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Prof. Dr. Jörg Heilmann

Prof. Heilmann

Lehrstuhlinhaber

Prof. Dr. Jörg Heilmann

Heilmann

Gebäude Chemie-Pharmazie, Zi. CH 14.2.81
Telefon: +49 (0)941 943-4759
Fax: +49 (0)941 943-4990
E-Mail: joerg.heilmann@chemie.uni-regensburg.de


Sekretariat

Verwaltungsangestellte

Hedwig Ohli

Ohli 201908

Gebäude Chemie-Pharmazie, Zi. CH 14.2.82
Telefon: +49 (0)941 943-4761
Fax: +49 (0)941 943-4990
E-Mail: hedwig.ohli@chemie.uni-regensburg.de


Vita

Geburtstag: 28.05.1966

Geburtsort: Mülheim an der Ruhr, Bundesrepublik Deutschland

Eltern: Wilhelm Heilmann, Helma Heilmann, geb. Löhr

Gegenwärtiger Wohnsitz: Regensburg (D)

Berufsausbildung

WS 1985/86 - SS 1990: Studium der Pharmazie an der Heinrich-Heine-Universität Düsseldorf

1990/1991: Pharmaziepraktikum, Löwen Apotheke, Mülheim an der Ruhr

1991: Approbation als Apotheker

Berufliche Tätigkeiten

1991/1992: Angestellter Apotheker, Löwen Apotheke, Mülheim an der Ruhr

1992-1997: Wissenschaftliche Hilfskraft und wissenschaftlicher Angestellter am Institut für Pharmazeutische Biologie der Heinrich-Heine-Universität, Düsseldorf

1997: Angestellter Apotheker, Alte Apotheke Bottrop

1997-1998: Post-Doc am Institut für Pharmazeutische Biologie der Heinrich-Heine-Universität Düsseldorf

1998-2002: Oberassistent und Dozent am Departement Angewandte Biowissenschaften der ETH Zürich, Abteilung Pharmakognosie/Phytochemie

Akademische Laufbahn

1994-1997: Ausbildung zum Fachapotheker für Pharmazeutische Analytik

1997: Promotion ("Phytochemische Untersuchungen der Blüten von Buphthalmum salicifolium L. sowie Studien zur antiphlogistischen Wirkung und zur Penetration von Flavonoiden und deren Metaboliten" unter Anleitung von Frau Prof. Dr. I. Merfort)

1997: Fachapotheker für Pharmazeutische Analytik

1997/1998: Post-Doc in der Arbeitgruppe von Prof. Dr. R. Bauer (Fragestellungen zur Aktivität von Naturstoffen in einem 5-Lipoxygenase Testsystem)

1998-2002: Oberassistent und Dozent in der Arbeitsgruppe von Prof. Dr. O. Sticher

2002: Abgabe der Habilitationsschrift (Biological and chemical investigations on the cytotoxicity and antioxidative activity of natural products)

07.01.2003: Ernennung zum Privatdozenten und Erteilung der Venia legendi für das Fachgebiet Pharmazeutische Biologie

01.04.2002 - 01.07.2003: Kommissarischer Leiter der Arbeitsgruppe Phytochemie/ Pharmakognosie

September 2003: Egon-Stahl Preis in Silber

Oktober 2003: A. Vogel Preis

01.04.2004: Vertretung der C-4 Professur für Pharmazeutische Biologie der Friedrich-Schiller-Universität Jena

August 2004: Ruf auf die C-4 Professur für Pharmazeutische Biologie der Universität Regensburg

01.12.2004: Annahme des Rufs nach Regensburg und Ernennung zum C-4 Professor


Publikationen

I.a. Original Paper

1. Kling B., Bücherl D., Palatzky P., Matysik F.M., Decker M, Wegener J, Heilmann J. Flavonoids, flavonoid metabolites, and phenolic acids inhibit oxidative stress in the neuronal cell line HT-22 monitored by ECIS and MTT assay: A comparative study. Journal of Natural Products in press 2014.

2. Macabeo A.-P.G., Lopez A.D.A., Schmidt S., Heilmann J., Dahse H.-M., Alejandro G.J.D., Franzblau S.G. Antitubercular and cytotoxic constituents from Goniothalamus gitingensis. Records of Natural Products 8, 41-45, 2013.

3. Scherübl R., Manns D., Heilmann J., Franz G. Comparison of HPLC versus HPTLC-densitometry for the quantification of chromone glucosides in Saposhnikoviae divaricatae radix. Chromatographia 76, 1537-1543, 2013.
4. Klein R., Müller E., Kraus B., Brunner G., Estrine B., Touraud D., Heilmann J., Kellermeier M., Kunz W. Biodegradability and cytotoxicity of choline soaps on human cell lines: effects of chain length and the cation. RSC Advances 3, 23347-23354, 2013.

5. Knuth S., Abdelsalam R.M., Khayyal M.T., Schweda F., Heilmann J, Kees M.G., Mair G., Kees F., Jürgenliemk G. Catechol conjugates are in-vivo metabolites of Salicis cartex. Planta Medica 79, 1489-1494, 2013.

6. Oberprieler C., Dietz L., Harlander C., Heilmann J. Molecular and phytochemical evidence for the taxonomic integrity of Salix alba, Salix fragilis and their hybrid S x rubens (Salicaceae) in mixed stands in SE germany. Plant Systematics and Evolution 299, 1107-1118, 2013.7. Barbic M., Willer E.A., Rothenhöfer M., Heilmann J., Fürst R., Jürgenliemk G. Spirostanol saponins and esculin from Rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells. Phytochemistry 90, 106-113, 2013.

8. Nedialkov P.T., Kokanova-Nedialkova Z., Bücherl D., Momekov G., Heilmann J., Nikolov S. 30-Normedicagenic acid glycosides from Chenopodium foliosum. Natural Products Communications 7, 1419-1422, 2012.

9. Schmidt S., Jürgenliemk G., Schmidt T.J., Skaltsa H., Heilmann J. Bi-, tri, and polycyclic acylphloroglucinols from Hypericum empetrifolium. Journal of Natural Products 75, 1697-1705.

10. Darras F., Kling B., Heilmann J., Decker M. Neuroprotective tri- and tetracyclic BChE inhibitors releasing reversible inhibitors upon carbamate transfer. Journal of Medicinal Chemistry Letters 3, 914-919, 2012.

11. Saugspier M., Dorn C., Czech B., Gehrig M., Heilmann J., Hellerbrand C. Hop bitter acids inhibit tumorgenicity of hepatocellular carcinoma cells in vitro. Oncology Reports 28, 1423-1428, 2012.

12. Dorn C., Massinger S., Wuzik A., Heilmann J, Hellerbrand C. Xanthohumol suppresses inflammatory response to warm ischaemia-reperfusion induced liver injury. Experimental and Molecular Pathology 94, 10-16, 2013.

13. Vo H.T., Nguyen N.-T.T., Nguyen H.T., Do K.Q., Connolly J.D., Maas G., Heilmann J., Werz U.R., Pham H.D., Nguyen L.-H.D., Cytotoxic tetraoxygenated xanthones from the bark of Garcinia schomburgkiana, Phytochemistry Letters 5, 553-557, 2012.

14. Ulrich-Merzenich G., Kelber O., Koptina A., Freischmidt A., Heilmann J., Müller J., Zeitler H., Seidel M.F., Ludwig M., Heinrich E.U., Winterhoff H.. Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine. Phytomedicine 19, 930-939, 2012.

15. Nguyen L.-T.T., Nguyen H.T., Harrison L.J., Barbič M., Brunner G., Heilmann J., Pham H.D., Nguyen D.M., Lien-Hoa D. Nguyen L.-H.D. Polyisoprenylated acylphloroglucinols and a polyisoprenylated tetracyclic xanthone from the bark of Calophyllum thorelii. Tetrahedron Letters 53, 4487-4493, 2012.

16. Rothenhöfer M., Scherübl R., Bernhardt G., Heilmann J., Buschauer A. Qualitative and quantitative analysis of hyaluronan oligosaccharides with high performance thin layer chromatography using reagent-free derivatization on amino-modified silica and electrospray ionisation−quadrupole time-of-flight mass spectrometry coupling on normal phase. Journal of Chromatography A 1248, 169-177, 2012.

17. Chen X., Zenger K., Lupp A., Kling B., Heilmann J., Fleck C., Kraus B., Decker M.. A Tacrine-Silibinin co-drug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo. Journal of Medicinal Chemistry 55, 5231-5242, 2012.

18. Dorn C., Heilmann J., Hellerbrand C. Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis. International Journal of Clinical and Experimental Pathology 5, 29-36, 2012.

19. Schmidt S., Jürgenliemk G., Skaltsa H., Heilmann J. Phloroglucinol derivatives from Hypericum empetrifolium with antiproliferative activity on endothelial cells. Phytochemistry 77, 218-225, 2012.20. Win T., Htwe T.T., Shwe H.H., Heilmann J. Lavandulyl flavanones from the stems of Hypericum calycinum L. Chemistry and Biodiversity 9, 1198-1204, 2012.

21. Saugspier M., Dorn C., Thasler W.E., Gehrig M., Heilmann J., Hellerbrand C. Hop bitter acids exhibit anti-fibrogenic effects on hepatic stellate cells in vitro. Experimental and Molecular Pathology 92, 222-229, 2012.

22. Ulrich-Merzenich G, Koptina A, Kelber O, Freischmidt A, Heilmann J, Müller J, Sadeghlar F, Zeitler H, Wagner H. Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine. Phytomedicine 19, 322-329, 2012.

23. Freischmidt A., Jürgenliemk G., Kraus B., Okpanyi S.N., Müller J., Kelber O., Weiser D., Heilmann J. Contribution of flavonoids and catechol to the reduction of ICAM-1 expression in endothelial cells by a standardized Willow bark extract. Phytomedicine 19, 245-252, 2012.

24. Motyl M., Kraus B., Heilmann J. Pitfalls in cell culture work with xanthohumol. Die Pharmazie 67, 91-94, 2012.

25. Wolff H, Motyl M, Hellerbrand C, Heilmann J, Kraus B. Xanthohumol uptake and intracellular kinetics in hepatocytes, hepatic stellate cells and intestinal cells. Journal of Agricultural and Food Chemistry 59, 12893-12901, 2011.

26. Kokanova-Nedialkova Z., Bücherl D., Nikolov S., Heilmann J., Nedialkov P.T., Flavonol glycosides from Chenopodium foliosum Asch. Phytochemistry Letters 4, 367-371, 2011.

27. Bradacs G., Heilmann J., Weckerle C.S. Medicinal plant use in Vanuatu, South Pacific: A comparative ethnobotanical study of three islands. Journal of Ethnopharmacology 137, 434-448, 2011.

28. Sutor S., Heilmann J., Seifert, R. Impact of Fusion to Gαi2 and Co-Expression with RGS proteins on pharmacological properties of hCBR Journal of Pharmacy and Pharmacology 63, 1043-1055, 2011.

29. Oberprieler Ch., Hartl S., Schauer K. Heilmann, J. Morphological, phytochemical, and genetic variation in mixed stands and a hybrid swarm of Senecio germanicus and S. ovatus (Compositae, Senecioneae). Plant Systematics and Evolution 293, 177-191, 2011.

30. Macabeo A.P.G., Vidar W.S., Chen X., Decker M., Heilmann J., Wan B., Franzblau S.G., Galvez E.V., Aguinaldo M.A.M., Cordell G.A. Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa. European Journal of Medicinal Chemistry 46, 3118-3123, 2011.

31. Schempp H., Vogel S., Hückelhoven R., Heilmann J. Re-evaluation of superoxide scavenging capacity of xanthohumol. Free Radical Research 44, 1435-1444, 2010.

33. Geiger S., Nickl K., Schneider E.H., Seifert R., Heilmann J. Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands; Naunyn Schmiedebergs Archives of Pharmacology 382, 177-191, 2010.

34. Barbic M., Macabeo A.P.G., Kreft S., Heilmann J. (2010) Cycloastragenol glycosides from Astragalus illyricus. Biochemical Systematics and Ecology 38, 460-462.

35. Dorn C., Bataille F., Gaebele E., Heilmann J., Hellerbrand C. Xanthohumol feeding does not impair organ function and homoeostasis in mice. Food and Chemical Toxicology 48, 1890-1897, 2010.

36. Oberprieler C., Barth A., Schwarz S., Heilmann J. Morphological and phytochemical variation, genetic structure, and phenology in an introgressive hybrid swarm of Senecio hercynicus and S. ovatus (Compositae, Senecioneae). Plant Systematics and Evolution 286, 153-166, 2010.

37. Rook Y., Schmidtke K.-U., Gaube F., Schepmann D., Wünsch B., Heilmann J., Lehmann J., Winckler T. Bivalent β-carbolines as potential multi-target anti-Alzheimer agents. Journal of Medicinal Chemistry 53, 3611-3617, 2010.

38. Kraus B., Wolff H., Elstner E.F., Heilmann J. Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages. Naunyn Schmiedeberg’s Archives of Pharmacology 381, 541-553, 2010.

39. Vogel S., Barbic M., Jürgenliemk G., Heilmann J. Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-Ring modifications on the pharmacological effect. European Journal of Medicinal Chemistry 45, 2206-2213, 2010.

40. Seemann A., Wallner T., Poschlod P., Heilmann J. Variation of sesquiterpene lactone contents in different Arnica montana populations: Influence of ecological parameters. Planta Medica 76, 837-842, 2010.

41. Dorn C., Weiss T.S., Heilmann J., Hellerbrand C. Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells. International Journal of Oncology 36, 435-441, 2010.

42. Dorn C., Kraus B., Motyl M., Weiss T. S., Gehrig M., Heilmann J., Hellerbrand C. Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis. Molecular Nutrition and Food Research 54, Suppl.2, S205-S213, 2010.

43. Shwe H.H., Aye M., Sein M.M., Htay K.T., Kreitmeier P., Gertsch J., Reiser O., Heilmann J. Cytotoxic steroidal saponins from the rhizomes of Tacca integrifolia. Chemistry & Biodiversity 7, 610-623, 2010.

44. Bradacs G., Maes L., Heilmann J. In vitro cytotoxic, antiprotozoal and antimicrobial activities of medicinal plants from Vanuatu. Phytotherapy Research 24, 800-809, 2010.

45. Korte G., Dreiseitel A., Schreier P., Oehme A., Geiger S., Heilmann J., Sand P.G. Tea catechins’ affinity for human cannabinoid receptors. Phytomedicine 17, 19-22, 2010.

46. Šlapetová T., Šmejkal K., Innocenti G., Dall’Acqua S., Heilmann J., Babula P. Hamzová T., Žemlička M. Glycosylated nervogenic acid derivatives from Liparis condylobulbon (Reichb.f.) leaves. Carbohydrate Research 344, 1770-44, 2009.

47. Hartkorn A., Hoffmann F., Ajamieh H., Vogel S., Heilmann J., Gerbes A.L., Vollmar A.M., Zahler S. Antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury. Journal of Natural Products 72, 1741-1747, 2009.

48. Vlachy N., Tourad D., Heilmann J., Kunz W. (2009) Determining the cytotoxicity of catanionic surfactant mixtures on HeLa cells. Colloids Surf B Biointerfaces 70, 278-280, 2009.

49. Eggert M., Pellett P., Nickl K., Geiger S., Graetz, S., Seifert R., Heilmann J., König B. Synthesis and cannabinoid receptor activity of ketoalkenes from Echinacea pallida and non-natural analogues. Chemistry-A European Journal 14, 10978-10984 , 2008.

50. Vogel S., Heilmann J. Synthesis, cytotoxicity and anti-oxidative activity of minor prenylated chalcones from Humulus lupulus. Journal of Natural Products 71, 1237-1241, 2008.

51. Vlachy N., Merle C., Touraud D., Schmidt J., Talmon Y., Heilmann J., Kunz W. Spontaneous formation of bilayers and vesicles in mixtures of single-chain alkyl carboxylates: Effect of pH and aging and cytotoxicity studies. Langmuir 24, 9983-9988,

52. Fang L., Kraus B., Lehmann J., Heilmann J., Zhang Y., Decker M. Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates. Bioorganic and Medicinal Chemistry Letters 18, 2905-2909, 2008.

53. Vogel S., Ohmayer S., Brunner G., Heilmann J. Natural and non-natural prenylated chalcones: Synthesis, cytotoxicity and anti-oxidative activity. Bioorganic and Medicinal Chemistry 16, 4286-4293, 2008.

54. Nickl K., Gardner E., Geiger S., Heilmann J., Seifert R. Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein Galphai2beta1gamma2. Neuroscience Letters 447, 68-72, 2008.

55. Decker M., Kraus B., Heilmann J. Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties. Bioorganic and Medicinal Chemistry 16, 4252-4261, 2008.

56. Kraus B., Wolff H., Heilmann J., Elstner E.F. Influence of Hypericum perforatum extract and its single compounds on amyloid- mediated toxicity in microglial cells. Life Sciences 81, 884-894, 2007.

57. Karioti A., Skopeliti M., Tsitsilonis, O., Heilmann, J., Skaltsa H. Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum. Phytochemistry 68, 1587-1594, 2007.

58. Romagnoli R., Baraldi P.G., Carrion M.D., Cruz-Lopez O., Preti D., Tabrizi M. A., Fruttarolo F., Heilmann J., Bermelo J., Estevez F. Hybrid molecules containing benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazole and alpha-bromoacryloyl moieties as potent apoptosis inducers on human myeloid leukaemia cells. Bioorganic and Medicinal Chemistry Letters 17, 2844-2848, 2007.

59. Gousiadou C., Karioti A., Heilmann J., Skaltsa H. Iridoids from Scutellaria albida ssp. albida. Phytochemistry 68, 1799-1813, 2007.

60. Saraglou V., Karioti A., Heilmann J., Kypriotakis Z., Skaltsa H. Sesquiterpene lactones from Anthemis melanolepis. Helvetica Chimica Acta 90, 171-175, 2007.

61. Parakevi P., Lazari D., Karioti A., Souleles C., Heilmann J., Hajipavlou-Litina D., Skaltsa H. Phenolic compounds with antioxidant activity from Anthemis tinctoria L. subsp. tinctoria var. pallida DC. (Asteraceae). Zeitschrift für Naturforschung C 62, 326-330, 2007.

62. Skaltsa H., Georgakopoulos P., Lazari D., Karioti A., Heilmann J., Sticher O., Constantinidis Th. Flavonoids as chemotaxonomic markers in the polymorphic Stachys swainsonii (Lamiaceae). Biochemical Systematics and Ecology 35, 317-320, 2007.

63. Çalış I., Birincioğlu S.S., Kırmızıbekmez H., Pfeiffer B., Heilmann J. Secondary Metabolites from Asphodelus aestivus. Zeitschrift für Naturforschung 61b, 1304-1310, 2006.

64. Kelber O., Wittwer A., Lapke C., Kroll U., Weiser D., Okpanyi S.N., Heilmann J. Ex vivo/in vitro absorption of STW 5 (Iberogast®) and its extract components. Phytomedicine 13 Suppl. 1, 107-113, 2006.

65. Romagnoli R., Baraldi P.G., Iaconinoto M.A., Carrion M.D., Tabrizi M.A., Gambari R., Borgatti M., Heilmann J. Synthesis and biological activity of alpha-bromoacryloyl lexitropsin conjugates. European Journal of Medicinal Chemistry 40, 1123-1128, 2005.

66. Karioti A., Heilmann J., Skaltsa H. Labdane diterpenes from Marrubium velutinum and Marrubium cylleneum, Phytochemistry 66, 1060-1066, 2005.

67. Karioti A., Heilmann J., Skaltsa H. Secondary metabolites from Marrubium velutinum, growing wild in Greece. Zeitschrift für Naturforschung 60b, 328-332, 2005.

68. Cottiglia F., Casu L., Bonsignore L., Casu M. Floris C., Leonti M., Gertsch J., Heilmann J. New cytotoxic prenylated isoflavonoids from Bituminaria morisiana. Planta Medica 71, 254-260, 2005.

69. Meremeti A., Karioti A., Skaltsa H., Heilmann J., Sticher O. Secondary metabolites from Stachys ionica. Biochemical Systematics and Ecology 32, 139-151, 2004.

70. Cottiglia F., Dhanapal B., Sticher O., Heilmann J. New chromanone acids with anti-bacterial activity from Calophyllum brasiliense. Journal of Natural Products 67, 537-541, 2004.

71. Gertsch J., Sticher O., Schmidt T.J., Heilmann J. Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T-cells and human peripheral blood cells: Anti-inflammatory and cytotoxic effects. Biochemical Pharmacology 66, 2141-2153, 2003.

72. Hördegen P., Hertzberg H., Heilmann J., Gray D., Langhans W., Maurer V. The anthelmintic efficacy of five plant products against gastrointestinal trichostrongylids in artificially infected lambs. Veterinary Parasitology, 17, 56-60, 2003.

73. Hilmi F., Gertsch J., Bremner P., Valovic S., Heinrich M., Sticher O., Heilmann J. Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-type sesquiterpene lactones. Bioorganic and Medicinal Chemistry 11, 3659-3663, 2003.

74. Winkelmann K., Metin S., Kypriotakis Z., Skaltsa H., Bosilij B., Heilmann J. Antibacterial and cytotoxic activity of prenylated bicyclic acylphloroglucinol derivatives from Hypericum amblycalyx. Zeitschrift für Naturforschung 58c, 527-532, 2003.

75. Karioti A., Skaltsa H., Heilmann J., Sticher O. Acylated flavonoid and phenylethanoid glycosides from Marrubium velutinum. Phytochemistry 64, 655-660, 2003.

76. Gertsch J., Thöni Tobler R., Brun R., Sticher O., Heilmann J. Antifungal, antiprotozoal, cytotoxic and properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum. Planta Medica 69, 413-419, 2003.

77. Akbay P., Çalis I. Heilmann J., Sticher, O. Ionone, iridoid and phenylethanoid glycosides from Ajuga salicifolia. Zeitschrift für Naturforschung 58c, 177-180, 2003.

78. Akbay P., Çalis I., Heilmann J., Sticher O. New stigmastane sterols from Ajuga salicifolia. Journal of Natural Products 66, 461-465 2003.

79. Sagen A.-L., Gertsch J., Becker R., Heilmann J., Sticher O. Quinolizidine alkaloids from the curare plant Clathrothropis glaucophylla. Phytochemistry 61, 975-978, 2002.

80. Heilmann J., Winkelmann K., Sticher O. Studies on the antioxidative activity of phloroglucinol derivatives isolated from Hypericum species. Planta Medica 69, 193-201, 2003.

81. Mian P., Heilmann J., Bürgi H.-R., Sticher O. Biological screening of terrestrial and freshwater cyanobacteria for antimicrobial activity, brine shrimp lethality, and cytotoxicity. Pharmaceutical Biology 41, 243-247, 2003.

82. Hilmi F., Sticher O., Heilmann J. Further new cytotoxic sesquiterpene lactones from Warionia saharae. Planta Medica 69, 459-461, 2003.

83. Gertsch J., Güttinger M., Heilmann J., Sticher O. Curcumin differentially modulates mRNA profiles in Jurkat T and human mononuclear cells. Bioorganic and Medicinal Chemistry 11, 1057-1063, 2003.

84. Schmidt T.J., Heilmann J. Quantitative Structure-Cytotoxicity Relationships of sesquiterpene lactones derived from partial charge-based fractional Accessible Surface Area Descriptors (Q_frASAs). Quantitative Structure Activity Relationships 21, 277-287, 2002.

85. Akbay P., Çalıs I., Gertsch J., Heilmann J., Zerbe O., Sticher O. Novel antileukemic sterol glycosides from Ajuga salicifolia. Helvetica Chimica Acta 85, 1930-1942, 2002.

86. Prinz S., Müllner U., Heilmann J., Winkelmann K., Sticher O., Haslinger E., Hüfner A. New oxidation products of abietic acid and its methyl ester. Journal of Natural Products 65, 1530-1534, 2002.

87. Hilmi F., Sticher O., Heilmann J. New cytotoxic 6,7-cis and 6,7-trans configured guaianolides from Warionia saharae. Journal of Natural Products 65, 523-526, 2002.

88. Gertsch J., Güttinger M., Sticher O., Heilmann J. Relative quantification of mRNA levels in Jurkat T cells with RT – real time – PCR: New possibilities for the screening of anti-inflammatory and cytotoxic natural compounds. Pharmaceutical Research 19, 1235-1242, 2002.

89. Jager H., Meinel L., Dietz B., Lapke C., Bauer R., Merkle H.P., Heilmann J. Transport of alkamides from Echinacea species through Caco-2 monolayers. Planta Medica 68, 469-471, 2002.

90. Winkelmann K., Heilmann J., Zerbe O., Rali T., Sticher O. Further prenylated bi- and tricyclic phloroglcinol derivatives from Hypericum papuanum. Helvetica Chimica Acta 84, 3380-3392, 2001.

91. Heilmann J., Wasescha M.R., Schmidt T.J. The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells. Bioorganic and Medicinal Chemistry 9, 2189-2194, 2001.

92. Heilmann J., Brun R., Mayr S., Rali T., Sticher O. Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum. Phytochemistry 57, 1281-1285, 2001.

93. Çalis I., Heilmann J., Tasdemir D., Linden A., Ireland C., Sticher O. Flavonoid, iridoid and lignan glycosides from Putoria calabrica. Journal of Natural Products 64, 961-964, 2001.

94. Dietz B., Heilmann J., Bauer R. Absorption of dodeca-2E, 4E, 8Z, 10 E/Z-tetraenoic acid isobutylamides after oral application of Echinacea purpurea tincture. Planta Medica 67, 863-864, 2001.

95. Winkelmann K., Heilmann J., Zerbe O., Rali T., Sticher O. New prenylated bi- and tricyclic phloroglucinol derivatives from Hypericum papuanum. Journal of Natural Products 64, 701-706, 2001.

96. Resch M., Heilmann J., Steigel A., Bauer R. Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity. Planta Medica 67, 437-442, 2001.

97. Heilmann J., Mayr S., Brun R., Rali T., Sticher O. Antiprotozoal activityand cytotoxicity of novel 1,7-dioxa-dispiro[5.1.5.2]pentadeca-9,12-dien-11-one derivatives from Amomum aculeatum. Helvetica Chimica Acta 83, 2939-2945, 2000.

98. Liu H., Heilmann J., Rali T., Sticher O. New Tirucallane-type triterpenes from Dysoxylum variabile. Journal of Natural Products 64, 159-163, 2001.

99. Jaki B., Zerbe O., Heilmann J., Sticher, O. Two novel cyclic peptides with antifungal activity from the cyanobacterium Tolypothrix byssoidea (EAWAG 195). Journal of Natural Products 64, 154-158, 2001.

100. Wirz A., Simmen U., Heilmann J., Çalis I., Meier B., Sticher O. Bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors. Phytochemistry 55, 941-947, 2000.

101. Jaki B., Heilmann J., Sticher O. New antibacterial metabolites from the cyanobacterium Nostoc commune (EAWAG 122b). Journal of Natural Products 63, 1283-1285, 2000.

102. Quadri-Spinelli T., Heilmann J., Rali T., Sticher O. Bioactive coumarin derivatives from the fern Cyclosorus interruptus. Planta Medica 66, 728-733, 2000.

103. Schühly W., Heilmann J., Çalis I., Sticher O. Novel triterpene saponins from Zizyphus joazeiro. Helvetica Chimica Acta 83, 1509-1515, 2000.

104. Heilmann J., Çalis I, Kirmizbekmez H., Schühly W., Harput S., Sticher O. Radical scavenger activity of phenylethanoid glycosides in FMLP stimulated human polymorphonuclear leukocytes – structure activity relationships. Planta Medica 66, 746-748, 2000.

105. Schmidt T.J., Heilmann J. Tetrahydrofuran lignans from Illicium floridanum and their activity in a luminol enhanced chemiluminescence assay. Planta Medica 66,749-751, 2000.

106. Ankli A., Heilmann J., Heinrich M., Sticher O. Cytotoxic cardenolides and anti¬bacterial terpenoids from Crossopetalum gaumeri. Phytochemistry 54,531-537, 2000.

107. Winkelmann K., Heilmann J., Zerbe O., Rali T., Sticher O. New phloroglucinol derivatives from Hypericum papuanum. Journal of Natural Products 63, 104-108, 2000.

108. Jaki B., Orjala J., Heilmann J., Vogler B., Sticher O. Novel extracellular diterpenoids with biological activity from cyanobacterium Nostoc commune. Journal of Natural Products 63, 339-343, 2000.

109. Schühly W., Heilmann J., Çalis I., Sticher, O. New triterpenoids with antibacterial activity from Zizyphus joazeiro. Planta Medica 65, 740-743, 1999.

110. Heilmann J., Müller E., Merfort I. Flavonoid glucosides and dicaffeoylquinic acids from flowerheads of Buphthalmum salicifolium. Phytochemistry 51, 713-718, 1999.

111. Lobitz G.O., Heilmann J., Zschocke S., Tamayo-Castillo G., Bauer R., Merfort I. Bornyl cinnamate derivatives with anti-inflammatory activity from Verbesina turbacensis. Pharmaceutical and Pharmacological Letters 8, 115-118, 1998.

112. Heilmann J., Resch M., Bauer R. Antioxidant activity of constituents from Atractylodes lancea. Pharmaceutical and Pharmacological Letters 8, 69-71, 1998.

113. Merfort I., Heilmann J., Weiss M., Pietta P., Gardana C. Radical scavenger activity of three flavonoid metabolites studied by inhibition of chemiluminescence in human PMNs. Planta Medica 62, 289-292, 1996.

114. Heilmann J., Merfort I., Weiss M. Radical scavenger activity of different 3’,4’-dihydroxy-flavonols and 1,5-dicaffeoylquinic acid studied by inhibition of chemiluminescence. Planta Medica 61, 435-438, 1995.

115. Merfort I., Heilmann J., Hagedorn-Leweke U., Lippold B.C. In vivo skin penetration studies of chamomile flavones. Pharmazie 49, 509-511, 1994.

I.b. Reviews

1. Heilmann J., Wirkstoffe auf der Basis von biologisch aktiven Naturstoffen, Chemie in unserer Zeit 41, 376-389, 2007.

2. v. Raison J., Heilmann J., Merfort I., Schmidt T.J., Brock F.E., Leven W., Bomme U., Bauer R. Arnika - Arzneipflanze mit Tradition und Zukunft, Zeitschrift für Phytotherapie 21, 39-54, 2000.

3. Heilmann J., Merfort I. Aktueller Kenntnisstand zum Metabolismus von Flavonoiden. II. Resorption und Metabolismus von Flavonen, Flavanonen, Flavanen, Proanthocyanidinen und Isoflavonoiden, Pharmazie in unserer Zeit 27, 173-183, 1998.

4. Heilmann J., Merfort I. Aktueller Kenntnisstand zum Metabolismus von Flavonoiden. I. Resorption und Metabolismus von Flavonolen, Pharmazie in unserer Zeit 27, 58-65, 1998.

5. Merfort I., Heilmann J. Bericht über die 41. Jahrestagung der Gesellschaft für Arzneipflanzenforschung in Düsseldorf, Pharmazie in unserer Zeit 22, 323-328, 1993.

I.c. Buchkapitel

1. Functions of plant secondary metabolites and their applications in biotechnology, Annual Plant Reviews, Volume 3 (1999/2010), Edited by Michael Wink, Sheffield Academic Press Ltd.. Medical applications of plant secondary metabolites.



  1. STARTSEITE UR

Pharmazeutische Biologie

Prof. Dr.
Jörg Heilmann
Heilmann1
SeKRETARIAT

Raum CH 14.2.82
Tel.: 0941-943-4761
Fax: 0941-943-4990
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