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• "Folding Mechanism of an Extremely Thermostable (βα)8-Barrel Enzyme: A High Kinetic Barrier Protects the Protein from Denaturation", Carstensen, Zoldák, Schmid, Sterner, 2012

  Publication

  HisF, the cyclase subunit of imidazole glycerol phosphate synthase (ImGPS) from Thermotoga maritima, is an extremely thermostable (beta...

  Publication on epub.uni-regensburg.de: "Folding Mechanism of an Extremely Thermostable (βα)8-Barrel Enzyme: A High Kinetic Barrier Protects the Protein from Denaturation" (external link, opens in a new window)

• "Conservation of the Folding Mechanism between Designed Primordial (βα)8-Barrel Proteins and Their Modern Descendant", Carstensen, Sperl, Bocola, List, Schmid, Sterner, 2012

  Publication

  The (beta alpha)(8)-barrel is among the most ancient, frequent, and versatile enzyme structures. It was proposed that modern (beta alpha)(8)-barrel...

  Publication on epub.uni-regensburg.de: "Conservation of the Folding Mechanism between Designed Primordial (βα)8-Barrel Proteins and Their Modern Descendant" (external link, opens in a new window)

• "Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments", Dietrich, Borst, Schlee, Schneider, Janda, Sterner, Merkl, 2012

  Publication

  The analysis of a multiple-sequence alignment (MSA) with correlation methods identifies pairs of residue positions whose occupation with amino acids...

  Publication on epub.uni-regensburg.de: "Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple sequence alignments" (external link, opens in a new window)

• "Establishing catalytic activity on an artificial (βα)8‐barrel protein designed from identical half‐barrels", Sperl, Rohweder, Rajendran, Sterner, 2013

  Publication

  It has been postulated that the ubiquitous (beta alpha)(8)-barrel enzyme fold has evolved by duplication and fusion of an ancestral (beta...

  Publication on epub.uni-regensburg.de: "Establishing catalytic activity on an artificial (βα)8‐barrel protein designed from identical half‐barrels" (external link, opens in a new window)

• "Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase", Schlee, Dietrich, Kurćon, Delaney, Goodey, Sterner, 2013

  Publication

  The (beta alpha)(8)-barrel enzyme indole-3-glycerol phosphate synthase (IGPS) catalyzes the multistep transformation of...

  Publication on epub.uni-regensburg.de: "Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase" (external link, opens in a new window)

• "Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template", Meier, Rajendran, Malisi, Fox, Xu, Schlee, Barondeau, Höcker, Sterner, Raushel, 2013

  Publication

  Rapid evolution of enzymes provides unique molecular insights into the remarkable adaptability of proteins and helps to elucidate the relationship...

  Publication on epub.uni-regensburg.de: "Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template" (external link, opens in a new window)

• "Evidence for the Existence of Elaborate Enzyme Complexes in the Paleoarchean Era", Reisinger, Sperl, Holinski, Schmid, Rajendran, Carstensen, Schlee, Blanquart, Merkl, Sterner, 2014

  Publication

  Due to the lack of macromolecular fossils, the enzymatic repertoire of extinct species has remained largely unknown to date. In an attempt to solve...

  Publication on epub.uni-regensburg.de: "Evidence for the Existence of Elaborate Enzyme Complexes in the Paleoarchean Era" (external link, opens in a new window)

• "Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors", Reisinger, Kuzmanovic, Löffler, Merkl, König, Sterner, 2014

  Publication

  The activity of the metabolic branch-point enzyme PriA from Mycobacterium tuberculosis (mtPriA) can be controlled reversibly by light. Two-pronged...

  Publication on epub.uni-regensburg.de: "Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors" (external link, opens in a new window)

• "A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization", Peterhoff, Beer, Rajendran, Kumpula, Kapetaniou, Guldan, Wierenga, Sterner, Babinger, 2014

  Publication

  Geranylgeranylglyceryl phosphate synthase (GGGPS) family enzymes catalyse the formation of an ether bond between glycerol-1-phosphate and polyprenyl...

  Publication on epub.uni-regensburg.de: "A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization" (external link, opens in a new window)

• "TrpB2 Enzymes are O-Phospho-l-serine Dependent Tryptophan Synthases", Busch, Rajendran, Mayans, Löffler, Merkl, Sterner, 2014

  Publication

  The rapid increase of the number of sequenced genomes asks for the functional annotation of the encoded enzymes. We used a combined...

  Publication on epub.uni-regensburg.de: "TrpB2 Enzymes are O-Phospho-l-serine Dependent Tryptophan Synthases" (external link, opens in a new window)