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Please note that it is mandatory to state the source of funding in publications:
„Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), project number 387509280, SFB 1350“. 

                    

2021

Zacharias HU, Altenbuchinger M, Schultheiss UT, Raffler J, Kotsis F, Ghasemi S, Ali I, Kollerits B, Metzger M, Steinbrenner I, Sekula P, Massy ZA, Combe C, Kalra PA, Kronenberg F, Stengel B, Eckardt KU, Köttgen A, Schmid M, Gronwald W, Oefner PJ; GCKD Investigators.
A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests.
Am J Kidney Dis. 2021 Jul 20:S0272-6386(21)00729-0. doi: 10.1053/j.ajkd.2021.05.018. Epub ahead of print. PMID: 34298143.
Pubmed

Forst AL, Reichold M, Kleta R, Warth R.
Distinct Mitochondrial Pathologies Caused by Mutations of the Proximal Tubular Enzymes EHHADH and GATM.
Front Physiol. 2021 Jul 19;12:715485.
Pubmed

Cabrita I, Benedetto R, Wanitchakool P, Lerias J, Centeio R, Ousingsawat J, Schreiber R, Kunzelmann K.
TMEM16A Mediates Mucus Production in Human Airway Epithelial Cells.
Am J Respir Cell Mol Biol. 2021 Jan;64(1):50-58. doi: 10.1165/rcmb.2019-0442OC. PMID: 33026825.
Pubmed

Benz K, Ferrazzi F, Galiano M, Sauerstein K, Vonbrunn E, Daniel C, Büttner-Herold M, Amann K.
Relevance of glomerular C4d deposition in pediatric patients with Henoch-Schönlein Purpura compared to IgA nephritis.
J Nephropathol. 2021;10(2):e16.DOI: 10.34172/jnp.2021.16.
Link

Pfister F, Vonbrunn E, Ries T, Jäck HM, Überla K, Lochnit G, Sheriff A, Herrmann M, Büttner-Herold M, Amann K, Daniel C.
Complement Activation in Kidneys of Patients With COVID-19.
Front Immunol. 2021 Jan 29;11:594849. doi: 10.3389/fimmu.2020.594849. PMID: 33584662; PMCID: PMC7878379.
PubMed

Amann K, Boor P, Wiech T, Singh J, Vonbrunn E, Knöll A, Hermann M, Büttner-Herold M, Daniel C, Hartmann A.
COVID-19-Auswirkungen auf die Niere [COVID-19 effects on the kidney].
Pathologe. 2021 Feb 1:1–5. German. doi: 10.1007/s00292-020-00899-1. Epub ahead of print. PMID: 33527157; PMCID: PMC7849614.
PubMed

Schmid F, Grigo C, Büttner-Herold M, von Hörsten S, Amann K, Daniel C.
CD161a-positive natural killer (NK) cells and α-smooth muscle actin-positive myofibroblasts were upregulated by extrarenal DPP4 in a rat model of acute renal rejection.
Diabetes Res Clin Pract. 2021 Feb 4:108691. doi: 10.1016/j.diabres.2021.108691. Epub ahead of print. PMID: 33549675.
PubMed

Ilyaskin AV, Korbmacher C, Diakov A.
Inhibition of the epithelial sodium channel (ENaC) by connexin 30 involves stimulation of clathrin-mediated endocytosis.
J Biol Chem. 2021 Feb 9:100404. doi: 10.1016/j.jbc.2021.100404. Epub ahead of print. PMID: 33577799.
PubMed

Schrankl J, Fuchs M, Broeker K, Daniel C, Kurtz A, Wagner C.
Localization of Angiotensin II Type 1 receptor gene expression in rodent and human kidneys.
Am J Physiol Renal Physiol. 2021 Feb 22. doi: 10.1152/ajprenal.00550.2020. Epub ahead of print. PMID: 33615887.
PubMed

Essigke D, Ilyaskin AV, Wörn M, Bohnert BN, Xiao M, Daniel C, Amann K, Birkenfeld AL, Szabo R, Bugge TH, Korbmacher C, Artunc F.
Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice.
Acta Physiol (Oxf). 2021 Mar 1:e13640. doi: 10.1111/apha.13640. Epub ahead of print. PMID: 33650216.
PubMed

Fuchs MAA, Broeker KAE, Schrankl J, Burzlaff N, Willam C, Wagner C, Kurtz A.
Inhibition of transforming growth factor β1 signaling in resident interstitial cells attenuates profibrotic gene expression and preserves erythropoietin production during experimental kidney fibrosis in mice.
Kidney Int. 2021 Mar 8:S0085-2538(21)00278-7. doi: 10.1016/j.kint.2021.02.035. Epub ahead of print. PMID: 33705825.
PubMed

Buerger K, Schmidt KN, Fokkema J, Gerritsen HC, Maier O, de Vries U, Zaytseva Y, Rachel R, Witzgall R.
On-section correlative light and electron microscopy of large cellular volumes using STEM tomography.
Methods Cell Biol. 2021;162:171-203. doi: 10.1016/bs.mcb.2020.09.002. Epub 2020 Oct 31. PMID: 33707012.
PubMed

Schlingmann KP, Renigunta A, Hoorn EJ, Forst AL, Renigunta V, Atanasov V, Mahendran S, Barakat TS, Gillion V, Godefroid N, Brooks AS, Lugtenberg D, Lake J, Debaix H, Rudin C, Knebelmann B, Tellier S, Rousset-Rouvière C, Viering D, deBaaij JHF, Weber S, Palygin O, Staruschenko A, Kleta R, Houillier P, Bockenhauer D, Devuyst O, Vargas-Poussou R, Warth R, Zdebik AA, Konrad M.
Defects in KCNJ16 Cause a Novel Tubulopathy with Hypokalemia, Salt Wasting, Disturbed Acid-Base Homeostasis, and Sensorineural Deafness.
J Am Soc Nephrol. 2021 Jun 1;32(6):1498-1512.
Pubmed

Geisberger S, Bartolomaeus H, Neubert P, Willebrand R, Zasada C, Bartolomaeus T, McParland V, Swinnen D, Geuzens A, Maifeld A, Krampert L, Vogl M, Mähler A, Wilck N, Marko L, Tilic E, Forslund SK, Binger KJ, Stegbauer J, Dechend R, Kleinewietfeld M, Jantsch J, Kempa S, Müller DN.
Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes.
Circulation. 2021 Apr 28. doi: 10.1161/CIRCULATIONAHA.120.052788. Epub ahead of print. PMID: 33906377.
PubMed

Jobin K, Müller DN, Jantsch J, Kurts C.
Sodium and its manifold impact on our immune system.
Trends Immunol. 2021 Jun;42(6):469-479. doi: 10.1016/j.it.2021.04.002. Epub 2021 May 4. PMID: 33962888.
PubMed

Steines L, Poth H, Schuster A, Amann K, Banas B, Bergler T.
Disruption of Tfh:B Cell Interactions Prevents Antibody-Mediated Rejection in a Kidney Transplant Model in Rats: Impact of Calcineurin Inhibitor Dose.
Front Immunol. 2021 May 31;12:657894. doi: 10.3389/fimmu.2021.657894. PMID: 34135891; PMCID: PMC8201497.
PubMed

Häckl M, Tauber P, Schweda F, Zacharias HU, Altenbuchinger M, Oefner PJ, Gronwald W.
An R-Package for the Deconvolution and Integration of 1D NMR Data: MetaboDecon1D. Metabolites. 2021 Jul 13;11(7):452. doi: 10.3390/metabo11070452. PMID: 34357346; PMCID: PMC8305572.
PubMed

Zacharias HU, Altenbuchinger M, Schultheiss UT, Raffler J, Kotsis F, Ghasemi S, Ali I, Kollerits B, Metzger M, Steinbrenner I, Sekula P, Massy ZA, Combe C, Kalra PA, Kronenberg F, Stengel B, Eckardt KU, Köttgen A, Schmid M, Gronwald W, Oefner PJ.

GCKD investigators. A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests.
Am J Kidney Dis. 2021 Jul 11:S0272-6386(21)00729-0. doi: 10.1053/j.ajkd.2021.05.018. Epub ahead of print. PMID: 34298143.
PubMed

Schuster AM, Miesgang N, Steines L, Bach C, Banas B, Bergler T.
B-cell activating factor BAFF as a novel alert marker for the immunological risk stratification after kidney transplantation.
Immunol Res. 2021 Aug 10. doi: 10.1007/s12026-021-09205-4. Epub ahead of print. PMID: 34373996.
PubMed
 


2020

    

Doevelaar AAN, Hölzer B, Seibert FS, Bauer F, Stervbo U, Rohn BJ, Zgoura P, Schenker P, Vonbrunn E, Amann K, Viebahn R, Babel N, Westhoff TH.
Lessons for the clinical nephrologist: recurrence of nephrotic syndrome induced by SARS-CoV-2.
J Nephrol. 2020 Dec;33(6):1369-1372. doi: 10.1007/s40620-020-00855-5. Epub 2020 Sep 5. PMID: 32892322; PMCID: PMC7474570.
PubMed

Weitzel A, Samol C, Oefner PJ, Gronwald W.
Robust Metabolite Quantification from J-Compensated 2D 1H-13C-HSQC Experiments.
Metabolites. 2020 Nov 7;10(11):E449. doi: 10.3390/metabo10110449. PMID: 33171777.  
PubMed

Westhoff TH, Seibert FS, Bauer F, Stervbo U, Anft M, Doevelaar AAN, Rohn BJ, Winnekendonk G, Dittmer U, Schenker P, Vonbrunn E, Amann K, Viebahn R, Babel N.
Allograft infiltration and meningoencephalitis by SARS-CoV-2 in a pancreas-kidney transplant recipient.
Am J Transplant. 2020 Nov;20(11):3216-3220. doi: 10.1111/ajt.16223. Epub 2020 Aug 30. PMID: 32713123.
PubMed

Gorski M, Jung B, Li Y, Matias-Garcia PR, Wuttke M, Coassin S, Thio CHL, Kleber ME, Winkler TW, Wanner V, Chai JF, Chu AY, Cocca M, Feitosa MF, Ghasemi S, Hoppmann A, Horn K, Li M, Nutile T, Scholz M, Sieber KB, Teumer A, Tin A, Wang J, Tayo BO, Ahluwalia TS, Almgren P, Bakker SJL, Banas B, Bansal N, Biggs ML, Boerwinkle E, Bottinger EP, Brenner H, Carroll RJ, Chalmers J, Chee ML, Chee ML, Cheng CY, Coresh J, de Borst MH, Degenhardt F, Eckardt KU, Endlich K, Franke A, Freitag-Wolf S, Gampawar P, Gansevoort RT, Ghanbari M, Gieger C, Hamet P, Ho K, Hofer E, Holleczek B, Xian Foo VH, Hutri-Kähönen N, Hwang SJ, Ikram MA, Josyula NS, Kähönen M, Khor CC, Koenig W, Kramer H, Krämer BK, Kühnel B, Lange LA, Lehtimäki T, Lieb W; Lifelines cohort study; Regeneron Genetics Center, Loos RJF, Lukas MA, Lyytikäinen LP, Meisinger C, Meitinger T, Melander O, Milaneschi Y, Mishra PP, Mononen N, Mychaleckyj JC, Nadkarni GN, Nauck M, Nikus K, Ning B, Nolte IM, O'Donoghue ML, Orho-Melander M, Pendergrass SA, Penninx BWJH, Preuss MH, Psaty BM, Raffield LM, Raitakari OT, Rettig R, Rheinberger M, Rice KM, Rosenkranz AR, Rossing P, Rotter JI, Sabanayagam C, Schmidt H, Schmidt R, Schöttker B, Schulz CA, Sedaghat S, Shaffer CM, Strauch K, Szymczak S, Taylor KD, Tremblay J, Chaker L, van der Harst P, van der Most PJ, Verweij N, Völker U, Waldenberger M, Wallentin L, Waterworth DM, White HD, Wilson JG, Wong TY, Woodward M, Yang Q, Yasuda M, Yerges-Armstrong LM, Zhang Y, Snieder H, Wanner C, Böger CA, Köttgen A, Kronenberg F, Pattaro C, Heid IM.
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.
Kidney Int. 2020 Oct 30:S0085-2538(20)31239-4. doi: 10.1016/j.kint.2020.09.030. Epub ahead of print. PMID: 33137338.
PubMed

Steines L, Poth H, Herrmann M, Schuster A, Banas B, Bergler T.
B Cell Activating Factor (BAFF) is Required for the Development of Intra-Renal Tertiary Lymphoid Organs in Experimental Kidney Transplantation in Rats.
Int J Mol Sci. 2020 Oct 28;21(21):E8045. doi: 10.3390/ijms21218045. PMID: 33126753.
Pubmed

Safi W, Kraus A, Grampp S, Schödel J, Buchholz B.
Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner.
J Mol Med (Berl). 2020 Sep 4. doi: 10.1007/s00109-020-01964-1.
Pubmed

Cabrita I, Kraus A, Scholz JK, Skoczynski K, Schreiber R, Kunzelmann K, Buchholz B.
Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo.
Nat Commun. 2020 Aug 28;11(1):4320. doi: 10.1038/s41467-020-18104-5.
Pubmed

Leppkes M, Knopf J, Naschberger E, Lindemann A, Singh J, Herrmann I, Stürzl M, Staats L, Mahajan A, Schauer C, Kremer AN, Völkl S, Amann K, Evert K, Falkeis C, Wehrfritz A, Rieker RJ, Hartmann A, Kremer AE, Neurath MF, Muñoz LE, Schett G, Herrmann M.
Vascular occlusion by neutrophil extracellular traps in COVID-19.
EBioMedicine. 2020 Aug;58:102925. doi: 10.1016/j.ebiom.2020.102925. Epub 2020 Jul 31. PMID: 32745993; PMCID: PMC7397705.
PubMed

Berg P, Svendsen S L, Sorensen M V,  Larsen C K, Andersen J F, Jensen-Fangel S, Jeppesen M, Schreiber R, Cabrita I, Kunzelmann K, Leipziger J.
Impaired Renal HCO3- Excretion in Cystic Fibrosis.
J Am Soc Nephrol. J Am Soc Nephrol. 2020 Aug;31(8):1711-1727.
Pubmed

Rachel R, Walther P, Maaßen C, Daberkow I, Matsuoka M, Witzgall R.
Dual-axis STEM tomography at 200 kV: setup, performance, limitations.
J Struct Biol. 2020;107551. doi:10.1016/j.jsb.2020.107551
Pubmed

Neubert P, Homann A, Wendelborn D, Bär AL, Krampert L, Trum M, Schröder A, Ebner S, Weichselbaum A, Schatz V, Linz P, Veelken R, Schulte-Schrepping J, Aschenbrenner AC, Quast T, Kurts C, Geisberger S, Kunzelmann K, Hammer K, Binger KJ, Titze J, Müller DN, Kolanus W, Schultze JL, Wagner S, Jantsch J.
NCX1 represents an ionic Na+ sensing mechanism in macrophages.
PLoS Biol. 2020 Jun 22;18(6):e3000722. doi: 10.1371/journal.pbio.3000722.
Pubmed

Broeker KAE, Fuchs MAA, Schrankl J, Kurt B, Nolan KA, Wenger RH, Kramann R, Wagner C, Kurtz A.
Different Subpopulations of Kidney Interstitial Cells Produce Erythropoietin and Factors Supporting Tissue Oxygenation in Response to Hypoxia in Vivo.
Kidney Int. 2020 May 23;S0085-2538(20)30542-1.doi: 10.1016/j.kint.2020.04.040.
PubMed

Cabrita I, Buchholz B, Schreiber R, Kunzelmann K.
TMEM16A Drives Renal Cyst Growth by Augmenting Ca 2+ Signaling in M1 Cells.
J Mol Med (Berl). 2020 May;98(5):659-671. doi: 10.1007/s00109-020-01894-y. Epub 2020 Mar 18.
PubMed

Pinto MC., Schreiber R,  Lerias J, Ousingsawat J, Duarte A,  Amaral M, Kunzelmann K.
Regulation of TMEM16A by CK2 and Its Role in  Cellular Proliferation. Cells. 2020 May 5;9(5): E1138. doi: 10.3390/cells9051138.
Pubmed

Amann K, Daniel C, Büttner-Herold M.
Das Komplementsystem – ein „hot topic“ nicht nur bei Nierenerkrankungen [The complement system-a "hot topic" not only for kidney diseases].
Pathologe. 2020 May;41(3):238-247. German. doi: 10.1007/s00292-020-00773-0. PMID: 32240352.
PubMed

Wiesener A, Knaup KX, Büttner-Herold M, Dieterle A, Stoeckert J, Riedl B, Morath C, Wald A, Vondran F, Braun F, Schödel J, Schueler M, Schiffer M, Amann K, Reis A, Kraus C, Wiesener MS.
Molecular diagnosis of kidney transplant failure based on urine.
Am J Transplant. 2020 May;20(5):1410-1416. doi: 10.1111/ajt.15738. Epub 2020 Jan 20.
Pubmed

Steines L, Poth H, Schuster A, Geissler EK, Amann K, Banas B, Bergler T. Anti-BAFF Treatment Interferes With Humoral Responses in a Model of Renal Transplantation in Rats.
Transplantation. 2020 Jan;104 (1):e16-e22. doi: 10.1097/TP.0000000000002992.
Pubmed

Morin M, Forst AL, Pérez-Torre P, Jiménez-Escrig A, Barca-Tierno V, García-Galloway E, Warth R, Lopez-Sendón Moreno JL, Moreno-Pelayo MA
Novel mutations in the KCNJ10 gene associated to a distinctive ataxia, sensorineural hearing loss and spasticity clinical phenotype.
Neurogenetics. 2020 Feb 15. doi: 10.1007/s10048-020-00605-6.
Pubmed

Penton D, Vohra T, Banki E, Wengi A, Weigert M, Forst AL, Bandulik S, Warth R, Loffing J.
Collecting system-specific deletion of Kcnj10 predisposes for thiazide- and low-potassium diet-induced hypokalemia.
Kidney Int. 2020 Jun;97(6):1208-1218.
Pubmed


2019

Fandrey J, Schödel J, Eckardt KU, Katschinski DM, Wenger RH.
Now a Nobel gas: oxygen.
Pflugers Arch. 2019 Nov 22. doi: 10.1007/s00424-019-02334-8. [Epub ahead of print] Review.
Pubmed

Lauer V, Grampp S, Platt J, Lafleur V, Lombardi O, Choudhry H, Kranz F, Hartmann A, Wullich B, Yamamoto A, Coleman ML, Ratcliffe PJ, Mole DR, Schödel J.
Hypoxia drives glucose transporter 3 expression through HIF-mediated induction of the long non-coding RNA NICI.
J Biol Chem. 2019 Nov 5. pii: jbc.RA119.009827. doi: 10.1074/jbc.RA119.009827. [Epub ahead of print]
Pubmed

Ousingsawat J, Schreiber R, Kunzelmann K.
TMEM16F/Anoctamin 6 in Ferroptotic Cell Death.
Cancers 2019, 11(5), 625; doi.org/10.3390/cancers11050625 (registering DOI)
Pubmed

Schödel J, Ratcliffe PJ.
Mechanisms of hypoxia signalling: new implications for nephrology.
Nat Rev Nephrol. 2019 Oct;15(10):641-659. doi: 10.1038/s41581-019-0182-z. Epub 2019 Sep 5. Review.
Pubmed

Kunzelmann K, Centeio R, Wanitchakool P, Cabrita I, Benedetto R, Saha T, Hoque KM, Schreiber R.
Control of Ion Transport by Tmem16a Expressed in Murine Intestine.
Front Physiol. 2019 Oct 4;10:1262. doi: 10.3389/fphys.2019.01262.
Pubmed

Tin A, Marten J, Halperin Kuhns VL, Li Y, Wuttke M, Kirsten H, Sieber KB, Qiu C, Gorski M, Yu Z, Giri A, Sveinbjornsson G, Li M, Chu AY, Hoppmann A, O'Connor LJ, Prins B, Nutile T, Noce D, Akiyama M, Cocca M, Ghasemi S, van der Most PJ, Horn K, Xu Y, Fuchsberger C, Sedaghat S, Afaq S, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boerwinkle E, Bottinger EP, Boutin TS, Brumat M, Burkhardt R, Campana E, Campbell A, Campbell H, Carroll RJ, Catamo E, Chambers JC, Ciullo M, Concas MP, Coresh J, Corre T, Cusi D, Felicita SC, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Delgado G, Demirkan A, Devuyst O, Dittrich K, Eckardt KU, Ehret G, Endlich K, Evans MK, Gansevoort RT, Gasparini P, Giedraitis V, Gieger C, Girotto G, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V; German Chronic Kidney Disease Study, Haller T, Hamet P, Harris TB, Hayward C, Hicks AA, Hofer E, Holm H, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Lewis RM, Ingelsson E, Jakobsdottir J, Jonsdottir I, Jonsson H, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kanai M, Kerr SM, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Krämer BK, Kronenberg F, Kubo M, Kühnel B, La Bianca M, Lange LA, Lehne B, Lehtimäki T; Lifelines Cohort Study, Liu J, Loeffler M, Loos RJF, Lyytikäinen LP, Magi R, Mahajan A, Martin NG, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Metspalu A, Milaneschi Y; V. A. Million Veteran Program, O'Donnell CJ, Wilson OD, Gaziano JM, Mishra PP, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Müller-Nurasyid M, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell JR, Olafsson I, Padmanabhan S, Penninx BWJH, Perls T, Peters A, Pirastu M, Pirastu N, Pistis G, Polasek O, Ponte B, Porteous DJ, Poulain T, Preuss MH, Rabelink TJ, Raffield LM, Raitakari OT, Rettig R, Rheinberger M, Rice KM, Rizzi F, Robino A, Rudan I, Krajcoviechova A, Cifkova R, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Salvi E, Schmidt H, Schmidt R, Shaffer CM, Smith AV, Smith BH, Spracklen CN, Strauch K, Stumvoll M, Sulem P, Tajuddin SM, Teren A, Thiery J, Thio CHL, Thorsteinsdottir U, Toniolo D, Tönjes A, Tremblay J, Uitterlinden AG, Vaccargiu S, van der Harst P, van Duijn CM, Verweij N, Völker U, Vollenweider P, Waeber G, Waldenberger M, Whitfield JB, Wild SH, Wilson JF, Yang Q, Zhang W, Zonderman AB, Bochud M, Wilson JG, Pendergrass SA, Ho K, Parsa A, Pramstaller PP, Psaty BM, Böger CA, Snieder H, Butterworth AS, Okada Y, Edwards TL, Stefansson K, Susztak K, Scholz M, Heid IM, Hung AM, Teumer A, Pattaro C, Woodward OM, Vitart V, Köttgen A.
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
Nat Genet. 2019 Oct;51(10):1459-1474. doi: 10.1038/s41588-019-0504-x. Epub 2019 Oct 2. PMID: 31578528; PMCID: PMC6858555.
PubMed

Teumer A, Li Y, Ghasemi S, Prins BP, Wuttke M, Hermle T, Giri A, Sieber KB, Qiu C, Kirsten H, Tin A, Chu AY, Bansal N, Feitosa MF, Wang L, Chai JF, Cocca M, Fuchsberger C, Gorski M, Hoppmann A, Horn K, Li M, Marten J, Noce D, Nutile T, Sedaghat S, Sveinbjornsson G, Tayo BO, van der Most PJ, Xu Y, Yu Z, Gerstner L, Ärnlöv J, Bakker SJL, Baptista D, Biggs ML, Boerwinkle E, Brenner H, Burkhardt R, Carroll RJ, Chee ML, Chee ML, Chen M, Cheng CY, Cook JP, Coresh J, Corre T, Danesh J, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Dittrich K, Divers J, Eckardt KU, Ehret G, Endlich K, Felix JF, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Gansevoort RT, Giedraitis V, Gögele M, Grundner-Culemann F, Gudbjartsson DF, Gudnason V, Hamet P, Harris TB, Hicks AA, Holm H, Foo VHX, Hwang SJ, Ikram MA, Ingelsson E, Jaddoe VWV, Jakobsdottir J, Josyula NS, Jung B, Kähönen M, Khor CC, Kiess W, Koenig W, Körner A, Kovacs P, Kramer H, Krämer BK, Kronenberg F, Lange LA, Langefeld CD, Lee JJ, Lehtimäki T, Lieb W, Lim SC, Lind L, Lindgren CM, Liu J, Loeffler M, Lyytikäinen LP, Mahajan A, Maranville JC, Mascalzoni D, McMullen B, Meisinger C, Meitinger T, Miliku K, Mook-Kanamori DO, Müller-Nurasyid M, Mychaleckyj JC, Nauck M, Nikus K, Ning B, Noordam R, Connell JO, Olafsson I, Palmer ND, Peters A, Podgornaia AI, Ponte B, Poulain T, Pramstaller PP, Rabelink TJ, Raffield LM, Reilly DF, Rettig R, Rheinberger M, Rice KM, Rivadeneira F, Runz H, Ryan KA, Sabanayagam C, Saum KU, Schöttker B, Shaffer CM, Shi Y, Smith AV, Strauch K, Stumvoll M, Sun BB, Szymczak S, Tai ES, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorsteinsdottir U, Tönjes A, Tremblay J, Uitterlinden AG, van der Harst P, Verweij N, Vogelezang S, Völker U, Waldenberger M, Wang C, Wilson OD, Wong C, Wong TY, Yang Q, Yasuda M, Akilesh S, Bochud M, Böger CA, Devuyst O, Edwards TL, Ho K, Morris AP, Parsa A, Pendergrass SA, Psaty BM, Rotter JI, Stefansson K, Wilson JG, Susztak K, Snieder H, Heid IM, Scholz M, Butterworth AS, Hung AM, Pattaro C, Köttgen A.
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.
Nat Commun. 2019 Sep 11;10(1):4130. doi: 10.1038/s41467-019-11576-0. PMID: 31511532; PMCID: PMC6739370.
PubMed

Altenbuchinger M, Zacharias HU, Solbrig S, Schäfer A, Büyüközkan M, Schultheiß UT, Kotsis F, Köttgen A, Spang R, Oefner P, Krumsiek J, Gronwald W.
A multi-source data integration approach reveals novel associations between metabolites and renal outcomes in the German Chronic Kidney Disease study.
Sci. Reports. 2019 9, 13954 doi: 10.1038/s41598-019-50346-2
Pubmed

Cabrita, I., Benedetto, R., Schreiber, R., Kunzelmann, K.
Niclosamide repurposed for the treatment of inflammatory airway disease.
JCI Insight. 2019 Aug 8;4(15). pii: 128414. doi: 10.1172/jci.insight.128414.
PubMed

Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, Tin A, Wang L, Chu AY, Hoppmann A, Kirsten H, Giri A, Chai JF, Sveinbjornsson G, Tayo BO, Nutile T, Fuchsberger C, Marten J, Cocca M, Ghasemi S, Xu Y, Horn K, Noce D, van der Most PJ, Sedaghat S, Yu Z, Akiyama M, Afaq S, Ahluwalia TS, Almgren P, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boehnke M, Boerwinkle E, Boissel M, Bottinger EP, Boutin TS, Brenner H, Brumat M, Burkhardt R, Butterworth AS, Campana E, Campbell A, Campbell H, Canouil M, Carroll RJ, Catamo E, Chambers JC, Chee ML, Chee ML, Chen X, Cheng CY, Cheng Y, Christensen K, Cifkova R, Ciullo M, Concas MP, Cook JP, Coresh J, Corre T, Sala CF, Cusi D, Danesh J, Daw EW, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Delgado G, Demirkan A, Di Angelantonio E, Dittrich K, Divers J, Dorajoo R, Eckardt KU, Ehret G, Elliott P, Endlich K, Evans MK, Felix JF, Foo VHX, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Friedlander Y, Froguel P, Gansevoort RT, Gao H, Gasparini P, Gaziano JM, Giedraitis V, Gieger C, Girotto G, Giulianini F, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V, Haller T, Hamet P, Harris TB, Hartman CA, Hayward C, Hellwege JN, Heng CK, Hicks AA, Hofer E, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Indridason OS, Ingelsson E, Ising M, Jaddoe VWV, Jakobsdottir J, Jonas JB, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kammerer CM, Kanai M, Kastarinen M, Kerr SM, Khor CC, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Kraja AT, Krajcoviechova A, Kramer H, Krämer BK, Kronenberg F, Kubo M, Kühnel B, Kuokkanen M, Kuusisto J, La Bianca M, Laakso M, Lange LA, Langefeld CD, Lee JJ, Lehne B, Lehtimäki T, Lieb W; Lifelines Cohort Study, Lim SC, Lind L, Lindgren CM, Liu J, Liu J, Loeffler M, Loos RJF, Lucae S, Lukas MA, Lyytikäinen LP, Mägi R, Magnusson PKE, Mahajan A, Martin NG, Martins J, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Melander O, Metspalu A, Mikaelsdottir EK, Milaneschi Y, Miliku K, Mishra PP; V. A. Million Veteran Program, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Mychaleckyj JC, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell J, O'Donoghue ML, Olafsson I, Oldehinkel AJ, Orho-Melander M, Ouwehand WH, Padmanabhan S, Palmer ND, Palsson R, Penninx BWJH, Perls T, Perola M, Pirastu M, Pirastu N, Pistis G, Podgornaia AI, Polasek O, Ponte B, Porteous DJ, Poulain T, Pramstaller PP, Preuss MH, Prins BP, Province MA, Rabelink TJ, Raffield LM, Raitakari OT, Reilly DF, Rettig R, Rheinberger M, Rice KM, Ridker PM, Rivadeneira F, Rizzi F, Roberts DJ, Robino A, Rossing P, Rudan I, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Sabanayagam C, Salomaa V, Salvi E, Saum KU, Schmidt H, Schmidt R, Schöttker B, Schulz CA, Schupf N, Shaffer CM, Shi Y, Smith AV, Smith BH, Soranzo N, Spracklen CN, Strauch K, Stringham HM, Stumvoll M, Svensson PO, Szymczak S, Tai ES, Tajuddin SM, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorleifsson G, Toniolo D, Tönjes A, Tremblay J, Tzoulaki I, Uitterlinden AG, Vaccargiu S, van Dam RM, van der Harst P, van Duijn CM, Velez Edward DR, Verweij N, Vogelezang S, Völker U, Vollenweider P, Waeber G, Waldenberger M, Wallentin L, Wang YX, Wang C, Waterworth DM, Bin Wei W, White H, Whitfield JB, Wild SH, Wilson JF, Wojczynski MK, Wong C, Wong TY, Xu L, Yang Q, Yasuda M, Yerges-Armstrong LM, Zhang W, Zonderman AB, Rotter JI, Bochud M, Psaty BM, Vitart V, Wilson JG, Dehghan A, Parsa A, Chasman DI, Ho K, Morris AP, Devuyst O, Akilesh S, Pendergrass SA, Sim X, Böger CA, Okada Y, Edwards TL, Snieder H, Stefansson K, Hung AM, Heid IM, Scholz M, Teumer A, Köttgen A, Pattaro C.
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
Nat Genet. 2019 Jun;51(6):957-972. doi: 10.1038/s41588-019-0407-x. Epub 2019 May 31. PMID: 31152163; PMCID: PMC6698888.
PubMed

Benedetto R, Ousingsawat J, Cabrita I, Pinto M, Lérias JR, Wanitchakool P, Schreiber R, Kunzelmann K.
Plasma membrane-localized TMEM16 proteins are indispensable for expression of CFTR.
J Mol Med (Berl). 2019 May;97(5):711-722. doi: 10.1007/s00109-019-01770-4. Epub 2019 Mar 26.
Pubmed

Bohnert BN, Daiminger S, Wörn M, Sure F, Staudner T, Ilyaskin AV, Batbouta F, Janessa A, Schneider JC, Essigke D, Kanse S, Haerteis S, Korbmacher C, Artunc F.
Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.
Acta Physiol (Oxf). 2019 Apr 21:e13286. doi: 10.1111/apha.13286. [Epub ahead of print]
Pubmed

Schrankl J, Neubauer B, Fuchs M, Gerl K, Wagner C, Kurtz A.
Apparently normal kidney development in mice with conditional disruption of ANGII-AT1 receptor genes in FoxD1 positive stroma cell precursors
Am J Physiol Renal Physiol 2019 Apr 10 doi: 10.1152/ajprenal.00305.2018
Pubmed

Kunzelmann K, Ousingsawat J, Benedetto R, Cabrita I, Schreiber R.
Contribution of Anoctamins to Cell Survival and Cell Death.
Cancers (Basel). 2019 Mar 19;11(3). pii: E382. doi: 10.3390/cancers11030382.
Pubmed

Zacharias HU, Altenbuchinger M, Schultheiss UT, Samol C, Kotsis F, Poguntke I, Sekula P, Krumsiek J, Köttgen A, Spang R, Oefner PJ, Gronwald W.
A novel metabolic signature to predict the requirement of dialysis or renal transplantation in patients with chronic kidney disease.
J Proteome Res. 2019 Feb 28. doi: 10.1021/acs.jproteome.8b00983. [Epub ahead of print]
Pubmed

Schreiber, R., Buchholz, B., Kraus, A., Schley, G., Scholz, J., Ousingsawat, J., Kunzelmann, K.
Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A.
J Am Soc Nephrol. 2019 Feb;30(2):228-242. doi: 10.1681/ASN.2018010039. Epub 2019 Jan 3.
PubMed



  1. Deutsche Forschungsgemeinschaft (DFG)
  2. Friedrich-Alexander Universität Erlangen-Nürnberg

MISSION

"Interdisciplinary kidney research to advance understanding of disease mechanisms and develop new therapeutic concepts"

 

Nierenzentrum REN

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Contact:
Dr. Michaela Kritzenberger
Email
Tel.: ++49 (0)941/943-2885
 

Nierenzentrum REN

Molecular Medicine