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Prof. Dr. Klaus Stark

Lebenslauf

  • 1991-1996 Studium der Biologie (Diplom) an der Universität Regensburg
  • 1996-2002 Wissenschaftlicher Mitarbeiter am Lehrstuhl für Genetik der Universität Regensburg
  • 1999 Promotion zum Dr. rer. nat.
  • 2002-2004 Wissenschaftlicher Mitarbeiter bei NeuroProfile GmbH
  • 2004-2012 Forschungslaborleiter an der Klinik und Poliklinik für Innere Medizin II des Universitätsklinikums Regensburg
  • 2011 Feststellung der Lehrbefähigung durch die Fakultät für Medizin der Universität Regensburg und Erteilung der Lehrbefugnis für das Fachgebiet Experimentelle Medizin
  • Seit 2012 Wissenschaftlicher Mitarbeiter am Lehrstuhl für Genetische Epidemiologie, Institut für Epidemiologie und Präventivmedizin, Universität Regensburg
  • 2020 Ernennung zum außerplanmäßigen Professor

Forschungsschwerpunkte

  • Molekulare und Genetische Epidemiologie
  • Augenstudie der Universität Regensburg (AugUR)
  • Kardiovaskuläre Erkrankungen
  • Metabolische Phänotypen
  • Rheumatologie

Ausgewählte Publikationen

  • Winkler TW, Grassmann F, Brandl C, Kiel C, Gunther F, Strunz T, Weidner L, Zimmermann ME, Korb CA, Poplawski A, Schuster AK, Muller-Nurasyid M, Peters A, Rauscher FG, Elze T, Horn K, Scholz M, Canadas-Garre M, McKnight AJ, Quinn N, Hogg RE, Kuchenhoff H, Heid IM, Stark KJ, Weber BHF. Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease. BMC Med Genomics 2020;13(1):120.
  • Peter K, Siska PJ, Roider T, Matos C, Bruns H, Renner K, Singer K, Weber D, Gullstorf M, Kroger N, Wolff D, Herr W, Ayuk F, Holler E, Stark K, Heid IM, Kreutz M. 1,25-dihydroxyvitamin-D3 but not the clinically applied marker 25-hydroxyvitamin-D3 predicts survival after stem cell transplantation. Bone Marrow Transplant 2020.
  • Guenther F, Brandl C, Winkler TW, Wanner V, Stark K, Kuechenhoff H, Heid IM. Chances and challenges of machine learning-based disease classification in genetic association studies illustrated on age-related macular degeneration. Genet Epidemiol 2020.
  • Brandl C, Brucklmayer C, Gunther F, Zimmermann ME, Kuchenhoff H, Helbig H, Weber BHF, Heid IM, Stark KJ. Retinal Layer Thicknesses in Early Age-Related Macular Degeneration: Results From the German AugUR Study. Invest Ophthalmol Vis Sci 2019;60(5):1581-94.
  • Brandl C, Zimmermann ME, Gunther F, Barth T, Olden M, Schelter SC, Kronenberg F, Loss J, Kuchenhoff H, Helbig H, Weber BHF, Stark KJ, Heid IM. On the impact of different approaches to classify age-related macular degeneration: Results from the German AugUR study. Sci Rep 2018;8(1):8675.
  • Winkler TW, Brandl C, Grassmann F, Gorski M, Stark K, Loss J, Weber BHF, Heid IM, International Age-related Macular Degeneration Genomics C. Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci. PLoS One 2018;13(3):e0194321.
  • Esslinger U, Garnier S, Korniat A, Proust C, Kararigas G, Muller-Nurasyid M, Empana J P, Morley M P, Perret C, Stark K, Bick A G, Prasad S K, Kriebel J, Li J, Tiret L, Strauch K, O'Regan D P, Marguiles K B, Seidman J G, Boutouyrie P, Lacolley P, Jouven X, Hengstenberg C, Komajda M, Hakonarson H, Isnard R, Arbustini E, Grallert H, Cook S A, Seidman C E, Regitz-Zagrosek V, Cappola T P, Charron P, Cambien F, Villard E. Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy. PLoS One 2017; 12(3): e0172995.
  • Grassmann F, Kiel C, Zimmermann M E, Gorski M, Grassmann V, Stark K, International A M D G C, Heid I M, Weber B H. Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. Genome Medicine 2017; 9(1): 29.
  • Brandl C, Breinlich V, Stark K J, Enzinger S, Assenmacher M, Olden M, Grassmann F, Graw J, Heier M, Peters A, Helbig H, Kuchenhoff H, Weber B H, Heid I M. Features of Age-Related Macular Degeneration in the General Adults and Their Dependency on Age, Sex, and Smoking: Results from the German KORA Study. PLoS One 2016; 11(11): e0167181.
  • Dietl A, Stark K, Zimmermann M E, Meisinger C, Schunkert H, Birner C, Maier L S, Peters A, Heid I M, Luchner A. NT-proBNP Predicts Cardiovascular Death in the General Population Independent of Left Ventricular Mass and Function: Insights from a Large Population-Based Study with Long-Term Follow-Up. PLoS One 2016; 11(10): e0164060.
  • Brandl C, Stark K J, Wintergerst M, Heinemann M, Heid I M, Finger R P. Epidemiology of age-related macular degeneration. Ophthalmologe 2016; 113(9): 735-745.
  • Fritsche L G, Igl W, Bailey J N, Grassmann F, Sengupta S, Bragg-Gresham J L, Burdon K P, Hebbring S J, Wen C, Gorski M, Kim I K, Cho D, Zack D, Souied E, Scholl H P, Bala E, Lee K E, Hunter D J, Sardell R J, Mitchell P, Merriam J E, Cipriani V, Hoffman J D, Schick T, Lechanteur Y T, Guymer R H, Johnson M P, Jiang Y, Stanton C M, Buitendijk G H, Zhan X, Kwong A M, Boleda A, Brooks M, Gieser L, Ratnapriya R, Branham K E, Foerster J R, Heckenlively J R, Othman M I, Vote B J, Liang H H, Souzeau E, McAllister I L, Isaacs T, Hall J, Lake S, Mackey D A, Constable I J, Craig J E, Kitchner T E, Yang Z, Su Z, Luo H, Chen D, Ouyang H, Flagg K, Lin D, Mao G, Ferreyra H, Stark K, von Strachwitz C N, Wolf A, Brandl C, Rudolph G, Olden M, Morrison M A, Morgan D J, Schu M, Ahn J, Silvestri G, Tsironi E E, Park K H, Farrer L A, Orlin A, Brucker A, Li M, Curcio C A, Mohand-Said S, Sahel J A, Audo I, Benchaboune M, Cree A J, Rennie C A, Goverdhan S V, Grunin M, Hagbi-Levi S, Campochiaro P, Katsanis N, Holz F G, Blond F, Blanche H, Deleuze J F, Igo R P, Jr., Truitt B, Peachey N S, Meuer S M, Myers C E, Moore E L, Klein R, Hauser M A, Postel E A, Courtenay M D, Schwartz S G, Kovach J L, Scott W K, Liew G, Tan A G, Gopinath B, Merriam J C, Smith R T, Khan J C, Shahid H, Moore A T, McGrath J A, Laux R, Brantley M A, Jr., Agarwal A, Ersoy L, Caramoy A, Langmann T, Saksens N T, de Jong E K, Hoyng C B, Cain M S, Richardson A J, Martin T M, Blangero J, Weeks D E, Dhillon B, van Duijn C M, Doheny K F, Romm J, Klaver C C, Hayward C, Gorin M B, Klein M L, Baird P N, den Hollander A I, Fauser S, Yates J R, Allikmets R, Wang J J, Schaumberg D A, Klein B E, Hagstrom S A, Chowers I, Lotery A J, Leveillard T, Zhang K, Brilliant M H, Hewitt A W, Swaroop A, Chew E Y, Pericak-Vance M A, DeAngelis M, Stambolian D, Haines J L, Iyengar S K, Weber B H, Abecasis G R, Heid I M. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet 2016; 48(2): 134-143.
  • Stark K, Olden M, Brandl C, Dietl A, Zimmermann M E, Schelter S C, Loss J, Leitzmann M F, Boger C A, Luchner A, Kronenberg F, Helbig H, Weber B H, Heid I M. The German AugUR study: study protocol of a prospective study to investigate chronic diseases in the elderly. BMC Geriatrics 2015, 15: 130.
  • Fuerstenau-Sharp M, Zimmermann M E, Stark K, Jentsch N, Klingenstein M, Drzymalski M, Wagner S, Maier L S, Hehr U, Baessler A, Fischer M, Hengstenberg C. Generation of highly purified human cardiomyocytes from peripheral blood mononuclear cell-derived induced pluripotent stem cells. PLoS One 2015; 10(5): e0126596.

  • Stark K, Straub R H, Rovensky J, Blazickova S, Eiselt G, Schmidt M. CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women. Arthritis Research & Therapy 2015; 17(1): 56.

  • Ruedel A, Stark K, Kaufmann S, Bauer R, Reinders J, Rovensky J, Blazicková S, Oefner PJ, Bosserhoff AK (2014). N-cadherin promoter polymorphisms and risk of osteoarthritis. FASEB J 28(2):683-91.
  • Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E, Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Brænne I, Nöthen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C, Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li SC, März W, Reilly M, Kathiresan S, McPherson R, Walter U; CARDIoGRAM, Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H (2013). Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature 504(7480):432-6.
  • Luchner A, Behrens G, Stritzke J, Markus M, Stark K, Peters A, Meisinger C, Leitzmann M, Hense HW, Schunkert H, Heid IM (2013). Long-term pattern of brain natriuretic peptide and N-terminal pro brain natriuretic peptide and its determinants in the general population: contribution of age, gender, and cardiac and extra-cardiac factors. Eur J Heart Fail 15(8):859-67.
  • Zollbrecht C, Grassl M, Fenk S, Höcherl R, Hubauer U, Reinhard W, Esslinger UB, Ebert S, Langmann T, Stark K, Hengstenberg C (2013).                             Expression pattern in human macrophages dependent on 9p21.3 coronary artery disease risk locus. Atherosclerosis 227(2): 244-9.
  • Raffler J, Römisch-Margl W, Petersen AK, Pagel P, Blochl F, Hengstenberg C, Illig T, Meisinger C, Stark K, Wichmann HE, Adamski J, Gieger C, Kastenmüller G, Suhre K (2013). Identification and MS assisted interpretation of genetically influenced NMR signals in human plasma.
    Genome Med 5(2): 13.
  • CARDIoGRAMplusC4D Consortium (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 45(1): 25-33.
  • Birner C, Dietl A, Deutzmann R, Schröder J, Schmid P, Jungbauer C, Resch M, Endemann D, Stark K, Riegger G, Luchner A (2012). Proteomic profiling implies mitochondrial dysfunction in tachycardia-induced heart failure.
    J Card Fail 18(8): 660-73.
  • Petersen AK, Stark K, Musameh MD, Nelson CP, Römisch-Margl W, Kremer W, Raffler J, Krug S, Skurk T, Rist MJ, Daniel H, Hauner H, Adamski J, Tomaszewski M, Döring A, Peters A, Wichmann HE, Kaess BM, Kalbitzer HR, Huber F, Pfahlert V, Samani NJ, Kronenberg F, Dieplinger H, Illig T, Hengstenberg C, Suhre K, Gieger C, Kastenmüller G (2012). Genetic Associations with Lipoprotein Subfractions Provide Information on their Biological Nature. Hum Mol Genet 21(6): 1433-43.
  • CARDIoGRAM Consortium (2011). Large-Scale Association Analysis Identifies 13 New Susceptibility Loci for Coronary Artery Disease. Nat Genet 43(4): 333-8.
  • The IBC 50K CAD Consortium (2011). Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease. PLoS Genet 7(9): e1002260.
  • Stark K, Esslinger UB, Reinhard W, Petrov G, Winkler T, Komajda M, Isnard R, Charron P, Villard E, Cambien F, Tiret L, Aumont MC, Dubourg O, Trochu JN, Fauchier L, DeGroote P, Richter A, Maisch B, Wichter T, Zollbrecht C, Grassl M, Schunkert H, Linsel-Nitschke P, Erdmann J, Baumert J, Illig T, Klopp N, Wichmann HE, Meisinger C, Koenig W, Lichtner P, Meitinger T, Schillert A, König IR, Hetzer R, Heid IM, Regitz-Zagrosek V, Hengstenberg C (2010). Genetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated Cardiomyopathy. PLoS Genet 6(10): e1001167.
  • Myocardial Infarction Genetics Consortium (2009). Genome-Wide Association of Early-Onset Myocardial Infarction with Single Nucleotide Polymorphisms and Copy Number Variants. Nat Genet 41: 334-341.
  • Stark K, Rovensky J, Blazickova S, Grosse-Wilde H, Ferencik S, Hengstenberg C, Straub RH (2009). Association of Common Polymorphisms in Known Susceptibility Genes with Rheumatoid Arthritis in a Slovak population Using Osteoarthritis Patients as Controls. Arthritis Res Ther 11(3): R70.
  • Stark K, Reinhard W, Neureuther K, Wiedmann S, Sedlacek K, Baessler A, Fischer M, Weber S, Kaess B, Erdmann J, Schunkert H, Hengstenberg C (2008). Association of Common Polymorphisms in GLUT9 Gene with Gout but not with Coronary Artery Disease in a Large Case-Control Study. PLoS ONE 3: e1948.
  • Stark K, Neureuther K, Sedlacek K, Hengstenberg W, Fischer M, Baessler A, Wiedmann S, Holmer S, Erdmann J, Schunkert H, Hengstenberg C (2007). The Common Y402H Variant in Complement Factor H Gene is not Associated with Susceptibility to Myocardial Infarction and its Related Risk Factors. Clin Sci 113: 213-21.


  1. Fakultät für Medizin

Prof. Dr. Klaus Stark

Lehrstuhl für Genetische Epidemiologie

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Telefon: 0941 944-5214
Telefax: 0941 944-5212
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