Chiral separations of stereoisomers

• Preparative separation of enantiomers via
  • fractionated crystallization of diastereomeric salts
  • normal or reversed phase HPLC of diastereomeric derivatives
• Analytical separation by CE using cyclodextrins as chiral selectors or by HPLC using chiral stationary phases

Selected Publications:

• A. Schuster, G. Bernhardt, E. Eibler, A. Buschauer, W. Hesselink, Chiral separation of 3-phenyl-3-(2-pyridyl)propylamines, and analogous guanidines and guanidine-N-carboxylic acid esters with HPLC and CZE. J. Chromatogr. A 793, 77-90 (1998).
• A. Schuster, S. Bollwein, A. Uffrecht, V. Krey, C. Götte, G. Bernhardt, A. Buschauer, Stereochemical Investigations on Intermediates for the Synthesis of Histamine H₂ Receptor Agonists and Neuropeptide Y Y₁ Antagonists: Chiral Separation of Phenyl(pyridyl)alkanoic Acids by HPLC and CE. Sci. Pharm. 66, 263-278 (1998).
• M. Zabel, J. Breu, F. Rau, K.-J. Range, V. Krey, A. Uffrecht, A. Buschauer, Absolute configuration of (-)-4-(3,4-dichlorophenyl)-4-(2-pyridyl)butanoic acid: essential information to determine crucial steric feature of arpromidine-type histamine H₂ receptor agonists. Acta Cryst. C 56, 250-251 (2000)
• A. Schuster, C. Götte, G. Bernhardt, A. Buschauer, Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods.
  Chirality, 13, 285-93 (2001)