Heterogeneity is a fundamental property in biology. We strive to identify and describe biological heterogeneity and diversity on the organismic and molecular level and aim to understand how biological heterogeneity drives the function of molecular machineries.
On the organismic level, we are committed to expand our understanding of microbial diversity on our planet. Having isolated more than 1.000 archaeal strains from all over the world over the last three decades, we are especially intrigued by organisms from the third domain of life, Archaea, and are home of the Archaea Centre Regensburg. In addition, we also look on the evolutionary journey of fundamental biological machineries and molecular processes that are present in all living cells. Here, we focus on processes along the gene expression pathway including the regulation of gene expression at the transcriptional (transcription factors and transcription machinery) and posttranscriptional level (RNA processing, RNA-guided interference and archaeal Sm like proteins) as well as prokaryotic defence system (CRISPR-Cas and prokaroytic Argonaute).
copyright for all images: Universität Regensburg, Lehrstuhl Mikrobiologie