Our lab is focused on the design of new biomaterials, the investigation of strategies for the repair or replacement of damaged tissues, and the development of innovative drug delivery systems. We always welcome undergraduates, graduate students, and researchers with background in fields such as pharmacy, chemistry, and biology to apply and join our research team. For more information, please contact Prof. Dr. Achim Göpferich and submit a brief statement of your reason for applying.
Nanoparticles are subject to limited biodistribution due to their size and physicochemical properties which is a severe handicap for their therapeutic application. An exception is tumor tissue into which nanoparticles may extravasate through endothelial fenestrations. These openings stem from changes in malignant tissue blood vessels, particularly in capillaries. But endothelial fenestrations also exist in the capillaries of healthy tissues such as the kidneys’ glomeruli and the choroid... more.
Interactions of cells or tissues on the one side and materials on the other side play a crucial role in numerous applications in pharmaceutical science or biomedicine. Specific interactions between the two may be applied to trigger a desired cell behavior that is beneficial for cell culture or tissue engineering to mention two examples. In these cases the material surface area can exceed the cellular surface area by orders of magnitude. However, also in the reverse scenario when nanomaterials encounter cells or tissues, specific interactions play an outstanding role too. In this context our group focuses on investigatiing interactions of functionalized nanoparticles with therapeutically relevant target-cells...more.
The pharmacological properties of drug substances are the basis of an effective pharmacotherapy. Nevertheless, their physicochemical properties often impede an application using conventional dosage forms. Due to insufficient stability, low solubility or unfavorable biodistribution of drug molecules, their therapeutic efficacy can be moderate... more.