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Publications

Selected Publications (1-30).

For all publications please go to PubMed

 

1.           Cabrita I, Kraus A, Scholz JK, Skoczynski K, Schreiber R, Kunzelmann K, Buchholz B. Cyst growth in adpkd is prevented by pharmacological and genetic inhibition of tmem16a in vivo. Nature communications 2020;11(1):4320.

2.           Neubert P, Homann A, Wendelborn D, Bär AL, Krampert L, Trum M, Schröder A, Ebner S, Weichselbaum A, Schatz V, et al. Ncx1 represents an ionic na+ sensing mechanism in macrophages. PLoS biology 2020;18(6):e3000722.

3.           Park JH, Ousingsawat J, Cabrita I, Bettels RE, Große-Onnebrink J, Schmalstieg C, Biskup S, Reunert J, Rust S, Schreiber R, et al. Tmem16a deficiency: A potentially fatal neonatal disease resulting from impaired chloride currents. J Med Genet 2020.

4.           Cabrita I, Benedetto R, Wanitchakool P, Lerias J, Centeio R, Ousingsawat J, Schreiber R, Kunzelmann K. Tmem16a mediated mucus production in human airway epithelial cells. American journal of respiratory cell and molecular biology 2020.

5.           Berg P, Svendsen SL, Sorensen MV, Larsen CK, Andersen JF, Jensen-Fangel S, Jeppesen M, Schreiber R, Cabrita I, Kunzelmann K, et al. Impaired renal hco(3) (-) excretion in cystic fibrosis. J Am Soc Nephrol 2020.

6.           Schreiber R, Buchholz B, Kraus A, Schley G, Scholz J, Ousingsawat J, Kunzelmann K. Lipid peroxidation drives renal cyst growth in vitro through activation of tmem16a J Am Soc Nephrol 2019;30:228-242.

7.           Cabrita I, Benedetto R, Schreiber R, Kunzelmann K. Niclosamide repurposed for the treatment of inflammatory airway disease. JCI insight 2019;8:128414.

8.           Benedetto R, Ousingsawat J, Cabrita I, Pinto M, Lerias J, Wanitchakool P, Schreiber R, Kunzelmann K. Plasma membrane localized tmem16 proteins are indispensable for expression of cftr. J Mol Med 2019;97:711-722.

9.           Benedetto R, Cabrita I, Schreiber R, Kunzelmann K. Tmem16a is indispensable for basal mucus secretion in airways and intestine. FASEB J 2019;33:4502-4512.

10.         Schreiber R, Ousingsawat J, Wanitchakool P, Sirianant L, Benedetto R, Reiss K, Kunzelmann K. Regulation of tmem16a/ano1 and tmem16f/ano6 ion currents and phospholipid scrambling by ca2+ and plasma membrane lipid J Physiology (London) 2018;596:217-229.

11.         Ousingsawat J, Wanitchakool P, Schreiber R, Kunzelmann K. Contribution of tmem16f to pyroptotic cell death. Cell Death Dis 2018;9(3):300.

12.         Cabrita I, Benedetto R, Fonseca A, Wanitchakool P, Sirianant L, Skryabin BV, Schenk LK, Pavenstadt H, Schreiber R, Kunzelmann K. Differential effects of anoctamins on intracellular calcium signals. Faseb j 2017;31:2123-2134.

13.         Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K. Epithelial chloride transport by cftr requires tmem16a. Scientific Reports 2017;7:12397.

14.         Sommer A, Kordowski F, Buch J, Maretzky T, Evers A, Andra J, Dusterhoft S, Michalek M, Lorenzen I, Somasundaram P, et al. Phosphatidylserine exposure is required for adam17 sheddase function. Nature communications 2016;7:11523.

15.         Ousingsawat J, Wanitchakool P, Kmit A, Romao AM, Jantarajit W, Schreiber S, Kunzelmann K. Anoctamin 6 mediates effects essential for innate immunity downstream of p2x7-receptors in macrophages. Nat Commun 2015;6:6245-.

16.         Faria D, Schlatter E, Witzgall R, Grahammer F, Bandulik S, Schweda F, Bierer S, Rock JR, Heitzmann D, Kunzelmann K, et al. The calcium activated chloride channel anoctamin 1 contributes to the regulation of renal function. Kindey Int 2014;85:1369-1381.

17.         Buchholz B, Faria D, Schley G, Schreiber R, Eckardt KU, Kunzelmann K. Anoctamin 1 induces calcium-activated chloride secretion and tissue proliferation in polycystic kidney disease. Kidney Int 2014;85:1058-1067.

18.         Almaca J, Faria D, Sousa M, Uliyakina I, Conrad C, Sirianant L, Clarke LA, Martins JP, Santos M, Heriche JK, et al. High-content sirna screen reveals global enac regulators and potential cystic fibrosis therapy targets. Cell 2013;154:1390-1400.

19.         Duvvuri U, Shiwarski DJ, Xiao D, Bertrand C, Huang X, Edinger RS, Rock JR, Harfe BD, Henson BJ, Kunzelmann K, et al. Tmem16a, induces mapk and contributes directly to tumorigenesis and cancer progression. Cancer Res 2012;72:3270-3281.

20.         Martins JR, Faria D, Kongsuphol P, Reisch B, Schreiber R, Kunzelmann K. Anoctamin 6 is an essential component of the outwardly rectifying chloride channel. Proc Natl Acad Sci U S A 2011;108:18168-18172.

21.         Ousingsawat J, Martins JR, Schreiber R, Rock JR, Harfe BD, Kunzelmann K. Loss of tmem16a causes a defect in epithelial ca2+ dependent chloride transport. J Biol Chem 2009;284:28698-28703.

22.         Huber TB, Schermer B, Muller RU, Hohne M, Bartram M, Calixto A, Hagmann H, Reinhardt C, Koos F, Kunzelmann K, et al. Podocin and mec-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A 2006;103:17079-17086.

23.         Kunzelmann K, Bachhuber T, Regeer RR, Markovich D, Sun J, Schreiber R. Purinergic inhibition of the epithelial na+ channel enac via hydrolysis of pip2. FASEB J 2005;18:142-163.

24.         Kunzelmann K, Mall M. Electrolyte transport in the colon: Mechanisms and implications for disease. Physiological Reviews 2002;82:245-289.

25.         König J, Schreiber R, Voelcker T, Mall M, Kunzelmann K. Cftr  inhibits enac through an increase in the intracellular cl- concentration. EMBO Reports 2001;2:1-5.

26.         Kunzelmann K, Beesley AH, King NJ, Karupiah G, Young JA, Cook DI. Influenza virus inhibits amiloride- sensitive na+ channels in respiratory epithelia. Proc Natl Acad Sci U S A 2000;97:10282-10287.

27.         Schreiber R, Hopf A, Mall M, Greger R, Kunzelmann K. The first nucleotide binding fold of the cystic fibrosis transmembrane conductance regulator is important for inhibition of the epithelial na+ channel. Proc Natl Acad Sci USA 1999;96:5310-5315.

28.         Kunzelmann K. The cystic fibrosis transmembrane conductance regulator and its function in epithelial transport. Rev Physiol Biochem Pharmacol 1999;137:1-70.

29.         Mall M, Bleich M, Greger R, Schreiber R, Kunzelmann K. The amiloride inhibitable na+ conductance is reduced by cftr in normal but not in cf airways. J Clin Invest 1998;102:15-21.

30.         Kunzelmann K, Legendre J-Y, Knoell DL, Escobar LC, Xu Z, Gruenert DC. Gene targeting of cftr DNA in cf epithelial cells. Gene Therapy 1996;3:859-867.

PubMed


  1. Fakultät für Biologie und Vorklinische Medizin
  2. INSTITUT FÜR PHYSIOLOGIE

Prof. Dr. med. Karl Kunzelmann


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