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GWAS summary statistics

Regensburger GEM Plattform

GWAS summary statistics

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Prof. Dr. Iris Heid, Dr. Thomas Winkler, Dr. Mathias Gorski, Kira Stanzick


Estimated glomerular filtration rate (Stanzick et al. 2020)

Here will be posted GWAS summary stats for eGFR (based on creatinine) from a meta-analysis of CKDGen and UK Biobank (see our preprint Stanzick et al. bioRxiv 2020 for details). 

The data will be posted after acceptance of the paper, which is currently under review.

If you would like to access the data before publication, please contact thomas.winkler@ukr.de with a short project description.


Rapid kidney function decline (Gorski et al. 2020)

Rapid kidney function decline - Summary Statistics

Download summary statistics: 

[available soon]

If you use this data, please cite: 

Gorski M, et al. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline. Kidney Int. 2020 Oct 30:S0085-2538(20)31239-4. doi: 10.1016/j.kint.2020.09.030. Epub ahead of print. PMID: 33137338.

Format: 

rsid: rs identifier

chr: Chromosom

pos_b37: Base position (b37)

ea: Effect allele

oa: Other allele

eaf: Effect allele frequency

beta: Genetic effect (per ea)

se: Standard error of beta (single study-specific GC correction)

se_2gc: Standard error of beta (double GC correction)

p: Association P value (single study-specific GC correction)

p_2gc: Association P value (double GC correction) 

n_cases: Number of early AMD cases

n_ctrls: Number of controls

Contact: 

mathias.gorski@ukr.de, iris.heid@ukr.de


Early AMD (Winkler et al. 2020)

Early AMD - Summary Statistics

This site provides a download link for the summary statistics from our genome-wide association meta-analysis for early AMD (17,539 early AMD cases; 105,395 controls). The meta-analysis included summary statistics from 11 sources, including data from the International AMD Genomics Consortium (IAMDGC) and the UK Biobank.

Download summary statistics: 

winkler_et_al_earlyamd_meta.gz

The data is also available from the GWAS catalogue.

If you use this data, please cite: 

Winkler, T.W., Grassmann, F., Brandl, C. et al. Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease. BMC Med Genomics 13, 120 (2020). https://doi.org/10.1186/s12920-020-00760-7

Format: 

rsid: rs identifier

chr: Chromosom

pos_b37: Base position (b37)

ea: Effect allele

oa: Other allele

eaf: Effect allele frequency

beta: Genetic effect (per ea)

se: Standard error of beta (single study-specific GC correction)

se_2gc: Standard error of beta (double GC correction)

p: Association P value (single study-specific GC correction)

p_2gc: Association P value (double GC correction) 

n_cases: Number of early AMD cases

n_ctrls: Number of controls

Contact: 

thomas.winkler@ukr.de, iris.heid@ukr.de

  1. Fakultät für Medizin

Lehrstuhl für Genetische Epidemiologie

Institut für Epidemiologie und Präventivmedizin

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Universitätsklinikum Regensburg
Franz-Josef-Strauß-Allee 11
93053 Regensburg