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Service Projects

 

Service Projects make state-of-the-art technologies available to all research projects of the Collaborative Research Centre.


Service Project Z1-2P

Intravital multiphoton microscopy

Prof. Dr. Hayo Castrop
Physiology
Universität Regensburg

The Service Project Z1 has the mission of providing an imaging service platform for the members of CRC 1350. The main focus of the Collaborative Research Center is on the function of the tubular system and the interstitium of the kidney, including the crosstalk between these compartments. Several projects will benefit from this state-of-the-art imaging method that facilitates studying simultaneously the renal structure and function in the live animal. Furthermore, our recently established method for serial imaging can be used to unravel structural and functional changes of the kidney in the same animal over prolonged periods of time.


Service Project Z1-EM

Electron microscopy

Prof. Dr. Ralph Witzgall
Molecular and Cellular Anatomy
Universität Regensburg

Prof. Dr. Reinhard Rachel
Center for Electron Microscopy
Universität Regensburg

We will support research groups with optimized sample preparation and imaging of kidney samples / cell cultures by electron microscopy analysis of ultra- and semithin sections, including immuno-labeling if requested, and also tomographic analysis and reconstruction. This will provide structural information within the sample in the nm range, in all dimensions. We will investigate samples by correlative (fluorescent) light and electron microscopy / tomography, including suitable sample preparation preserving the fluorescent label, with the goal of ultrastructural fine localization of the tagged molecule in 2D and in 3D, ultimately inside tomograms obtained by TEM or STEM tomography.


Service Project Z2

Proteome and metabolome analyses

PD Dr. Katja Dettmer-Wilde
Functional Genomics
Universität Regensburg

Prof. Dr. Wolfram Gronwald
Functional Genomics
Universität Regensburg

Prof. Dr. Peter Oefner
Functional Genomics
Universität Regensburg

The aim of Service Project Z2 is the comprehensive and quantitative analysis of proteomic and metabolomic alterations to unravel the molecular mechanisms of the renal (patho-) physiological processes. The service project provides analytical as well as bioinformatical and statistical expertise to the different projects of CRC 1350. For this, in accordance with our project partners, already established analytical and bioinformatic procedures will be further optimized and adapted. Employed experimental techniques are mainly based on hyphenated mass-spectrometry and NMR spectroscopy.

  1. FACULTY OF BIOLOGY AND PRECLINICAL MEDICINE
  2. FACULTY OF MEDICINE

Mission

"Interdisciplinary kidney research to advance understanding of disease mechanisms and develop new therapeutic concepts"

 

Nierenzentrum REN

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Contact:
Dr. Michaela Kritzenberger
Tel.: ++49 (0)941/943-2885
Fax: ++49 (0)941/943-2896

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