Impressive New Insights
- into fundamental molecular processes inside the cell,
- mechanisms of metastasis formation,
- immune responses upon allogeneic hematopoietic stem-cell transplantation,
- the interplay of tubular epithelia and interstitial cells of the kidney and the development of innovative therapeutic methods and tools
have been advanced by several DFG-funded Collaborative Research Centers/Transregios (CRC/TRR) coordinated at UR.
© UR | Photo: Julia Dragan
Exceptional Research @UR
The CRC/TRR 305 Striking a moving target: From mechanisms of metastatic organ colonization to novel systemic therapies investigates tumor progression and metastatic colonization dynamic processes.
What kind of genetic, epigenetic and functional armament do disseminated cancer cells use?
Answers provided to those questions are supporting the development of novel adjuvant therapies to prevent early metastatic colony formation and to eradicate candidate metastasis founders.
Allogeneic hematopoietic stem-cell transplantation is a curative treatment option for patients with high-risk leukemia and lymphoma and for some inherited or acquired hematopoietic deficiencies.
Scientists of the CRC/TRR 221 Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation develop and investigate innovative immune modulation strategies in order to enhance the safety and efficacy of life-saving stem-cell transplantation in the future.
The CRC/TRR 374 Tubule System and Interstitium of the Kidney: (Patho-) Physiology and Crosstalk is focusing on chronic kidney disease by investigating the diverse functions and interplay of tubular epithelia and interstitial cells.
The CRC’s current goal is to further deepen the knowledge of the (patho-) physiology of the tubular system and the renal interstitium, with a focus on developing new diagnostic and therapeutic strategies.
Mental health as an essential prerequisite for a high quality of life, performance, and social integration is explored at UR as well. The main objective of the Research Training Group (RTG) 2174 Neurobiology of social and emotional dysfunctions is to investigate the neurobiological mechanisms underlying mental disorders, such as anxiety disorders and major depression using appropriate laboratory animal models of impaired social interactions and emotionality.
PhD students are involved in translational research projects performed on molecular, genetic, epigenetic, cellular and systemic levels, and bridges three faculties and several UR institutes with the aim to contribute to the development of new treatment options.
In the ever-expanding realm of machine learning and medical research, Professor Merle Behr, Chair of Machine Learning at the University of Regensburg, stands at the intersection, connecting the dots between algorithms, diseases, and health care sector. Her commitment to collaboration, interpretability in algorithms, and bridging the gap between academia and industry showcases a visionary approach that promises to reshape the landscape of machine learning research in the years to come.
Physician scientist: Research in the field of stem cell transplantation, immuno-oncology
Project: "Reprogramming CD8+ T cell metabolism and fate by MSC mitochondrial transfer"
COGNITIVE CONTROL - How to outsmart ants
UR's researchers are developing immune and cell therapies to treat severe diseases.
New Head of the Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses IZI-BB
"Outstanding achievements in the field of synthetic immunology."
"My research focuses on the chorioallantoic membrane model, which enables investigating different tumor types and their growth."
Complex interconnections between neurons regulate social and emotional behavior under physiological and pathological conditions: In addition to neurons producing oxytocin (red), brain astrocytes (green), for example in the hypothalamus, are playing an important role in the development of psychopathologies
Courtesy of Inga Neumann © RTG 2174 Neurobiology of Socio-Emotional Dysfunctions, Carl-Philipp Meinung, PhD Thesis, 2021