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Dr. Anna Bludau



Molecular mechanisms regulating social fear in adolescence and adulthood

Social interactions are essential for mammalian survival and evolution. Being presented as complex combination of visual, olfactory, auditory, and tactile stimuli, social situations require coordinated orchestration of multiple neuronal and molecular pathways within the brain. 
I am interested in post-transcriptional regulators of gene expression, such as non-coding RNAs and microRNAs, which are known to be involved in somatic and affective disorders and were also shown to modulate social and emotional behaviours. In this context, I aim to reveal how microRNAs orchestrate molecular underpinnings of anxiety-related behaviour and of social fear / social avoidance using the social fear conditioning paradigm. Adolescence is a critical phase of enhanced vulnerability towards social trauma and the subsequent development of social and emotional dysfunctions. 

I am specifically interested in investigating the underlying neuropeptidergic and molecular mechanisms leading to acute and persistent consequences of social stress in adolescence.
Answering these questions requires a combination of molecular, behavioural, and pharmacological approaches, such as microRNA Deep Sequencing, RNAScope, qPCR, immunohistochemistry, western blotting, in vitro stimulation of cell cultures, social and cued fear conditioning, social preference testing, and general anxiety testing in combination with viral and pharmacological manipulations in selected brain regions using stereotactic surgeries.



Since 2020 Postdoctoral researcher in Prof. Dr. ID Neumann´s group, Department of Behavioural and Molecular Neurobiology. 
Research focus: Molecular mechanisms regulating social fear in adolescence and adulthood
2015-2019 PhD student in Prof. Dr. ID Neumann´s laboratory, Department of Behavioural and Molecular Neurobiology
2013-2015 M.Sc. in Biology at the University of Regensburg
Focus: Immunology, molecular Human Biology, Neuroscience
Master thesis with Prof. Dr. ID Neumann, Department of Behavioural and Molecular Neurobiology
2010-2013 B.Sc. in Biology at the University of Regensburg
Bachelor thesis with Prof. Dr. PJ Flor, Department of Molecular and Cellular Neurobiology

Born January 27th in Straubing, Germany.




Leschik J, Gentile A, Cicek C, Péron S, Tevosian M, Beer A, Radyushkin K, Bludau A, Ebner K, Neumann I, Singewald N, Berninger B, Lessmann V, Lutz B. Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis. Progress in Neurobiology.

Royer M, Pai B, Menon R, Bludau A, Gryksa K, Perry RB, Ulitsky I, Meister G, Neumann ID. Transcriptome and chromatin alterations in social fear indicate association of MEG3 with successful extinction of fear. Molecular Psychiatry.

Menon R, Süß T, Oliveira VEM, Neumann ID, Bludau A. Neurobiology of the lateral septum: regulation of social behavior. Trends in Neuroscience.


Winter J, Meyer M, Berger I, Royer M, Bianchi M, Kuffner K, Peters S, Stang S, Langgartner D, Hartmann F, Schmidtner AK, Reber SO, Bosch OJ, Bludau A, Slattery DA, van den Burg EH, Jurek B, Neumann ID. Chronic oxytocin-driven alternative splicing of Crfr2α induces anxiety. Molecular Psychiatry.

Oliveira VEM, Lukas M, Wolf HN, Durante E, Lorenz A, Mayer AL, Bludau A, Bosch OJ, Grinevich V, Egger V, de Jong TR, Neumann ID. Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats. Nature Communications.


Tang Y, Benusiglio D, Lefevre A, Hilfiger L, Althammer F, Bludau A, Hagiwara D, Baudon A, Darbon P, Schimmer J, Kirchner MK, Roy RK, Wang S, Eliava M, Wagner S, Oberhuber M, Conzelmann KK, Schwarz M, Stern JE, Leng G, Neumann ID, Charlet A, Grinevich V. Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons. Nature Neuroscience.


Bludau A, Royer M, Meister G, Neumann ID, Menon R. Epigenetic Regulation of the Social Brain. Trends in Neuroscience.



Peterlik D, Stangl C, Bauer A, Bludau A, Keller J, Grabski D, Killian T, Schmidt D, Zajicek F, Jaeschke G, Lindemann L, Reber SO, Flor PJ, Uschold-Schmidt N. Blocking metabotropic glutamate receptor subtype 5 relieves maladaptive chronic stress consequences. Brain Behavior, and Immunity.

Peterlik D, Stangl C, Bludau A, Grabski D, Strasser R, Schmidt D, Flor PJ, Uschold-Schmidt N. Relief from detrimental consequences of chronic psychosocial stress in mice deficient for the metabotropic glutamate receptor subtype 7. Neuropharmacology.


Jong TR, Menon R, Bludau A, Grund T, Biermeier V, Klampfl SM, Jurek B, Bosch OJ, Hellhammer J, Neumann ID. Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the TSST: The Regensburg Oxytocin Challenge (ROC) study. Psychoneuroendocrinology.

  1. Fakultäten
  2. Fakultät für Biologie und Vorklinische Medizin

Dr. Anna Bludau


Bludau Anna

Bio D4.2.315
Tel. +49-941-943-3119