Schwerpunkte
- Synthesis of selective ligands for G-protein coupled receptors (GPCRs) (e.g. histamine receptors, dopamine receptors) and orphan GPCRs (e.g. GPR3)
- Development of selective Caspase-2 inhibitors for the treatment of neurodegenerative diseases
- Development of NanoBRET-based assays for G-protein coupled receptors (functional and binding assays)
- Synthesis and characterization of radioligands and fluorescence ligands for G-protein coupled receptors (e.g. histamine receptors, dopamine receptors)
- Bivalent ligands for the D1-H3 and D2-H3 heteroreceptor dimer