Alumni

Dr. Iris Aiglstorfer

Dissertation: Argininamide und Argininamid-Analoga: Synthese und Struktur-Wirkungsbeziehungen neuer Neuropeptid Y Y1-Rezeptorantagonisten

Dr. Peter Altenschöpfer

Dissertation: Tumorpharmakologische und analytische Untersuchungen zur Optimierung neuer Zytostatika-beladener bioabbaubarer Implantate für die Chemotherapie maligner Hirntumoren

Dr. Paul Baumeister

Dissertation: Molecular tools for G-protein coupled receptors:
Synthesis, pharmacological characterization and [3H]-labeling of subtype-selective ligands for histamine H4 and NPY Y2 receptors. Dissertation, Universität Regensburg

Dr. Tobias Birnkammer

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Highly potent and selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships of mono- and bivalent ligands

Dr. Alexander Botzki

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Structure-based design of hyaluronidase inhibitors

Dr. Stephan Braun

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships

Dr. Albert Brennauer

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity

Dr. Irena Brunskole

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Molecular and cellular analysis of aminergic G protein-coupled receptors: histamine H2, H4 and β2-adrenergic receptors, a scientific paradigm

Dr. Noemi Colombo

Dissertation: Synthesis and Conformational Analysis of Polypeptides Related to the Inhibitor of DNA Binding and Cell Differentiation Id2

Dr. Stefanie Dukorn

Dissertation: Pharmacological tools for the NPY receptors: [35 S]GTPyS binding assays, luciferase gene reporter assays and labeled peptides

Dr. Daniela Erdmann

Dissertation: Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools

Dr. Miriam Ertel

Dissertation: Ambivalence of drug metabolism: Exploration of cilazapril and candesartan prodrugs for transdermal delivery and search for toxic reactive intermediates of N(G)-acylated hetarylpropylguanidines

Dr. Johannes Felixberger

Dissertation: Luciferase complementation for the determination of arrestin recruitment: investigaions at histamine and NPY receptors

Dr. Stephan Fellner

Dissertation: Pharmakokinetische und pharmakodynamische Untersuchungen zur Koapplikation von MDR-Modulatoren (SDZ PSC 833) und Hyaluronidase bei der Chemotherapie maligner Gliome

Dr. Karin Geßele

Dissertation: Zelluläre Testsysteme zur pharmakologischen Charakterisierung neuer Neuropeptid Y-Rezeptorantagonisten: Rezeptorbindungsstudien und funktionelle Untersuchungen zur Calciummobilisierung und cAMP-Bildung

Dr. Roland Geyer

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Hetarylalkyl(aryl)cyanoguanidines as histamine H4 receptor ligands: Synthesis, chiral separation, pharmacological characterization, structure-activity and -selectivity relationships

Dr. Prasanta Ghorai

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity

Dr. Detlef Glaß

Dissertation: Synthese und Pharmakologie nonsteroidaler Kardiotonika mit kombinierter Histamin H2-agonistischer und PDE III-inhibitorischer Aktivität

Dr. Carsten Götte

Dissertation: Synthese, Enantiomerentrennung und Struktur-Wirkungs-Beziehungen neuer Histamin H2-Rezeptoragonisten des Arpromidin-Typs

Dr. Florian Graichen

Dissertation: Neuropeptid Y Y1-Rezeptorantagonisten der Argininamid-Reihe: Entwicklung von Synthesemethoden an polymeren Trägern und Strategien zur Herstellung von Radioliganden

Dr. Dietmar Gross

Dissertation: New approaches to the chemotherapy of glioblastoma: investigations on doxorubicin nanoparticles, inhibition of PDGF receptors and kinesin Eg5, with emphasis on confocal laser-scanning microscopy

Dr. Ulrich Gürtler

Dissertation: Entwicklung eines computerunterstützten Rattenmodels für die hypertherme isolierte Extremitätenperfusion

Dr. Janina Hamberger

Dissertation: Characterization of mammalian hyaluronidase-2 activity and identification of inhibitors of Streptococcal hyaluronan lyase

Dr. Peter Höcherl

Dissertation: New tariquidar-like ABCB1 modulators in cancer chemotherapy: Preclinical pharmacokinetic, pharmacodynamic investigations and computational studies

Dr. Julia Hoechstetter

Dissertation: Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy

Dr. Edith Hofinger

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Recombinant expression, purification and characterization of human hyaluronidases

Dr. Tobias Holzammer

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Homology modeling, molecular dynamics simulations and site-directed mutagenesis of histamine H2 receptors

Dr. Martina Hubensack

Dissertation: Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor

Dr. Stefan Huber

Dissertation: Investigations on bendamustine esters as new antitumor agents and the role of ABCG2 as a surogate marker of breast cancer initiating cells

Dr. Christoph Hutzler

Dissertation: Synthese und pharmakologische Aktivität neuer Neuropeptid Y Rezeptorliganden: Von N,N-disubstitutierten Alkanamiden zu hochpotenten Y1-Antagonisten der Argininamid-Reihe

Dr. Patrick Igel

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Synthesis and structure-activity relationships of NG-acylated arylalkylguanidines and related compounds as histamine receptor ligands: searching for selective H4R agonists

Dr. Peter Jarzyna

Dissertation: Preclinical investigations on the effect of the human hyaluronidase Hyal-1 on growth and metastasis of human colon carcinoma

Dr. Melanie Kaske

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: In search for potent and selective NPY Y4 receptor ligands: acylguanidines, argininamides and peptide analogs

Dr. Stephan Kießling

Dissertation: Funktionelle Untersuchungen zur Expression des Interleukin-11 Rezeptors α in humanen Kolonepithelzellen

Dr. Sebastian Donatus Kiewitz

Dissertation: Structural investigations of the Id helix-loop-helix dimerization domain

Dr. Sebastian Knieps

Dissertation: Guanidine der Arpromidin-Reihe als Modellsubstanzen zur Entwicklung nichtpeptidischer Neuropeptid Y-Rezeptorliganden: Synthese und pharmakologische Prüfung neuer NPY Y1-Antagonisten

Dr. Julia Kracht

Dissertation: Bestimmung der Affinität und der funktionellen Aktivität subtypselektiver Histamin- und Neuropeptid Y-Rezeptorliganden an konventionellen und neuen pharmakologischen In-vitro-Modellen

Dr. Anja Kraus

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships

Dr. Matthias Kühnle

Dissertation: Experimental therapy and detection of glioblastoma: investigation of nanoparticles, ABCG2 modulators and optical imaging of intracerebral xenografts

Dr. Kilian Kuhn

Member of Research Training Group Medicinal Chemistry GRK 1910

Dissertation: Molecular Tools for NPY Y4Receptor Derived from the C-Terminus of hPP and from Argininamide-type Y1R Antagonist

Dr. Liantao Li

Dissertation: Synthesis and Pharmacological Activity of Fluorescent Ligands for Neuropeptide Y, Histamine H1 und H2 Receptors

Dr. Sebastian Lieb

Dissertation: Investigations on histamine and neuropeptide Y receptors by label-free and label-dependent methods

Dr. Miroslaw Lopuch

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Investigations on neuropeptide Y and histamine receptors by fluorescence-based and radiochemical methods

Dr. Matthias Mayer

Dissertation: Entwicklung fluorimetrischer Methoden zur Bestimmung der Affinität und Aktivität von Liganden G-Protein-gekoppelter Rezeptoren an intakten Zellen

Dr. Adolf Meister

Dissertation: Pharmakologische Charakterisierung neuer Histamin- und Neuropeptid Y-Rezeptorliganden: Etablierung und Validierung funktioneller Testmodelle an isolierten Organen

Dr. Martin Memminger

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells

Dr. Carolin Meyer

Dissertation: Synthesis and structure-activity relationships of inhibitors of bacterial hyaluronidase - An approach to obtain compounds with drug-like properties

Dr. Johannes Mosandl

Member of Research Training Group Medicinal Chemistry GRK 760

Dissertation: Radiochemical and luminescence-based binding and functional assays for human histamine receptors using genetically engineered cells

Dr. Christiane Moser

Dissertation: Pharmakologische Untersuchungen zur Neuropeptid Y Y1-, Y2- und Y5-Rezeptorselektivität peptidischer und nichtpeptidischer Liganden: Klonierung und funktionelle Expression des humanen Y5-Rezeptors in HEC-1-B-Zellen

Dr. Ingo Muckenschnabel

Dissertation: Analytische Untersuchungen zum Einsatz von Hyaluronidase als Adjuvans in der Krebschemotherapie

Dr. Christine Müller

Dissertation: New approaches to the therapy of glioblastoma: investigations on RNA interference, kinesin Eg5 and ABCB1/ABCG2 inhibition

Dr. Manfred Müller

Dissertation: Neue Leitstrukturen zur Entwicklung nichtpeptidischer Neuropeptid Y Y1-Rezeptor¬antagonisten: Synthese und Struktur-Wirkungs-Beziehungen basisch substituierter Carbonsäureamide

Dr. Uwe Nordemann

Dissertation: Radioligand binding and reporter gene assays for histamine H3 and H4 receptor species orthologs

José Esteban Obreque-Balboa

Dr. Senthil Kumar Palaniappan

Postdoctoral Researcher

Research project: Design and synthesis of neuropeptide Y Y₄ receptor antagonists

Dr. Andrea Pegoli

Dissertation: Dibenzodiazepinone-type mAChR ligands: radio- and fluorescence labeling enable unveiling of dualsteric M₂R binding and conjugation to short peptides as an avenue to highly selective M₂R ligands

Dr. Nicole Plank

Dissertation: Dimeric histamine H2 receptor agonists as molecular tools and genetically engineered HEK293T cells as an assay platform to unravel signaling pathways of hH1R and hH2R

Dr. Nikola Pluym

Dissertation: Application of the guanidine–acylguanidine bioisosteric approach to NPY Y2 receptor antagonists: bivalent, radiolabeled and fluorescent pharmacological tools

Dr. Nathalie Pop

Dissertation: Development of functional assays for human neuropeptide Y (Y1,2,4,5) receptors exploiting GTPase activity and (bio)luminescence as readout

Dr. Hendrik Preuß

Dissertation: Species-selective interactions of histamine H2 receptors with guanidine-type agonists: molecular modelling, site-directed mutagenesis and pharmacological analysis

Dr. Martin Rothenhöfer

Dissertation: Analytical approaches to the study of hyaluronan and hyaluronidases: Development and application of hyphenated chromatographic and electrophoretic methods

Dr. Sunnhil Salmen

Dissertation: Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships

Dr. Fabian Schalkhaußer

Dissertation: Herstellung unsymmetrischer Guanidine in Lösung und an polymeren Trägern: Synthese und pharmakologische Wirkung neuer hochpotenter Histamin H2-Rezeptoragonisten

Dr. Erich Schneider

Dissertation: Development of Fluorescence-Based Methods fort he Determination of Ligand Affinity, Selectivity and Activity at G-Protein Coupled Receptors

Dr. Andreas Schuster

Dissertation: Enantiomerenanalytik von Histamin-H2-Rezeptoragonisten der Arpromidin-Reihe, deren Ester-Prodrugs- und Synthesebausteinen mit HPLC und CE

Dr. Oksana Sereda

Postdoctoral Researcher

Dr. Xueke She

associated Member of Research Training Group Medicinal Chemistry GRK 1910

Dissertation: Synthesis and pharmacological characterization of dibenzodiazepinone-type heterodimeric and fluorescently labeled muscarinic receptor ligands

Dr. Martin Spickenreither

Dissertation: Inhibitors of Bacterial and Mammalian Hyaluronidases: Design, Synthesis and Structure-Activity Relationships with Focus on Human Enzymes

Dr. Shangjun Teng

Postdoctoral Researcher

Dr. Christian Textor

Dissertation: Small Molecules as inhibitors of streptococcal hyaluronidases: A computer-assisted and multicomponent synthesis approach

Dr. Anka Uffrecht

Dissertation: Synthese und in-vitro-Pharmakologie nichtpeptidischer und peptidischer Neuropeptid Y-Antagonisten mit Guanidin- oder Argininamid-Partialstruktur

Dr. Jianfei Wan

associated Member of Research Training Group Medicinal Chemistry GRK 1910

Dissertation: Synthesis and pharmacological characterization of homo- and hetero-dimeric compounds, targeting the hH₁R and/or hH₄R

Dr. David Wifling

Postdoctoral Researcher

Dr. Ralf Ziemek

Dissertation: Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors

Dr. Jochen Zimmermann

Dissertation: Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation.