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Fakultät für Biologie und Vorklinische Medizin
Institute of Biochemistry, Genetics and Microbiology
Department of Structural Biology



[50] Errasti-Murugarren E, Fort J, Bartoccioni P, Díaz L, Pardon E, Carpena X,
Espino-Guarch M, Zorzano A, Ziegler C, Steyaert J, Fernández-Recio J, Fita I,
Palacín M. L amino acid transporter structure and molecular bases for the
asymmetry of substrate interaction.
Nat Commun. 18;10(1):1807. doi: 10.1038/s41467-019-09837-z (2019).
[49] Leone V, Waclawska I, Kossmann K, Koshy C, Sharma M, Prisner TF, Ziegler
C, Endeward B, Forrest LR. Interpretation of spectroscopic data using molecular simulations for the secondary active transporter BetP.
J Gen Physiol. 151(3):381-394. doi: 10.1085/jgp.201812111 (2019).
[48] Allolio C, Magarkar A, Jurkiewicz P, Baxová K, Javanainen M, Mason PE,
Šachl R, Cebecauer M, Hof M, Horinek D, Heinz V, Rachel R, Ziegler CM,
Schröfel A, Jungwirth P. Arginine-rich cell-penetrating peptides induce
membrane multilamellarity and subsequently enter via formation of a fusion
Proc Natl Acad Sci U S A. 115(47):11923-11928.
doi:0.1073/pnas.1811520115 (2018).
[48] Mycielska ME, Dettmer K, Rümmele P, Schmidt K, Prehn C, Milenkovic VM,
Jagla W, Madej GM, Lantow M, Schladt M, Cecil A, Koehl GE, Eggenhofer E,
Wachsmuth CJ, Ganapathy V, Schlitt HJ, Kunzelmann K, Ziegler C, Wetzel CH, Gaumann A, Lang SA, Adamski J, Oefner PJ, Geissler EK. Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo.
Cancer Res. 78(10):2513-2523. doi: 10.1158/0008-5472.CAN-17-2959 (2018).
[47] Madej MG, Ziegler CM. Dawning of a new era in TRP channel structural
biology by cryo-electron microscopy.
Pflugers Arch. 470(2):213-225. doi: 10.1007/s00424-018-2107-2 (2018).
[46] Ziegler C. Preface.
Methods Enzymol. 594:xi-xii. doi: 10.1016/S0076-6879(17)30277-X (2017).
 [45] Jazi AA, Ploetz E, Arizki M, Dhandayuthapani B, Waclawska I, Krämer R,
Ziegler C*, Cordes T. Caging and Photoactivation in Single-Molecule Förster
Resonance Energy Transfer Experiments.
Biochemistry 56(14):2031-2041. doi: 10.1021/acs.biochem.6b00916.

[44] Wilkes M, Madej MG, Kreuter L, Rhinow D, Heinz V, De Sanctis S, Ruppel S,
Richter RM, Joos F, Grieben M, Pike AC, Huiskonen JT, Carpenter EP, Kühlbrandt W, Witzgall R, Ziegler C. *. Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2.
Nat Struct Mol Biol. 24(2):123-130. doi: 10.1038/nsmb.3357 (2017).

[43] Parey, K., Fielding, A.J., Sörgel, M., Rachel, R., Huber, H., Ziegler, C., Rajendran, C. In meso crystal structure of a novel membrane-associated octaheme cytochrome c from the Crenarchaeon Ignicoccus hospitalis.
FEBS J. 283(20):3807-3820. doi: 10.1111 (2016).

[42]Güler, G., Gärtner, R.M., Ziegler, C*., Mäntele, W.: Lipid-Protein Interactions in the Regulated Betaine Symporter BetP Probed by Infrared Spectroscopy.
J Biol Chem. 291(9):4295-307 (2016).

[41]Schweikhard, E.S., Burckhardt, B.C., Joos, F., Fenollar-Ferrer, C., Forrest, L.R., Kempson, S.A., Ziegler, C*.: Role of N-glycosylation in renal betaine transport.
Biochem J. 470(2):169-79 (2015).

[40]Spindler, P.E., Waclawska, I., Endeward, B., Plackmeyer, J., Ziegler, C., Prisner, T.F: Carr-Purcell Pulsed Electron Double Resonance with Shaped Inversion Pulses.
J Phys Chem Lett. 6(21):4331-5 (2015).

[39]Koshy, C., Ziegler, C.: Structural insights into functional lipid-protein interactions in secondary transporters.
Biochim Biophys Acta. 1850(3):476-87 (2015).

[38] Perras, A.K., Daum, B., Ziegler, C., Takahashi, L.K., Ahmed, M., Wanner, G., Klingl, A., Leitinger, G., Kolb-Lenz, D., Gribaldo, S., Auerbach, A., Mora, M., Probst, A.J., Bellack, A., Moissl-Eichinger, C.: S-layers at second glance? Altiarchaeal grappling hooks (hami) resemble archaeal S-layer proteins in structure and sequence.
Front Microbiol. 6:543 (2015).

[37]Waclawska, I., Ziegler, C*.: Regulatory role of charged clusters in the N-terminal domain of BetP from Corynebacterium glutamicum.
Biol Chem. 396(9-10):1117-26 (2015).

[36] Keller, R., Ziegler, C. , Schneider, D.: When two turn into one: evolution of membrane transporters from half modules.
Biol Chem. 395(12):1379-88 (2014).

[35] Schweikhard, E.S, Kempson, S.A., Ziegler, C., Burckhardt, B.C.: Mutation of a single threonine in the cytoplasmic NH2 terminus disrupts trafficking of renal betaine-GABA transporter 1 during hypertonic stress.
Am J Physiol Renal Physiol. 307(1):F107-15 (2014).

[34]Perez, C., Faust, B., Mehdipour, A.R., Francesconi, K.A., Forrest, L.R., Ziegler, C*.: Substrate-bound outward-open state of the betaine transporter BetP providesinsights into Na+ coupling.
Nat Commun. 5:4231 (2014).

[33] Koshy, C., Schweikhard, E., Gärtner, R., Perez, C., Yildiz, O., and Ziegler, C.*: Structural evidence for functional lipid interactions in the betaine transporter BetP.
EMBO J. 32(23):3096-105 (2013).

[32]Sand, M., Stahl, J., Waclawska, I., Ziegler, C., and Averhoff, B.: Identification of an osmo-dependent and an osmo-independent choline transporter in Acinetobacter baylyi: implications in osmostress protection and metabolic adaptation.
Environ. Microbiol. 6:1490-502 (2013).

[31]Perez, C., and Ziegler, C.*: Mechanistic aspects of sodium-binding sites in LeuT-like fold symporters.
Biol. Chem. 394 (5) 641-8 (2013).

[30]Korkmaz, F., Ressl, S., Ziegler, C.*, and Mäntele, W.: K(+)-induced conformational changes in the trimeric betaine transporter BetP monitored by ATR-FTIR spectroscopy.
Biochim. Biophys. Acta. 1828(4) 1181-91 (2013).

[29]Schweikhard, E.S., and Ziegler, C*.: Amino acid secondary transporters: toward a common transport mechanism.
Curr. Top. Membr. 70 1-28 (2012).

[28]Khafizov, K., Perez, C., Koshy, C., Quick, M., Fendler, K., Ziegler, C.*, and Forrest, L.R.: Investigation of the sodium-binding sites in the sodium-coupled betaine transporter BetP.
Proc. Natl. Acad. Sci. U S A 109 (44) E3035-44 (2012).

[27]Perez, C., Koshy, C., Yildiz, O., and Ziegler, C. *: Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP.
Nature 490 (7418) 126-30 (2012).

[26] Marinelli, F., Kuhlmann, S.I., Grell, E., Kunte, H.J., Ziegler, C.*, and Faraldo-Gómez, J.D.: Evidence for an allosteric mechanism of substrate release from membrane-transporter accessory binding proteins.
Proc. Natl. Acad. Sci. 108 (49) E1285-92 (2011)

[25] Gärtner, R.M., Perez, C., Koshy, C., and Ziegler, C.*: Role of bundle helices in a regulatory crosstalk in the trimeric betaine transporter BetP.
J. Mol. Biol. 414 (3) 327-36 (2011)

[24]Forrest, L., Krämer, R. and Ziegler, C.: The Structural Basis of Secondary Active Transport Mechanisms.
Biochim. Biophys. Acta. 1807 (2) 167-88 (2011)

[23]Ge, L., Perez, C., Waclawska, I., Ziegler, C.*, and Müller, D.J.: Locating an extracellular K+-dependent interaction site that modulates betaine-binding of the Na+-coupled betaine symporter BetP.
Proc. Natl. Acad. Sci. 108 (43) E890-8 (2011)

[22]Perez, C., Khafizov, K., Forrest, L.R., Krämer, R., and Ziegler, C.*: The role of trimerization in the osmoregulated betaine transporter BetP.
EMBO Rep. 12 (8) 804-10 (2011)

[21]Perez, C., Koshy, C., Ressl, S., Nicklisch, S., Krämer, R., and Ziegler, C.*: Substrate specificity and ion coupling in the Na+/betaine symporter BetP.
EMBO J. 30 (7) 1221-9 (2011).

[20]Tsai, C.J., Khafizov, K., Hakulinen, J., Forrest, L.R., Krämer, R., Kühlbrandt, W., and Ziegler C.*: Structural asymmetry in a trimeric Na+/betaine symporter, BetP, from Corynebacterium glutamicum.
J. Mol. Biol. 407 (3) 368-81 (2011).

[19]Tsai CJ and Ziegler C.*: Coupling electron cryomicroscopy and X-ray crystallography to understand secondary active transport.
Curr. Opin. Struct. Biol. 20 (4) 448-55 (2010).

[18]Ziegler, C., Bremer, E. and Krämer, R.: The BCCT family of carriers: from physiology to crystal structure.
Mol. Micro. Mini Rev.78 (1) 13-34 (2010)

[17]Schweikhard, E., Kuhlmann, S., Kunte, H.-J., Grammann, K. and Ziegler, C.*: Structure and function of the universal stress protein TeaD and its role in regulating the ectoine transporter TeaABC of Halomonas elongata DSM 2581(T).
Biochemistry 49 (10) 2194-204 (2010).

[16]Krämer, R.and Ziegler, C.*: Regulative interactions of the osmosensing C-terminal domain in the trimeric glycine betaine transporter BetP from Corynebacterium glutamicum.
Biol. Chem. 390 (8) 685-691 (2009).

[15]Appel, M., Hizlan, D., Vinothkumar, K.R., Ziegler, C., and Kühlbrandt, W.:
Conformations of NhaA, the Na+/H+ exchanger from Escherichia coli, in the pH-activated and ion-translocating states.
J. Mol. Biol. 388 (3) 659-672 (2009).

[14]Ressl, S., Terwisscha van Scheltinga, A.C., Vonrhein, C., Ott, V. and Ziegler, C.*: Molecular basis of transport and regulation in the Na(+)/betaine symporter BetP.
Nature 458 (7234) 47-52 (2009).

[13]Kuhlmann, S.I., Terwisscha van Scheltinga, A.C., Bienert, R., Kunte, H.J., and Ziegler, C. *: 1.55 A structure of the ectoine binding protein TeaA of the osmoregulated TRAP-transporter TeaABC from Halomonas elongata.
Biochemistry 47 (36) 9475-9485 (2008).

[12]Kedrov, A., Appel, M., Baumann, H., Ziegler, C.* and Müller, D.J.: Examining the Dynamic Energy landscape of an antiporter upon inhibitor binding.
J. Mol. Biol. 375 1258-1266 (2008).

[11]Tsai, C.J., Ejsing, C.S., Shevchenko, A. and Ziegler, C.*: The role of lipids in two-dimensional crystallization of BetP, a glycine-betaine transporter from Corynebacterium glutamicum.
J. Struc. Biol. 160 275-286 (2007).

[10]Kedrov, A., Ziegler, C. and Müller, D.J.: Differentiating ligand and inhibitor interactions of a single antiporter.
J. Mol. Biol. 362 (5) 925-932 (2006).

[9]Kedrov, A., Janovjak, H., Ziegler, C., Kühlbrandt, W. and Müller, D.J.: Observing folding pathways and kinetics of a single sodium-proton antiporter from Escherichia coli.
J. Mol. Biol. 355 (1) 2-8 (2006)

[8]Tsai, C.-J. and Ziegler, C.*: Structure determination of secondary transport proteins by electron crystallography: Two-dimensional crystallization of the betaine uptake system BetP.
J. Mol. Microbiol. Biotechnol. 10 197-207 (2005).

[7]Kedrov, A., Krieg, M., Ziegler, C., Kühlbrandt, W. and Müller, D.J.: Locating ligand binding and activation of a single antiporter.
EMBO Rep. 6 (7) 668-674 (2005).

[6]Kedrov, A., Ziegler, C., Janovjak, H., Kühlbrandt, W. and Müller, D.J.: Controlled unfolding and refolding of a single sodium-proton antiporter using atomic force microscopy.
J. Mol. Biol. 340 (5)1143-1152 (2004).

[5]Ziegler, C., Morbach, S., Schiller, D., Krämer, R., Tziatzios, C., Schubert, D., and Kühlbrandt, W.: (2004). Projection structure and oligomeric state of the osmoregulated sodium/glycine betaine symporter BetP of Corynebacterium glutamicum.
J. Mol. Biol. 337(5) 1137-47 (2004).

[4]Ziegler, C., Bonnefont-Rousselot, D., Delacroix, S., Habrand, J.L. and Mazal A.:Effectiveness of protons and argon ions in initiating lipid peroxidation in low-density lipoproteins.
Radiat. Res. 150 (4) 483-487 (1998).

[3]Ziegler, C. and Wessels, J.M.: Investigation of lipid peroxidation in liposomes induced by heavy ion irradiation.
Radiat. Environ. Biophys. 37(2) 95-100 (1998).

[2]Kinder, R., Ziegler, C., Wessels, J.M.: Gamma-irradiation and UV-C light-induced lipid peroxidation: a Fourier transform-infrared absorption spectroscopic study.
Int. J. Radiat. Biol. 71 (5) 561-571 (1997).

[1]Schön, W., Ziegler, C., Gärtner, H. and Kraft, G.
Heavy ion induced membrane damage: hemolysis of erythrocytes and changes in erythrocyte membrane fluidity.
Radiat. Environ. Biophys. 33 (3) 233-241 (1994)