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Publications / Veröffentlichungen

Fakultät für Biologie und Vorklinische Medizin
Lehrstuhl für Neurobiologie und Tierphysiologie
Publications / Veröffentlichungen


List of publications 2006-2024                                     Prof. Dr. Inga D. Neumann

(1)   Peer-reviewed papers


Grossmann CP, Sommer C, Fahliogullari IF, Neumann ID, Menon R. Mating-induced release of oxytocin in the mouse lateral septum: Implications for soical fear extinction: Psychoneuroendocrinology 2024;166:107083.doi:10.1016/j.psyneuen.2024.107083.


Neumann ID, Menon R. Detection, processing, and reinforcement of social cues: regulation by the oxytocin system. Nat Rev Neurosci. 2023;doi:10.1038/s41583-023-00759-w. Online ahead of print

Neumann ID. Monitoring oxytocin signaling in the brain: More than a love story. Compr. Psychoneuroendocrinology 2023;(16)100206.  

Pandamooz S, Salehi MS, Jurek B, Meinung CP, Azarpira N, Dianatpour M, Neumann ID.Oxytocin Receptor Expression in Hair Follicle Stem Cells: A Promising Model for Biological and Therapeutic Discovery in Neuropsychiatric Disorders. Stem Cell Rev Rep 2023;doi: 10.1007/s12015-023-10603-4. Online ahead of print.

Tabak BA, Leng G, Parker KJ, Verbarlis JG, Ziegler TE, Lee MR, Neumann ID, Mende AJ. Advances in human oxytocin measurement: challenges and proposed solutions. Mol Psych 2023;28(1):127-140.     

Bludau A, Neumann ID, Menon R. HDAC1-mediated regulation of GABA signaling within the lateral septum facilitates long-lasting social fear extinction in male mice. Transl Psychiatry 2023;13:10 ; https://doi.org/10.1038/s41398-023-02310-y.

Gryksa K, Schmidtner AK, Masís-Calvo M, Rodríguez-Villagra OA, Havasi A, Wirobski G, Maloumby R, Jägle H, Bosch OJ, Slattery DA, Neumann ID. Selective breeding of rats for high (HAB) and low (LAB) anxiety-related behaviour: A unique model for comorbid depression and social dysfunctions. Neurosci Biobehav Rev 2023;152:105292. doi: 10.1016/j.neubiorev.2023.105292.


Oliveira VEM, de Jong TR, Neumann ID. Syntetic Oxytocin and Vasopressin act within the central Amygdala to exacerbate agression in female wistar rats. Front Neurosci 2022;16:906617.

Leschik J, Gentile A, Cicek C, Péron S, Tevosian M, Beer A, Radyushkin K, Bludau A, Ebner K, Neumann ID, Singewald N, Berninger B, Lessmann V, Lutz B. Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis. Prog Neurobiol 2022;217:102333.

Cohen AJ, Neumann ID. A model for the social neurscience of music productions begins on a dubious note: Commentary on Greenberg et al. Am Psychol 2022;(4)616-18.

Rupprecht R, Wetzel CH, Dorostkar M, Herms J, Albert NL, Schwarzbach J, Schumacher M, Neumann ID. Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders? Review Mol Psychiatry 2022;27(7):2918-2926.

Royer M, Pai B, Menon R, Bludau A, Gryksa K, Perry RB, Ulitsky I, Meister G, Neumann ID. Transcriptome and chromatin alterations in social fear indicate association of MEG3 with successful fear extinction. Mol Psych 2022;27(10): 4064–4076.

Meyer M, Jurek B, Alfonso-Prieto M, Ribeiro R, Milenkovic VM, Winter J, Hoffmann P, Wetzel CH, Giorgetti A, Carloni P, Neumann ID. Structure-function relationships of the disease-linked A218T oxytocin receptor variant. Mol Psychiatry 2022; 27(2);907-917.

Gryksa K, Neumann ID. Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system. Psychoneuroendocrinology 2022;135:105601.

Carboni L, El Khoury A, Beiderbeck DI, Neumann ID, Mathé AA. Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours. Eur Neuropsychopharmacol 2022;7;57:1-14.

Menon R, Suess T, Oliveira VEM, Neumann ID, Bludau A. Neurobiology of the lateral septum: regulation of social behavior. Trends Neurosci 2022; 45(1):27-40.


Winter J, Meyer M, Berger I, Royer M, Bianchi M, M. Sc., Kuffner K, Peters S, Stang S, Langgartner D, Hartmann F, Schmidtner AK, Reber SO, Bosch OJ, Bludau A, Slattery DA, van den Burg E, Jurek B, Neumann ID (2021). Chronic oxytocin-driven alternative splicing of CRFR2α induces anxiety. Mol Psychiatry 2021; doi: 10.1038/s41380-021-01141-x.

Oliveira VEM, Lukas M, Wolf HN, Durante E, Lorenz A, Mayer AL, Bludau A, Bosch O, Grinevich V, Egger V, de Jong TR, Neumann  ID (2021) Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats. Nat Commun 2021;12(1):2900.

Salehi MS, Neumann ID, Jurek B, Pandamooz S. Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors affect hypothalamic neurospheroid size. Int J Mol Sci 2021;22(16):8464.

Grinevich V, Neumann ID. Brain oxytocin: how puzzle stones from animal studies translate into psychiatry. Mol Psychiatry 2021;26(1):265-79.

Albantakisa L, Brandia ML, Brückl T, Gebert D, Auer MK, Kopczak A, Stalla GK, Neumann ID, Schilbach L. Oxytocin and cortisol concentrations in adults with and without autismspectrum disorder in response to physical exercise. Psychoneuroendocrinology 2021;(5)100027.


Tang Y, Benusiglio D, Lefevre A, Hilfiger L, Althammer F, Bludau A, Hagiwara D, Baudon A, Schimmer J, Kirchner MK, Roy RK, WangvS, Eliava M, Wagner S, Conzelmann KK, Schwarz M, Stern JE, Leng G, Charlet A, Grinevich V, Neumann ID. Social touch promotes inter-female communication via oxytocin parvocellular neurons. Nat Neurosci 2020;(9):1125-1137.

Grinevich V, Neumann ID. Brain oxytocin: how puzzle stones from animal studies translate into psychiatry. Mol Psychiatry 2020;1-15.

Meyer M, Kuffner K, Winter J, Neumann ID, Wetzel CH, Jurek B. Myocyte Enhancer Factor 2A (MEF2A) Defines Oxytocin-Induced Morphological Effects and Regulates Mitochondrial Function in Neurons. Int J Mol Sci. 2020;21(6):2200.

Anpilov S, Shemesh Y, Eren N, Harony-Nicolas H, Benjamin A, Dine J, Oliveira VEM, Forkosh O, Karamihalev S, Hüttl RE, Feldman N, Berger R, Dagan A , Chen G, Neumann ID, Wagner S, Yizhar O, Chen A. Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors. Neuron. 2020;107(4):644-655.e7.

Zoicas I, Mühle C, Schmidtner AK, Gulbins E, Neumann ID, Kornhuber J. Anxiety and Depression Are Related to Higher Activity of Sphingolipid Metabolizing Enzymes in the Rat Brain. Cells 2020;9(5):E1239.

Malik VA, Zajicek F,  Mittmann LA, Klaus J, Unterseer S, Rajkumar S, Pütz B, Deussing JM, Neumann ID, Rupprecht R, Di Benedetto B. GDF15 promotes simultaneous astrocyte remodeling and tight junction strengthening at the blood-brain barrier. J Neurosci Res.98(7):1433-1456. 


Martinetz S, Meinung CP, Jurek B, von Schack D, von den Burg EH, Slattery DA, Neumann ID. De Novo protein synthesis mediated by the eukaryotic elongation factor 2 is required for the anxiolytic effect of oxytocin. Biol Psychiatry;85(10):802-11

Grund T, Tang Y, Benusiglio D, Althammer F, Probst S, Oppenländer L, Neumann ID, Grinevich V. Chemogentic activation of oxytocin neurons: Temporal dynamics, hormonal release and behavioral consequences. Psychoneuroendocrinology;106:77-84

Bludau A, Royer M, Meister G, Neumann ID, Menon R. Epigenetic regulation of the social brain. J Neurosci; Review

Neumann ID, Landgraf R. Tracking oxytocin functions in the rodent brain during the last 30 years: From push-pull perfusion to chemogenetic silencing. J Neuroendocrinology;(3)e12695.soi:10.1111/jne.12695

Oliveira VEM, Neumann ID, de Jong TR. Post-weaning isolation exacerbates aggression in both sexes and affects the vasopressin and oxytocin system in a sex-specific manner. Neuropharmacology;doi:10.1016/j.neuropharm.2019.01.019 (epub ahead of print)

Grund T, Neumann ID. Brain neuropeptide S: Via GPCR activation to a powerful neuromodulator of socio-emotional behaviors. Cell Tissue Res;375(1):123-32


Menon R, Grund T, Zoicas I, Althammer F, Fiedler D, Biermeier V, Bosch OJ, Hiraoka Y, Nishimori K, Eliava M, Grinevich V, Neumann ID. Oxytocin signalling in the lateral septum prevents social fear during lactation. Curr Biol

Jurek B, Neumann ID. The Oxytocin Receptor: From Intracellular signalling to behavior: Physiol Rev. 98 (3):1805-08

Masís-Calvo M, Schmidtner AK, de Moura Oliveira VE, Grossmann CP, de Jong TR, Neumann ID. Animal models of social stress: the dark side of social interactions. Stress;21(5)417-32 1-16

Bowen MT, Neumann ID. Mulitdimensional therapeutic potential of targeting the brain oxytocin system for the treatment of substance use disorders. Curr Top Behav Neurosci. 35:269-87

Bernhard A, van der Merwe C, Ackermann K, Martinelli A, Neumann ID, Freitag CM. Adolescent oxytocin response to stress and its behavioral and endocrine correlates. Horm Behav;105:157-65

Grund T, Neumann ID. Brain neuropeptide S: via GPCR activation to a powerful neuromodulator of socio-emotional behaviors. Cell Tissue Res;43(5):1156-63

Bosch OJ, Pohl TT, Neumann ID, Young LJ. Abandoned prairie vole mothers show normal maternal care but altered emotionality: Potential influence of the brain corticotropin-releasing factor system. Behav Brain Res.; 341:114-121

de Jong TR, Neumann ID. Oxytocin and Aggression. Curr Top Behav Neurosci. 35:175-92

Grund T, Neumann ID. Neuropeptide S Induces Acute Anxiolysis by Phospholipase C-Dependent Signaling within the Medial Amygdala. Neuropsychopharmacology 43(5):1156-63.


Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF. Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Sci Signal.;10(508).

Bowen MT, Neumann ID. Rebalancing the addicted brain: Oxytocin interference with the neuronal substrates of addiction. Trends Neurosci.40(12):691-708

Grund T, Goyon S, Li Y, Eliava M, Liu H, Charlet A, Grinevich V, Neumann ID. Neuropeptide S activates paraventricular oxytocin neurons to induce anxiolysis. J Neurosci.; 37:12214-12225

Schladt TM, Nordmann GC, Emilius R, Kudielka BM, de Jong TR, Neumann ID. Choir versus solo singing: effects on mood, and salivary oxytocin and cortisol concentrations. Front Hum Neurosci. 14;11:430

Grund T, Neumann ID. Neuropeptide S induces acute anxiolysis by phospholipase c-dependent signaling within the medial amygdala. Neurospychopharmacology. doi: 10.1038/npp.2017.169

Torner L, Plotsky PM, Neumann ID, de Jong TR. Corrigendum to "Forced swimming-induced oxytocin release into blood and brain: Effects of adrenalectomy and corticosterone treatment". Psychoneuroendocrinology; 85:218

Torner L, Plotsky PM, Neumann ID, de Jong TR. Forced swimming-induced oxytocin release into blood and brain: Effects of adrenalectomy and corticosterone treatment. Psychoneuroendocrinology; 77:165-74

Peters ST, Bowen MT, Bohrer K, McGregor IS, Neumann ID. Oxytocin inhibits ehtanol consumption and ethanol-induced dopamine release in the nucleus accumbens. Addict Biol.;22(3):702-711

Slattery DA, Neumann ID, Flor PJ, Zoicas I. Pharmacological modulation of metatropic glutamate receptor subtype 5 and 7 impairs extinction of social fear in a time-point-dependant manner. Behav Brain Res.;328:57-61

Perani CV, Langgartner D, Uschold-Schmidt N, Füchsl AM, Neumann ID, Reber SO, Slattery DA. Adrenal gland plasticity in lactating rats and mice is sufficient to maintain basal hypersecretion of corticosterone. Stress;3:303-311


Sartori SB, Maurer V, Murphy C, Schmuckermair C, Muigg P, Neumann ID, Whittle N, Singewald N. Combined Neuropeptide S and D-Cycloserine augmentation prevents the return of fear in extinction-impaired rodents: advantage of dual versus single drug approaches. Int J Neuropsychopharmacol.; 19(06)

Carnevali L, Andrews PL, Neumann ID, Nalivaiko E, Sgoifo A. Autonomic changes induced by provocative motion in rats bred for high (HAB) and low (LAB) anxiety-related behavior: paradoxical responses in LAB animals. Physiol Behav.;167:363-73

Zoicas I, Menon R, Neumann ID. Neuropeptide S reduced fear and avoidance of con-specifics induced by social fear conditioning and social fear defeat, respectively. Neuropharmacology; 108:284-91

Bosch OJ, Dabrowska J, Modi ME, Johnson ZV, Keebaugh AC, Barrett CE, Ahem TH, Guo J, Grinevich V, Rainnie DG, Neumann ID, Young LJ. Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles. Psychoneuroendocrinology; 64:66-78

Martinetz S, Neumann ID. The potential of osytocin as a therapeutic target for psychiatric disorders. Expert Opin Ther Targets; 20:515-8

Bayerl DS, Kaczmarek V, Jurek B, van den Burg EH, Neumann ID, Gaßner BM, Klampfl SM, Bosch OJ. Antagonism ov V1b receptors promotes maternal motivation to retrieve pups in the MPOA and impairs pup-directed behavior during maternal defens in the mpBNST of lactating rats. Horm Behav.; 79:18-27

Di Benedetto B, Malik VA, Begum S, Jablonowski L, Gómez-Gonzáles GB, Neumann ID, Rupprecht R. Fluoxetine requires the endfeet protein aquporin-4 to enhance plasticity of astrocyte processes. Front Cell Neurosci.; 10:8

Zoicas I, Neumann ID. Maternal separation facilitates extinction of social fear in adult male mice. Behav Brain Res.; 297:323-8

Neumann ID, Slattery DA. Oxytocin in general anxiety and social fear: A translational approach. Biol Psychiatry; 79(3):213-21


Perani CV, Neumann ID, Reber SO, Slattery DA. High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis. Sci Rep. 7;5:14821.

Jong TR, Menon R, Bludau A, Grund T, Biermeier V, Klampfl SM, Jurek B, Bosch OJ, Hellhammer J, Neumann ID. Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the TSST: The Regensburg Oxytocin Challenge (ROC) study. Psychoneuroendocrinology ;62:381-8.

Carnevali L, Vacondio F, Rossi S, Macchi E, Spadoni G, Bedini A, Neumann ID, Rivara S, Mor M, Sgoifo A. Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Sci Rep.;5:18218.

Bernhard A, Martinelli A, Ackermann K, Neumann ID, Kirschbaum C, Freitag CM. Reactivity of oxytocin in the Trier Social Stress Test: A proof of concept study.Psychoneuroendocrinology;61:73.

Frijling JL, van Zuiden M, Nawijn L, Koch SB, Neumann ID, Veltman DJ, Olff M. Salivary oxytocin and vasopressin levels in police officers with and without post-traumatic stress disorder. J Neuroendocrinol.; 27:743-51.

van den Burg EH, Stindl J, Grund T, Neumann ID, Strauss O. Oxytocin Stimulates Extracellular Ca2+ Influx Through TRPV2 Channels in Hypothalamic Neurons to Exert its Anxiolytic Effects. Neuropsychopharmacology; 40:2938-47

Shiban Y, Reichenberger J, Neumann ID, Mühlberger A. Social conditioning and extinction paradigm: a translational study in virtual reality. Front Psychol.;6:400

Slattery DA, Naik RR, Grund T, Yen YC, Sartori SB, Fuechsl A, Finger BC, Elfving B, Nordemann U, Guerrini R, Calo G, Wegener G, Math AA, Singewald N, Czibere L, Landgraf L, Neumann ID. Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity. J Neurosci.; 35:4599-613

Jurek B, Slattery DA, Hiraoka Y, Liu Y, Nishimori K, Aguilera G , Neumann ID, van den Burg EH. Oxytocin regulates stress-induced CRF gene transcription through CREB-regulated transcription coactivator 3 (CRTC3). J Neurosci.;35:12248-60

Bowen MT, Peters ST, Absalom N, Chebib M, Neumann ID, McGregor IS. Oxytocin prevents ethanol actions at δ subunit-containing GABAA receptors and attenuates ethanol-induced motor impairment in rats. Proc Natl Acad Sci U S A.;112:3104-9

de Jong TR, Neumann ID. Moderate Role of Oxytocin in the Pro-Ejaculatory Effect of the 5-HT1A Receptor Agonist 8-OH-DPAT. J Sex Med.;12:17-28


Bosch OJ, Slattery DA, Neumann ID. The 5th parental brain conference. J Neuroendocrinol;625-6

Lonstein JS, Maguire J, Meinlschmidt G, Neumann ID. Emotion and Mood Adaptations in the Peripartum Female: Complementary Contributions of GABA and Oxytocin. J Neuroendocrinol;649-64.

Haller J, Harold G, Sandi C, Neumann ID. Effects of adverse early-life events on aggression and anti-social behaviours in animals and humans. J Neuroendocrinol;724-38

Beiderbeck DI, Lukas M, Neumann ID. Anti-aggressive effects of neuropeptide S independent of anxiolysis in male rats. Front Behav Neurosci.;30;8:185. eCollection 2014.

Zoicas I, Slattery DA, Neumann ID. Brain Oxytocin in Social Fear Conditioning and its Extinction: Involvement of the Lateral Septum. Neuropsychopharmacology;39(13):3027-35

Zamorano M, Ledesma-Colunga MG, Adán N, Vera-Massieu C, Lemini M, Méndez I, Moreno-Carranza B, Neumann ID, Thebault S, Martínez de la Escalera G, Torner L, Clapp C. Prolactin-derived vasoinhibins increase anxiety- and depression-related behaviors. Psychoneuroendocrinology;44:123-32

de Jong TR, Beiderbeck DI, Neumann ID. Measuring virgin female aggression in the female intruder test (FIT): effects of oxytocin, estrous cycle, and anxiety. PLoS One;9(3):e91701

Lukas M, Neumann ID. Social preference and maternal defeat-induced social avoidance in virgin female rats: Sex differences in involvement of brain oxytocin and vasopressin. J Neurosci Methods;234:101-7

Calcagnoli F, de Boer SF, Beiderbeck DI, Althaus M, Koolhaas JM, Neumann ID. Local oxytocin expression and oxytocin receptor binding in the male rat brain is associated with aggressiveness. Behav Brain Res;15;261:315-22

Füchsl AM, Neumann ID, Reber SO. Stress resilience-a low-anxiety genotype protects male mice from the consequences of chronic psychosocial stress. Endocrinology;155(1):117-26

Peters S, Slattery DA, Uschold-Schmidt N, Reber SO, Neumann ID. Dose-dependent effects of chronic central infusion of oxytocin on anxiety, oxytocin receptor binding and stress-related parameters in mice. Psychoneuroendocrinology; 42,225—236

Carnevali L, Trombini M, Graiani G, Madeddu D, Quaini F, Landgraf R, Neumann ID, Nalivaiko E, Sgoifo A. Low vagally-mediated heart rate variability and increased susceptibility to ventricular arrhythmias in rats bred for high anxiety. Physiol Behav;128;16-25

Hillerer KM, Neumann ID, Couillard-Despres S, Aigner L, Slattery DA. Lactation-induced reduction in hippocampal neurogenesis is reversed by repeated stress exposure. Hippocampus;6;673-83

Forkwa TK, Neumann ID, Tamm ER, Ohlmann A, Reber SO. Short-term psychosocial stress protects photoreceptors from damage via corticosterone-mediated activation of the AKT pathway. Exp Neurol;252:28-36



Lukas M, Neumann ID. Oxytocin and vasopressin in rodent behaviors related to social dysfunctions in autism spectrum disorders. Behav Brain Res;15;251:85-94.

Czech B, Neumann ID, Müller M, Reber SO, Hellerbrand C. Effect of chronic psychosocial stress on nonalcoholic steatohepatitis in mice. Int J Clin Exp Pathol;15;6(8):1585-93

Toth I, Neumann ID. Animal models of social avoidance and social fear. Cell Tissue Res; 354(1):107-18

Klampfl SM, Neumann ID, Bosch OJ. Reduced brain corticotropin-releasing factor receptor activation is required for adequate maternal care and maternal aggression in lactating rats. Eur J Neurosci; 38(5):2742-50

Peters S, Slattery DA, Flor PJ, Neumann ID, Reber SO. Differential effects of baclofen and oxytocin on the increased ethanol consumption following chronic psychosocial stress in mice. Addict Biol;18:66-77

Carnevali L, Sgoifo A, Trombini M, Landgraf R, Neumann ID, Nalivaiko E. Different patterns of respiration in rat lines selectively bred for high or low anxiety. PLoS One; 17;8(5): e64519

Neumann ID, Maloumby R, Beiderbeck DI, Lukas M, Landgraf R. Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice. Psychoneuroendocrinology; 38(10):1985-93

Toth I, Neumann ID, Slattery DA. Social fear conditioning as an animal model of social anxiety disorder. Curr Protoc Neurosci;Chapter 9;Unit 9.42.

Hillerer KM, Neumann ID, Couillard-Despres S, Aigner L, Slattery DA. Sex-dependent regulation of hippocampal neurogenesis under basal and chronic stress conditions in rats. Hippocampus; 23(6):476-87.

Bertsch K, Schmidinger I, Neumann ID, Herpertz SC. Reduced plasma oxytocin levels in female patients with borderline personality disorder. Horm Behav; 63(3):424-9

Lukas M, Toth I, Veenema AH, Neumann ID. Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: Male juvenile versus female adult conspecifics. Psychoneuroendocrinology; 38(6):916-26



Nyuyki KD, Beiderbeck DI, Lukas M, Neumann ID, Reber SO. Chronic Subordinate Colony Housing (CSC) as a Model of Chronic Psychosocial Stress in Male Rats. PLoS One;7(12):e52371.

Bartlang MS, Neumann ID, Slattery DA, Uschold-Schmidt N, Kraus D, Helfrich-Förster C, Reber SO. Time matters: pathological effects of repeated psychosocial stress during the active, but not inactive, phase of male mice. J Endocrinol;15(3):425-37.

Jurek B, Slattery DA, Maloumby R, Hillerer K, Koszinowski S, Neumann ID, van den Burg EH. Differential contribution of hypothalamic MAPK activity to anxiety-like behaviour in virgin and lactating rats. PLoS One;7(5):e37060

Okimoto N, Bosch OJ, Slattery DA, Pflaum K, Matsushita H, Wei FY, Ohmori M, Nishiki T, Ohmori I, Hiramatsu Y, Matsui H, Neumann ID, Tomizawa K. RGS2 mediates the anxiolytic effect of oxytocin. Brain Res; 1453:26-33.

Neumann ID, Landgraf R. The brain oxytocin and vasopressin systems in anxiety and depression: Link to Sociality. Trends in Neurosciences;35(11):649-659

Beiderbeck D, Reber SO, Havasi A, Veenema A, Neumann ID. High and abnormal forms of aggression in rats with extremes in trait anxiety – involvement of the dopamine system in the nucleus accumbens. Psychoneuroendocrinology ;37(12):1969-80.

Toth I, Neumann ID, Slattery DA. Central administration of oxytocin receptor ligands affects cued fear extinction in rats and mice in a timepoint-dependent manner. Psychopharmacology ; 223(2):149-58

Toth I, Neumann ID, Slattery DA. Social fear conditioning - a novel and specific animal model to study social anxiety disorder. Neuropsychopharmacology ; 37(6):1433-43

Slattery DA, Uschold N, Magoni  M, Baer J, Popoli M, Neumann ID, Reber SO. Behavioural consequences of two chronic psychosocial stress paradigms: anxiety without depression. Psychoneuroendocrinology ; 37(5) ;702-14

Lukas M, Neumann ID. Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: Social versus non-social effects. Neuropharmacology ;62(1);398-405

Nyuyki KD, Maloumby R, Reber SO, Neumann ID. Comparison of corticosterone responses to acute stressors: chronic jugular vein versus trunk blood samples in mice. Stress;15(6);618-26

Peters S, Grunwald N, Rümmele N, Endlicher E, Lechner A, Obermeier F, Reber SO. Chronic psychosocial stress increases the risk for inflammation-related colon cancerogenesis in male mice. Stress;15(4);403-15

Toth I, Dietz M, Fendt M, Neumann, ID, Flor P, Slattery D. Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear. Neuropharmacology ;62;1619-26

Uschold-Schmidt N, Nyuyki KD, Füchsl AM, Neumann ID, Reber SO. Chronic psychosocial stress results in sensitization of the HPA axis to acute heterotypic stressors despite a reduction of adrenal in vitro ACTH responsiveness. Psychoneuroendocrinology ; 37(10) ;1676-87.

Wegener G, Mathe AA, Neumann ID. Selectively bred rodents as models of depression and anxiety. Curr Top Behav Neurosci ;12;139-87.

Bosch OJ, Neumann ID. Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: from central release to sites of action. Horm Behav ;61(3):293-303.



Jurek B, Slattery DA, Maloumby R, Hillerer K, Brockmann M, Neumann ID, vd Burg E. The MAPK signalling pathway within the hypothalamic PVN is critically involved in both lactation- and oxytocin-induced anxiolysis: pharmacological evidence. Endocrinology ;152(10);3930-40

Hillerer KM, Reber SO, Neumann ID, Slattery DA. Exposure to chronic pregnancy stress reverses peripartum associated adaptations: implications for post-partum anxiety and mood disorders. Endocrinology;152; 3930-40

Nyuyki K, Waldherr M, Bäuml, S, Neumann ID. Yes, I Am ready now: Differential effects of paced versus unpaced mating on anxiety and central oxytocin release in female rats. PloS One;6(8);e23599

Lukas M, Toth I, Reber SO, Slattery DA, Veenema AH, Neumann ID. The neuropeptide oxytocin facilitates pro-social behavior and prevents social avoidance in rats and mice. Neuropsychopharmacology; 36;2159-68

Lukas M, Bredewold R, Landgraf R, Neumann ID, Veenema AH. Early life stress impairs social recognition due to a blunted response of vasopressin release within the septum of adult male rats. Psychoneuroendocrinology; 36(6);843-853.

Reber SO, Peters S, Slattery DA, Hofmann C, Schölmerich J, Neumann ID, Obermeier F. Mucosal immunosuppression and epithelial barrier defects are key events in murine psychosocial stress-induced colitis. Brain Behav Immun; 25(6);1153-1161

Wegener G, Finger BC, Elfving B, Keller K, Liebenberg N, Fischer CW, Singewald N, Slattery DA, Neumann ID, Mathé AA. Neuropeptide S alters anxiety, but not depression-like behaviour in Flinders Sensitive Line rats: a genetic animal model of depression. Int J Neuropsychopharmacol; 9;1-13

Kessler MS, Bosch OJ, Bunck M, Landgraf R, Neumann ID. Maternal care differs in mice bred for high vs. low trait anxiety: Impact of brain vasopressin and cross-fostering. Soc Neurosci ;6;156-168

Van den Burg EH, Neumann ID. Bridging the gap between GPCR activation and behaviour: oxytocin and prolactin signalling in the hypothalamus. J Mol Neurosci;43(2);200-208



Bosch OJ, Pförtsch J, Beiderbeck DI, Landgraf R, Neumann ID. Maternal behaviour is associated with vasopressin release in the medial preoptic area and bed nucleus of the stria terminalis in the rat. J Neuroendocrinol; 22(5) ;420-429

Bosch OJ, Neumann ID. Vasopressin released within the central amygdala promotes maternal aggression. Eur J Neurosci; 31(5);883-891

Veenema AH, Beiderbeck DI, Lukas M, Neumann ID. Distinct correlations of vasopressin release within the lateral septum and the bed nucleus of the stria terminalis with the display of intermale aggression. Horm Behav; 58(2) ;273-281

Slattery DA, Neumann I, Cryan JF. Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat. J Psychopharmacol; 25(10);1295-303

Meinlschmidt G, Martin C, Neumann ID, Heinrichs M. Maternal cortisol in late pregnancy and hypothalamic–pituitary–adrenal reactivity to psychosocial stress postpartum in women. Stress;13(2);163-71

Lukas M, Bredewold R, Neumann ID, Veenema AH. Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Neuropharmacology; 58(1);78-87

Waldherr M, Nyuyki K, Maloumby R, Bosch OJ, Neumann ID. Attenuation of the neuronal stress responsiveness and corticotrophin releasing hormone synthesis after sexual activity in male rats. Horm Behav; 57(2);222-9

Slattery DA, Neumann ID. Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats. Neuropharmacology ; 58(1);56-61



Wagner K, Couillard-Despres S, Lehner B, Brockhoff G, Rivera FJ, Blume A, Neumann I, Aigner L. Prolactin induces MAPK signaling in neural progenitors without alleviating glucocorticoid-induced inhibition of in vitro neurogenesis. Cell Physiol Biochem; 24(5-6);397-406

Blume A, Torner L, Liu Y, Subburaju S, Aguilera G, Neumann ID. Prolactin induces Egr-1 gene expression in cultured hypothalamic cells and in the rat hypothalamus. Brain Res;1302;34-41

Ross HE, Cole CD, Smith Y, Neumann ID, Landgraf R, Murphy AZ, Young LJ. Characterization of the oxytocin system regulating affiliative behavior in female prairie voles. Neuroscience; 162(4);892-903

Donner N, Neumann ID. Effects of chronic intracerebral prolactin on the oxytocinergic and vasopressinergic system of virgin ovariectomized rats. Neuroendocrinology; 90(3);315-22

Bosch OJ, Nair HP, Ahern TH, Neumann ID, Young LJ The CRF system mediates increased passive stress-coping behavior following the loss of a bonded partner in a monogamous rodent. Neuropsychopharmacology;  34;1406-1415

Veenema AH, Neumann ID. Maternal separation enhances offensive play-fighting, corticosterone and hypothalamic vasopressin mRNA expression in juvenile male rats. Psychoneuroendocrinology; 34;463-467

Lucassen PJ, Bosch O, Jousma E, Krömer SA, Andrew R, Seckl JR and Neumann ID. Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low anxiety: possible key role of placental 11β-hydroxysteroid dehydrogenase type 2. Eur J Neurosci; 29; 97-103

Blume A, Torner L, Liu Y, Subburaju S, Aguilera G, Neumann ID. Prolactin activates mitogen-activated protein (MAP) kinase signaling and corticotropin releasing hormone (CRH) transcription in rat hypothalamic neurons. Endocrinology; 150(4);1841-9

Singewald GM, Nguyen NK, Neumann ID, Singewald N, Reber SO. Effect of chronic psychosocial stress-induced by subordinate colony (CSC) housing on brain neuronal activity patterns in mice. Stress; 12(1);58–69

Torner L, Karg S, Blume A, Kandasamy M, Kuhn H-G, Winkler J, Aigner L, Neumann ID. Prolactin prevents chronic stress-induced decrease of hippocampal neurogenesis & promotes neuronal fate. J Neurosci; 29;1826-33

Neumann ID. The advantage of social living: brain neuropeptides mediate the beneficial consequences of sex and motherhood. Front Neuroendocrinol.; 30(4):483-96. Review



Bosch OJ, Neumann ID. Brain vasopressin is an important regulator of maternal behavior independent of dams' trait anxiety. Proc Natl Acad Sci USA; 105;17139-144

Bosch OJ, Nair HP, Ahern TH, Neumann ID, Young LJ. The CRF system mediates increased passive stress-coping following the loss of a bonded partner in a monogamous rodent. Neuropsychopharmacology ; 1-10

Reber SO and Neumann ID. Defensive behavioural strategies and enhanced state anxiety during chronic subordinate colony housing are accompanied by reduced hypothalamic vasopressin, but not oxytocin, expression. Stress, Neurotransmitters, and Hormones, Ann. N.Y. Acad. Sci; 1148;184-195

Reber SO, Obermeier F, Straub RH, Veenema AH, Neumann ID. Aggravation of DSS-induced colitis after chronic subordinate colony (CSC) housing is partially mediated by adrenal mechanisms. Stress; 11(3);225-34

Neumann ID. Brain oxytocin: A key regulator of emotional and social behaviours in both females and males. J. Neuroendocrinol ; 20(6);858-865

Blume A, Bosch OJ, Miklos S, Torner L, Wales L, Waldherr M, Neumann ID. Oxytocin reduces anxiety via ERK1/2 activation: local effect within the rat hypothalamic paraventricular nucleus. Eur J Neurosci; 27(8);1947-56

Veenema AH, Reber SO, Selch S, Obermeier F, Neumann ID. Early life stress enhances the vulnerability to chronic psychosocial stress and experimental colitis in adult mice. Endocrinology; 149(6);2727-36


Waldherr M, Neumann ID. Centrally released oxytocin mediates mating-induced anxiolysis in male rats. Proc Natl Acad Sci U S A;104(42);16681-4

Bosch OJ, Sartori SB, Singewald N, Neumann ID. Extracellular amino acid levels in the paraventricular nucleus and the central amygdala in high- and low-anxiety dams rats during maternal aggression: Regulation by oxytocin. Stress; 10(3);261-70

Ditzen B, Neumann ID, Bodenmann G, von Dawans B, Turner RA, Ehlert U, Heinrichs M. Effects of different kinds of couple interaction on cortisol and heart rate responses to stress in women. Psychoneuroendocrinology; 32 (5);565-74

Jochum T, Boettger MK, Wigger A, Beiderbeck DI, Neumann I, Landgraf R, Sauer H, Baer KJ. Decreased sensitivity to thermal pain in rats bred for high anxiety-related behaviour is attenuated by citalopram or diazepam treatment. Behav Brain Res; 183(1);18-24

Veenema AH, de Kloet ER, de Wilde MC, Roelofs AJ, Buwalda B, Neumann ID, Koolhaas JM, Lucassen PJ. Differential effects of stress on adult hippocampal cell proliferation in low and high aggressive mice. J Neuroendocrin; 19(7);489-98

Veenema AH, Bredewold R, Neumann ID. Opposite effects of maternal separation on intermale and maternal aggression in C57BL/6 mice: Link to hypothalamic vasopressin and oxytocin immunoreactivity. Psychoneuroendocrinology; 32(5);437-50

Donner N, Bredewold R, Maloumby R, Neumann ID. Chronic intracerebral prolactin attenuates neuronal stress circuitries in virgin rats. Eur J Neurosci; 25;1804-14

Douglas AJ, Meddle SL, Kroemer S, Muesch W, Bosch OJ, Neumann ID.  Social stress induces hypothalamo-pituitary-adrenal axis responses in lactating rats bred for high trait anxiety. Eur J Neurosci; 25(5);1599-603

Bosch OJ, Musch W, Bredewold R, Slattery DA, Neumann ID. Prenatal stress increases HPA axis activity and impairs maternal care in lactating female offspring: Implications for postpartum mood disorder. Psychoneuroendocrinology; 32(3);267-78

Muigg P, Hoelzl U, Palfrader K, Neumann I, Wigger A, Landgraf R, Singewald N. Altered brain activation pattern associated with drug-induced attenuation of enhanced depression-like behavior in rats bred for high anxiety. Biol Psychiatry; 61(6);782-96

Reber SO, Birkeneder L, Obermeier F, Falk W, Straub RH, Neumann ID. Adrenal insufficiency and colonic inflammation after a novel chronic psycho-social stress paradigm in mice: implications and mechanisms. Endocrinology ; 148(2);670-82

Veenema AH, Torner L, Blume A, Beiderbeck DI, Neumann ID. Low inborn anxiety correlates with high intermale aggression: Link to ACTH response and neuronal activation of the hypothalamic paraventricular nucleus. Horm Behav; 51(1);11-9

Neumann, ID. Veränderungen oder emotionalen und neuroendokrinen Stressreaktion während Schwangerschaft und Laktation – Einfluss intrazerebraler Neuropeptide. Psychodynamische Psychotherapie 6; 27-38. review

Bosch OJ, Muesch W, Bredewold R, Slattery DA, Neumann ID. Opposing effects of prenatal stress on HPA axis activity and maternal care in lactating female offspring: implications for postpartum mood disorders. Psychoneuroendocrinology ; 32;267-278

Reber SO, Birkeneder L, Veenema AH, Obermeier F, Falk W, Straub RH, Neumann ID. Effects of a chronic psychosocial stressor (subdominant colony housing) on histological damage of the murine colon: underlying neuronal and neuroendocrine mechanisms. Endocrinology; 148(2);670-82



Veenema AH, Blume A, Niederle D, Buwalda B, Neumann ID. Effects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin. Eur J Neurosci; 24(6);1711

Reber SO, Obermeier F, Straub RH, Falk W, Neumann ID. Chronic intermittent psycho-social stress in mice increases the severity of an acute DSS-induced colitis and additionally impairs regeneration. Endocrinology; 147(10);4968-4976

Neumann ID, Torner L, Toschi N, Veenema AH. Oxytocin actions within the supraoptic and paraventricular nuclei: differential effects on peripheral and intranuclear vasopressin release. Am J Physiol (Regul. Integr. Comp. Physiol.); 291(1);R29-36

Bosch OJ, Kromer SA, Neumann ID. Prenatal stress: opposite effects on anxiety and hypothalamic expression of vasopressin and corticotropin-releasing hormone in rats selectively bred for high and low anxiety. Eur J Neurosci; 23(2),541-551


(2)  Edited books

Landgraf, R, Neumann ID. Editors. Oxytocin and vasopressin: From molecule to disease. Prog. Brain Res. 246. 2008

Neumann, ID, Bosch O, Slattery, D (in prep). Novel discoveries on the Maternal and Paternal Brain



(3)  Reviews and Book chapters since 2008

Neumann ID, Landgraf R. The brain oxytocin and vasopressin systems in anxiety and depression: Link to Sociality. Trends in Neuroscience 2012; 35(11);649-59.

Lukas M and Neumann ID. Brain Oxytocin is A Main Regulator of prosocial behaviour: Link to psychopathology. In: Autism - a neurodevelopmental journey from genes to behaviour (Eapen V, Ed): InTech; pp 197-212

Hillerer KM, Neumann ID, Slattery DA. From Stress to Postpartum Mood and Anxiety Disorders: How Chronic Peripartum Stress Can Impair Maternal Adaptations. Neuroendocrinology 2012;95(1);22-38.

Bosch OJ, and Neumann ID. Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: From central release to sites of action Hormones, Brain and Behavior 2012;61;293-303. Invited Review

Neumann ID and van den Burg EH. Oxytocin and vasopressin release and their receptor-mediated intracellular pathways that determine their behavioral effects. In: Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior. 2011; Choleris E, Pfaff DW, Kavaliers M (Eds), Cambridge University Press, invited review

Neumann ID, Wegener G, Homberg JR, Cohen H, Slattery DA, Zohar J, Olivier JD, Mathé AA. Animal models of depression and anxiety: What do they tell us about human condition? Prog Neuropsychopharmacol Biol Psychiatry 2011;35(6);1357-75; Invited review.

Neumann ID, Veenema AH, Beiderbeck DI. Aggression and anxiety: social context and neurobiological links. Front Behav Neurosci 2010;4;12-32. Invited Review

Slattery DA and Neumann ID. Oxytocin and Major Depressive Disorder: Experimental and Clinical Evidence for Links to Aetiology and Possible Treatment. Pharmaceuticals 2010; 3;702-724. Review

Neumann ID. The advantage of social living: brain neuropeptides mediate the beneficial consequences of sex and motherhood. Front Neuroendocrinol  2009; 30(4);483-96. Review

Wiehager S, Beiderbeck DI, Gruber SH, El-Khoury A, Wamsteeker J, Neumann ID, Petersén A, Mathé AA. Increased levels of cocaine and amphetamine regulated transcript in two animal models of depression and anxiety. Neurobiol Dis 2009; 34(2);375-80.

Slattery DA, Neumann ID. No stress please! Mechanisms of stress hyporesponsiveness of the maternal brain. J Physiol 2008;586(2);377-85.

Neumann ID. Brain oxytocin mediates beneficial consequences of close social interactions: From Maternal love and sex. In: Hormones and Social Behavior 2008; Pfaff, DW, Kordon C, Chanson P, Christen Y (Eds.), Springer, pp. 81-101.

Veenema AH, Neumann ID. Central vasopressin and oxytocin release: regulation of complex social behaviours. Prog Brain Res 2008;170;261-76.

Beiderbeck DI, Neumann ID, Veenema AH. Differences in intermale aggression are accompanied by opposite vasopressin release patterns within the septum in rats bred for low and high anxiety. Eur J Neurosci 2007; 26(12);3597-605.

Neumann ID. Oxytocin: The neuropeptide of love reveals some of its secrets. Cell Metabolism 2007;5;231-233.

Neumann ID. Stimuli and consequences of dendritic release of oxytocin within the brain. Biochem Soc Trans 2007;35(Pt 5);1252-7. Review.

Veenema AH, Neumann ID. Neurobiological mechanisms of aggression & stress coping: A comparative study in mouse & rat selection lines. Brain Behav Evol 2007;70;274-85.

  1. Fakultäten
  2. Fakultät für Biologie und Vorklinische Medizin

Neurobiologie und Tierphysiologie



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