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Publications

Selected Publications
 


Inga V. Hochheiser, Michael Pilsl, Gregor Hagelueken, Jonas Moecking, Michael Marleaux, Rebecca Brinkschulte, Eicke Latz, Christoph Engel, Matthias Geyer

Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3

Nature, 2022


Florian B. Heiss, Julia L. Daiß, Philipp Becker, and Christoph Engel$.                    Conserved strategies of RNA polymerase I hibernation and activation
Nature communications 12, 758, 2021
 


William J. Andrews; Swagat Ray; Tatiana Panova; Christoph Engel; Konstantin I Panov
DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription
Genes 12 (9)., 2021


Cathia Rausch, Peng Zhang, Corella S Casas-Delucchi, Julia L Daiß, Christoph Engel, Gideon Coster, Florian D Hastert, Patrick Weber, M Cristina Cardoso
Cytosine base modifications regulate DNA duplex stability and metabolism
Nucleic acids research
2021


Philipp E Merkl, Michael Pilsl, Tobias Fremter, Katrin Schwank, Christoph Engel, Gernot Längst, Philipp Milkereit, Joachim Griesenbeck, Herbert Tschochner
 RNA polymerase I (Pol I) passage through nucleosomes depends on Pol I subunits binding its lobe structur

The Journal of biological chemistry 295 (15), S. 4782–4795, 2020


Kevin Kramm, Tim Schröder, Jerome Gouge, Andrés M Vera, Kapil Gupta, Florian B Heiss, Tim Liedl, Christoph Engel, Imre Berger, Alessandro Vannini, Philip Tinnefeld, Dina Grohman
DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability. 
Nature Communications 11,  2828, 2020
 


Michael Pilsl, and Christoph Engel$ 
Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting 
Nature Communications 11, 1206, 2020
 


Ewan P Ramsay*, Guillermo Abascal-Palacios*, Julia L Daiß*, Helen King, Jerome Gouge, Michael Pilsl, Fabienne Beuron, Edward Morris, Philip Gunkel, Christoph Engel$, Alessandro Vannini$ 
Structure of human RNA polymerase III 
Nature communications 11, 6409, 2020
 


Kevin Kramm; Christoph Engel; Dina Grohmann
Transcription initiation factor TBP: old friend new questions
Biochemical Society transactions 47 (1), S. 411–423
., 2019


Christoph Engel$, Simon Neyer, and Patrick Cramer$
Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II
Annu Rev Biophys . 47, 425-446, 2018
 


Christoph Engel*, Tobias Gubbey*, Simon Neyer*, Sarah Sainsbury, Christiane Oberthuer, Carlo Baejen, Carrie Bernecky, and Patrick Cramer 
Structural basis of RNA polymerase I transcription initiation 
Cell, , 169(1), 120-131, 2017
 


Simon Neyer*, Michael Kunz*, Christian Geiss, Merle Hantsche, Victor-Valentin Hodirnau, Anja Seybert, Christoph Engel, Margot Scheffer, Patrick Cramer, and Achilleas S. Frangakis 
Structure of RNA polymerase I transcribing rDNA gene 
Nature, 540 (7634), 607-610, 2016
 


Christoph Engel, Jürgen Plitzko, and Patrick Cramer 
RNA polymerase I-Rrn3 complex at 4.8 Å resolution
Nature Communications, 7:12129, 2016 Jul 15
 


Christoph Engel$
Purification of crystallization-grade RNA polymerase I from S. cerevisiae
Methods Mol Biol, 1455, 85-97., 2016
 


Ana Lisica, Christoph Engel*, Marcus Jahnel*, Eric A. Galburt*, Edgar Roldan, Patrick Cramer and Stephan W. Grill: 
Mechanisms of backtrack recovery by RNA polymerases I and II
Proc Natl Acad Sci U S A, 113(11):2946-51, 2016 Mar 15
 


Dirk Kostrewa*, Claus Kuhn*, Christoph Engel and Patrick Cramer: 
An alternative RNA polymerase I structure reveals a dimer hinge
Acta Crystallogr D, 71(Pt 9):1850-5, 2015, Sep
 


Christoph Engel, Sarah Sainsbury, Alan C. Cheung, Dirk Kostrewa and Patrick Cramer: 
RNA polymerase I structure and transcription regulation 
Nature, 502(7473):650-5., 2013
 


Gert Bange*, Nico Kuemmerer*, Christoph Engel, Gunes Bozkurt, Klemens Wild and Irmgard Sinning: 
FlhA provides the adaptor for coordinated delivery of late flagella building blocks to the type III secretion system 
Proc Natl Acad Sci U S A, 107(25):11295-300, 2010 Jun 22
 


These authors contributed equally

$ Corresponding author

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Structural Biochemistry

Prof. Dr. Christoph Engel

W2 Professor

for Structural Biochemistry



Universitätsstraße 31

93053 Regensburg

Phone: +49 (941) 943 2718

Fax: +49 (943) 2474