The overarching aim of our research is to understand how local immune responses are orchestrated to maintain tissue homeostasis under inflammatory conditions. Specifically, we want to understand the crosstalk of tissue resident immune cells and the surrounding tissue and to understand the underlying molecular mechanisms by which pro- and anti-inflammatory stimuli determine the outcome of local immune responses. Deficiencies in local immune regulation often lead to inflammation-associated diseases, such as fibrotic diseases, atherosclerosis or arthritis, as well as to auto-immune diseases or allergies. Thus, a better understanding of the fundamental mechanisms that regulate local immune responses are of central importance in order to find more efficient ways of treating such diseases.
Together with researchers from the University Hospital Regensburg and from the Leibnitz Institute for Immunotherapy we intend to use this knowledge to develop novel therapeutic approaches for the treatment of inflammation-associated diseases.
2021 - current Chair for Immune Cell Communication, University Hospital Regensburg / Institute of Immune Medicine, Regensburg, Germany
2017 - current Reader in Immunology, University of Edinburgh / Institute of Immunology and Infection Research
2013 - 2017 Lecturer in Immunology and Chancellor's Fellow, University of Edinburgh / Institute of Immunology and Infection Research
2006 - 2013 Group Leader, University of Utrecht, The Netherlands, Faculty of Veterinary Medicine (Immunology)
2002 - 2005 Post-Doc, University of Rochester, NY, USA- Dr. Tim Mosmann (Immunology)
1996 - 2000 Ph.D., Humboldt University, Berlin - Dr. P-M. Kloetzel (Cell Biology)
1993 - 1996 M.Sc. Syracuse University, NY, USA - Dr. John Belote (Cell and Molecular Biology)
Minutti CM, Modak RV, Macdonald F, Li F, Smyth DJ, Dorward DA, Blair N, Husovsky C, Muir A, Giampazolias E, Dobie R, Maizels RM, Kendall TJ, Griggs DW, Kopf M, Henderson NC, Zaiss DM*. (2019) A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation. Immunity 50:645-654
Zaiss DM* & Coffer PJ* (2018) Forkhead box transcription factors as context-dependent regulators of immune homeostasis. Nat Rev Immunol. 18: 703-15
Minutti CM, Blair N, Schwartz C, Drube S, Kamradt T, Sibilia M, Sijts AJ, Fallon PG, Maizels RM, Zaiss DM*. (2017) Epidermal growth factor receptor expression licenses Th2 cells to function in a TCR-independent way. Immunity 47:710-722
Minutti CM, Jackson-Jones LH, García-Fojeda B, Logan N, Rinqvist E, Guillamat-Prats R, Artigas A, Stamme C, Chroneos ZC, Zaiss DM, Casals C*, Allen JE.* (2017) Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver. Science 356: 1076-8
Zaiss DM*, Gause WC*, Osborne LC, Artis D* (2015) Emerging functions of Amphiregulin in orchestrating immunity, inflammation, and tissue repair. Immunity 42: 216-26
Zaiss DM*., van Loosdregt J., Gorlani A., Bekker CJ., Gröne A., Sibilia M., van Bergen en Henegouwen PM., Roovers RC, Coffer PJ, Sijts AJ. (2013) Amphiregulin enhances regulatory T cell suppressive function via the epidermal growth factor receptor. Immunity 38: 275-28
van Loosdregt J., Fleskens V., Tiemessen MM., van Boxtel R., Mokry M., Meerding J., Pals CE., Kurek D., Baert MR., Delemarre EM., Gröne A., Sijts AJ., Maurice MM., van Es JH., ten Berge D., Staal FJ., Zaiss DM., Prakken BJ., and Coffer PJ.* (2013) Canonical Wnt signaling negatively modulates T regulatory cell function. Immunity 39: 298-310
van Loosdregt J., Fleskens V., Fu J., Brenkman AB., Bekker CJ., Pals CE., Meerding J., Berkers CR., Barbi J., Gröne A., Sijts AJ., Maurice MM., Kalkhoven E., Prakken BJ., Ovaa H., Pan F., Zaiss DM., and Coffer PJ.* (2013) USP7/HAUSP mediated stabilization of FoxP3 increases Treg suppressive capacity. Immunity 39: 259-271
Zaiss DM, Yang L, Shah PR, Kobie JJ, Urban JF, Mosmann TR.* (2006) Amphiregulin, a TH2 cytokine enhancing resistance to nematodes. Science 314:1746.
Schubert D, Schmidt M, Zaiss D, Jungblut P, Kamradt T.* (2002) Autoantibodies against GPI and creatine kinase in rheumatoid arthritis. Nature Immunol. 3: 411