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Silke Wiesner



Our group studies the molecular mechanisms underlying protein ubiquitylation using NMR spectroscopy, X-ray crystallography and biochemical methods. Many proteins localize in the cell to specific compartments and function only for a limited amount of time. To remove mislocalized or no longer required proteins ubiquitin, a ~10 kD protein, is attached to these proteins. The ubiquitylation reaction involves three enzymes whose exact catalytic mechanisms are unknown. Mutations in ubiquitylation enzymes give rise to severe cellular dysfunctions that cause numerous human diseases including cancer. We seek to understand how ubiquitylation enzymes function on an atomic level, how their activities are controlled and how ubiquitylation regulates cellular behavior.



1998 - 2003: Undergraduate studies in Chemistry ("Vordiplom") and Biochemistry ("Diplom"), Free University of Berlin, Germany
1997 - 1998: Erasmus Exchange student at the Ecole Nationale Superieure de Chimie, Montpellier, France
1998: Diploma Thesis at Lund University, Sweden
1998 - 2003: Gruduate student at EMBL Heidelberg, Germany
2003: PhD, Free University of Berlin / EMBL Heidelberg
2003 - 2008: Postdoctoral fellow, Hospital for Sick Children, University of Toronto, Canada
2008 - 2017: Group Leader, Max Planck Institute for Developmental Biology, Tübingen, Germany
Since 2017: Group Leader / Lecturer, University of Regensburg, Germany


Ubiquitin-dependent Cell Signaling


Phone: +49-(0)941-943-7752


E-mail: Silke.Wiesner [at] ur.de