Lanthanide complexes are well soluble in biological fluids and show narrow emission bands and long luminescence decay times which is useful for anion sensing but also in food analysis.
Due to their high coordination number, lanthanide complexes can be appended with multiple ligands. Using complexes bearing ligands with various pK-values, sensor foils with a response over 8 pH units were created. This overcomes the classical limitation of optical pH sensors that respond only over 3 pH units.
We also developed ruthenium complexes for bioconjugation to amines or thiol groups in biomolecules, as DNA-intercalators and as probes for polarization immunoassays. These complexes may also be used for quantitation of saccharides or of tumor markers.
Selected publications:
Yegorova A, Skrypynets Y, Leonenko I, Duerkop A, 2023, New terbium complex as a luminescent probe for determination of chlorogenic acid in green coffee and roasted coffee infusions, Anal Bioanal Chem, 415:235-244, DOI: 10.1007/s00216-022-04411-x (externer Link, öffnet neues Fenster)
De Rosa C, Melchior A, Sanadar M, Tolazzi M, Duerkop A, Piccinelli F, 2021, Isoquinoline-based Eu(III) complexes: valuable luminescent probes for citrate sensing in complex matrix, Dalton Trans, 50:4700-4712, DOI: 10.1039/D1DT00511A. (externer Link, öffnet neues Fenster)
Waleed Al-Qaisy W, Duerkop A, 2019, Sensor and sensor microtiterplate with expanded pH detection range and their use in real samples, Sensors & Actuators B Chemical 298:126848, DOI: 10.1016/j.snb.2019.126848 (externer Link, öffnet neues Fenster)
Waleed Al-Qaisy W, Duerkop A, 2018, Luminescent europium complex for wide-range pH sensor and sensor microtiterplate, Analyst, 143:3176 – 3183, DOI: 10.1039/C8AN00775F (externer Link, öffnet neues Fenster)
Kele P, Li X, Duerkop A, 2013, Luminescent Ruthenium Complexes for Diacetyl Detection, Microchem J108:156–160, DOI: 10.1016/j.microc.2012.10.012 (externer Link, öffnet neues Fenster)