Publications
Selected Publications
Inga V. Hochheiser, Michael Pilsl, Gregor Hagelueken, Jonas Moecking, Michael Marleaux, Rebecca Brinkschulte, Eicke Latz, Christoph Engel, Matthias Geyer
Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
Nature, 2022
Florian B. Heiss, Julia L. Daiß, Philipp Becker, and Christoph Engel$. Conserved strategies of RNA polymerase I hibernation and activation
Nature communications 12, 758, 2021
William J. Andrews; Swagat Ray; Tatiana Panova; Christoph Engel; Konstantin I Panov
DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription
Genes 12 (9)., 2021
Cathia Rausch, Peng Zhang, Corella S Casas-Delucchi, Julia L Daiß, Christoph Engel, Gideon Coster, Florian D Hastert, Patrick Weber, M Cristina Cardoso
Cytosine base modifications regulate DNA duplex stability and metabolism
Nucleic acids research, 2021
Philipp E Merkl, Michael Pilsl, Tobias Fremter, Katrin Schwank, Christoph Engel, Gernot Längst, Philipp Milkereit, Joachim Griesenbeck, Herbert Tschochner
RNA polymerase I (Pol I) passage through nucleosomes depends on Pol I subunits binding its lobe structur
The Journal of biological chemistry 295 (15), S. 4782–4795, 2020
Kevin Kramm, Tim Schröder, Jerome Gouge, Andrés M Vera, Kapil Gupta, Florian B Heiss, Tim Liedl, Christoph Engel, Imre Berger, Alessandro Vannini, Philip Tinnefeld, Dina Grohman
DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability.
Nature Communications 11, 2828, 2020
Michael Pilsl, and Christoph Engel$
Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting
Nature Communications 11, 1206, 2020
Ewan P Ramsay*, Guillermo Abascal-Palacios*, Julia L Daiß*, Helen King, Jerome Gouge, Michael Pilsl, Fabienne Beuron, Edward Morris, Philip Gunkel, Christoph Engel$, Alessandro Vannini$
Structure of human RNA polymerase III
Nature communications 11, 6409, 2020
Kevin Kramm; Christoph Engel; Dina Grohmann
Transcription initiation factor TBP: old friend new questions
Biochemical Society transactions 47 (1), S. 411–423., 2019
Christoph Engel$, Simon Neyer, and Patrick Cramer$
Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II.
Annu Rev Biophys . 47, 425-446, 2018
Christoph Engel*, Tobias Gubbey*, Simon Neyer*, Sarah Sainsbury, Christiane Oberthuer, Carlo Baejen, Carrie Bernecky, and Patrick Cramer
Structural basis of RNA polymerase I transcription initiation
Cell, , 169(1), 120-131, 2017
Simon Neyer*, Michael Kunz*, Christian Geiss, Merle Hantsche, Victor-Valentin Hodirnau, Anja Seybert, Christoph Engel, Margot Scheffer, Patrick Cramer, and Achilleas S. Frangakis
Structure of RNA polymerase I transcribing rDNA gene
Nature, 540 (7634), 607-610, 2016
Christoph Engel, Jürgen Plitzko, and Patrick Cramer
RNA polymerase I-Rrn3 complex at 4.8 Å resolution
Nature Communications, 7:12129, 2016 Jul 15
Christoph Engel$
Purification of crystallization-grade RNA polymerase I from S. cerevisiae
Methods Mol Biol, 1455, 85-97., 2016
Ana Lisica, Christoph Engel*, Marcus Jahnel*, Eric A. Galburt*, Edgar Roldan, Patrick Cramer and Stephan W. Grill:
Mechanisms of backtrack recovery by RNA polymerases I and II
Proc Natl Acad Sci U S A, 113(11):2946-51, 2016 Mar 15
Dirk Kostrewa*, Claus Kuhn*, Christoph Engel and Patrick Cramer:
An alternative RNA polymerase I structure reveals a dimer hinge
Acta Crystallogr D, 71(Pt 9):1850-5, 2015, Sep
Christoph Engel, Sarah Sainsbury, Alan C. Cheung, Dirk Kostrewa and Patrick Cramer:
RNA polymerase I structure and transcription regulation
Nature, 502(7473):650-5., 2013
Gert Bange*, Nico Kuemmerer*, Christoph Engel, Gunes Bozkurt, Klemens Wild and Irmgard Sinning:
FlhA provides the adaptor for coordinated delivery of late flagella building blocks to the type III secretion system
Proc Natl Acad Sci U S A, 107(25):11295-300, 2010 Jun 22
Mona Höcherl - 21.02.2022 13:04 
