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Publications of GRK Students

Alzahofi N, Welz T, Robinson CL, Page EL, Briggs DA, Stainthorp AK, Reekes J, Elbe DA, Straub F, Kallemeijn WW, Tate EW, Goff PS, Sviderskaya EV, Cantero M, Montoliu L, Nedelec F, Miles AK, Bailly M, Kerkhoff E, Hume AN (2020) Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins. Nat Commun 11:349510.1038/s41467-020-17212-6.

Anpilov S, Shemesh Y, Eren N, Harony-Nicolas H, Benjamin A, Dine J, Oliveira VEM, Forkosh O, Karamihalev S, Huttl RE, Feldman N, Berger R, Dagan A, Chen G, Neumann ID, Wagner S, Yizhar O, Chen A (2020) Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors. Neuron 107:644-655 e64710.1016/j.neuron.2020.05.028.

Bahr LM, Maurer F, Weigl J, Weber K, Melchner D, Dorfelt A, Wechsler TF, Bauer O, Reinders J, Milenkovic VM, Wetzel CH, Wetter TC, Rupprecht R, Muhlberger A, Nothdurfter C (2021) Dissociation of endocrine responses to the Trier Social Stress Test in Virtual Reality (VR-TSST) by the benzodiazepine alprazolam and the translocator protein 18 kDa (TSPO) ligand etifoxine. Psychoneuroendocrinology 124:10510010.1016/j.psyneuen.2020.105100.

Bauer O, Milenkovic VM, Hilbert S, Sarubin N, Weigl J, Bahr LM, Wetter TC, Heckel B, Wetzel CH, Rupprecht R, Nothdurfter C (2020) Association of Chemokine (C-C Motif) Receptor 5 and Ligand 5 with Recovery from Major Depressive Disorder and Related Neurocognitive Impairment. Neuroimmunomodulation 27:152-16210.1159/000513093.

Bludau A, Royer M, Meister G, Neumann ID, Menon R (2019) Epigenetic Regulation of the Social Brain. Trends Neurosci 42:471-48410.1016/j.tins.2019.04.001.

Bludau A, Neumann ID, Menon R (2023) HDAC1-mediated regulation of GABA signaling within the lateral septum facilitates long-lasting social fear extinction in male mice. Transl Psychiatry 13:10. doi: 10.1038/s41398-023-02310-y

Bosch OJ, Pohl TT, Neumann ID, Young LJ (2018) Abandoned prairie vole mothers show normal maternal care but altered emotionality: Potential influence of the brain corticotropin-releasing factor system. Behav Brain Res 341:114-12110.1016/j.bbr.2017.12.034.

Brunner LM, Maurer F, Weber K, Weigl J, Milenkovic VM, Rupprecht R, Nothdurfter C, Muhlberger A (2022) Differential effects of the translocator protein 18 kDa (TSPO) ligand etifoxine and the benzodiazepine alprazolam on startle response to predictable threat in a NPU-threat task after acute and short-term treatment. Psychopharmacology (Berl) 239:2233-224410.1007/s00213-022-06111-x.

Demarchi L, Pawluski JL, Bosch OJ (2021) The brain oxytocin and corticotropin-releasing factor systems in grieving mothers: What we know and what we need to learn. Peptides 143: 170593. https://doi.org/10.1016/j.peptides.2021.170593

Demarchi L, Sanson A, Bosch OJ (2023) Brief vs long maternal separation in lactating rats: consequences on maternal behavior, emotionality, and brain oxytocin receptor binding. J Neuronedocrinol e13252 doi.org/10.1111/jne.13252

Grund T, Neumann ID (2018) Neuropeptide S Induces Acute Anxiolysis by Phospholipase C-Dependent Signaling within the Medial Amygdala. Neuropsychopharmacology 43:1156-116310.1038/npp.2017.169.

Grund T, Neumann ID (2019) Brain neuropeptide S: via GPCR activation to a powerful neuromodulator of socio-emotional behaviors. Cell Tissue Res 375:123-13210.1007/s00441-018-2902-2.

Grund T, Goyon S, Li Y, Eliava M, Liu H, Charlet A, Grinevich V, Neumann ID (2017) Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis. J Neurosci 37:12214-1222510.1523/JNEUROSCI.2161-17.2017.

Grund T, Tang Y, Benusiglio D, Althammer F, Probst S, Oppenlander L, Neumann ID, Grinevich V (2019) Chemogenetic activation of oxytocin neurons: Temporal dynamics, hormonal release, and behavioral consequences. Psychoneuroendocrinology 106:77-8410.1016/j.psyneuen.2019.03.019.

Gryksa K, Neumann ID (2022) Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system. Psychoneuroendocrinology 135:10560110.1016/j.psyneuen.2021.105601.

Gryksa K, Mittmann L, Bauer A, Peterlik D, Flor PJ, Uschold-Schmidt N, Bosch OJ (2020) Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice. Genes Brain Behav 19:e1262710.1111/gbb.12627.

Gryksa K, Schmidtner AK, Masís-Calvo M, Rodríguez-Villagra OA, Havasi A, Wirobski G, Maloumby R, Jägle H, Bosch OJ, Slattery DA, Neumann ID (2023) Selective breeding of rats for high (HAB) and low (LAB) anxiety-related behaviour: A unique model for comorbid depression and social dysfunctions. Neurosci Biobehav Rev 152:105292. doi: 10.1016/j.neubiorev.2023.105292

Jurek B, Neumann ID (2018) The Oxytocin Receptor: From Intracellular Signaling to Behavior. Physiol Rev 98:1805-190810.1152/physrev.00031.2017.

Jurek B, Meyer M (2020) Anxiolytic and Anxiogenic? How the Transcription Factor MEF2 Might Explain the Manifold Behavioral Effects of Oxytocin. Front Endocrinol (Lausanne) 11:18610.3389/fendo.2020.00186.

Kuffner K, Triebelhorn J, Meindl K, Benner C, Manook A, Sudria-Lopez D, Siebert R, Nothdurfter C, Baghai TC, Drexler K, Berneburg M, Rupprecht R, Milenkovic VM, Wetzel CH (2020) Major Depressive Disorder is Associated with Impaired Mitochondrial Function in Skin Fibroblasts. Cells 9:88410.3390/cells9040884.

Leschik J, Gentile A, Cicek C, Péron S, Tevosian M, Beer A, Radyushkin K, Bludau A, Ebner K, Neumann ID, Singewald N, Berninger B, Lessmann V, Lutz B (2023) Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis. Prog Neurobiol 217:102333. doi: 10.1016/j.pneurobio.2022.102333

Levine SM, Pfaller M, Reichenberger J, Shiban Y, Muhlberger A, Rupprecht R, Schwarzbach JV (2018) Relating experimentally-induced fear to pre-existing phobic fear in the human brain. Soc Cogn Affect Neurosci 13:164-17210.1093/scan/nsx147.

Lukas M, Suyama H, Egger V (2019) Vasopressin Cells in the Rodent Olfactory Bulb Resemble Non-Bursting Superficial Tufted Cells and Are Primarily Inhibited upon Olfactory Nerve Stimulation. eNeuro 610.1523/ENEURO.0431-18.2019.

Martinetz S, Meinung CP, Jurek B, von Schack D, van den Burg EH, Slattery DA, Neumann ID (2019) De Novo Protein Synthesis Mediated by the Eukaryotic Elongation Factor 2 Is Required for the Anxiolytic Effect of Oxytocin. Biol Psychiatry 85:802-81110.1016/j.biopsych.2019.01.010.

Masis-Calvo M, Schmidtner AK, de Moura Oliveira VE, Grossmann CP, de Jong TR, Neumann ID (2018) Animal models of social stress: the dark side of social interactions. Stress 21:417-43210.1080/10253890.2018.1462327.

Menon R, Suss T, Oliveira VEM, Neumann ID, Bludau A (2022) Neurobiology of the lateral septum: regulation of social behavior. Trends Neurosci 45:27-4010.1016/j.tins.2021.10.010.

Menon R, Grund T, Zoicas I, Althammer F, Fiedler D, Biermeier V, Bosch OJ, Hiraoka Y, Nishimori K, Eliava M, Grinevich V, Neumann ID (2018) Oxytocin Signaling in the Lateral Septum Prevents Social Fear during Lactation. Curr Biol 28:1066-1078 e106610.1016/j.cub.2018.02.044.

Meyer M, Berger I, Winter J, Jurek B (2018) Oxytocin alters the morphology of hypothalamic neurons via the transcription factor myocyte enhancer factor 2A (MEF-2A). Mol Cell Endocrinol 477:156-16210.1016/j.mce.2018.06.013.

Meyer M, Kuffner K, Winter J, Neumann ID, Wetzel CH, Jurek B (2020) Myocyte Enhancer Factor 2A (MEF2A) Defines Oxytocin-Induced Morphological Effects and Regulates Mitochondrial Function in Neurons. Int J Mol Sci 2110.3390/ijms21062200.

Meyer M, Jurek B, Alfonso-Prieto M, Ribeiro R, Milenkovic VM, Winter J, Hoffmann P, Wetzel CH, Giorgetti A, Carloni P, Neumann ID (2022) Structure-function relationships of the disease-linked A218T oxytocin receptor variant. Mol Psychiatry 27:907-91710.1038/s41380-021-01241-8.

Muttenthaler M, Andersson A, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF (2017) Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Sci Signal 1010.1126/scisignal.aan3398.

Oliveira VEM, Neumann ID, de Jong TR (2019) Post-weaning social isolation exacerbates aggression in both sexes and affects the vasopressin and oxytocin system in a sex-specific manner. Neuropharmacology 156:10750410.1016/j.neuropharm.2019.01.019.

Oliveira VEM, Lukas M, Wolf HN, Durante E, Lorenz A, Mayer AL, Bludau A, Bosch OJ, Grinevich V, Egger V, de Jong TR, Neumann ID (2021) Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats. Nat Commun 12:290010.1038/s41467-021-23064-5.

Oliveira VEM, de Jong TR, Neumann ID (2022) Synthetic Oxytocin and Vasopressin Act Within the Central Amygdala to Exacerbate Aggression in Female Wistar Rats. Front Neurosci 16:906617. doi: 10.3389/fnins.2022.906617

Oliveira VEM, de Jong TR, Neumann ID (2022) Modelling sexual violence in male rats: the sexual aggression test (SxAT). Transl Psychiatry 12(1):207. doi: 10.1038/s41398-022-01973-3

Pandamooz S, Salehi MS, Jurek B, Meinung CP, Azarpira N, Dianatpour M, Neumann ID (2023) Oxytocin Receptor Expression in Hair Follicle Stem Cells: A Promising Model for Biological and Therapeutic Discovery in Neuropsychiatric Disorders. Stem Cell Rev Rep; doi: 10.1007/s12015-023-10603-4.

Pohl TT, Young LJ, Bosch OJ (2019) Lost connections: Oxytocin and the neural, physiological, and behavioral consequences of disrupted relationships. Int J Psychophysiol 136:54-6310.1016/j.ijpsycho.2017.12.011.

Pohl TT, Jung O, Di Benedetto B, Young LJ, Bosch OJ (2021) Microglia react to partner loss in a sex- and brain site-specific manner in prairie voles. Brain Behav Immun 96:168-18610.1016/j.bbi.2021.05.026.

Reichenberger J, Pfaller M, Muhlberger A (2020) Gaze Behavior in Social Fear Conditioning: An Eye-Tracking Study in Virtual Reality. Front Psychol 11:3510.3389/fpsyg.2020.00035.

Reichenberger J, Pfaller M, Forster D, Gerczuk J, Shiban Y, Muhlberger A (2019) Men Scare Me More: Gender Differences in Social Fear Conditioning in Virtual Reality. Front Psychol 10:161710.3389/fpsyg.2019.01617.

Roman C, Egert L, Di Benedetto B (2021) Astrocytic-neuronal crosstalk gets jammed: Alternative perspectives on the onset of neuropsychiatric disorders. Eur J Neurosci 54:5717-572910.1111/ejn.14900.

Royer M, Pai B, Menon R, Bludau A, Gryksa K, Perry RB, Ulitsky I, Meister G, Neumann ID (2022) Transcriptome and chromatin alterations in social fear indicate association of MEG3 with successful extinction of fear. Mol Psychiatry 10.1038/s41380-022-01481-2.

Salehi MS, Neumann ID, Jurek B, Pandamooz S (2021) Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size. Int J Mol Sci 22(16):8464. doi: 10.3390/ijms22168464

Sanson A, Bosch OJ (2022) Dysfunctions of brain oxytocin signaling: Implications for poor mothering. Neuropharmacology 211:10904910.1016/j.neuropharm.2022.109049.

Sanson A, Bosch OJ (2022) Dysfunctions of brain oxytocin signaling: Implications for poor mothering. Neuropharmacology 211: 109049. doi.org/10.1016/j.neuropharm.2022.109049

Schmidtner AK, Slattery DA, Glasner J, Hiergeist A, Gryksa K, Malik VA, Hellmann-Regen J, Heuser I, Baghai TC, Gessner A, Rupprecht R, Di Benedetto B, Neumann ID (2019) Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner. Transl Psychiatry 9:22310.1038/s41398-019-0556-9.

Seidel P, Levine SM, Tahedl M, Schwarzbach JV (2020) Temporal Signal-to-Noise Changes in Combined Multislice- and In-Plane-Accelerated Echo-Planar Imaging with a 20- and 64-Channel Coil. Sci Rep 10:553610.1038/s41598-020-62590-y.

Tang Y, Benusiglio D, Lefevre A, Hilfiger L, Althammer F, Bludau A, Hagiwara D, Baudon A, Darbon P, Schimmer J, Kirchner MK, Roy RK, Wang S, Eliava M, Wagner S, Oberhuber M, Conzelmann KK, Schwarz M, Stern JE, Leng G, Neumann ID, Charlet A, Grinevich V (2020) Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons. Nat Neurosci 23:1125-113710.1038/s41593-020-0674-y.

Triebelhorn J, Cardon I, Kuffner K, Bader S, Jahner T, Meindl K, Rothhammer-Hampl T, Riemenschneider MJ, Drexler K, Berneburg M, Nothdurfter C, Manook A, Brochhausen C, Baghai TC, Hilbert S, Rupprecht R, Milenkovic VM, Wetzel CH (2022) Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties. Mol Psychiatry 10.1038/s41380-022-01660-1.

Winter J, Jurek B (2019) The interplay between oxytocin and the CRF system: regulation of the stress response. Cell Tissue Res 375:85-9110.1007/s00441-018-2866-2.

Winter J, Meyer M, Berger I, Royer M, Bianchi M, Kuffner K, Peters S, Stang S, Langgartner D, Hartmann F, Schmidtner AK, Reber SO, Bosch OJ, Bludau A, Slattery DA, van den Burg EH, Jurek B, Neumann ID (2021) Chronic oxytocin-driven alternative splicing of Crfr2alpha induces anxiety. Mol Psychiatry 10.1038/s41380-021-01141-x.

Zoicas I, Muhle C, Schmidtner AK, Gulbins E, Neumann ID, Kornhuber J (2020) Anxiety and Depression Are Related to Higher Activity of Sphingolipid Metabolizing Enzymes in the Rat Brain. Cells 910.3390/cells9051239.