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• "[Hierarchies in the structure and function of oxygen-binding proteins]", Decker, Sterner, 1990

  Publication

  The structures of respiratory proteins such as hemoglobins and hemocyanins show obvious hierarchies. They belong to the class of allosteric...

  Publication on epub.uni-regensburg.de: "[Hierarchies in the structure and function of oxygen-binding proteins]" (external link, opens in a new window)

• "Retracing the Rapid Evolution of an Herbicide-Degrading Enzyme by Protein Engineering", Busch, Drexler, Mahato, Hiefinger, Osuna, Sterner, 2023

  Publication

  The mechanisms underlying the rapid evolution of novel enzymatic activities from promiscuous side activities are poorly understood. Recently emerged...

  Publication on epub.uni-regensburg.de: "Retracing the Rapid Evolution of an Herbicide-Degrading Enzyme by Protein Engineering" (external link, opens in a new window)

• "Improving enzyme functional annotation by integrating in vitro and in silico approaches: The example of histidinol phosphate phosphatases", Kinateder, Mayer, Nazet, Sterner, 2024

  Publication

  Advances in sequencing technologies have led to a rapid growth of public protein sequence databases, whereby the fraction of proteins with...

  Publication on epub.uni-regensburg.de: "Improving enzyme functional annotation by integrating in vitro and in silico approaches: The example of histidinol phosphate phosphatases" (external link, opens in a new window)

• "Conformational Modulation of a Mobile Loop Controls Catalysis in the (βα)8-Barrel Enzyme of Histidine Biosynthesis HisF", Hupfeld, Schlee, Wurm, Rajendran, Yehorova, Vos, Ravindra Raju, Kamerlin, Sprangers, Sterner, 2024

  Publication

  The overall significance of loop motions for enzymatic activity is generally accepted. However, it has largely remained unclear whether and how such...

  Publication on epub.uni-regensburg.de: "Conformational Modulation of a Mobile Loop Controls Catalysis in the (βα)8-Barrel Enzyme of Histidine Biosynthesis HisF" (external link, opens in a new window)

• "Photocontrolling the Enantioselectivity of a Phosphotriesterase via Incorporation of a Light-Responsive Unnatural Amino Acid", Hiefinger, Zinner, Fürtges, Narindoshvili, Schindler, Bruckmann, Rudack, Raushel, Sterner, 2025

  Publication

  The external control of catalytic activity and substrate specificity of enzymes by light has aroused great interest in the fields of biocatalysis and...

  Publication on epub.uni-regensburg.de: "Photocontrolling the Enantioselectivity of a Phosphotriesterase via Incorporation of a Light-Responsive Unnatural Amino Acid" (external link, opens in a new window)

• "Diversity of bacteria and archaea from two shallow marine hydrothermal vents from Vulcano Island", Antranikian, Suleiman, Schäfers, Adams, Bartolucci, Blamey, Birkeland, Bonch-Osmolovskaya, da Costa, Cowan, Danson, Forterre, Kelly, Ishino, Littlechild, Moracci, Noll, Oshima, Robb, Rossi, Santos, Schönheit, Sterner, Thauer, Thomm, Wiegel, Stetter, 2017

  Publication

  To obtain new insights into community compositions of hyperthermophilic microorganisms, defined as having optimal growth temperatures of 80 degrees C...

  Publication on epub.uni-regensburg.de: "Diversity of bacteria and archaea from two shallow marine hydrothermal vents from Vulcano Island" (external link, opens in a new window)

• "Rosetta:MSF: a modular framework for multi-state computational protein design", Merkl, Löffler, Schmitz, Hupfeld, Sterner, 2017

  Publication

  Computational protein design (CPD) is a powerful technique to engineer existing proteins or to design novel ones that display desired properties....

  Publication on epub.uni-regensburg.de: "Rosetta:MSF: a modular framework for multi-state computational protein design" (external link, opens in a new window)

• "Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase", Schlee, Klein, Schumacher, Nazet, Merkl, Steinhoff, Sterner, 2018

  Publication

  It is important to understand how the catalytic activity of enzymes is related to their conformational flexibility. We have studied this...

  Publication on epub.uni-regensburg.de: "Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase" (external link, opens in a new window)

• "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures", Linde, Heyn, Merkl, Sterner, Babinger, 2018

  Publication

  The cell membranes of all archaea contain ether lipids, and a number of archaea are hyperthermophilic. Consequently, the enzymes that catalyze the...

  Publication on epub.uni-regensburg.de: "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures" (external link, opens in a new window)

• "Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex", Wurm, Sung, Kneuttinger, Hupfeld, Sterner, Wilmanns, Sprangers, 2021

  Publication

  Imidazole glycerol phosphate synthase (HisFH) is a heterodimeric bienzyme complex operating at a central branch point of metabolism. HisFH is...

  Publication on epub.uni-regensburg.de: "Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex" (external link, opens in a new window)