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Mustroph J, Wagemann O, Lücht CM, Trum M, Hammer KP, Sag CM, Lebek S, Tarnowski D, Reinders J, Perbellini F, Terracciano C, Schmid C, Schopka S, Hilker M, Zausig Y, Pabel S, Sossalla ST, Schweda F, Maier LS, Wagner S.

Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes.

ESC Heart Fail. 2018 Aug 5 (4): 642-648.

doi: 10.1002/ehf2.12336

 

Meurer M, Ebert K, Schweda F, Höcherl K.

The renal vasodilatory effect of prostaglandins is ameliorated in isolated-perfused kidneys of endotoxemic mice.

Pflugers Arch. 2018 Jul 19.

doi: 10.1007/s00424-018-2183-3

 

Špiranec K, Chen W, Werner F, Nikolaev VO, Naruke T, Koch F, Werner A, Eder-Negrin P, Diéguez-Hurtado R, Adams RH, Baba HA, Schmidt H, Schuh K, Skryabin BV, Movahedi K, Schweda F, Kuhn M.

Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure.

Circulation. 2018 Apr 6. pii: CIRCULATIONAHA.117.033383.

doi: 10.1161/CIRCULATIONAHA.117.033383

 

Staffel J, Valletta D, Federlein A, Ehm K, Volkmann R, Füchsl AM, Witzgall R, Kuhn M, Schweda F.

Natriuretic Peptide Receptor Guanylyl Cyclase-A in Podocytes is Renoprotective but Dispensable for Physiologic Renal Function.

J Am Soc Nephrol. 2017 Jan;28(1):260-277.

doi: 10.1681/ASN.2015070731.

Czogalla J, Schweda F, Loffing J.

The Mouse Isolated Perfused Kidney Technique.

J Vis Exp. 2016 Nov 17;(117).

doi: 10.3791/54712. PubMed PMID: 27911373.

 

Penton D, Czogalla J, Wengi A, Himmerkus N, Loffing-Cueni D, Carrel M,

Rajaram RD, Staub O, Bleich M, Schweda F, Loffing J.

Extracellular K(+) rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl(-) -dependent and independent mechanisms.

J Physiol. 2016 Nov 1;594(21):6319-6331.

doi: 10.1113/JP272504.

 

Koehler S, Brähler S, Kuczkowski A, Binz J, Hackl MJ, Hagmann H, Höhne M, Vogt MC, Wunderlich CM, Wunderlich FT, Schweda F, Schermer B, Benzing T, Brinkkoetter PT.

Single and Transient Ca(2+) Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion.

Sci Rep. 2016 Oct 19;6:35400.

doi: 10.1038/srep35400. PubMed PMID: 27759104; PubMed Central PMCID: PMC5069688.

 

Heitzmann D, Buehler P, Schweda F, Georgieff M, Warth R, Thomas J.

The in vivo respiratory phenotype of the adenosine A1 receptor knockout mouse.

Respir Physiol Neurobiol. 2016 Feb 1;222:16-28.

doi: 10.1016/j.resp.2015.11.005.

 

Wirth A, Wang S, Takefuji M, Tang C, Althoff TF, Schweda F, Wettschureck N, Offermanns S.

Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling.

Cardiovasc Res. 2016 Jan 1;109(1):131-40.

doi: 10.1093/cvr/cvv249.

 

Hennig R, Ohlmann A, Staffel J, Pollinger K, Haunberger A, Breunig M, Schweda F, Tamm ER, Goepferich A.

Multivalent nanoparticles bind the retinal and choroidal vasculature.

J Control Release. 2015 Dec 28;220(Pt A):265-274.

doi: 10.1016/j.jconrel.2015.10.033.

 

Camacho Londoño JE, Tian Q, Hammer K, Schröder L, Camacho Londoño J, Reil JC, He T, Oberhofer M, Mannebach S, Mathar I, Philipp SE, Tabellion W, Schweda F, Dietrich A, Kaestner L, Laufs U, Birnbaumer L, Flockerzi V, Freichel M, Lipp P.

A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling.

Eur Heart J. 2015 Sep 1;36(33):2257-66.

doi: 10.1093/eurheartj/ehv250.

 

Schweda F.
Salt feedback on the renin-angiotensin-aldosterone system.
Pflugers Arch. 2014 Dec 13. [Epub ahead of print] 

 

Tinning AR, Jensen BL, Schweda F, Machura K, Hansen PB, Stubbe J, Gramsbergen JB, Madsen K.
The water channel aquaporin-1 contributes to renin cell recruitment during chronic stimulation of renin production.
Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1215-26. doi: 10.1152/ajprenal.00136.2014. Epub 2014 Oct 22. 

 

Demerath T, Staffel J, Schreiber A, Valletta D, Schweda F.
Natriuretic peptides buffer renin-dependent hypertension.
Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1489-98. 

 

Faria D, Rock JR, Romao AM, Schweda F, Bandulik S, Witzgall R, Schlatter E, Heitzmann D, Pavenstädt H, Herrmann E, Kunzelmann K, Schreiber R.
The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function.
Kidney Int. 2014 Jun;85(6):1369-81.

 

Knuth S, Abdelsalam RM, Khayyal MT, Schweda F, Heilmann J, Kees MG, Mair G, Kees F, Jürgenliemk G.
Catechol conjugates are in vivo metabolites of Salicis cortex.
Planta Med. 2013 Nov;79(16):1489-94.

 

Mederle K, Schweda F, Kattler V, Doblinger E, Miyata K, Höcherl K, Oike Y, Castrop H.
The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension.
Crit Care. 2013 Jul 11;17(4):R130.

 

Braeunig JH, Schweda F, Han PL, Seifert R.
Similarly potent inhibition of adenylyl cyclase by P-site inhibitors in hearts from wild type and AC5 knockout mice.
PLoS One. 2013 Jul 1;8(7):e68009.

 

Bandulik S, Tauber P, Penton D, Schweda F, Tegtmeier I, Sterner C, Lalli E, Lesage F, Hartmann M, Barhanin J, Warth R.
Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system.
Endocrinology. 2013 Aug;154(8):2712-22.

 

Schmid J, Oelbe M, Saftig P, Schwake M, Schweda F.
Parallel regulation of renin and lysosomal integral membrane protein 2 in renin-producing cells: further evidence for a lysosomal nature of renin secretory vesicles.
Pflugers Arch. 2013 Jun;465(6):895-905.

 

Castrop H, Kurtz A, Schweda F.
A special issue on the renin-angiotensin system.
Pflugers Arch. 2013 Jan;465(1):1. doi: 10.1007/s00424-012-1179-7.

 

Penton D, Bandulik S, Schweda F, Haubs S, Tauber P, Reichold M, Cong LD, El Wakil A, Budde T, Lesage F, Lalli E, Zennaro MC, Warth R, Barhanin J.
Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension.
Endocrinology. 2012 Oct;153(10):4740-8.

 

Birner C, Ulucan C, Bratfisch M, Götz T, Dietl A, Schweda F, Riegger GA, Luchner A.
Antihypertrophic effects of combined inhibition of the renin-angiotensin system (RAS) and neutral endopeptidase (NEP) in progressive, tachycardia-induced experimental heart failure.
Naunyn Schmiedebergs Arch Pharmacol. 2012 Nov;385(11):1117-25.

 

Schreiber A, Shulhevich Y, Geraci S, Hesser J, Stsepankou D, Neudecker S, Koenig S, Heinrich R, Hoecklin F, Pill J, Friedemann J, Schweda F, Gretz N, Schock-Kusch D.
Transcutaneous measurement of renal function in conscious mice.
Am J Physiol Renal Physiol. 2012 Jun 13. [Epub ahead of print] 

 

Schreiber A, Theilig F, Schweda F, Höcherl K.
Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney.
Kidney Int. 2012 Jul;82(1):53-9. 

 

Schweda F, Kurtz A.
Regulation of renin release by local and systemic factors.
Rev Physiol Biochem Pharmacol. 2011;161:1-44. Review.

 

Höcherl K, Gerl M, Schweda F.
Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release.
Hypertension. 2011 Oct;58(4):611-8.

 

Lübkemeier I, Machura K, Kurtz L, Neubauer B, Dobrowolski R, Schweda F, Wagner C, Willecke K, Kurtz A.
The connexin 40 A96S mutation causes renin-dependent hypertension.
J Am Soc Nephrol. 2011 Jun;22(6):1031-40.

 

Aldehni F, Tang T, Madsen K, Plattner M, Schreiber A, Friis UG, Hammond HK, Han PL, Schweda F.
Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6.
Hypertension. 2011 Mar;57(3):460-8. 

 

Raupach T, Lüthje L, Kögler H, Duve C, Schweda F, Hasenfuss G, Andreas S.
Local and systemic effects of angiotensin receptor blockade in an emphysema mouse model.
Pulm Pharmacol Ther. 2011 Apr;24(2):215-20.

 

Hausmann R, Kuppe C, Egger H, Schweda F, Knecht V, Elger M, Menzel S, Somers D, Braun G, Fuss A, Uhlig S, Kriz W, Tanner G, Floege J, Moeller MJ.
Electrical forces determine glomerular permeability.
J Am Soc Nephrol. 2010 Dec;21(12):2053-8. 

 

Wagner C, Jobs A, Schweda F, Kurtz L, Kurt B, Lopez ML, Gomez RA, van Veen TA, de Wit C, Kurtz A.
Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension.
Kidney Int. 2010 Oct;78(8):762-8.

 

Mathar I, Vennekens R, Meissner M, Kees F, Van der Mieren G, Camacho Londoño JE, Uhl S, Voets T, Hummel B, van den Bergh A, Herijgers P, Nilius B, Flockerzi V, Schweda F, Freichel M.
Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice.
J Clin Invest. 2010 Sep;120(9):3267-79.

 

Milenkovic VM, Brockmann M, Meyer C, Desch M, Schweda F, Kurtz A, Todorov V, Strauss O.
Regulation of the renin expression in the retinal pigment epithelium by systemic stimuli.
Am J Physiol Renal Physiol. 2010 Aug;299(2):F396-403.

 

Castrop H, Höcherl K, Kurtz A, Schweda F, Todorov V, Wagner C.
Physiology of kidney renin.
Physiol Rev. 2010, 90(2):607-73.

 

Oppermann M, Gess B, Schweda F, Castrop H.
Atrap deficiency increases arterial blood pressure and plasma volume.
J Am Soc Nephrol. 2010 Mar;21(3):468-77.

 

Desch M, Schreiber A, Schweda F, Madsen K, Friis UG, Weatherford ET, Sigmund CD, Sequeira Lopez ML, Gomez RA, Todorov VT.
Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells.
Hypertension. 2010 Mar;55(3):660-6.

 

Reinhold SW, Uihlein DC, Böger CA, Kloiber S, Frölich K, Bergler T, Banas B, Schweda F, Krämer BK.
Renin, Endothelial NO Synthase and Endothelin Gene Expression in the 2Kidney-1clip Goldblatt Model of Long-term Renovascular Hypertension.
Eur J Med Res. 2009 Dec 14;14(12):520-5.

 

Niedermeier M, Reich B, Rodriguez Gomez M, Denzel A, Schmidbauer K, Göbel N, Talke Y, Schweda F, Mack M.
CD4+ T cells control the differentiation of Gr1+monocytes into fibrocytes.
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17892-7.

 

Rupprecht K, Schmidt C, Raspé A, Schweda F, Shipkova M, Fischer W, Bucher M, Kees F, Faerber L.
Bioavailability of mycophenolate mofetil and enteric-coated mycophenolate sodium is differentially affected by pantoprazole in healthy volunteers.
J Clin Pharmacol. 2009 Oct;49(10):1196-201.

 

Wagner C, Kurtz L, Schweda F, Simon AM, Kurtz A.
Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney.
Pflugers Arch. 2009 Nov;459(1):151-8.

 

Schweda F, Kurtz L, de Wit C, Janssen-Bienhold U, Kurtz A, Wagner C.
Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension.
Kidney Int. 2009 Mar;75(5):482-9.

 

Schmid U, Stopper H, Schweda F, Queisser N, Schupp N.
Angiotensin II induces DNA damage in the kidney.
Cancer Res. 2008 Nov 15;68(22):9239-46.

 

Heitzmann D, Derand R, Jungbauer S, Bandulik S, Sterner C, Schweda F, El Wakil A, Lalli E, Guy N, Mengual R, Reichold M, Tegtmeier I, Bendahhou S, Gomez-Sanchez CE, Aller MI, Wisden W, Weber A, Lesage F, Warth R, Barhanin J.
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis.
EMBO J. 2008 Jan 9;27(1):179-87.

 

Schweda F, Friis U, Wagner C, Skott O, Kurtz A.
Renin release.
Physiology (Bethesda). 2007 Oct;22:310-9. Review.

 

Schmidt C, Höcherl K, Schweda F, Bucher M.
Proinflammatory cytokines cause down-regulation of renal chloride entry pathways during sepsis.
Crit Care Med. 2007 Sep;35(9):2110-9.

 

Kees F, Bucher M, Schweda F, Gschaidmeier H, Faerber L, Seifert R.
Neoimmun versus Neoral: a bioequivalence study in healthy volunteers and influence of a fat-rich meal on the bioavailability of Neoimmun.
Naunyn Schmiedebergs Arch Pharmacol. 2007 Aug;375(6):393-9.

 

Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schütz G, Schweda F.
Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
J Am Soc Nephrol. 2007 Apr;18(4):1150-6.

 

Kurtz L, Schweda F, de Wit C, Kriz W, Witzgall R, Warth R, Sauter A, Kurtz A, Wagner C.
Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium.
J Am Soc Nephrol. 2007 Apr;18(4):1103-11.

 

Schmidt C, Höcherl K, Schweda F, Kurtz A, Bucher M.
Regulation of renal sodium transporters during severe inflammation.
J Am Soc Nephrol. 2007 Apr;18(4):1072-83.

 

Wagner C, de Wit C, Kurtz L, Grünberger C, Kurtz A, Schweda F.
Connexin40 is essential for the pressure control of renin synthesis and secretion.
Circ Res. 2007 Mar 2;100(4):556-63.

 

Grünberger C, Obermayer B, Klar J, Kurtz A, Schweda F.
The calcium paradoxon of renin release: calcium suppresses renin exocytosis by inhibition of calcium-dependent adenylate cyclases AC5 and AC6.
Circ Res. 2006 Nov 24;99(11):1197-206.

 

Kees F, Bucher M, Schweda F, Gschaidmeier H, Burhenne J, Mikus G, Faerber L.
Comparative bioavailability of the microemulsion formulation of cyclosporine (Neoral) with a generic dispersion formulation (Cicloral) in young healthy male volunteers.
Ther Drug Monit. 2006 Jun;28(3):312-20.

 

Castrop H, Oppermann M, Weiss Y, Huang Y, Mizel D, Lu H, Germain S, Schweda F, Theilig F, Bachmann S, Briggs J, Kurtz A, Schnermann J.
Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene.
Physiol Genomics. 2006 Apr 13;25(2):277-85.

 

Kurtz A, Schweda F.
Osmolarity-induced renin secretion from kidneys: evidence for readily releasable renin pools.
Am J Physiol Renal Physiol. 2006 Apr;290(4):F797-805.

 

Klar J, Sigl M, Obermayer B, Schweda F, Krämer BK, Kurtz A.
Calcium inhibits renin gene expression by transcriptional and posttranscriptional mechanisms.
Hypertension. 2005 Dec;46(6):1340-6.

 

Schweda F, Segerer F, Castrop H, Schnermann J, Kurtz A.
Blood pressure-dependent inhibition of Renin secretion requires A1 adenosine receptors.
Hypertension. 2005 Oct;46(4):780-6.

 

Jung O, Brandes RP, Kim IH, Schweda F, Schmidt R, Hammock BD, Busse R, Fleming I.
Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension.
Hypertension. 2005 Apr;45(4):759-65.

  1. STARTSEITE UR

Institut für Physiologie

SFB 1350 "NIERE"

 

 

Prof. Dr. med. Frank Schweda

Lehrstuhl Physiologie II

Frank Schweda
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