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• "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures", Linde, Heyn, Merkl, Sterner, Babinger, 2018

  Publication

  The cell membranes of all archaea contain ether lipids, and a number of archaea are hyperthermophilic. Consequently, the enzymes that catalyze the...

  Publication on epub.uni-regensburg.de: "Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures" (external link, opens in a new window)

• "Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand", Kneuttinger, Winter, Simeth, Heyn, Merkl, König, Sterner, 2018

  Publication

  The artificial regulation of proteins by light is an emerging subdiscipline of synthetic biology. Here, we used this concept to photocontrol both...

  Publication on epub.uni-regensburg.de: "Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand" (external link, opens in a new window)

• "The Discovery of N2,N2-Dimethylguanine Hydrolases Unravels General Molecular Principles of Enzyme Evolvability and Promiscuity", Drexler, Duran, Osuna, Sterner, 2026

  Publication

  The widespread use of xenobiotics has driven the rapid emergence of microbial degradation pathways. A prominent example is enzymes involved in the...

  Publication on epub.uni-regensburg.de: "The Discovery of N2,N2-Dimethylguanine Hydrolases Unravels General Molecular Principles of Enzyme Evolvability and Promiscuity" (external link, opens in a new window)

• "Quaternary Structure of the Tryptophan Synthase α-Subunit Homolog BX1 from Zea mays", Norris, Busch, Schupfner, Sterner, Wysocki, 2020

  Publication

  BX1 from Zea mays (zmBX1) is an enzyme of plant secondary metabolism that generates indole for the synthesis of plant defensins. It is a homologue of...

  Publication on epub.uni-regensburg.de: "Quaternary Structure of the Tryptophan Synthase α-Subunit Homolog BX1 from Zea mays" (external link, opens in a new window)

• "Significance of the Protein Interface Configuration for Allostery in Imidazole Glycerol Phosphate Synthase", Kneuttinger, Rajendran, Simeth, Bruckmann, König, Sterner, 2020

  Publication

  Imidazole glycerol phosphate synthase (ImGPS) from Thermotoga maritima is a model enzyme for studying allostery. The ImGPS complex consists of the...

  Publication on epub.uni-regensburg.de: "Significance of the Protein Interface Configuration for Allostery in Imidazole Glycerol Phosphate Synthase" (external link, opens in a new window)

• "Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase", Simeth, Kinateder, Rajendran, Nazet, Merkl, Sterner, König, Kneuttinger, 2020

  Publication

  Light regulation of drug molecules has gained growing interest in biochemical and pharmacological research in recent years. In addition, a serious...

  Publication on epub.uni-regensburg.de: "Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase" (external link, opens in a new window)

• "Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole", Fleming, Schupfner, Busch, Baslé, Ehrmann, Sterner, Mayans, 2018

  Publication

  Tryptophan synthase (TrpS) is a heterotetrameric alpha beta beta alpha enzyme that exhibits complex substrate channeling and allosteric mechanisms and...

  Publication on epub.uni-regensburg.de: "Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole" (external link, opens in a new window)

• "Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase", Semmelmann, Straub, Nazet, Rajendran, Merkl, Sterner, 2019

  Publication

  Allosteric communication between different subunits in metabolic enzyme complexes is of utmost physiological importance but only understood for few...

  Publication on epub.uni-regensburg.de: "Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase" (external link, opens in a new window)

• "Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia", Semmelmann, Kabeya, Malcicka, Bruckmann, Broschwitz, Straub, Merkl, Monroig, Sterner, Ruther, Ellers, 2019

  Publication

  Insect pheromones are often derived from fatty acid metabolism. Fatty acid desaturases, enzymes introducing double bonds into fatty acids, are crucial...

  Publication on epub.uni-regensburg.de: "Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia" (external link, opens in a new window)

• "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases", Semmelmann, Hupfeld, Heizinger, Merkl, Sterner, 2019

  Publication

  The members of the glutamine amidotransferase (GATase) family catalyze the incorporation of ammonia within numerous metabolic pathways and can be...

  Publication on epub.uni-regensburg.de: "A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases" (external link, opens in a new window)