Search

Search results

• "Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology", Kneuttinger, Zwisele, Straub, Bruckmann, Busch, Kinateder, Gaim, Wysocki, Merkl, Sterner, 2019

  Publication

  The spatiotemporal control of enzymes by light is of growing importance for industrial biocatalysis. Within this context, the photo-control of...

  Publication on epub.uni-regensburg.de: "Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology" (external link, opens in a new window)

• "Quaternary Structure of the Tryptophan Synthase α-Subunit Homolog BX1 from Zea mays", Norris, Busch, Schupfner, Sterner, Wysocki, 2020

  Publication

  BX1 from Zea mays (zmBX1) is an enzyme of plant secondary metabolism that generates indole for the synthesis of plant defensins. It is a homologue of...

  Publication on epub.uni-regensburg.de: "Quaternary Structure of the Tryptophan Synthase α-Subunit Homolog BX1 from Zea mays" (external link, opens in a new window)

• "Significance of the Protein Interface Configuration for Allostery in Imidazole Glycerol Phosphate Synthase", Kneuttinger, Rajendran, Simeth, Bruckmann, König, Sterner, 2020

  Publication

  Imidazole glycerol phosphate synthase (ImGPS) from Thermotoga maritima is a model enzyme for studying allostery. The ImGPS complex consists of the...

  Publication on epub.uni-regensburg.de: "Significance of the Protein Interface Configuration for Allostery in Imidazole Glycerol Phosphate Synthase" (external link, opens in a new window)

• "Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase", Semmelmann, Straub, Nazet, Rajendran, Merkl, Sterner, 2019

  Publication

  Allosteric communication between different subunits in metabolic enzyme complexes is of utmost physiological importance but only understood for few...

  Publication on epub.uni-regensburg.de: "Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase" (external link, opens in a new window)

• "Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia", Semmelmann, Kabeya, Malcicka, Bruckmann, Broschwitz, Straub, Merkl, Monroig, Sterner, Ruther, Ellers, 2019

  Publication

  Insect pheromones are often derived from fatty acid metabolism. Fatty acid desaturases, enzymes introducing double bonds into fatty acids, are crucial...

  Publication on epub.uni-regensburg.de: "Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia" (external link, opens in a new window)

• "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases", Semmelmann, Hupfeld, Heizinger, Merkl, Sterner, 2019

  Publication

  The members of the glutamine amidotransferase (GATase) family catalyze the incorporation of ammonia within numerous metabolic pathways and can be...

  Publication on epub.uni-regensburg.de: "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases" (external link, opens in a new window)

• "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction", Schupfner, Straub, Busch, Merkl, Sterner, 2019

  Publication

  Tryptophan synthase (TS) is a heterotetrameric alpha beta beta alpha complex. It is characterized by the channeling of the reaction intermediate...

  Publication on epub.uni-regensburg.de: "Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction" (external link, opens in a new window)

• "Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase", Schlee, Klein, Schumacher, Nazet, Merkl, Steinhoff, Sterner, 2018

  Publication

  It is important to understand how the catalytic activity of enzymes is related to their conformational flexibility. We have studied this...

  Publication on epub.uni-regensburg.de: "Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase" (external link, opens in a new window)

• "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures", Linde, Heyn, Merkl, Sterner, Babinger, 2018

  Publication

  The cell membranes of all archaea contain ether lipids, and a number of archaea are hyperthermophilic. Consequently, the enzymes that catalyze the...

  Publication on epub.uni-regensburg.de: "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures" (external link, opens in a new window)

• "Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand", Kneuttinger, Winter, Simeth, Heyn, Merkl, König, Sterner, 2018

  Publication

  The artificial regulation of proteins by light is an emerging subdiscipline of synthetic biology. Here, we used this concept to photocontrol both...

  Publication on epub.uni-regensburg.de: "Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand" (external link, opens in a new window)