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Research Area C

  

Research Area C includes projects on integrative topics of the tubulo-interstitium with a focus on the interactions between different cell types and (epi-) genetics.

 

C-projekte Engl 700x370

  

  


Project C2

Complement-mediated crosstalk between tubular and interstitial cells in renal transplantation - focus on the lectin-activated pathway

Prof. Dr. Kerstin Amann
Nephropathology
Friedrich-Alexander-Universität Erlangen-Nürnberg

PD Dr. Maike Büttner-Herold
Nephropathology
Friedrich-Alexander-Universität Erlangen-Nürnberg

Prof. Dr. Dr. Christoph Daniel
Nephropathology
Friedrich-Alexander-Universität Erlangen-Nürnberg

In this project, we will comprehensively characterize the activation of the complement pathway, in particular of the lectin pathway, during renal transplantation, with specific focus on the crosstalk of renal tubular epithelial cells and inflammatory cells. For this, we will use human renal biopsies and renal tissue from experimental studies in rats. Using either an inhibitory antibody directed against the activator of the lectin-activated complement pathway MASP-2, or a C5-blocker inhibiting the terminal route of all complement pathways, we aim to target complement activation to prevent graft deterioration and graft loss. In addition, interaction of various complement factors with renal tubular cells will be investigated in vitro.


Project C3

Endocrine communication of renal tubules

Prof. Dr. Frank Schweda
Physiology
Universität Regensburg

The kidneys are important endocrine organs. In addition to specialized endocrine cells, tubular cells also release autacoids and hormones, which act on adjacent cells of the tubules and the interstitium and thus influence kidney function. Our project aims at a better understanding of the regulation of tubular hormones and of their functional importance in the healthy and diseased kidney. Based on preliminary data, we will focus on the local, tubular renin-angiotensin system and tubular natriuretic peptides. Moreover, new tubular hormones, autacoids and metabolites will be identified and their functional significance will be clarified.


Project C4

Pathogenesis of Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD)

Prof. Dr. Michael Wiesener
Nephrology
Friedrich-Alexander-Universität Erlangen-Nürnberg

The most frequent form of ADTKD is caused by a specific frameshift mutation of the mucin 1 gene. Since the molecular consequences of this mutation leading to disease are unknown, our project intends to identify binding partners and study cellular effects of the frameshift mucin 1 protein in immortalized and primary tubular cells of affected patients. Kidney biopsies from ADTKD patients with different disease subforms will be studied by immunodetection and electron microscopy, in order to identify similarities but also differences. Finally, we will generate a mouse model that will induce an unfolded protein response (UPR) in the distal tubules, which may be a unifying feature of all subforms of ADTKD. This mouse model will be valuable to analyze pathomechanisms and investigate effects of drugs to inhibit UPR.


Project C5

Epigenetic identity and plasticity of renal tubular and interstitial cells

PD Dr. Dr. Johannes Schödel
Nephrology
Friedrich-Alexander-Universität Erlangen-Nürnberg

Disturbances in the homeostasis of kidney function, e.g. driven by hypoxic insults in acute or chronic kidney diseases, may lead to an epigenetic re-programing of transcriptional responses and cellular function. Hypoxia-inducible transcription factors (HIF) dictate expression of genes which are directly involved in modifying DNA or histone proteins, and activity of some of the chromatin modifying enzymes is dependent on the presence of oxygen. This project assesses the influence of hypoxia and HIF-stabilization on epigenetic factors in the normal kidney as well as during acute kidney injury.


Project C6

Prioritizing genes for kidney function decline in the population and high risk groups

Prof. Dr. Iris Heid
Genetic Epidemiology
Universität Regensburg

Prof. Dr. Carsten Boeger
Nephrology
Universität Regensburg and Hospital Traunstein

Genome-wide association studies (GWAS) and their meta-analyses (GWAMAs) are among the most successful approaches to identify genetic factors for multi-factorial diseases. Our overarching aim is the identification and characterization of the genetics of kidney function decline in general populations and high risk subgroups. Moreover, we will develop a systematic approach to join various kinds of information on “kidney genes” (e.g. condition- and disease-dependent gene and protein expression, pathways and regulation) into a tool for GenePrioritiSation (GPS). This web-based searchable GPS tool will provide a comprehensive body of information to researchers of CRC 1350 and to the public.

  1. Deutsche Forschungsgemeinschaft (DFG)
  2. Friedrich-Alexander Universität Erlangen-Nürnberg

MISSION

"Interdisciplinary kidney research to advance understanding of disease mechanisms and develop new therapeutic concepts"

 

Nierenzentrum REN

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Contact:
Dr. Michaela Kritzenberger
Email
Tel.: ++49 (0)941/943-2885
 

Nierenzentrum REN

Molecular Medicine