, C. Englert.  Integration of cistromic and transcriptomic analyses identifies Nphs2, Mafb, and Magi2 as Wilms' tumor 1 target genes in podocyte differentiation and maintenance.  J. Am. Soc. Nephrol. 26: 2118-2128 (2015).   PDF                          


(62) Burghardt T., F. Hochapfel, B. Salecker, C. Meese, H.-J. Gröne, R. Rachel, G. Wanner, M. P. Krahn, R. Witzgall.  Advanced electron microscopic techniques provide a deeper insight into the peculiar features of podocytes.  Am. J. Physiol. Renal Physiol. 309: F1082-F1089 (2015).   PDF                            


(63) Schießl I. M., A. Hammer, V. Kattler, B. Gess, F. Theilig, R. Witzgall, H. Castrop.  Intravital imaging reveals angiotensin II-induced transcytosis of albumin by podocytes.  J. Am. Soc. Nephrol. 27: 731-744 (2016).   PDF        


(64) Staffel J, D. Valletta, A. Federlein, K. Ehm, R. Volkmann, A. M. Füchsl, R. Witzgall, M. Kuhn, F. Schweda. Natriuretic peptide receptor guanylyl cyclase-A in podocytes is renoprotective but dispensable for physiologic renal function. J. Am. Soc. Nephrol. 28: 260-277 (2017).   PDF                 


(65) Wilkes M., M. G. Madej, L. Kreuter, D. Rhinow, V. Heinz, S. de Sanctis, S. Ruppel, R. M. Richter, F. Joos, M. Grieben, A. C. W. Pike, J. T. Huiskonen, E. P. Carpenter, W. Kühlbrandt, R. Witzgall, C. Ziegler. Molecular insight into lipid-assisted Ca2+ regulation of the TRP channel polycystin-2. Nat. Struct. Mol. Biol. 24: 123-130 (2017).   PDF                            


(66) Ciolek J., H. Reinfrank, L. Quinton, S. Viengchareun, E. A. Stura, L. Vera, S. Sigismeau, B. Mouillac, H. Orcel, S. Peigneur, J. Tytgat, L. Droctové, F. Beau, J. Nevoux, M. Lombès, G. Mourier, E. De Pauw, D. Servent, C. Mendre, R. Witzgall, N. Gilles. Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease. Proc. Natl. Acad. Sci. USA 114: 7154-7159 (2017).   PDF 


(67) Hochapfel F., L. Denk, G. Mendl, U. Schulze, C. Maaßen, Y. Zaytseva, H. Paven- städt, T. Weide, R. Rachel, R. Witzgall, M. P. Krahn. Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes. Cell. Mol. Life Sci. 74: 4573-4586 (2017).  PDF


(68) Billot K., C. Coquil, B. Villiers, B. Josselin-Foll, N. Desban, C. Delehouzé, N.  Oumata, Y. Le Meur, A. Boletta, T. Weimbs, M. Gross, R. Witzgall, S. Saunier, E. Fischer, M. Pontoglio, A. Fautrel, M. Mrug, D. Wallace, P. V. Tran, M. Trudel, N. Bukanov, O. Ibraghimov-Beskrovnaya, L. Meijer. Casein kinase 1e and 1a as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8. Am. J. Physiol. Renal Physiol. 315: F57-F73 (2018).  PDF


(69) Reichold M., E. D. Klootwijk, J. Reinders, E. A. Otto, M. Milani, C. Broeker, C. Laing, J. Wiesner, S. Devi, W. Zhou, R. Schmitt, I. Tegtmeier, C. Sterner, H. Doellerer, K. Renner, P. J. Oefner, K. Dettmer, J. M. Simbuerger, R. Witzgall, H. C. Stanescu, S. Dumitriu, D. Iancu, V. Patel, M. Mozere, M. Tekman, G. Jaureguiberry, N. Issler, A. Kesselheim, S. B. Walsh, D. P. Gale, A. J. Howie, J. R. Martins, A. M. Hall, M. Kasghari- an, K. O'Brien, C. R. Ferreira, P. S. Atwal, M. Jain, A. Hammers, G. Charles-Edwards, C.-U. Choe, D. Isbrandt, A. Cebrian-Serrano, B. Davies, R. N. Sandford, C. Pugh, D. S. Konecki, S. Povey, D. Bockenhauer, U. Lichter-Konecki, W. A. Gahl, R. J. Unwin, R. Warth, R. Kleta. Glycine amidinotransferase (GATM), renal Fanconi syndrome, and kidney failure. J. Am. Soc. Nephrol. 29, 1849-1858 (2018).  PDF


(70) Asam C., K. Buerger, O. Felthaus, V. Brébant, R. Rachel, L. Prantl, R. Witzgall, S. Haerteis, T. Aung. Subcellular localization of the chemotherapeutic agent doxoru- bicin in renal epithelial cells and in tumor cells using correlative light and electron microscopy. Clin. Hemorheol. Microcirc. 73, 157-167 (2019).  PDF


(71) Maslanka Figueroa S., D. Fleischmann, S. Beck, P. Tauber, R. Witzgall, F. Schwe- da, da, A. Goepferich. Nanoparticles mimicking viral cell recognition strategies are superior transporters into mesangial cells. Adv. Sci. 7, 1903204 (2020).  PDF


(72) Fleischmann D., S. Maslanka Figueroa, S. Beck, K. Abstiens, R. Witzgall, F. Schweda, P. Tauber, A. Goepferich. Adenovirus-mimetic nanoparticles: Sequential ligand-receptor interplay as a universal tool for enhanced in vitro/in vivo cell identification. ACS Appl. Mater. Interfaces 12, 34689-34702 (2020).  PDF


(73) Rachel R., P. Walther, C. Maaßen, I. Daberkow, M. Matsuoka, R. Witzgall. Dual-axis STEM tomography at 200 kv: Setup, performance, limitations. J. Struct. Biol. 211, 107551 (2020).  PDF


(74) Ziegler V., K. Fremter, J. Helmchen, R. Witzgall, H. Castrop.  Mesangial cells regulate the single nephron GFR and preserve the integrity of the glomerular filtration barrier: An intravital multiphoton microscopy study.  Acta Physiol. 231, e13592 (2021).  PDF


(75) Buerger K., K. N. Schmidt, J. Fokkema, H. C. Gerritsen, O. Maier, U. de Vries, Y. Zaytseva, R. Rachel, R. Witzgall. On-section correlative light and electron microsco- py of large cellular volumes using STEM tomography.  Methods Cell Biol. 162, 171-203 (2021).  PDF


(76) Grosch M., K. Brunner, A. V. Ilyaskin, M. Schober, T. Staudner, D. Schmied, T. Stumpp, K. N. Schmidt, M. G. Madej, T. D. Pessoa, H. Othmen, M. Kubitza, L. Osten, U. de Vries, M. M. Mair, S. Somlo, M. Moser, K. Kunzelmann, C. Ziegler, S. Haerteis, C. Korbmacher, R. Witzgall. A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts.  J. Cell Sci. 134, jcs259013 (2021).  PDF




(1) Bonventre J.V., R. Witzgall.  Kid-1, a kidney transcription factor.  Exp. Nephrol. 3: 159-164 (1995).   PDF


(2) Witzgall R.  The proximal tubule phenotype and its disruption in acute renal failure and polycystic kidney disease.  Exp. Nephrol. 7: 15-19 (1999).   PDF


(3) Gallagher A. R., N. Obermüller, A. Cedzich, N. Gretz, R. Witzgall.  An ever-expanding story of cyst formation.  Cell Tissue Res. 300: 361-371 (2000).  PDF


(4) Gretz N., R. Witzgall, B. Dworniczak.  Tiermodelle mit Zystennieren:  Beispiel für die Bedeutung von Tiermodellen in der Nephrologischen Forschung.  medgen 12: 187-192 (2000).


(5) Endlich K., W. Kriz, R. Witzgall.  Update in podocyte biology.  Curr. Opin. Nephrol. Hypertens. 10: 331-340 (2001).   PDF


(6) Gallagher A. R., S. Hidaka, N. Gretz, R. Witzgall.  Molecular basis of autosomal-dominant polycystic kidney disease.  Cell. Mol. Life Sci. 59: 682-693 (2002).   PDF


(7) Witzgall R. New developments in the field of cystic kidney diseases. Curr. Mol. Med. 5: 455-465 (2005).   PDF


(8) Rascle A., H. Suleiman, T. Neumann, R. Witzgall. Role of transcription factors in podocytes. Nephron Exp. Nephrol. 106: e60-e66 (2007).   PDF


(9) Babinger, K., R. Witzgall.  Primary cilia and polycystic kidney disease.  Zellbiologie aktuell 36: 8-13 (2010).   PDF


(10) Kunzelmann K., P. Konsuphol, K. Chootip, C. Toledo, J. R. Martins, J. Almaca, Y. Tian, R. Witzgall, J. Ousingsawat, R. Schreiber.  Role of the Ca2+-activated Cl- channels bestrophin and anoctamin in epithelial cells.  Biol. Chem. 392: 125-134 (2011).   PDF 


(11) Witzgall R.  Nail-patella syndrome.  Pflügers Arch. - Eur. J. Physiol. 469: 927- 936 (2017).   PDF


(12) Witzgall R.  Golgi bypass of ciliary proteins.  Sem. Cell Dev. Biol. 83: 51-58 (2018).  PDF




(1) Bonventre J. V., R. Witzgall.  Cellular and molecular mechanisms of ischemic acute renal failure and repair.  Kapitel 2, pp. 15-42.  In: Mechanisms of injury in renal disease and toxicity.  By R. S. Goldstein (ed.).  CRC Press (1994).   PDF


(2) Witzgall R., J. V. Bonventre.  Transcription factors in kidney development and renal injury.  Kapitel 37, pp. 535-550.  In: Molecular Nephrology.  By J. V. Bonventre, D. Schlöndorff (ed.).  Marcel-Dekker (1995).   PDF


(3) Witzgall R., J. V. Bonventre.  Molecular responses to oxygen deprivation and ischemia.  Kapitel 22, pp. 429-447.  In:  Comprehensive Toxicology. Renal Toxicology.  By R. S. Goldstein (ed.).  Pergamon Press (1997).


(4) Witzgall R., TRPP2 channel regulation. Pp. 363-375. In: Handbook of Ex- perimental Pharmacology (vol. 179): Transient receptor potential (TRP) channels. By V. Flockerzi, B. Nilius (ed.). Springer (2007).   PDF


(5) Witzgall R. Nail-patella syndrome. Chapter 11, pp. 173-178. In: Molecular and Genetic Basis of Renal Disease. By D. B. Mount, M. R. Pollak (ed.). Saunders Elsevier (2008).   PDF


Als Artikel veröffentlichte Preisvorträge und Tagungsbeiträge:


(1) Witzgall R.  Polycystic kidney disease:  A tale of calcium channels and the actin cytoskeleton.  Ann. Anat.  183: 391-392 (2001).   PDF


(2) Witzgall R., B. Kränzlin, N. Gretz, N. Obermüller.  Impaired endocytosis may represent an obstacle to gene therapy in polycystic kidney disease.  Kidney Int.  61 (suppl. 1): S132-S137 (2002).   PDF


(3) Witzgall R. Polycystin-2 - an intracellular or plasma membrane channel? Nau-nyn-Schmiedeberg's Arch. Pharmacol. 371: 342-347 (2005).   PDF


Kommentare und Leitartikel:


(1) Witzgall R. Are renal proximal tubular epithelial cells constantly prepared for an emergency? Focus on "The proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells". Am. J. Physiol. Cell Physiol. 294: C1-C3 (2008).   PDF  


(2) Witzgall R. How are podocytes affected in nail-patella syndrome? Pediatr. Nephrol. 23: 1017-1020 (2008).   PDF




(1) Witzgall R.  Schwammnieren und löchrige Filter. Erbliche Nierenerkrankungen als Weg zu einem besseren Verständnis des chronischen Nierenversagens.  Blick in die Wissenschaft (Forschungsmagazin der Universität Regensburg)  21: 28-33 (2009).   PDF  


  1. Fakultät für Biologie und Vorklinische Medizin
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