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Biophysics I

Faculty of Biology and Preclinical Medicine
Regensburg Center for Biochemistry
Biophysics I


Remco Silke Nmr Druck

Research

The functions of proteins rely on their structures and the structural changes they can undergo. Structural biology hence provides unique insights into biomolecular function and thereby into cellular processes. Furthermore, the knowledge of protein structures is an invaluable starting point in the development of drugs to treat human disease. Nuclear magnetic resonance (NMR) spectroscopy is the only method available to study biomolecular structure and dynamics with atomic resolution in solution. NMR provides information on the three-dimensional fold of proteins and the way proteins interact with other biomolecules. Finally, NMR spectroscopy gives insights into how protein complexes move and change conformation, aspects that are important for many enzymatic reactions. The information gained by NMR about biomolecular structure, interactions and dynamics allows us to understand how proteins are able to perform specific tasks in the cell.

Group Picture 1 2021

top left to bottom right: Jan Overbeck, Remco Sprangers, Daniela Lazzaretti, Jakob Schneider, Philip Wurm, Kathi Glowacz, David Stelzig, Johanna Stöfl, Julian Huebner, Jobst Liebau, Simon-Peter Grunert, Alex Schmalix, Werner Kremer, Christina Krempl, Silke Wiesner, Olga Rudi.


Team

Name
Phone
room
Email
Team Leaders
Prof. Dr. Remco Sprangers 7751 7.2.07 Email
Prof. Dr. Werner Kremer 2185 7.2.09a Email
Dr. Silke Wiesner 7752 7.2.25 Email
Prof. Dr. Dr. Hans-Robert Kalbitzer (emeritus) 2594 7.2.09 Email
SECRETARIAT
Patricia Albrecht 2194 7.2.08 Email
Technical Assistants
Johanna Stöfl (wet lab) 7753 7.2.07 Email
Simon Peter Grunert (NMR) 4181 7.2.24 Email
Post-docs
Philip Wurm 2491 7.2.07 Email
Daniela Lazzaretti 2491 7.2.07 Email
Jobst Liebau 2491 7.2.07 Email
PHD  Students
Jan Overbeck 2491 7.2.07 Email
Carsten Stollmaier 4181 7.2.24 Email
Julian Hübner 2495 7.2.05 Email
Christina Krempl 2941 7.2.07 Email
Alexander Schmalix 4181 7.2.24 Email

 

Masters students
Jakob Schneider 2495 7.2.05 Email
David Stelzig 2941 7.2.07 Email
Bachelor students
visiting students

contact

Group Picture 2 2021

 
Address:

University of Regensburg
Universitätsstrasse 31
93053 Regensburg

How to get to us?

Due to ongoing construction sites on the campus, you might like to consult the university's navigation system UR walking.

If you prefer a map, look here.

Our labs and offices are located on the second floor.

 
Postal Address:
University of Regensburg
93040 Regensburg

Secretary:
Room 7.2.08
Phone +49-941-943 2194
Fax +49-941-943 2479

Overview of Telephone Numbers:

Office Remco Sprangers (7.2.07): 7751

Office Silke Wiesner (7.2.25): 7752

Office Werner Kremer (7.2.09a): 2185

Sekretariat (7.2.08): 2194

Office Team Sprangers I (7.2.06): 2491

Office Team Sprangers II (7.2.05): 2495

Office Team Wiesner (7.2.24): 4181

Lab Sprangers (7.2.03/04): 7753

Lab Wiesner (7.2.22/23): 7754

500 MHz Spectrometer: 2184 (only from inside University)

600 MHz Spectrometer: 4183 (only from inside University)

800 MHz Spectrometer: 2848 (only from inside University)

NMR Operating And Usage Concept


publications

Vacancies

Bachelor and Masters theses

Students interested in doing their Bachelor or Masters thesis in the Sprangers or Wiesner lab are welcome to contact us. There is a range of possible projects with a combination of structural biology and biochemical and biophysical methods.


PhD students and Postdocs

We have an open position for a Postdoc and for a PhD student.


Our lab is interested in applying and developing methods in NMR spectroscopy (including methyl TROSY techniques) for very large protein complexes (> 100 kDa). Our aim is to understand how motions in large enzyme complexes influence function.

Methodologically, we combine high resolution NMR spectroscopy with other structural techniques (X-ray crystallography, cryo-EM), biophysical methods (including ITC, fluorescence anisotropy), activity measurements and protein/RNA chemistry. From a biological point of view our interests are enzymes that are involved in the degradation of mRNA.

Our wetlabs and offices are newly renovated and fully equipped for modern molecular biology methods. In addition, we run three NMR spectrometers (800, 600 and 500 MHz) are equipped with new consoles and cryo/prodigy prodeheads.

Regensburg is a lively and attractive UNESCO world heritage city with a high density of pubs and bars. The faculty of biology at the Regensburg university has a focus on RNA biology.

We are looking for enthousisatic PhD/ Postdoc candidates with a strong interest and background in biomolecular NMR spectroscopy. In addition, experience in standard molecular biology techniques (cloning, protein expression and purification) is a strong plus.

Interested candidates should contact me directly (remco.sprangers@ur.de) and include names of two peers that can provide letters of recommendations. In addition, a concise description of skills, previous work experiences and scientific interest should be included.



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Biophysik 1

Bio-molecular NMR spectroscopy