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• "Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase", Schlee, Dietrich, Kurćon, Delaney, Goodey, Sterner, 2013

  Publication

  The (beta alpha)(8)-barrel enzyme indole-3-glycerol phosphate synthase (IGPS) catalyzes the multistep transformation of...

  Publication on epub.uni-regensburg.de: "Kinetic Mechanism of Indole-3-glycerol Phosphate Synthase" (external link, opens in a new window)

• "Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template", Meier, Rajendran, Malisi, Fox, Xu, Schlee, Barondeau, Höcker, Sterner, Raushel, 2013

  Publication

  Rapid evolution of enzymes provides unique molecular insights into the remarkable adaptability of proteins and helps to elucidate the relationship...

  Publication on epub.uni-regensburg.de: "Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template" (external link, opens in a new window)

• "Evidence for the Existence of Elaborate Enzyme Complexes in the Paleoarchean Era", Reisinger, Sperl, Holinski, Schmid, Rajendran, Carstensen, Schlee, Blanquart, Merkl, Sterner, 2014

  Publication

  Due to the lack of macromolecular fossils, the enzymatic repertoire of extinct species has remained largely unknown to date. In an attempt to solve...

  Publication on epub.uni-regensburg.de: "Evidence for the Existence of Elaborate Enzyme Complexes in the Paleoarchean Era" (external link, opens in a new window)

• "Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors", Reisinger, Kuzmanovic, Löffler, Merkl, König, Sterner, 2014

  Publication

  The activity of the metabolic branch-point enzyme PriA from Mycobacterium tuberculosis (mtPriA) can be controlled reversibly by light. Two-pronged...

  Publication on epub.uni-regensburg.de: "Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors" (external link, opens in a new window)

• "A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization", Peterhoff, Beer, Rajendran, Kumpula, Kapetaniou, Guldan, Wierenga, Sterner, Babinger, 2014

  Publication

  Geranylgeranylglyceryl phosphate synthase (GGGPS) family enzymes catalyse the formation of an ether bond between glycerol-1-phosphate and polyprenyl...

  Publication on epub.uni-regensburg.de: "A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization" (external link, opens in a new window)

• "TrpB2 Enzymes are O-Phospho-l-serine Dependent Tryptophan Synthases", Busch, Rajendran, Mayans, Löffler, Merkl, Sterner, 2014

  Publication

  The rapid increase of the number of sequenced genomes asks for the functional annotation of the encoded enzymes. We used a combined...

  Publication on epub.uni-regensburg.de: "TrpB2 Enzymes are O-Phospho-l-serine Dependent Tryptophan Synthases" (external link, opens in a new window)

• "Activation of a chimeric Rpb5/RpoH subunit using library selection", Sommer, Waege, Pöllmann, Seitz, Thomm, Sterner, Hausner, 2014

  Publication

  Rpb5 is a general subunit of all eukaryotic RNA polymerases which consists of a N-terminal and a C-terminal domain. The corresponding archaeal subunit...

  Publication on epub.uni-regensburg.de: "Activation of a chimeric Rpb5/RpoH subunit using library selection" (external link, opens in a new window)

• "Conversion of Anthranilate Synthase into Isochorismate Synthase: Implications for the Evolution of Chorismate‐Utilizing Enzymes", Plach, Löffler, Merkl, Sterner, 2015

  Publication

  Chorismate-utilizing enzymes play a vital role in the biosynthesis of metabolites in plants as well as free-living and infectious microorganisms....

  Publication on epub.uni-regensburg.de: "Conversion of Anthranilate Synthase into Isochorismate Synthase: Implications for the Evolution of Chorismate‐Utilizing Enzymes" (external link, opens in a new window)

• "Functional Assignment of an Enzyme that Catalyzes the Synthesis of an Archaea-Type Ether Lipid in Bacteria", Guldan, Matysik, Bocola, Sterner, Babinger, 2011

  Publication

  Angewandte Chemie International Edition 10.1002/anie.201101832

  Publication on epub.uni-regensburg.de: "Functional Assignment of an Enzyme that Catalyzes the Synthesis of an Archaea-Type Ether Lipid in Bacteria" (external link, opens in a new window)

• "A Fast and Precise Approach for Computational Saturation Mutagenesis and its Experimental Validation by Using an Artificial (βα)8-Barrel Protein", Fischer, Seitz, Lochner, Sterner, Merkl, Bocola, 2011

  Publication

  We present a computational saturation mutagenesis protocol (CoSM) that predicts the impact on stability of all possible amino acid substitutions for a...

  Publication on epub.uni-regensburg.de: "A Fast and Precise Approach for Computational Saturation Mutagenesis and its Experimental Validation by Using an Artificial (βα)8-Barrel Protein" (external link, opens in a new window)